The impact of ellagic acid on some apoptotic gene expressions: a new perspective for the regulation of pancreatic Nrf-2/NF-κB and Akt/VEGF signaling in CCl4-induced pancreas damage in rats

AbstractThe presence of FMS-like tyrosine kinase 3-internal tandem duplication (FLT3-ITD) is one of the most frequent mutations in acute myeloid leukemia (AML) and is associated with an unfavorable prognosis. FLT3 inhibitors, such as midostaurin, are used clinically but fail to entirely eradicate FLT3-ITD + AML. This study introduces a new perspective and highlights the impact of RAC1-dependent actin cytoskeleton remodeling on resistance to midostaurin in AML. RAC1 hyperactivation leads resistance via hyperphosphorylation of the positive regulator of actin polymerization N-WASP and antiapoptotic BCL-2. RAC1/N-WASP, through ARP2/3 complex activation, increases the number of actin filaments, cell stiffness and adhesion forces to mesenchymal stromal cells (MSCs) being identified as a biomarker of resistance. Midostaurin resistance can be overcome by a combination of midostaruin, the BCL-2 inhibitor venetoclax and the RAC1 inhibitor Eht1864 in midostaurin-resistant AML cell lines and primary samples, providing the first evidence of a potential new treatment approach to eradicate FLT3-ITD + AML.

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Policy and institutions facilitating entrepreneurial spin-offs: USA, Asia and Europe

Journal of Entrepreneurship and Public Policy ◽

10.1108/jepp-04-2013-0013 ◽

2014 ◽

Vol 3 (2) ◽

pp. 186-196 ◽

Cited By ~ 13

Author(s):

Rosa Caiazza ◽

David Audretsch ◽

Tiziana Volpe ◽

Julie Debra Singer

Keyword(s):

Institutional Setting ◽

Policy Debate ◽

Content Type ◽

Factors Affecting ◽

Institutional Settings ◽

The Usa ◽

New Perspective ◽

National Analysis ◽

The Impact ◽

Cross National

Purpose – Existing work documents the role that institutional setting plays in the process of spin-off creation. However, despite decades of studies, scholars have not clearly explained why some regions are more involved in spin-off activity than others. Drawing from institutional theory, the purpose of this paper is to compare different institutional settings identifying factors affecting the general environment capability to support spin-off activity of a specific region. Design/methodology/approach – The authors utilize a cross-national analysis of American, Asian, and European areas identifying factors affecting their different rate of spin-off activity. This study contributes to the policy debate concerning entrepreneurship and how best to spur spin-off activities. Findings – In this paper, the authors identify the general and specific factors that explain the cross-national diversity in spin-off creation. The authors then perform an analysis of the impact of these factors in various regions of the USA, Asia, and Europe, providing evidence for the necessity of specific combinations of these factors. Originality/value – The paper offers a new perspective on the causes of spin-offs through a cross-national analysis of many areas around the world.

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The Impact of House Prices on Consumption in the UK: a New Perspective

Economica ◽

10.1111/ecca.12237 ◽

2017 ◽

Vol 85 (337) ◽

pp. 92-123 ◽

Cited By ~ 3

Author(s):

Vivien Burrows

Keyword(s):

House Prices ◽

New Perspective ◽

The Uk ◽

The Impact

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A New Perspective for Understanding School Managers’ Roles: The Impact of Principals’ Boundary Activities on the Effectiveness of School Management Teams

Teachers College Record ◽

10.1177/016146811812000301 ◽

2018 ◽

Vol 120 (3) ◽

pp. 1-40

Author(s):

Pascale Benoliel ◽

Anit Somech

Keyword(s):

Public Schools ◽

School Leadership ◽

Structural Equation ◽

Equation Model ◽

Management Teams ◽

Role Performance ◽

New Perspective ◽

Mean Differences ◽

The Impact

Background/Context Increasingly, educational leadership research has stressed that leadership is not solely embedded in formal roles but often emerges from relationships between individuals. Senior management teams (SMTs) are an important expression of a formal management structure based on the principle of distributed leadership. Such structures may require a reconceptualization of school leadership and the role of the principal in such a way as to better meet new challenges and enable principals to manage SMTs more effectively. Accordingly, it is proposed that to improve effectiveness, principals engage in boundary activities, the principals’ internal activities directed toward the SMT aimed at dealing with internal team matters and the principals’ external activities directed toward external agents in the team's focal environment to acquire resources and protect the team. Purpose/Objective The present study attempts to advance a theoretical model of principals’ internal and external activities toward their SMTs. This study's purpose is twofold: First, the study tries to determine which of the internal and external activities principals engage in more frequently and less frequently and to what extent. Second, the study attempts to determine how these activities are related to the SMT effectiveness outcomes: in-role performance and innovation. Taking on a distributive perspective to school leadership, our goal is to extend our knowledge about the activities that might facilitate SMT effectiveness, by highlighting the principal boundary activities as fundamental. Research Design Quantitative study. Data Collection and Analysis Data were collected from two sources to minimize problems associated with same source bias: 92 SMTs and their principals from 92 public schools in Israel. Principals evaluated the SMTs’ effectiveness through validated surveys of team in-role performance and team innovation, and SMT members evaluated the internal and external activities of the principal. Findings/Results ANOVA analyses indicate significant mean differences between the principal's internal and external activities. Results from Structural Equation Model indicate that internal activities were related to SMT performance, whereas external activities were related to SMT innovation. Conclusions/Recommendations Principals who manage both the internal SMT dynamic by promoting SMT identity and building team trust, while also promoting a common mission, serve the role of coordinator between SMT members and constituencies external to the SMT, enhancing SMT effectiveness. It may be, then, that studying new models of school leadership and management, including the relationship of the principal and the SMT, may deepen our understanding of the increasingly complex role of principals today.

