scholarly journals Associations of Serum Lipids with Risk of Cognitive Impairment in Chinese Centenarians

2021 ◽  
Author(s):  
Yujian Chen ◽  
Ya Huang ◽  
ChaoXue Ning ◽  
Qiao Zhu ◽  
Yao Yao ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Cognitive Functions ◽  
Serum Lipids ◽  
Low Density Lipoprotein ◽  
Multiple Logistic Regression Analysis ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Inverse Association ◽  
Cross Sectional ◽  
Low Hdl

Abstract Background Dyslipidaemia and cognitive impairment are common in old adults and risks of both of them increase with increasing age. However, the relationship between lipids and cognitive impairment in longevous people is still unclear. This study aimed to assess the association between serum lipids and cognitive impairment in Chinese centenarians. Methods In a cross-sectional study, total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) were biochemically measured in 924 centenarians and cognitive functions were evaluated. Multiple logistic regression analysis was used to examine the associations of lipids with cognitive impairment and the risks for cognitive impairment associated with quartile of serum lipid concentrations. Results The results demonstrated HDL-C was an independent beneficial factor for cognitive impairment after controlling for the potential covariates (Odds ratio, OR = 0.350, 95% Confidence interval, CI = 0.159–0.774; P = 0.009). An inverse association of HDL-C with cognitive impairment was found (P for trend = 0.001) and the association remained significant after adjusting for possible cofounders (P for trend = 0.012). The OR of cognitive impairment for the lowest versus highest quartiles of HDL-C was 1.96 (95%CI, 1.09–3.45). Conclusions The results indicated that low HDL-C is likely to be harmful for cognitive functions in centenarians. The cognitive function of longevous persons with low HDL-C concentrations deserves more attention.

scholarly journals Associations of Serum Lipids With Risk of Cognitive Impairment in Chinese Centenarians

2021 ◽  
Author(s):  
Yujian Chen ◽  
Ya Huang ◽  
ChaoXue Ning ◽  
Qiao Zhu ◽  
Yao Yao ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Cognitive Functions ◽  
Serum Lipids ◽  
Low Density Lipoprotein ◽  
Multiple Logistic Regression Analysis ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Inverse Association ◽  
Cross Sectional ◽  
Low Hdl

Abstract Background: Dyslipidaemia and cognitive impairment are common in old adults and risks of both of them increase with increasing age. However, the relationship between lipids and cognitive impairment in longevous people is still unclear. This study aimed to assess the association between serum lipids and cognitive impairment in Chinese centenarians.Methods: In a cross-sectional study , total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) were biochemically measured in 924 centenarians and cognitive functions were evaluated. Multiple logistic regression analysis was used to examine the associations of lipids with cognitive impairment and the risks for cognitive impairment associated with quartile of serum lipid concentrations.Results: The results demonstrated HDL-C was an independent beneficial factor for cognitive impairment after controlling for the potential covariates (Odds ratio, OR=0.350, 95% Confidence interval, CI=0.159–0.774; P=0.009). An inverse association of HDL-C with cognitive impairment was found (P for trend=0.001) and the association remained significant after adjusting for possible cofounders (P for trend =0.012). The OR of cognitive impairment for the lowest versus highest quartiles of HDL-C was 1.96 (95%CI, 1.09–3.45).Conclusions: The results indicated that low HDL-C is likely to be harmful for cognitive functions in centenarians. The cognitive function of longevous persons with low HDL-C concentrations deserves more attention.

scholarly journals High prevalence of dyslipidaemia subtypes and their associated personal and clinical attributes in Malaysian adults: the REDISCOVER study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Mohamed-Syarif Mohamed-Yassin ◽  
Noorhida Baharudin ◽  
Aqil Mohammad Daher ◽  
Najmin Abu Bakar ◽  
Anis Safura Ramli ◽  
...  
Keyword(s):  
Low Density Lipoprotein ◽  
Management Strategies ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Cross Sectional ◽  
Main Driver ◽  
Low Hdl ◽  
History Of ◽  
A Prospective Study ◽  
Lipid Abnormalities

