Vitamin D in respiratory viral infections: a key immune modulator?

Author(s):  
Mostafa Vaghari-Tabari ◽  
Iraj Mohammadzadeh ◽  
Durdi Qujeq ◽  
Maryam Majidinia ◽  
Forough Alemi ◽  
...  
2016 ◽  
Vol 27 (1) ◽  
pp. e1909 ◽  
Author(s):  
Mihnea T. Zdrenghea ◽  
Heidi Makrinioti ◽  
Cristina Bagacean ◽  
Andy Bush ◽  
Sebastian L. Johnston ◽  
...  

2020 ◽  
Vol 8 (5) ◽  
pp. 60-74
Author(s):  
Mohammed I. Hamzah ◽  
◽  
Israa A. Abdul Kareem ◽  
Sabah Hasan Shindakh Nooraldeen ◽  
◽  
...  

Author(s):  
Devi Dayal

<p>Vitamin D deficiency (VDD) is presumed to play a role in several infective and non-infective conditions such as acute respiratory infections, tuberculosis, diabetes, hypertension, stroke etc. Most of the respiratory viral infections occur during winter season when the vitamin D levels in most individuals are generally low. The current pandemic of coronavirus disease 2019 (COVID-19) which began during winter season similar to the previous epidemics due to coronaviruses, has again stirred a debate on the role of VDD in the initiation and spread of the pandemic. The data on vitamin D status in patients with COVID-19 is however lacking. Different vitamin D supplementation strategies have recently been suggested as part of several countermeasures aimed at reducing the impact of COVID-19 pandemic. This brief narrative review discusses the evidence for the link between VDD and COVID-19 and the approaches suggested for vitamin D supplementation.</p>


2021 ◽  
Vol 9 (E) ◽  
pp. 1109-1114
Author(s):  
S. B. Dyussenova ◽  
M. Y. Gordiyenko ◽  
M. S. Askarov ◽  
G. K. Tuleuova ◽  
S. B. Suleimenova ◽  
...  

Clinical studies and meta-analyzes have shown that reduced levels of 25 (OH) D in the blood contribute to impaired immunity and stimulate excessive inflammation that adversely affects the health of children: the risk of developing bronchial asthma (BA), obstructive bronchitis, and allergic rhinitis increases. The main purpose of this review is to summarize the current literature data on the relationship between vitamin D, VRI and other infectious diseases with a clinical example.


Author(s):  
Mamtha Balla ◽  
Ganesh Prasad Merugu ◽  
Venu Madhav Konala ◽  
Vikram Sangani ◽  
Hema Kondakindi ◽  
...  

2014 ◽  
Vol 142 (9) ◽  
pp. 1789-1801 ◽  
Author(s):  
K. J. BRYSON ◽  
A. A. NASH ◽  
M. NORVAL

SUMMARYThe active form of vitamin D has effects on both innate and adaptive immune responses that may influence the outcome in many infectious diseases. Observational studies conclusively show that a low vitamin D status is associated with an increased occurrence of respiratory viral infections, which globally represent significant health and financial burdens. However, no consistent protective effects are evident in prospective clinical trials carried out to date where vitamin D was provided as a dietary supplement, except possibly in cases where the starting vitamin D status of the individual was considered deficient. Thus far, vitamin D has not been found to enhance the immune response to vaccines. The design of future prospective clinical trials assessing a role for vitamin D in respiratory viral infections requires very careful planning to avoid the uncertainties associated with the data available currently.


COVID-19 spread across the world, like a wildfire during the first half of the year 2020. It coincided with the flu season in countries located in northern and southern latitudes, during their respective winter periods. Whereas in the middle east, during its summertime people develop hypovitaminosis D, when people completely avoid the sun due to extreme heat. Consequently, people stay away from the hot sun and consequently, vitamin D concertation and the innate immunity reduce, increaseing the risks of acquiring respiratory viral infections. Thus, it is not necessary the low temperature and high humidity but the lack of exposure to ultraviolet (UV) B rays from the sunlight that reduces the population vitamin D concentration, which weakens the immunity, thereby increasing the risk of contracting COVID-19, and to develop associated complications and deaths. The effective public health modes for prevention of COVID-19 includes, wearing face masks properly covering nose and mouth, avoid crowd gatherings, especially in enclosed spaces, washing hands each time returned to office or home, and having a balance diet with adequate micronutrients, and these use of UVC lamps. At present there is no specific antiviral, or safe, effective, and affordable vaccine against COVID-19; it is unlikely such would materialize during the year 2020 or even beyond. At present, the only proven intervention that prevent COVID-19 and reduces its complications and deaths is vitamin D.


2011 ◽  
Vol 31 (4) ◽  
pp. 341-356 ◽  
Author(s):  
Virginia Amanatidou ◽  
Apostolos Zaravinos ◽  
Stavros Apostolakis ◽  
Demetrios A. Spandidos

2017 ◽  
Vol 96 (4) ◽  
pp. 22-27 ◽  
Author(s):  
I. V. Babachenko ◽  
◽  
L. A. Alekseeva ◽  
O. M. Ibragimova ◽  
Т. V. Bessonova ◽  
...  

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