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The Relationship between Team Hometown Diversity and Team Creativity: From the Chinese Perspective

Sustainability ◽

10.3390/su10103458 ◽

2018 ◽

Vol 10 (10) ◽

pp. 3458

Author(s):

Jingli Li ◽

Min Zhao ◽

Guanjun Xia ◽

Chao Liu

Keyword(s):

Information Exchange ◽

Mediation Effect ◽

Team Leaders ◽

Team Creativity ◽

Team Members ◽

Chinese Perspective ◽

New Perspective ◽

The Impact ◽

The Relationship

Since no specialized work has researched the relationship between team members’ hometown diversity (team hometown diversity) and team creativity, we investigated their underlying relationship by conducting a two-wave survey from 304 employees in 54 teams and 54 team leaders from 17 companies. The results proved that team hometown diversity was negatively related to both team information exchange and team creativity, while team information exchange was significantly positively associated with team creativity and the mediation effect of team information exchange between team hometown diversity and team creativity was verified. The moderation role of team identification in the relationship between team hometown diversity and team information exchange as well as the moderation function of team conformity on the relationship between team information exchange and team creativity were both verified. This work made at least four contributions. Firstly, it was among the first to research the impact of team hometown diversity on team creativity, which supplemented the gap and provided a new perspective for exploration of team creativity in future. Secondly, we adopted a two-wave design to check the dynamic impact of earlier team information exchange and team conformity on team creativity afterwards, which can be replicated for future studies. Thirdly, by using supervisor and subordinate ratings together and conducting electronic and paper surveys together, the results were more persuasive. Finally, we included a large dataset from a broad range of companies, which maximized the variables and generated our results. The implications and limitations were also illustrated.

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Confronting a Paradox: A New Perspective of the Impact of Uncertainty in Suspense

Frontiers in Psychology ◽

10.3389/fpsyg.2018.01392 ◽

2018 ◽

Vol 9 ◽

Cited By ~ 4

Author(s):

Pablo Delatorre ◽

Carlos León ◽

Alberto Salguero ◽

Manuel Palomo-Duarte ◽

Pablo Gervás

Keyword(s):

New Perspective ◽

The Impact

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The Microbiotic Highway to Health—New Perspective on Food Structure, Gut Microbiota, and Host Inflammation

Nutrients ◽

10.3390/nu10111590 ◽

2018 ◽

Vol 10 (11) ◽

pp. 1590 ◽

Cited By ~ 13

Author(s):

Nina Hansen ◽

Anette Sams

Keyword(s):

Immune System ◽

Gut Microbiota ◽

Dietary Habits ◽

Gut Hormones ◽

Host Immune System ◽

Inflammatory Conditions ◽

Food Structure ◽

New Perspective ◽

And Function ◽

The Impact

This review provides evidence that not only the content of nutrients but indeed the structural organization of nutrients is a major determinant of human health. The gut microbiota provides nutrients for the host by digesting food structures otherwise indigestible by human enzymes, thereby simultaneously harvesting energy and delivering nutrients and metabolites for the nutritional and biological benefit of the host. Microbiota-derived nutrients, metabolites, and antigens promote the development and function of the host immune system both directly by activating cells of the adaptive and innate immune system and indirectly by sustaining release of monosaccharides, stimulating intestinal receptors and secreting gut hormones. Multiple indirect microbiota-dependent biological responses contribute to glucose homeostasis, which prevents hyperglycemia-induced inflammatory conditions. The composition and function of the gut microbiota vary between individuals and whereas dietary habits influence the gut microbiota, the gut microbiota influences both the nutritional and biological homeostasis of the host. A healthy gut microbiota requires the presence of beneficial microbiotic species as well as vital food structures to ensure appropriate feeding of the microbiota. This review focuses on the impact of plant-based food structures, the “fiber-encapsulated nutrient formulation”, and on the direct and indirect mechanisms by which the gut microbiota participate in host immune function.