Abstract Background Dyslipidaemia refers to lipid abnormalities consisting of either one or any combination of the following: elevated total cholesterol (TC), elevated low-density lipoprotein cholesterol (LDL-c), elevated triglycerides (TG), and low high-density lipoprotein cholesterol (HDL-c). The prevalence of hypercholesterolaemia is steadily increasing in Malaysia. However, data on the prevalence of dyslipidaemia subtypes among Malaysians are lacking. This is important as it may have implications for preventive and management strategies for this increasing public health challenge. This study is aimed at determining the prevalence of dyslipidaemia subtypes and their associated personal and clinical attributes in Malaysians. Methods REDISCOVER, a prospective study, enrolled 11,288 adults where sociodemographic data, anthropometric and blood pressure measurements, fasting lipid profile and glucose, and history of diabetes, hypertension, and smoking were obtained. The cross-sectional analytic sample presented in this article comprised 10,482 participants from baseline recruitment. The data was analysed by descriptive statistics and multivariable logistic regression. Results The overall prevalence of elevated TC, elevated LDL-c, elevated TG, low HDL-c, and elevated non-HDL-c were 64.0% (95% CI 63.0–65.0), 56.7% (CI 55.7–57.7), 37.4% (CI 36.5–38.4), 36.2% (CI 35.2–37.1), and 56.2% (CI 55.3–57.2), respectively. Overweight, obesity, and central obesity were highly prevalent and significantly associated with elevated TC and all dyslipidaemia subtypes. Older age was associated with elevated TC, elevated LDL-c and elevated non-HDL-c. Hypertension was associated with elevated TC, elevated TG, and elevated non-HDL-c, while diabetes was associated with elevated TG and low HDL-c. Conclusions Elevated TC and all dyslipidaemia subtypes are highly prevalent in Malaysia where increased body mass seems the main driver. Differences in the prevalence and associated personal and clinical attributes may facilitate specific preventive and management strategies.

6-Year trends in lipids among adults in Shenzhen, China

2019 ◽  
Vol 42 (4) ◽  
pp. e468-e476 ◽  
Author(s):  
Xueli Yuan ◽  
Wenqing Ni ◽  
Rui Wang ◽  
Hongshan Chi ◽  
Yuanying Sun ◽  
...  
Keyword(s):  
Low Density Lipoprotein ◽  
Multivariate Logistic Regression Analysis ◽  
Density Lipoprotein ◽  
Blood Lipid ◽  
Current Smoker ◽  
Lipoprotein Cholesterol ◽  
Chi Square ◽  
Cross Sectional ◽  
Low Hdl ◽  
Chi Square Test

Abstract Background There may be a beneficial effect on lipid levels in Shenzhen in recent years. In this study, we aimed to examine trends in serum lipids in population in Shenzhen between 2009 and 2015. Methods We enrolled 2210 adults aged 18–70 years from two independent cross-sectional studies conducted in 2009 and 2015. Blood lipid profiles, such as total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C), were measured. Chi-square test, t-test and multivariate logistic regression analysis were applied for data analysis. Results From 2009 to 2015, mean LDL-C declined from 3.05 ± 0.76 mmol/L in 2009 to 2.27 ± 0.75 mmol/L in 2015 (P < 0.001). Similarly, a significant 7.09% decrease in the prevalence of high LDL-C was observed over the same period (P < 0.001). There was an increasing trend in the prevalence of low HDL-C among adults in Shenzhen (P < 0.001). A no-significant increase in prevalence of dyslipidemia was also observed over this 6-year interval (P = 0.139). The prevalence of dyslipidemia was closely related with increasing age, male gender, current smoker, diabetes, obesity and overweight. Conclusion This study shows a favourable downward trend in LDL-C concentration in Shenzhen. However, more intense strategies are needed to control dyslipidemia.

scholarly journals Dyslipidemia and Associated Risk Factors among Nigerians with Hypertension

2020 ◽  
Vol 3 (4) ◽  
pp. 155-161
Author(s):  
Olufisayo Gabriel Ayoade ◽  
Idongesit Umoh ◽  
Collins Amadi
Keyword(s):  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Tertiary Hospital ◽  
High Plasma ◽  
Cross Sectional Study ◽  
Lipoprotein Cholesterol ◽  
Atherosclerotic Cardiovascular Disease ◽  
Cross Sectional ◽  
Hypertensive Patients ◽  
Low Hdl

