A Gift of Good Health from Mother Nature: Presenting Moringa oleifera, a Plant with Multiple Anticancer Activities

2021 ◽  
Vol 6 (4) ◽  
pp. 284-291
Author(s):  
Madhushree Das Sarma
Keyword(s):  
Moringa Oleifera ◽  
Biological Activities ◽  
Good Health ◽  
Anticancer Activities ◽  
Nutritional Values ◽  
Low Concentrations ◽  
The World ◽  
Low Toxicity ◽  
Different Parts ◽  
Moringa Oleifera Lam

Moringa oleifera Lam. (Moringaceae) is a multifarious beneficial tree and widely cultivated in the tropical and subtropical regions all over the world. All parts of this plants are edible and used as a plentiful source of phytochemicals with high nutritional values. Since antiquity, this plant was recognized as a panacea for the treatment of several ailments in ethnomedicinal system. In last few decades, this fact is further reconfirmed by various scientific research works in which the plant was found to show broad spectrum of biological activities including antioxidant, anti-inammatory, antiurolithic, antimicrobial, anangesic, antidiabetic, antihypertensive, antiproliferative, hepatoprotective, cardioprotective, etc. Different parts of this plant exhibited significant inhibitory activity against a variety of cancer cells at moderate to low concentrations and also possess low toxicity in normal cells. This review mainly focuses a brief overview on the anticancer profile of this wonderful tree.

scholarly journals Formulation of More Efficacious Curcumin Delivery Systems Using Colloid Science: Enhanced Solubility, Stability, and Bioavailability

Molecules ◽  
2020 ◽  
Vol 25 (12) ◽  
pp. 2791 ◽  
Author(s):  
Bingjing Zheng ◽  
David Julian McClements
Keyword(s):  
Water Solubility ◽  
Biological Activities ◽  
Anticancer Activities ◽  
Potential Health ◽  
Colloid Science ◽  
Enhanced Solubility ◽  
Alkaline Conditions ◽  
Low Toxicity ◽  
Neutral Conditions ◽  
Bioactive Constituent

Curcumin is a bioactive constituent isolated from turmeric that has historically been used as a seasoning, pigment, and herbal medicine in food. Recently, it has become one of the most commonly studied nutraceuticals in the pharmaceutical, supplement, and food areas because of its myriad of potential health benefits. For instance, it is claimed to exhibit antioxidant, anti-inflammatory, antimicrobial, antiparasite, and anticancer activities when ingested as a drug, supplement, or food. Toxicity studies suggest that it is safe to consume, even at relatively high levels. Its broad-spectrum biological activities and low toxicity have meant that it has been widely explored as a nutraceutical ingredient for application in functional foods. However, there are several hurdles that formulators must overcome when incorporating curcumin into commercial products, such as its low water solubility (especially under acidic and neutral conditions), chemical instability (especially under neutral and alkaline conditions), rapid metabolism by enzymes in the human body, and limited bioavailability. As a result, only a small fraction of ingested curcumin is actually absorbed into the bloodstream. These hurdles can be at least partially overcome by using encapsulation technologies, which involve trapping the curcumin within small particles. Some of the most commonly used edible microparticles or nanoparticles utilized for this purpose are micelles, liposomes, emulsions, solid lipid particles, and biopolymer particles. Each of these encapsulation technologies has its own benefits and limitations for particular product applications and it is important to select the most appropriate one.

scholarly journals Phytochemical Analyses, Antioxidant and Anticancer Activities of Ethanolic Leaf Extracts of Moringa oleifera Lam. Varieties

Plants ◽  
2021 ◽  
Vol 10 (11) ◽  
pp. 2348
Author(s):  
Bilques Farooq ◽  
Bhupendra Koul ◽  
Deveshi Mahant ◽  
Dhananjay Yadav
Keyword(s):  
Antioxidant Activity ◽  
Moringa Oleifera ◽  
Sugar Content ◽  
Soluble Proteins ◽  
Mature Stage ◽  
Cytotoxic Activities ◽  
Anticancer Activities ◽  
Leaf Extracts ◽  
Anticancer Compounds ◽  
Moringa Oleifera Lam