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Cross-Fertilizing Deep Web Analysis and Ontology Enrichment

10.31219/osf.io/b3fvz ◽

2017 ◽

Author(s):

Marilena Oita ◽

Antoine Amarilli ◽

Pierre Senellart

Keyword(s):

Domain Knowledge ◽

Deep Web ◽

Web Pages ◽

Complete Understanding ◽

Specific Knowledge ◽

Domain Specific ◽

Domain Specific Knowledge ◽

Web Crawlers ◽

New Perspective ◽

The Impact

Deep Web databases, whose content is presented as dynamically-generated Web pages hidden behind forms, have mostly been left unindexed by search engine crawlers. In order to automatically explore this mass of information, many current techniques assume the existence of domain knowledge, which is costly to create and maintain. In this article, we present a new perspective on form understanding and deep Web data acquisition that does not require any domain-specific knowledge. Unlike previous approaches, we do not perform the various steps in the process (e.g., form understanding, record identification, attribute labeling) independently but integrate them to achieve a more complete understanding of deep Web sources. Through information extraction techniques and using the form itself for validation, we reconcile input and output schemas in a labeled graph which is further aligned with a generic ontology. The impact of this alignment is threefold: first, the resulting semantic infrastructure associated with the form can assist Web crawlers when probing the form for content indexing; second, attributes of response pages are labeled by matching known ontology instances, and relations between attributes are uncovered; and third, we enrich the generic ontology with facts from the deep Web.

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An Analysis of Ibn-Khaldun’s Theory in light of Covid-19 Pandemic

International Journal of Criminology and Sociology ◽

10.6000/1929-4409.2021.10.03 ◽

2020 ◽

Vol 10 ◽

pp. 15-21

Author(s):

Mohammed Musallem Binham Alameri ◽

◽

Khawlah M. AL- Tkhayneh

Keyword(s):

Social Change ◽

Human Factors ◽

Way Of Life ◽

Ibn Khaldun ◽

Factors Affecting ◽

Natural Factors ◽

Current Events ◽

Future Events ◽

New Perspective ◽

The Impact

This argumentative paper presents a new perspective on Ibn-khaldun’s theory of social change in light of Covid-19. It argues that when examining the theory, it can be found that it makes an association between social change and natural factors, such as epidemics and human factors, such as government changes. The target theory which is explored in this study is the cyclical theory of Ibn-khaldun. This study adopts the former theory in order to analyze the effects of Covid-19 on the Arab-Islamic society, and how this theory was able to predict many of the current events and possible future events using social and historical approaches. The paper consists of four parts as follows: First, an overview of Ibn-khaldun’s theory of social change and its philosophy is provided. Second, the role of human factors in social change according to Ibn-khaldun is explored. Third, natural factors affecting social change according to Ibn-khaldun are discussed. Finally, the impact of Covid-19 on our way of life in relation to Ibn-khaldun’s theory of social change is examined.

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The effect of the CEO media coverage on corporate brand equity: evidence from Poland

Oeconomia Copernicana ◽

10.24136/oc.2021.017 ◽

2021 ◽

Vol 12 (2) ◽

pp. 499-523

Author(s):

Anna Górska ◽

Grzegorz Mazurek

Keyword(s):

Brand Equity ◽

Media Coverage ◽

Value Added ◽

Corporate Brand ◽

Personal Brand ◽

Data Points ◽

New Perspective ◽

Media Monitoring ◽

The Impact ◽

The Relationship

Research background: Despite increased attention in the literature to the importance of the CEO?s brand for companies, understanding of the effect of the CEO brand on the corporate brand remains limited. To contribute to this discussion, this paper investigates different facets of the impact of the CEO brand, and particularly its media coverage, on corporate brand equity. Purpose of the article: This study investigates the relationship between the different aspects of the CEO brand?s media coverage and corporate brand equity. Methods: Comprehensive media monitoring in the press and online sourcing of CEOs from the strongest Polish brands were conducted. For three years (2014?2017), media monitoring covered 81 CEOs, resulting in over 44,000 data points for this study. Regression analysis was conducted to determine whether a relationship exists between different facets of the CEO?s personal brand and company brand equity. Findings & value added: This study provides a new perspective on the relationship between the CEO and corporate brands and showcases empirical evidence of the CEO brand?s relationship with corporate brand equity. It introduces two relevant and novel variables (CEO brand reach and CEO brand advertising value equivalent [AVE]) to the literature, which have been limited to the number of mentions and its sentiment. Accordingly, this study contributes to the emerging literature of CEO branding within the branding field. Contrary to expectation, the intensity of media coverage alone was not significant. Results indicate that reach and AVE of CEO media exposure are reflected in the corporate brand equity. The study also finds that negative sentiment toward a CEO?s brand negatively affects corporate brand equity. The study adds to the growing stream of literature on the role of CEO brand.

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