<b><i>Background:</i></b> Abnormalities in serum lipids and lipoprotein levels with essential hypertension are vital independent causal factors for atherosclerotic cardiovascular disease (ASCVD). The coexistence of these factors has a synergistic effect in heightening the risk of cardiovascular events. The aim of the study was to evaluate the pattern of dyslipidemia among hypertensives and to determine some of its correlations in patients attending a tertiary hospital in South South Nigeria. <b><i>Methods:</i></b> This was a cross-sectional study conducted on 544 eligible hypertensive patients attending the Cardiology Clinic, University of Uyo Teaching Hospital (UUTH), Uyo, Nigeria, over a period of 6 months. Fasting lipids, total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) were evaluated. <b><i>Results:</i></b> Overall, 60.0% of the hypertensive patients had dyslipidemia, with 43.4.0% having high TC, 30.3% high LDL-C, 20.8% elevated TG, and 12.9% low HDL-C, respectively. There was a significant relationship between gender and lipoproteins, with women having significantly higher lipoproteins (TC, HDL-C, LDL-C, and non-HDL-C) than men. Women also had more measures of obesity with a higher body mass index and waist circumference. TC and non-HDL had a significant association with both systolic and diastolic blood pressure (BP). Altogether, 43.4% of the hypertensives had poorly controlled BP and significantly higher atherogenic lipoproteins (TC, LDL-C, and non-HDL-C). <b><i>Conclusion:</i></b> This study has demonstrated the relatively high prevalence of dyslipidemia among hypertensive patient in this population. High plasma TC is the most dominant pattern of dyslipidemia. Hypertensive patients with poorly controlled BP have worse atherogenic lipoprotein values and are more likely predisposed to ASCVD.

scholarly journals Decreased Serum Lipids in Patients with Probable Alzheimer´s Disease

2009 ◽  
Vol 9 (3) ◽  
pp. 215-220 ◽  
Author(s):  
Orhan Lepara ◽  
Amina Valjevac ◽  
Azra Alajbegović ◽  
Asija Zaćiragić ◽  
Emina Nakaš-Ićindić
Keyword(s):  
Total Cholesterol ◽  
Serum Lipids ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Epidemiologic Studies ◽  
Lipoprotein Cholesterol ◽  
Initial Assessment ◽  
Control Group ◽  
Cross Sectional ◽  
Control Subjects

Alzheimer’s disease (AD) is a multifactorial disease but its aetiology and pathophisiology are still not fully understood. Epidemiologic studies examining the association between lipids and dementia have reported conflicting results. High total cholesterol has been associated with both an increased, and decreased, risk of AD and/or vascular dementia (VAD), whereas other studies found no association. The aim of this study was to investigate the serum lipids concentration in patients with probable AD, as well as possible correlation between serum lipids concentrations and cognitive impairment.Our cross-sectional study included 30 patients with probable AD and 30 age and sex matched control subjects. The probable AD was clinically diagnosed by NINCDS-ADRDA criteria. Serum total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C) and triglyceride (TG) levels were determined at the initial assessment using standard enzymatic colorimetric techniques. Low-den- sity lipoprotein cholesterol (LDL-C) and very low density lipoprotein cholesterol (VLDL-C) levels were calculated. Subjects with probable AD had significantly lower serum TG (p<0,01), TC (p<0,05), LDL-C (p<0,05) and VLDL-C (p<0,01) compared to the control group. We did not observe signifi-cant difference in HDL-C level between patients with probable AD and control subjects. Negative, although not significant correlation between TG, TC and VLDL-C and MMSE in patients with AD was observed. In the control group of subjects there was a negative correlation between TC and MMSE but it was not statistically significant (r = -0,28). Further studies are required to explore the possibility for serum lipids to serve as diagnostic and therapeutic markers of AD.

scholarly journals Prevalence of Dyslipidemia in Students from Han, Uygur, and Kazakh Ethnic Groups in a Medical University in Xinjiang, China

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Jialin Abuzhalihan ◽  
Yong-Tao Wang ◽  
Dilare Adi ◽  
Yi-Tong Ma ◽  
Zhen-Yan Fu ◽  
...  
Keyword(s):  
Ethnic Groups ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Normal Weight ◽  
Overweight And Obesity ◽  
Lipoprotein Cholesterol ◽  
Cross Sectional ◽  
High Tc ◽  
Low Hdl ◽  
Medical University

