Coenzyme Q concentration and total antioxidant capacity of human milk at different stages of lactation in mothers of preterm and full-term infants

2006 ◽  
Vol 40 (2) ◽  
pp. 199-206 ◽  
Author(s):  
José L. Quiles ◽  
Julio J. Ochoa ◽  
M. Carmen Ramirez-Tortosa ◽  
Javier Linde ◽  
Stefano Bompadre ◽  
...  
Keyword(s):  
Human Milk ◽  
Antioxidant Capacity ◽  
Total Antioxidant Capacity ◽  
Coenzyme Q ◽  
Full Term ◽  
Term Infants ◽  
Total Antioxidant

scholarly journals The effect of lyophilization on selected biologically active components (vitamin C, catalase, lysozyme), total antioxidant capacity and lipid oxidation in human milk

2017 ◽  
Vol 112 (3) ◽  
pp. 121-128
Author(s):  
Dorota Martysiak-Żurowska ◽  
Małgorzata Puta ◽  
Anna Rodzik ◽  
Edyta Malinowska-Pańczyk
Keyword(s):  
Vitamin C ◽  
Human Milk ◽  
Lipid Oxidation ◽  
Antioxidant Capacity ◽  
Total Antioxidant Capacity ◽  
Freeze Drying ◽  
Biologically Active ◽  
Initial Water Content ◽  
Initial Water ◽  
Total Antioxidant

Human milk is rich in polyunsaturated fatty acids, as well as lysozyme, vitamin C and other bioactive compounds. The effect of lyophilization on the content of antioxidants (vitamin C and catalase CAT), bactericidal compounds (lysozyme), total antioxidant capacity (TAC) and lipid peroxidation in human milk was investigated in this study. Samples of mature human milk were collected from five healthy women who gave birth on the scheduled date and without complications. Freeze drying resulted in the removal of 88.2 % of the initial water content from milk. The human milk lyophilizate was readily soluble in water. Lyophilization had no effect on the content of primary (lipid peroxides LP) and secondary (thiobarbituric acid reactive substances TBARS) products of lipid oxidation. Freeze-drying led to a significant decrease in the vitamin C content and TAC values of milk (by 31 % and 16.5 %, respectively). Catalase and lysozyme were resistant to freeze-drying. Lyophilization induced a decrease in lysozyme content (9 %) and catalase activity (11 %) but these changes were not statistically significant. Low-temperature dehydration and rehydration of human milk lyophilizates promote satisfactory retention of biologically active ingredients and prevent the oxidation of human milk lipids. The results of this study indicate that lyophilization can be considered as an effective method for prolonging the shelf life of human milk.

Antioxidant Capacity of Breast Milk of Mothers who Delivered Prematurely is Higher Than That of Mothers who Delivered at Term

2011 ◽  
Vol 81 (6) ◽  
pp. 368-371 ◽  
Author(s):  
H. Turhan ◽  
Atıcı ◽  
Muslu
Keyword(s):  
Oxidative Stress ◽  
Breast Milk ◽  
Antioxidant Capacity ◽  
Preterm Infants ◽  
Total Antioxidant Capacity ◽  
Neonatal Period ◽  
Term Infants ◽  
Milk Samples ◽  
Total Antioxidant ◽  
The Mean

Background: The total antioxidant capacity of plasma of preterm infants has been suggested to be lower than that of term infants. The objective of this study was to compare the total antioxidant capacity of the breast milk of mothers who delivered prematurely with that of mothers who delivered at term. Materials and Methods: A total of 71 breast milk samples were collected, 41 from mothers who delivered preterm (27 to 37 weeks) and 30 from mothers who delivered at term (38 to 42 weeks). Results: The mean total antioxidant capacity of the breast milk of mothers who delivered prematurely was higher (2.19 ± 0.88 mmol/L) than that of mothers who delivered at term (1.7 ± 0.86 mmol/L) (p = 0.024). Conclusion: Breastfeeding may protect preterm infants against oxidative stress and related disorders in the neonatal period.

scholarly journals Macronutrient, immunoglobulin a and total antioxidant capacity profiles of human milk from 1 to 24 months: a cross-sectional study in Thailand

2020 ◽  
Vol 15 (1) ◽  
Author(s):  
Krongporn Ongprasert ◽  
Jetsada Ruangsuriya ◽  
Rungnapa Malasao ◽  
Ratana Sapbamrer ◽  
Pikul Suppansan ◽  
...  
Keyword(s):  
Human Milk ◽  
Antioxidant Capacity ◽  
Total Antioxidant Capacity ◽  
Energy Content ◽  
Immunoglobulin A ◽  
Milk Composition ◽  
Cross Sectional ◽  
Milk Samples ◽  
Carbohydrate Concentration ◽  
Total Antioxidant