Moringa oleifera Lam. (Moringaceae) is revered as s ‘miracle tree’ due to its remarkable nutritional, medicinal and industrial uses. In our study, a comparative analysis of the nutritional parameters (antioxidant activity, sugar content—TSS, total soluble proteins—TSP and mineral contents), phytochemicals (HPLC analysis of four anticancer compounds), and cytotoxicity of M. oleifera leaf extracts (MLEs) of five selected varieties (conventional, PKM-1, PKM-2, ODC, and Jaffna), was performed. Jaffna variety possessed the highest antioxidant activity (FRAP) followed by other four varieties. The trend observed was: Jaffna (9.47 µg/mL, 18.48 µg/mL, 29.39 µg/mL, and 35.37 µg/mL) > PKM-1 (4.82 µg/mL, 7.63 µg/mL, 22.33 µg/mL, and 27.71 µg/mL) > PKM-2 (2.10 µg/mL, 7.04 µg/mL, 13.18 µg/mL, and 21.78 µg/mL) > ODC (0.17 µg/mL, 2.10 µg/mL, 4.41 µg/mL and 13.94 µg/mL) > Conventional (0.05 µg/mL, 1.08 µg/mL, 2.86 µg/mL, and 5.40 µg/mL), total soluble proteins (TSP) [0.69 ± 0.01 and 0.94 ± 0.01 µg/mL (young and mature stage, respectively)], sugar content (TSS) [0.39 ± 0.01 and 0.51 ± 0.01 µg/mL (young and mature stage, respectively)], chlorophyll content [1.07 ± 0.01 (plantlet stage), 1.36 ± 0.003 (vegetative-stage), 0.82 ± 0.004 (reproductive stage) mg/g], followed by the other four varieties. The trend observed for cytotoxic activities of ethanolic MLEs on HepG2 cell line, based on the IC50 values, was conventional (1.22 mg/mL) > ODC (0.90 mg/mL) > PKM-2 (0.65 mg/mL) > PKM-1 (0.35 mg/mL) > Jaffna (0.15 mg/mL). The results of HPLC quantification of anticancer compounds [beta-sitosterol (0.244%), quercetin (0.216%), kaempferol (0.013%), and moringin (0.063%)] was also in consonance with that of MTT assay. In summary, the trend observed in all the parameters tested was Jaffna > PKM-1 > PKM-2 > ODC > conventional. Thus, Jaffna variety has a better potential to combat malnutrition and cancer and must be recommended for commercial plantations.

scholarly journals Nutritional and phytochemical profiles and biological activities of Moringa oleifera Lam. edible parts from Guinea-Bissau (West Africa)

2021 ◽  
Vol 341 ◽  
pp. 128229
Author(s):  
Ângela Fernandes ◽  
Aducabe Bancessi ◽  
José Pinela ◽  
Maria Inês Dias ◽  
Ângela Liberal ◽  
...  
Keyword(s):  
West Africa ◽  
Moringa Oleifera ◽  
Biological Activities ◽  
Guinea Bissau ◽  
Phytochemical Profiles ◽  
Edible Parts ◽  
Moringa Oleifera Lam

scholarly journals SHIGRU (Moringa oleifera Lam.) AS VISHAGNA DRAVYA- AN OVERVIEW

2021 ◽  
Vol 9 (2) ◽  
pp. 453-458
Author(s):  
Ananya, B ◽  
Ravikrishna S ◽  
Sreejith K ◽  
Chaithra Hebbar
Keyword(s):  
Nutritional Value ◽  
Moringa Oleifera ◽  
Root Bark ◽  
Medicinal Uses ◽  
Treat Ment ◽  
Medicinal Use ◽  
Cultivated Species ◽  
The Tropics ◽  
Different Parts ◽  
Moringa Oleifera Lam