AbstractIn the present study, we aimed to evaluate the prevalence of dyslipidemia in students from different ethnic groups in Xinjiang. It is an observational, cross-sectional study. The sample of 7096 students aged 21–25 years was randomly selected from the clinic of Xinjiang Medical University. Baseline data, serum concentration of total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C) and fasting plasma glucose (FPG) were reported. The prevalence of changes in lipid profile according to Body mass index (BMI) in three ethnic groups was calculated. Compared with Han and Uygur students, TC, LDL-C, TG and FPG levels were lower in kazakh sutdents, while HDL-C level was lower in Uygur students. The prevalence of high TC change was higher in Uygur students, and high LDL-C change was higher in Han students. The prevalence of low HDL-C change was higher in Uygur students, and high TG change was lower in Kazakh students. The prevalence of high TC, LDL-C, TG and low HDL-C changes was observed in normal weight, overweight and obesity groups according to the nutritional status by BMI among students of each ethnic group. The present study demonstrated the prevalence of dyslipidemia in students from different ethnic groups, and enriched the limited data on the early prevention and treatment of dyslipidemia and cardiovascular diseases in Xinjiang medical students crowd.

scholarly journals Prediction of Cardiorespiratory Fitness in Czech Adults: Normative Values and Association with Cardiometabolic Health

2021 ◽  
Vol 18 (19) ◽  
pp. 10251
Author(s):  
Geraldo A. Maranhao Neto ◽  
Iuliia Pavlovska ◽  
Anna Polcrova ◽  
Jeffrey I. Mechanick ◽  
Maria M. Infante-Garcia ◽  
...  
Keyword(s):  
Cardiorespiratory Fitness ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Cross Sectional Study ◽  
Normative Values ◽  
Cardiometabolic Health ◽  
Inverse Association ◽  
Cross Sectional ◽  
Low Hdl ◽  
The Impact

Cardiorespiratory fitness (CRF) is a strong independent predictor of morbidity and mortality. However, there is no recent information about the impact of CRF on cardiometabolic risk specifically in Central and Eastern Europe, which are characterized by different biological and social determinants of health. In this cross-sectional study normative CRF values were proposed and the association between CRF and cardiometabolic outcomes was evaluated in an adult Czechian population. In 2054 participants (54.6% females), median age 48 (IQR 19 years), the CRF was predicted from a non-exercise equation. Multivariable-adjusted logistic regressions were carried out to determine the associations. Higher CRF quartiles were associated with lower prevalence of hypertension, type 2 diabetes (T2D) and dyslipidemia. Comparing subjects within the lowest CRF, we see that those within the highest CRF had decreased chances of hypertension (odds ratio (OR) = 0.36; 95% CI: 0.22–0.60); T2D (OR = 0.16; 0.05–0.47), low HDL-c (OR = 0.32; 0.17–0.60), high low-density lipoprotein (OR = 0.33; 0.21–0.53), high triglycerides (OR = 0.13; 0.07–0.81), and high cholesterol (OR = 0.44; 0.29–0.69). There was an inverse association between CRF and cardiometabolic outcomes, supporting the adoption of a non-exercise method to estimate CRF of the Czech population. Therefore, more accurate cardiometabolic studies can be performed incorporating the valuable CRF metric.

scholarly journals Prevalence of and Trends for Dyslipidemia among Pilots from one Airline in China

2019 ◽  
Vol 7 (1) ◽  
pp. 18-22
Author(s):  
Tiebing Liu ◽  
Bing Qiu ◽  
Jinling Zheng ◽  
Chanyuan Zhang ◽  
Yanmin Qi ◽  
...  
Keyword(s):  
Southwest China ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Cross Sectional Study ◽  
Lipoprotein Cholesterol ◽  
Low Density Lipoprotein Cholesterol ◽  
Cross Sectional ◽  
High Tc ◽  
Low Hdl ◽  
Linear Trends

