scholarly journals Features of the 1st trimester of pregnancy course with severe deficiency of 25(OH)D

2021 ◽  
Vol 37 (sup1) ◽  
pp. 49-53
Author(s):  
M. Bakleicheva ◽  
O. Bespalova ◽  
I. Kovaleva
Keyword(s):  
Severe Deficiency

scholarly journals Non-association between low vitamin d levels and aeroallergen-positivity evaluated using multiple allergen simultaneous test in Korean adults

2021 ◽  
Vol 17 (1) ◽  
Author(s):  
Jee Hye Wee ◽  
Sung Woo Cho ◽  
Jeong-Whun Kim ◽  
Chae-Seo Rhee
Keyword(s):  
Vitamin D ◽  
Logistic Regression ◽  
Vitamin D Deficiency ◽  
House Dust Mites ◽  
Regression Analyses ◽  
Allergen Sensitization ◽  
Korean Adults ◽  
Simultaneous Test ◽  
Severe Deficiency ◽  
Vitamin D Levels

Abstract Background Studies on the association between vitamin D levels and allergen sensitization have reported conflicting results. We aimed to evaluate the association between low vitamin D levels and sensitization to 59 aeroallergens in Korean adults. Methods We retrospectively reviewed serum 25-hydroxyvitamin D (25[OH]D) measurements of participants (n = 57,467) in a healthcare center between May 2003 and June 2020. Serum 25(OH)D levels were categorized as follows: severe deficiency (< 10 ng/mL), deficiency (10 to < 20 ng/mL), insufficiency (20 to < 30 ng/mL), and sufficiency (≥ 30 ng/mL). Among all subjects, 1277 simultaneously underwent the multiple allergen simultaneous test. Multiple linear and logistic regression analyses were used to estimate coefficients and odds ratios (ORs) with 95% confidence interval (CI) for the association between serum vitamin D deficiency and aeroallergen sensitization after adjustment for potential confounders. Subgroup analyses were conducted for the types of aeroallergen (house dust mites, pollens, animal dander, foods, cockroach, and fungus). Results Vitamin D deficiency, defined as serum 25(OH)D level < 20 ng/mL, was noted in 56.4% of participants. There were significant differences in serum 25(OH)D levels according to sex, age, season, and bone mineral density (all P < 0.001). In multiple linear regression analyses, serum 25(OH)D levels were significantly lower in young subjects (adjusted coefficient [95% CI], 0.188 [0.101, 0.275]) and during winter (− 4.114 [− 6.528, − 1.699]). However, no significant association was observed between serum 25(OH)D levels and allergen sensitization (adjusted coefficients [95% CI], − 0.211 [− 1.989, 1.567], P = 0.816). In multivariate logistic regression analyses, male sex, young age, and winter season were significant risk factors for vitamin D deficiency. However, allergen sensitization showed no significant association with 25(OD)D levels after adjusting for confounders (adjusted OR [95% CI], 1.037 [0.642, 1.674] in insufficiency; 0.910 [0.573, 1.445] in deficiency; 0.869 [0.298, 2.539] in severe deficiency groups, P for trend = 0.334). There were consistent findings across subgroups regarding type of aeroallergen sensitized. Conclusion Vitamin D deficiency was prevalent but was not significantly associated with aeroallergen sensitization in Korean adults. To the best of our knowledge, this is the first large-scale study to evaluate the association between vitamin D deficiency and sensitization to 59 different aeroallergens.

The Relationship of the −5, −8, and −24 Variant Alleles in African Americans to Triosephosphate Isomerase (TPI) Enzyme Activity and to TPI Deficiency

Blood ◽  
1998 ◽  
Vol 92 (8) ◽  
pp. 2959-2962 ◽  
Author(s):  
Arthur Schneider ◽  
Linda Forman ◽  
Beryl Westwood ◽  
Catherine Yim ◽  
James Lin ◽  
...  
Keyword(s):  
Enzyme Activity ◽  
African American ◽  
African Americans ◽  
Triosephosphate Isomerase ◽  
Small Subset ◽  
Nucleotide Substitutions ◽  
Severe Deficiency ◽  
American Society ◽  
Relationship Of ◽  
The Relationship