Shigru is very common and well-known herbal medicine. The plant is botanically identified as Moringa oleifera Lam. which is distributed in many countries of the tropics and subtropics. It is fast-growing and the most widely cultivated species. It belongs to Moringacae family and Moringa genus. Different parts of Shigru like leaves, seed, bark, root bark etc. are used as Aushadi (medicine) and Ahara (food). The plant has an impressive range of medicinal uses with high nutritional value., It is traditionally used in the treat-ment of various ailments i.e. Visha (poison), Krimi (wormicidal), Kustha (skin disorders), Kandu (itching) Vatavyadhi, Ashmari (calculi), Sopha (Inflammation). This review focuses on the detailed literature review and the medicinal use of shigru in visha (poison)

scholarly journals Aglaomorpha quercifolia (L.) Hovenkamp & S. Linds a Wild Fern Used in Timorese Cuisine

Foods ◽  
2021 ◽  
Vol 10 (1) ◽  
pp. 87
Author(s):  
Hermenegildo R. Costa ◽  
Inês Simão ◽  
Helena Silva ◽  
Paulo Silveira ◽  
Artur M. S. Silva ◽  
...  
Keyword(s):  
Nutritional Value ◽  
East Timor ◽  
Gas Chromatography Mass Spectrometry ◽  
Chemical Profile ◽  
Nutritional Values ◽  
The World ◽  
Hexane Extracts ◽  
Medicinal Properties ◽  
First Time ◽  
Different Parts

Aglaomorpha quercifolia (L.) Hovenkamp & S. Linds is an extensively used species in traditional medicinal systems in several areas of the world due to some important medicinal properties such as antioxidant, antibacterial, analgesic, and anti-inflammatory activities. In East Timor, different parts of this fern are used either as remedies or as food. The ingestion of a broth made from its rhizome improves lactation, and young fronds of this fern are boiled and eaten with rice by the locals. Nevertheless, its chemical profile is far from being established. The present work aims to establish the chemical profile of both rhizomes and leaves n-hexane extracts by Gas Chromatography- Mass Spectrometry (GC-MS). The results showed the leaves richness in fatty acids with interesting nutritional values (ω−6/ω−3 = 0.68, AI = 0.59, TI = 0.30), being linolenic acid (253.71 ± 0.93 mg/g dry leaves) and palmitic acid (237.27 ± 0.59 mg/g dry leaves) the significant compounds in the extract. Whereas the rhizome extract is mostly rich in terpenoids, such as steroid, cycloartane, and hopanoid derivatives, being hop-16-ene (166.45 ± 0.53 mg/g dry rhizome) and β-sitosterol (50.76 ± 0.11 mg/g dry rhizome) the major compounds. Several compounds are reported for the first time in the species, and the data herein reported contributes to confirming the species nutritional value.

scholarly journals Identifikasi Senyawa Kimia Dan Nilai Gizi Ekstrak Air Daun Kelor (Moringa Oleifera L.) Sebagai Pengawet Alami Mie Basah

2019 ◽  
Vol 10 (2) ◽  
pp. 102-116
Author(s):  
Siti Rahayu Rachmawati ◽  
Junie Suriawati
Keyword(s):  
Moringa Oleifera ◽  
Microbial Contamination ◽  
Water Extract ◽  
Chemical Characterization ◽  
Plate Count ◽  
Nutritional Values ◽  
Water Solvent ◽  
Total Plate Count ◽  
Moringa Oleifera Lam

Moringa leaves or referred to Moringa oleifera Lam. are belong to the Moringaceae tribe. This plant is reported to have antibacterial activity and high nutritional value. To be used as an active ingredient in food preparations, it needs to be made in the form of extracts. The study aims to determine the characteristics of Moringa leaf water extract. In this study, Moringa leaves were extracted with a water solvent. Chemical characterization of Moringa leaf extract includes qualitative phytochemical tests and nutritional values ​​(water content, ash, protein, fat, and carbohydrate). Whereas in microbiology, they include microbial contamination (Total Plate Count and Total Yeast and Mold Count). The results of characterization testing of the extracts showed that the water extract of Moringa leaves contain active compounds: flavonoids, phenols, triterpenoids/steroids, saponins, and tannins. Microbial contamination contained in the water extract of Moringa leaves are Total Plate Count value of 0 colonies/g and Mold/Yeast count value of 0 colonies/g and contain nutritional values such as water (75.85%), ash (3.87%), protein (6.27%), fat (<2.20 %) and carbohydrate (14.01%).

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