ntroduction: Most of previous studies on dyslipidemia among pilots were cross-sectional surveys which cannot explore the temporal trend of dyslipidemia, and these studies were normally conducted at least five years ago. In addition, studies focusing on pilots in Southwest China are scarce. This study aimed to describe the prevalence of and trends in dyslipidemia among pilots from an airline in Southwest China. Methods: This cross-sectional study evaluated the prevalence of adverse concentrations of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglycerides (TG) among all pilots from one airline in Southwest China in 2015. Analyses of linear trends in age-adjusted prevalence of dyslipidemia were conducted overall across a 3-year period (2013, 2014, and 2015). Results: In 2015, 3.4% of participating pilots had a high TC concentration, 16.4% had a high TG concentration, 2.6% had a high LDL-C concentration, 25.1% had a low HDL-C concentration, and 33.1% had dyslipidemia. Between 2013 and 2015, there were decreasing linear trends in age-adjusted prevalence of high TG (32% vs. 19.9%; P<0.001) and dyslipidemia (51.9% vs. 38.4%; P<0.001). During this 3-year period, declining trends were also observed in age-adjusted prevalence of LDL-C (10.0% vs. 4%; P<0.001) and HDL-C (33.2% vs. 28.3%; P=0.015). However, there was no change from 2013 to 2015 in age-adjusted prevalence of high TC (2.8% vs. 5.0%; P=0.168). Conclusion: From 2013 to 2015, there were favorable trends in the prevalence of high TG, low HDL-C, high LDL-C, and overall dyslipidemia but no significant change in high TC among pilots from one airline in southwest China. The reasons for these trends need to be further explored.

Association of Circulating Cholesterol Level with Cognitive Function and Mild Cognitive Impairment in the Elderly: A Community-based Population Study

2020 ◽  
Vol 17 (6) ◽  
pp. 556-565
Author(s):  
Yujie Guo ◽  
Pengfei Li ◽  
Xiaojun Ma ◽  
Xiaochen Huang ◽  
Zhuoheng Liu ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Cognitive Function ◽  
Cholesterol Level ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Cross Sectional ◽  
Increased Risk ◽  
Aging Adults ◽  
Female Subjects

Background: The present study was designed to examine the association of circulating cholesterol with cognitive function in non-demented community aging adults. Methods: This was a cross-sectional study including 1754 Chinese adults aged 55-80 years. The association between serum cholesterol levels and cognitive function was examined. Participants were categorized into four groups according to the quartile of circulating TC (total cholesterol), High Density Lipoprotein Cholesterol (HDL-c), Low Density Lipoprotein Cholesterol (LDL-c) levels and HDLc/ LDL-c ratio. The difference in cognitive performance among the groups was compared. Logistic regression model was used to determine the association of circulating cholesterol level with the risk of Mild Cognitive Impairment (MCI). Results: Mild increase of serum LDL-c level correlated with better visual and executive, language, memory and delayed recall abilities. Higher circulating TC and HDL-c levels were found to be associated with poorer cognitive function, especially in aging female subjects. Higher circulating TC, HDL-c and HDL/LDL ratio indicated an increased risk of MCI, especially in female subjects. Conclusion: Slight increase in circulating LDL-c level might benefit cognitive function in aging adults. However, higher circulating TC and HDL-c levels might indicate a decline of cognitive function, especially in aging female subjects.

scholarly journals Modelling the Reallocation of Time Spent Sitting into Physical Activity: Isotemporal Substitution vs. Compositional Isotemporal Substitution

2021 ◽  
Vol 18 (12) ◽  
pp. 6210
Author(s):  
Gregory J. H. Biddle ◽  
Joseph Henson ◽  
Stuart J. H. Biddle ◽  
Melanie J. Davies ◽  
Kamlesh Khunti ◽  
...  
Keyword(s):  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Future Research ◽  
Cardiometabolic Health ◽  
Low Density Lipoprotein Cholesterol ◽  
Cross Sectional ◽  
Randomised Control Trials ◽  
Data Driven Decisions

Isotemporal substitution modelling (ISM) and compositional isotemporal modelling (CISM) are statistical approaches used in epidemiology to model the associations of replacing time in one physical behaviour with time in another. This study’s aim was to use both ISM and CISM to examine and compare associations of reallocating 60 min of sitting into standing or stepping with markers of cardiometabolic health. Cross-sectional data collected during three randomised control trials (RCTs) were utilised. All participants (n = 1554) were identified as being at high risk of developing type 2 diabetes. Reallocating 60 min from sitting to standing and to stepping was associated with a lower BMI, waist circumference, and triglycerides and higher high-density lipoprotein cholesterol using both ISM and CISM (p < 0.05). The direction and magnitude of significant associations were consistent across methods. No associations were observed for hemoglobin A1c, total cholesterol, or low-density lipoprotein cholesterol for either method. Results of both ISM and CISM were broadly similar, allowing for the interpretation of previous research, and should enable future research in order to make informed methodological, data-driven decisions.

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