Abstract In 424 African-American and 75 white subjects, we found that the −5 (TPI 592 A→G), −8 (TPI 589 G→A), and −24 (TPI 573 T→G) variants in the triosephosphate isomerase (TPI) gene occurred frequently (41.0%) in the African-American subjects but did not occur in the whites. These data suggest that this set of polymorphisms may turn out to be one of the higher-incidence molecular markers of African lineage, a surprising finding because others had reported that these nucleotide substitutions were restricted to a small subset of African Americans who had been characterized as TPI-deficiency heterozygotes. Additionally, we investigated the relationship of these variants to TPI-enzyme activity. Although the variant substitutions (occurring in three haplotypes: −5 alone, −5 −8, and −5 −8 −24) were associated with moderate reduction in enzyme activity, severe-deficiency heterozygotes could not be identified with certainty, and none of the haplotypes were restricted to subjects with marked reduction of enzyme activity. Three subjects were homozygous for the −5 −8 haplotype, a finding inconsistent with the putative role of this haplotype as the cause of a null variant incompatible with life in homozygotes. Despite these findings, the possibility remains that the −5 −8 or −5 −8 −24 haplotypes may in some instances contribute to compound heterozygosity and clinical TPI deficiency. © 1998 by The American Society of Hematology.

Relation of Severe Deficiency of Vitamin D to Cardiovascular Mortality During Acute Coronary Syndromes

2013 ◽  
Vol 111 (3) ◽  
pp. 324-327 ◽  
Author(s):  
Luis C.L. Correia ◽  
Fábio Sodré ◽  
Guilherme Garcia ◽  
Michael Sabino ◽  
Mariana Brito ◽  
...  
Keyword(s):  
Vitamin D ◽  
Cardiovascular Mortality ◽  
Acute Coronary Syndromes ◽  
Severe Deficiency ◽  
Coronary Syndromes

INHERITED FACTOR-VII DEFECT IN A NEGRO FAMILY

PEDIATRICS ◽  
1961 ◽  
Vol 27 (2) ◽  
pp. 204-213
Author(s):  
Helen I. Glueck ◽  
James M. Sutherland
Keyword(s):  
Prothrombin Time ◽  
Factor Vii ◽  
Homozygous State ◽  
Control Value ◽  
One Stage ◽  
First Case ◽  
Severe Deficiency ◽  
Low Levels ◽  
The Difference ◽  
The One

A case of factor-VII deficiency of a congenital nature in a Negro male child has been reported. As far as can be determined, this is the first case reported in this race. The defect was detected at 6 hours of age. Prothrombin, as contrasted to factor VII, after initially low levels normally found in infants, rose to adult levels. The patient's one-stage prothrombin time has ranged between 25 to 35 second (normal 11 to 12 seconds). In spite of this, he has never shown any manifestations of hemorrhage. The patient's family was studied and the findings indicate that the patient's defect represented a homozygous state and that both parents with a less severe deficiency were heterozygous for the trait. The defect is an autosomal disorder directly inherited. It is clinically apparent and easily detected only in the homozygous state. The heterozygous state is characterized by a very slight prolongation of the one-stage prothrombin time, the difference from the control value being so minimal as to be overlooked. In one subject studied, an aunt of the propositus, the quantitative defect (42% of normal) could not be regularly detected by the usual methods. Only by using the plasma of the propositus as the test plasma, was the defect in her plasma detected, thus explaining the transmission of the trait to her offspring. These findings explain the difficulties previously encountered in understanding the inheritance of the disorder.

