Biological activities of Moringa oleifera Lam. against anthracnose of mango caused by Colletotrichum gloeosporioides Penz.

2020 ◽  
Vol 53 (13-14) ◽  
pp. 659-672
Author(s):  
Dionisio de Guzman Alvindia ◽  
Mark Anthony Angeles Mangoba
2021 ◽  
Vol 341 ◽  
pp. 128229
Author(s):  
Ângela Fernandes ◽  
Aducabe Bancessi ◽  
José Pinela ◽  
Maria Inês Dias ◽  
Ângela Liberal ◽  
...  

2021 ◽  
Vol 6 (4) ◽  
pp. 284-291
Author(s):  
Madhushree Das Sarma

Moringa oleifera Lam. (Moringaceae) is a multifarious beneficial tree and widely cultivated in the tropical and subtropical regions all over the world. All parts of this plants are edible and used as a plentiful source of phytochemicals with high nutritional values. Since antiquity, this plant was recognized as a panacea for the treatment of several ailments in ethnomedicinal system. In last few decades, this fact is further reconfirmed by various scientific research works in which the plant was found to show broad spectrum of biological activities including antioxidant, anti-inammatory, antiurolithic, antimicrobial, anangesic, antidiabetic, antihypertensive, antiproliferative, hepatoprotective, cardioprotective, etc. Different parts of this plant exhibited significant inhibitory activity against a variety of cancer cells at moderate to low concentrations and also possess low toxicity in normal cells. This review mainly focuses a brief overview on the anticancer profile of this wonderful tree.


2020 ◽  
Vol 27 ◽  
Author(s):  
Leydianne Leite de Siqueira Patriota ◽  
Dayane Kelly Dias do Nascimento Santos ◽  
Bárbara Rafaela da Silva Barros ◽  
Lethícia Maria de Souza Aguiar ◽  
Yasmym Araújo Silva ◽  
...  

Background: Protease inhibitors have been isolated from plants and present several biological activities, including immunomod-ulatory action. Objective: This work aimed to evaluate a Moringa oleifera flower trypsin inhibitor (MoFTI) for acute toxicity in mice, hemolytic activity on mice erythrocytes and immunomodulatory effects on mice splenocytes. Methods: The acute toxicity was evaluated using Swiss female mice that received a single dose of the vehicle control or MoFTI (300 mg/kg, i.p.). Behavioral alterations were observed 15–240 min after administration, and survival, weight gain, and water and food consumption were analyzed daily. Organ weights and hematological parameters were analyzed after 14 days. Hemolytic activity of MoFTI was tested using Swiss female mice erythrocytes. Splenocytes obtained from BALB/c mice were cultured in the absence or presence of MoFTI for the evaluation of cell viability and proliferation. Mitochondrial membrane potential (ΔΨm) and reactive oxygen species (ROS) levels were also determined. Furthermore, the culture supernatants were analyzed for the presence of cytokines and nitric oxide (NO). Results: MoFTI did not cause death or any adverse effects on the mice except for abdominal contortions at 15–30 min after administration. MoFTI did not exhibit a significant hemolytic effect. In addition, MoFTI did not induce apoptosis or necrosis in splenocytes and had no effect on cell proliferation. Increases in cytosolic and mitochondrial ROS release, as well as ΔΨm reduction, were observed in MoFTI-treated cells. MoFTI was observed to induce TNF-α, IFN-γ, IL-6, IL-10, and NO release. Conclusion: These results contribute to the ongoing evaluation of the antitumor potential of MoFTI and its effects on other immunological targets.


2017 ◽  
Vol 6 (10) ◽  
pp. 5535
Author(s):  
Sachin Umesh Dubey ◽  
Madhu Kanta Kapoor

Moringa oleifera Lam., commonly found tree in sub-Himalayan tracts of India, Pakistan, Bangladesh and Afghanistan has a high nutrition value. The leaves, flowers and immature pods of Moringa are used as a vegetable in many countries. The leaves are highly nutritious and medicinal in nature. They are a rich source of iron, calcium, vitamin A, vitamin C, proteins, and essential amino acids. Hence Moringa leaves can be a good source of protein for the vegetarians and the under-nourished population. Present investigation deals with the study of monthly variation in the nutritional value of Moringa leaves from the month of June 2015 to January 2016. Impact of urban sewage pollution and roadside vehicular pollution on the amount of reducing and total sugars, chlorophylls (a, b and total), proteins, vitamin-C and pH of the leaves, was also studied. Results revealed that the highest amounts of reducing sugars, total sugars, chlorophyll b and total chlorophyll during October 2015 whereas proteins, chlorophyll a, vitamin C and pH were highest during January 2016. Leaf samples collected from all the study sites exhibited minimum amounts of reducing sugars, chlorophylls (a, b and total) and pH during July 2015 whereas total sugars were lowest during December 2015. Proteins and vitamin C values were lowest during August and June 2015 respectively. Sewage and vehicular pollution showed an adverse effect on the nutritional contents of Moringa oleifera leaves. Of the two polluted sites, samples from near the sewage flow showed higher impact.


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