How to measure the impact of premenstrual symptoms? Development and validation of the German PMS-Impact Questionnaire

2015 ◽  
Vol 56 (7) ◽  
pp. 807-826 ◽  
Author(s):  
Johanna N. Kues ◽  
Carolyn Janda ◽  
Maria Kleinstäuber ◽  
Cornelia Weise
Keyword(s):  
Premenstrual Symptoms ◽  
Development And Validation ◽  
The Impact

Development and Validation of an LC-MS/MS Method for Simultaneous Determination of Canagliflozin and Metformin HCl in Rat Plasma and its Application

2020 ◽  
Vol 16 (6) ◽  
pp. 752-762
Author(s):  
Vivek Nalawade ◽  
Vaibhav A. Dixit ◽  
Amisha Vora ◽  
Himashu Zade
Keyword(s):  
Internal Standard ◽  
Rat Plasma ◽  
Precipitation Method ◽  
Herbal Extracts ◽  
One Step ◽  
Precision And Accuracy ◽  
Development And Validation ◽  
The Impact ◽  
Metformin Hcl

Background: Food and herbal extracts rich in Quercetin (QRT) are often self-medicated by diabetics and can potentially alter the pharmacokinetics (PK) of Metformin HCl (MET) and Canagliflozin (CNG) leading to food or herb-drug interactions and reduced therapeutic efficacy. However, the impact of these flavonoids on the pharmacokinetic behaviour of MET and CNG is mostly unknown. Methods: A simple one-step protein precipitation method was developed for the determination of MET and CNG from rat plasma. The mobile phase chosen was MeOH 65% and 35% water containing 0.1% formic acid at a flow rate of 1mL/min. Results: The retention time of MET, internal standard (Valsartan) and CNG was 1.83, 6.2 and 8.2 min, respectively. The method was found to be linear in the range of 200 - 8000 ng/mL for CNG and 100 = 4000 ng/ml for MET. Precision and accuracy of the method were below 20% at LLOQ and below 15% for LQC, MQC, and HQC. Conclusion: The method was successfully applied for the determination of PK of MET and CNG by using 100 μL of rat plasma. QRT co-administration affects the PK parameters of MET and CNG. This alteration in PK parameters might be of significant use for clinicians and patients.

Revisiting rating scale development for rater-mediated language performance assessments: Modelling construct and contextual choices made by scale developers

2021 ◽  
pp. 026553222199405
Author(s):  
Ute Knoch ◽  
Bart Deygers ◽  
Apichat Khamboonruang
Keyword(s):  
Scale Development ◽  
Rating Scale ◽  
Language Assessment ◽  
Performance Assessments ◽  
Language Performance ◽  
Scale Development And Validation ◽  
Post Test ◽  
Development And Validation ◽  
The Impact ◽  
Different Sources

Rating scale development in the field of language assessment is often considered in dichotomous ways: It is assumed to be guided either by expert intuition or by drawing on performance data. Even though quite a few authors have argued that rating scale development is rarely so easily classifiable, this dyadic view has dominated language testing research for over a decade. In this paper we refine the dominant model of rating scale development by drawing on a corpus of 36 studies identified in a systematic review. We present a model showing the different sources of scale construct in the corpus. In the discussion, we argue that rating scale designers, just like test developers more broadly, need to start by determining the purpose of the test, the relevant policies that guide test development and score use, and the intended score use when considering the design choices available to them. These include considering the impact of such sources on the generalizability of the scores, the precision of the post-test predictions that can be made about test takers’ future performances and scoring reliability. The most important contributions of the model are that it gives rating scale developers a framework to consider prior to starting scale development and validation activities.

scholarly journals Induction Skull Melting of Ti-6Al-4V: Process Control and Efficiency Optimization

Metals ◽  
2019 ◽  
Vol 9 (5) ◽  
pp. 539
Author(s):  
Xabier Chamorro ◽  
Nuria Herrero-Dorca ◽  
Daniel Bernal ◽  
Iñaki Hurtado
Keyword(s):  
Complex Shape ◽  
Control Method ◽  
Melting Process ◽  
Optimization Strategy ◽  
Power Losses ◽  
Near Net Shape ◽  
Induction Skull Melting ◽  
Development And Validation ◽  
The Impact ◽  
Titanium Melt

Titanium investment casting is one of the leading and most efficient near-net-shape manufacturing processes, since complex shape components are possible to obtain with a very low amount of material waste. But melting these reactive alloys implies the usage of specific melting technologies such as the Induction Skull Melting (ISM) method. In this work the ISM was extensively studied with the aim of deepening the characteristics of this specific melting method and improving the too low energy efficiency and overall process performance. A 16 segment copper crucible and 3 turns coil was employed for the melting of 1 kg of Ti-6Al-4V alloy. Through the calorimetric balance, real-time evolution of the process parameters and power losses arising from the crucible and coil sub-assemblies was displayed. Results revealed the impact of coil working conditions in the overall ISM thermal efficiency and titanium melt properties, revealing the use of these conditions as an effective optimization strategy. This unstudied melting control method allowed more heat into charge and 13% efficiency enhancement; leading to a shorter melting process, less energy consumption and increased melt superheat, which reached 49 °C. The experimental data published in this paper represent a valuable empiric reference for the development and validation of current and future induction heating models.