Plasma levels of bigEndothelin-1 are associated with renal insufficiency and in-hospital mortality of immune thrombotic thrombocytopenic purpura

2021 ◽  
Author(s):  
Ruinan Lu ◽  
X. Long Zheng
Keyword(s):  
Hospital Mortality ◽  
Thrombotic Thrombocytopenic Purpura ◽  
Plasma Levels ◽  
Thrombus Formation ◽  
Microfluidic Channel ◽  
Thrombocytopenic Purpura ◽  
Severe Deficiency ◽  
Bioactive Product ◽  
First Time

Immune thrombotic thrombocytopenic purpura (iTTP) is caused by severe deficiency of plasma ADAMTS13 activity. Despite advances in early diagnosis and management, the mortality rate of acute iTTP remains high in a large part of world where access to some of the most novel therapies is limited. To determine the role of plasma bigEndothelin-1 (bigET-1) or its bioactive product ET-1 as a biomarker and/or a pathogenic factor in acute iTTP, plasma levels of bigET-1 were determined using an immunoassay in patients with iTTP on admission and during remission, as well as in healthy controls; moreover, the biological effect of ET-1 in thrombus formation was determined by a microfluidic assay. We show that plasma levels of bigET-1 were dramatically increased in patients with acute iTTP on admission, which was significantly decreased during clinical response/remission; elevated admission levels of plasma bigET-1 were associated with low estimated glomerular filtration rate, the need for intensive care unit admission or intubation, and in-hospital mortality. Moreover, an addition of a bioactive product ET-1 to cultured endothelial cells in a microfluidic channel dramatically accelerated the rate of thrombus formation under arterial flow. Our results demonstrate for the first time a potential role of measuring plasma bigET-1 in patients with acute iTTP in assessing the disease severity and risk of in-hospital mortality, which may help stratify patients for a more aggressive monitoring and therapeutic strategy; also, the bioactive ET-1, derived from bigET-1, may result in acute renal injury in TTP patient, likely through its vasoconstriction and prothrombotic properties.

PROVISION OF VITAMIN D FOR CHILDREN AND ADOLESCENTS IN THE CITY OF ULAN-UDE

2021 ◽  
Vol 100 (3) ◽  
pp. 295-300
Author(s):  
N.B. Gomboeva ◽  
◽  
E.I. Grigoryeva ◽  
Keyword(s):  
Vitamin D ◽  
Children And Adolescents ◽  
Vitamin D Deficiency ◽  
Respiratory Infections ◽  
Sharp Decrease ◽  
The Body ◽  
Severe Deficiency ◽  
Significant Difference ◽  
25 Oh Vitamin D ◽  
The City

The proven relationship between the frequency of influenza and acute respiratory infections in children with vitamin D deficiency and the data on the relationship between a high mortality rate from SARS-CoV-2 in patients with low levels of vitamin D in the body under conditions of a forced sharp decrease in the level of insolation in the period from March 11, 2020 dictated the relevance assessing the vitamin D supply of children and adolescents in educational organizations of the city of Ulan-Ude. Purpose of the study: to assess the vitamin D supply of children and adolescents living in the city of Ulan-Ude. Methods: in a non-randomized, single-center, transverse (one-stage) uncontrolled comparative study, the concentration of 25(OH) vitamin D – 25(OH)D – in the blood serum of children and adolescents in Ulan-Ude was studied from May 22 to May 24, 2020. Moderate vitamin D deficiency (deficiency) was determined when the content of 25(OH)D was in the range of 20–30 ng/ml, the deficiency was within the limits, and the severe deficiency was <10 ng/ml. Results: assessment of vitamin D provision was carried out in 60 children aged 10 to 17 years (15 [11; 16] years), of which 19 boys, 41 girls. Children were divided into 2 groups depending on age: 10–11 years old (grade 5) (n=27) and 15–17 years old (grades 9–11) (n=33). Deficiency of vitamin D was found in 4 (15%), 11 (33%); deficit – in 19 (70%), 18 (55%); severe deficiency – in 2 (7%), 4 (12%), respectively. Along with low indicators of the provision of children and adolescents in the city of Ulan-Ude, an even lower provision of children and adolescents of Buryats was noted. The concentration of vitamin D in Buryat children and adolescents below normal (less than 30 ng/ml) was found in 35 (100%) children and adolescents, deficiency – in 8 (23%) children, vitamin D deficiency – in 21 (60%) children and severe deficiency – in 6 (17%). A statistically significant difference in the content of 25(OH)D between children and adolescents of Russian nationality and Buryats was revealed (p=0,0056). Evaluation of the diet showed that the frequency of consumption of fish as a source of vitamin D by children and adolescents is low. Conclusion: there is a high incidence of vitamin D deficiency and deficiency, which amounted to 97% in the examined children and adolescents living in the city of Ulan-Ude, more pronounced in Buryat children and adolescents, which requires organizational measures to replenish the vitamin D deficiency.