Abstract Background An extended duration of breastfeeding of up to two years is encouraged by many health authorities, but information regarding the composition of milk after one year postpartum is limited. The goal of this study was to determine the association between the duration of lactation and macronutrient contents, immunoglobulin A (IgA) levels and total antioxidant capacity (TAC) in human milk (HM), from 1 to 24 months postpartum. Methods Cross-sectional milk samples were collected between January and April 2019 from mothers with healthy full-term children who had been lactating for 1 to 24 months. The HM was biochemically analyzed for protein and carbohydrate contents by colorimetric assays. The fat content was determined by capillary centrifugation, and the energy content was calculated from the results of centrifugation assays. IgA levels and TAC were determined by ELISA and a Trolox equivalent antioxidant capacity (TEAC) assay, respectively. Pearson’s correlation coefficient and Spearman’s rank correlation coefficient were used to determine associations between months of lactation and milk composition, and multiple regression analysis was used to assess associations between months of lactation and milk composition adjusted for relevant covariates. Differences were considered significant at p < 0.05. Results One hundred eighty-four milk samples were analyzed. The month of lactation was positively associated with the fat concentration (B = 0.31, SE = 0.09, p = 0.001), energy content (B = 3.11, SE = 0.92, p = 0.001), and IgA (B = 4.17, SE = 1.08, p < 0.001) but negatively associated with the carbohydrate concentration (B = − 0.22, SE = 0.01, p = 0.04). No association was observed between the month of lactation and the protein concentration or TAC after adjustment for maternal age, maternal BMI, birth order, and breastfeeding frequency. Conclusion The duration of lactation was found to be positively associated with the fat, energy, and IgA content in HM for up to two years postpartum, and negatively associated with carbohydrate concentration. More prospective cohort studies are needed to obtain evidence-based knowledge regarding the changes in HM composition throughout the course of lactation.

scholarly journals Macronutrient, immunoglobulin A and total antioxidant capacity profiles of human milk from 1 to 24 months postpartum

2020 ◽  
Author(s):  
krongporn ongprasert ◽  
Jetsada Ruangsuriya ◽  
Rungnapa Malasao ◽  
Ratana Sapbamrer ◽  
Pikul Suppansan ◽  
...  
Keyword(s):  
Human Milk ◽  
Antioxidant Capacity ◽  
Correlation Coefficient ◽  
Total Antioxidant Capacity ◽  
Energy Content ◽  
Immunoglobulin A ◽  
Trolox Equivalent Antioxidant Capacity ◽  
Healthy Children ◽  
Total Antioxidant ◽  
Extended Lactation

Abstract Background: A longer duration of breastfeeding of up to two years is encouraged by many health authorities, but there is limited information regarding the composition of milk after one year postpartum. The goal of this study was to determine the changes in human milk macronutrient, immunoglobulin A (IgA), and total antioxidant capacity (TAC) profiles during extended lactation.Methods: One hundred eighty-four breastfeeding mothers with full-term healthy children who had been lactating from 1 to 24 months were recruited from January 2019 to April 2019. Human milk was biochemically analyzed for protein and carbohydrate content by colorimetric assays. The fat content was determined by capillary centrifugation, and the energy content was calculated from the results of centrifugation assays. IgA levels and TAC were determined by ELISA and a Trolox equivalent antioxidant capacity (TEAC) assay, respectively. Pearson’s correlation coefficient and Spearman’s rank correlation coefficient were used to determine the association of milk composition with month of lactation.Results: The fat, energy and IgA contents were positively correlated with the duration of lactation (r = 0.229, p = 0.002 ; r = 0.229, p =0.002 and r = 0.304, p < 0.001, respectively). No significant correlations between protein, carbohydrate concentrations and TAC with the duration of lactation were observed (r = 0.106, p = 0.15; r = -0.032, p = 0.67; r = -0.056, p = 0.45, respectively).Conclusions: We demonstrated that fat, energy and IgA contents increased during extended lactation lasting up to two years postpartum, while protein and carbohydrate concentrations and TAC were not related to lactation duration. Based on these results, lactating mothers should be encouraged to continue breastfeeding for at least two years postpartum.

scholarly journals Macronutrient, immunoglobulin A and total antioxidant capacity profiles of human milk: cross-sectional surveys at ages 6, 12, 18 and 24 months.