scholarly journals Development and validation of an instrument to measure the impact of genetic testing on self-concept in Lynch syndrome

2011 ◽  
Vol 80 (5) ◽  
pp. 415-423 ◽  
Author(s):  
MJ Esplen ◽  
N Stuckless ◽  
S Gallinger ◽  
M Aronson ◽  
H Rothenmund ◽  
...  
Keyword(s):  
Genetic Testing ◽  
Lynch Syndrome ◽  
Self Concept ◽  
Development And Validation ◽  
The Impact

Advertising appeals and Malaysian culture norms

2018 ◽  
Vol 28 (1) ◽  
pp. 61-82 ◽  
Author(s):  
Syed Hassan Raza ◽  
Hassan Abu Bakar ◽  
Bahtiar Mohamad
Keyword(s):  
Cultural Context ◽  
Strategic Communication ◽  
Cultural Dimensions ◽  
Content Validation ◽  
Measurement Instruments ◽  
Advertising Appeals ◽  
Expert Rating ◽  
Validation Procedure ◽  
Development And Validation ◽  
The Impact

Abstract The ongoing development of the strategic communication research in the area of the advertising calls for the development and validation of the measurement instruments that can address the indulgence of the advertising appeals in a specific cultural context. Therefore, the present study examines and validate advertising appeals by considering the norms based on the GLOBE nine cultural dimensions in Malaysian context. The analysis involved data from 10 advertising expert for content validation, followed by 10 advertising expert rating and ranking of the scale of its relevance and clarity to assess the item-level content validation. The results provided to support the impact of cultural norms are substantial for Malaysian advertising, which are identified from content validation procedure.

scholarly journals Development and Validation of Work Environment Services Scale (WESS)

2021 ◽  
Vol 29 (2) ◽  
pp. 98-120
Author(s):  
Harold Andrew Patrick ◽  
◽  
Jacqueline Kareem ◽  
Keyword(s):  
Work Environment ◽  
Delphi Technique ◽  
Service Sector ◽  
Full Time ◽  
Service Employees ◽  
The People ◽  
Healthy Work ◽  
Work Environment Factors ◽  
Development And Validation ◽  
The Impact

Purpose: This study presents a nine-factor, 32-item measure of work environment scale in the service sector. A healthy work environment is one in which employees trust the people they work for, have pride in what they do, and enjoy working with the people (Levering and Moskowitz, 2004). Methodology: This instrument builds on the conceptual model espoused by Insel and Moos (1974), Gordon (1973), Fletcher and Nusbaum (2010), Amabile et al. (1996), and Spector (2003). The scale included items elicited through a literature review, the use of the Delphi technique with a panel of experts, and tested on 824 full-time employees from nine service sector industries and five major cities in India. Findings: The Work Environment Services Scale (WESS) is a reliable and valid scale useful for measuring the nine work environment factors in the Indian services organization, with its own norms and a detailed manual. Originality/Value: The prevailing scales for measuring work environment do not capture the influence of ethics, recreation facilities, and the impact of social giving on the work environment. Most scales were suitable for sectors in the Western context, and there were no Indian scales measuring service employees’ perception of their work environment.

scholarly journals Development and Validation of Nasal Polyposis Quality of Life Questionnaire (NPQ)

2020 ◽  
Author(s):  
Ilaria Baiardini ◽  
Giovanni Paoletti ◽  
Alessia Mariani ◽  
Luca Malvezzi ◽  
Francesca Pirola ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Convergent Validity ◽  
Nasal Polyposis ◽  
Minimal Important Difference ◽  
Dimensional Structure ◽  
Life Questionnaire ◽  
Quality Of Life Questionnaire ◽  
Development And Validation ◽  
The Impact

Abstract BACKGROUND: To date, no disease-specific tool is available to assess the impact of Chronic Rhinosinusitis with Nasal Polyps (CRSwNP) on Health Related Quality of Life (HRQoL). Therefore, the purpose of this study was to develop and validate a questionnaire specifically designed to this aim: the Nasal Polyposis Quality of Life questionnaire –NPQ.METHODS: According to the current guidelines, the development and validation of the NPQ occurred in two separate steps involving different groups of patients.RESULTS: In the development process of NPQ an initial list of items of 40 items was given to 60 patients with CRSwNP; the 27 most significant items were selected and converted into questions. The validation procedure involved 107 patients (mean age 52.9±12.4). NPQ revealed a five-dimensional structure and high levels of internal consistency (Cronbach's alpha 0.95). Convergent validity (Spearman’ coefficient r=0.75; p< 0.01), discriminant validity (sensitivity to VAS score), reliability in a sample of patients with a stable health status (Interclass Coefficient 0.882) were satisfactory. Responsiveness to clinical changes was accomplished. The minimal important difference was 7. CONCLUSIONS: NPQ is the first questionnaire for the assessment of HRQoL in CRSwNP. Our results provide that the new tool is valid, reliable, and sensitive to individual changes.

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