scholarly journals Chronic Obstructive Lung Disease in young: Alpha 1 anti trypsin deficiency

2015 ◽  
Vol 3 (2) ◽  
pp. 65-67
Author(s):  
S.S. Dhakal ◽  
K.K. Agrawaal ◽  
N.K. Bhatta
Keyword(s):  
Bronchial Asthma ◽  
Clinical Manifestations ◽  
Lower Lobe ◽  
Chronic Obstructive Lung Disease ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Severe Deficiency ◽  
History Of ◽  
Pulmonary Arterial ◽  
Alpha 1 Antitrypsin

Alpha-1 antitrypsin (AAT) deficiency is a clinically under recognized inherited disorder. The main clinical manifestations relate to three separate organs: the lung, the liver, and the skin. In the lung, severe deficiency of AAT predisposes to chronic obstructive pulmonary disease. We present a case of 34 years male with a history of recurrent chest infections in past and treated in the line of bronchial asthma but not relieved. He was admitted on 22nd May 2011 at BPKIHS. He presented with type 2 respiratory failure and had features of severe pulmonary arterial hypertension and left lower lobe pneumonia. The patient got improved with the treatment and is doing well on follow up. The diagnosis should be strongly suspected in patients with history suggestive of bronchial asthma and with obstructive features.Journal of Advances in Internal Medicine 2014;3(2):65-67

scholarly journals Glucose-6-Phosphate Dehydrogenase Deficiency among Children Attending the Emergency Department of Yankin Children’s Hospital, Yangon

2019 ◽  
Vol 31 (2) ◽  
pp. 143-147
Keyword(s):  
Emergency Department ◽  
G6pd Deficiency ◽  
Who Classification ◽  
G6pd Activity ◽  
World Health ◽  
In Vitro Test ◽  
Children's Hospital ◽  
Severe Deficiency ◽  
Test Kit ◽  
Children’S Hospital

Yankin Children’s Hospital is one of the tertiary children hospitals in Myanmar, where some oxidative medications are commonly used in the management of illnesses. Paediatrician’s awareness of G6PD status in this population is very important for effective management and prevention of complications in G6PD deficient children. This preliminary study aims to determine the prevalence of G6PD deficiency according to WHO classification among children seeking medical care at Emergency Department of Yankin Children’s Hospital (YKCH). It was a cross-sectional descriptive study on 124 children, aged 1 month to 13 years. G6PD enzyme activity was determined by spectrophotometric assay within 24 hours of sample collection. Randox G6PD quantitative in vitro test kit (Randox Laboratories, Crumlin, UK) was used and G6PD activity was calculated as unit per gram (U/g) of haemoglobin (Hb). For classification of G6PD deficiency, 10% and 60% level of normal enzyme activities were calculated according to the suggestion by World Health Organization (WHO); G6PD activity <10% was defined as severe deficiency and 10-60% was defined as moderate deficiency. According to WHO classification, 18.5% (23/124) of children in this study was classified as G6PD deficient, with 3.2% severe deficiency and 15.3% moderate deficiency. The prevalence of G6PD deficiency in Myanmar children is higher than the previous reported prevalence if quantitative spectrophotometric method is used for diagnosis, detecting more individuals with moderate deficiency. The high prevalence of G6PD deficiency in this study warrants for the need to do neonatal screening to avoid the potentially fatal complications of this disease.

scholarly journals Lethargic infant: severe deficiency of vitamin B12

2016 ◽  
Vol 17 (3) ◽  
pp. 173-176
Author(s):  
Daniela Janečková ◽  
Martina Suková ◽  
Lucie Šrámková ◽  
Elena Vodičková ◽  
Jan Starý
Keyword(s):  
Vitamin B12 ◽  
Severe Deficiency
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