2020 ◽  
Author(s):  
krongporn ongprasert ◽  
Jetsada Ruangsuriya ◽  
Rungnapa Malasao ◽  
Ratana Sapbamrer ◽  
Pikul Suppansan ◽  
...  
Keyword(s):  
Human Milk ◽  
Antioxidant Capacity ◽  
Correlation Coefficient ◽  
Total Antioxidant Capacity ◽  
Energy Content ◽  
Immunoglobulin A ◽  
Milk Composition ◽  
Milk Samples ◽  
Carbohydrate Concentration ◽  
Total Antioxidant

Abstract Background: A longer duration of breastfeeding of up to two years is encouraged by many health authorities, but information regarding the composition of milk after one year postpartum is limited. The goal of this study was to determine the associations of macronutrient contents, immunoglobulin A (IgA) levels, and the total antioxidant capacity (TAC) in human milk (HM) with the month of lactation from 1 to 24 months postpartum.Methods: Milk samples were collected from mothers with healthy full-term children who had been lactating from 1 to 24 months from January 2019 to April 2019. HM was biochemically analyzed for protein and carbohydrate contents by colorimetric assays. The fat content was determined by capillary centrifugation, and the energy content was calculated from the results of centrifugation assays. IgA levels and the TAC were determined by ELISA and a Trolox equivalent antioxidant capacity (TEAC) assay, respectively. Pearson’s correlation coefficient and Spearman’s rank correlation coefficient were used to determine associations between milk composition and the month of lactation, and multiple regression analysis was used to assess the association between covariates and milk composition. Differences were considered significant at p < 0.05.Results: One hundred eighty-four milk samples were analyzed. The month of lactation was positively associated with the fat concentration (B = 0.31, SE = 0.09, p = 0.001), energy content (B = 3.11, SE = 0.92, p = 0.001), and IgA (B = 4.17, SE = 1.08, p < 0.001) but negatively associated with the carbohydrate concentration (B = -0.22, SE = 0.01, p = 0.04). No association was observed between the month of lactation and the protein concentration and TAC after adjustment for maternal age, maternal BMI, birth order, and breastfeeding frequency.Conclusions: Based on our results, fat, energy, and IgA contents in HM were positively associated with the month of lactation, and a slight but significant negative association was detected for the carbohydrate concentration up to two years postpartum.

scholarly journals Macronutrient, immunoglobulin A and total antioxidant capacity profiles of human milk: cross-sectional surveys at ages 6, 12, 18 and 24 months.

2020 ◽  
Author(s):  
krongporn ongprasert ◽  
Jetsada Ruangsuriya ◽  
Rungnapa Malasao ◽  
Ratana Sapbamrer ◽  
Pikul Suppansan ◽  
...  
Keyword(s):  
Human Milk ◽  
Antioxidant Capacity ◽  
Correlation Coefficient ◽  
Total Antioxidant Capacity ◽  
Immunoglobulin A ◽  
Milk Composition ◽  
Trolox Equivalent Antioxidant Capacity ◽  
Carbohydrate Concentration ◽  
Total Antioxidant ◽  
Extended Lactation

Abstract Background: A longer duration of breastfeeding of up to two years is encouraged by many health authorities, but there is limited information regarding the composition of milk after one year postpartum. The goal of this study was to determine the association between human milk macronutrient, immunoglobulin A (IgA), and total antioxidant capacity (TAC) profiles during extended lactation.Methods: One hundred eighty-four breastfeeding mothers with full-term healthy children who had been lactating from 1 to 24 months were recruited from January 2019 to April 2019. Human milk was biochemically analyzed for protein and carbohydrate content by colorimetric assays. The fat content was determined by capillary centrifugation, and the energy content was calculated from the results of centrifugation assays. IgA levels and TAC were determined by ELISA and a Trolox equivalent antioxidant capacity (TEAC) assay, respectively. Pearson’s correlation coefficient and Spearman’s rank correlation coefficient were used to determine associations between milk composition with month of lactation, and multiple regression analysis was used to assess the association between covariate variables and milk composition. Differences were considered significant at p < 0.05.Results: The fat, energy and IgA contents were positively correlated with the duration of lactation (r = 0.229, p = 0.002; r = 0.229, p =0.002 and r = 0.304, p < 0.001, respectively). No significant correlations between protein, carbohydrate concentrations and TAC with the duration of lactation were observed (r = 0.106, p = 0.15; r = -0.032, p = 0.67; r = -0.056, p = 0.45, respectively). After adjusting for the covariates, the month of lactation was negatively associated with the carbohydrate concentration (p = 0.04), while similar results were observed for other components.Conclusions: We demonstrated that fat, energy, and IgA contents increased during extended lactation lasting up to two years postpartum. A slightly but significant decrease was detected in carbohydrate concentration. No association was observed in protein concentration and TAC with the duration of lactation. Based on these results, lactating mothers should be encouraged and supported to continue breastfeeding for at least two years postpartum.

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