3D printing and enteric coating of a hollow capsular device with controlled drug release characteristics prepared using extruded Eudragit® filaments

2021 ◽  
pp. 1-26
Author(s):  
Dinesh Choudhury ◽  
Upadhyayula Suryanarayana Murty ◽  
Subham Banerjee
Keyword(s):  
3D Printing ◽  
Drug Release ◽  
Controlled Drug Release ◽  
Enteric Coating ◽  
Capsular Device

scholarly journals A Study Based on Controlled Drug Release by 3D Printed Aloe-Vera Bi-Layer Tablet

2021 ◽  
pp. 522-531
Author(s):  
Anurag Verma ◽  
Piyush Mittal ◽  
Milind S. Pande ◽  
Neelanchal Trivedi
Keyword(s):  
3D Printing ◽  
Drug Release ◽  
Integral Functional ◽  
Aloe Vera ◽  
Controlled Drug Release ◽  
Immediate Release ◽  
Aloe Barbadensis ◽  
3D Printed ◽  
Medicinal Properties ◽  
Printing Techniques

Aloe-Vera or Aloe barbadensis (botanical name) is a plant with many medicinal properties and have great importance in Ayurveda. Its leaves are succulent, erect, forming a thick rosette. The internal translucent pulp of Aloe-Vera is bound to a waxy crust or cuticle, and its vascular tissues transport minerals as well as water from the soil. Aloe Vera is being used as a major skin rejuvenating product, although it has varied medicinal properties also. In the present study, an attempt to make a method to create bi-layer tablets of Aloe-Vera, utilizing 3D printing techniques is presented. The method created doesnt affect the integral functional characteristics of the tablet. The method here contains creating an immediate release and sustained release tablet for making the Aloe-Vera to be used directly by the person for its numerous health effects. The tablet is designed so to be consumed by vegans as well since it is completely herbal.

scholarly journals 3D printing of bioinspired compartmentalized capsular structure for controlled drug release

2021 ◽  
Vol 22 (12) ◽  
pp. 1022-1033
Author(s):  
Jingwen Li ◽  
Mingxin Wu ◽  
Wenhui Chen ◽  
Haiyang Liu ◽  
Di Tan ◽  
...  
Keyword(s):  
3D Printing ◽  
Drug Release ◽  
Controlled Drug Release

scholarly journals 3D Printing of Thermoresponsive Hydrogel Laden with an Antimicrobial Agent towards Wound Healing Applications

2021 ◽  
Vol 8 (6) ◽  
pp. 79
Author(s):  
Martyna Nizioł ◽  
Justyna Paleczny ◽  
Adam Junka ◽  
Amin Shavandi ◽  
Anna Dawiec-Liśniewska ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
3D Printing ◽  
Drug Release ◽  
Antimicrobial Agent ◽  
External Solution ◽  
Controlled Drug Release ◽  
Wound Dressings ◽  
Hydrogel Scaffolds ◽  
Thermoresponsive Hydrogel ◽  
Octenidine Dihydrochloride

Thermoresponsive hydrogel-based wound dressings with an incorporated antimicrobial agent can be fabricated employing 3D printing technology. A novel printable ink containing poly(N-isopropylacrylamide) (PNIPAAm) precursors, sodium alginate (ALG), methylcellulose (MC) that is laden with a mixture of octenidine dihydrochloride and 2-phenoxyethanol (Octenisept®, OCT) possess accurate printability and shape fidelity. This study also provides the protocol of ink’s use for the 3D printing of hydrogel scaffolds. The hydrogel’s physicochemical properties and drug release profiles from the hydrogel specimens to the external solution have been determined at two temperatures (20 and 37 °C). The release test showed a sustained OCT delivery into ultrapure water and the PBS solution. The temperature-responsive hydrogel exhibited antimicrobial activity against Staphylococcus aureus, Candida albicans, and Pseudomonas aeruginosa and demonstrated non-cytotoxicity towards fibroblasts. The thermoresponsive behavior along with biocompatibility, antimicrobial activity, and controlled drug release make this hydrogel a promising class of materials for wound dressing applications.

Reducing the Risk in Controlled Drug Release by Using Tannic Acid in Liposomal Formulations

2018 ◽  
Vol 68 (12) ◽  
pp. 2925-2918
Author(s):  
Gabriela Cioca ◽  
Maricel Agop ◽  
Marcel Popa ◽  
Simona Bungau ◽  
Irina Butuc
Keyword(s):  
Drug Release ◽  
Tannic Acid ◽  
Release Rate ◽  
Controlled Drug Release ◽  
Toxicity Threshold ◽  
Release System ◽  
Liposomal Formulations ◽  
Cross Linker ◽  
Natural Cross

One of the main challenges in designing a release system is the possibility to control the release rate in order to maintain it at a constant value below a defined limit, to avoid exceeding the toxicity threshold. We propose a method of overcoming this difficulty by introducing the drug into liposomes, prior to its inclusion in the hydrogel. Furthermore, a natural cross linker (as is tannic acid) is used, instead of the toxic cross linkers commonly used, thus reducing the toxicity of the release system as a whole.

Nanostructured Ketorolac-Tromethamine/MCF: Synthesis, Characterization and Application in Drug Release System

2018 ◽  
Vol 14 (5) ◽  
pp. 432-439 ◽  
Author(s):  
Juliana M. Juarez ◽  
Jorgelina Cussa ◽  
Marcos B. Gomez Costa ◽  
Oscar A. Anunziata
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Therapeutic Efficacy ◽  
Drug Delivery Systems ◽  
Controlled Drug Release ◽  
Delivery Systems ◽  
The Body ◽  
Fickian Diffusion ◽  
Ketorolac Tromethamine

Background: Controlled drug delivery systems can maintain the concentration of drugs in the exact sites of the body within the optimum range and below the toxicity threshold, improving therapeutic efficacy and reducing toxicity. Mesostructured Cellular Foam (MCF) material is a new promising host for drug delivery systems due to high biocompatibility, in vivo biodegradability and low toxicity. Methods: Ketorolac-Tromethamine/MCF composite was synthesized. The material synthesis and loading of ketorolac-tromethamine into MCF pores were successful as shown by XRD, FTIR, TGA, TEM and textural analyses. Results: We obtained promising results for controlled drug release using the novel MCF material. The application of these materials in KETO release is innovative, achieving an initial high release rate and then maintaining a constant rate at high times. This allows keeping drug concentration within the range of therapeutic efficacy, being highly applicable for the treatment of diseases that need a rapid response. The release of KETO/MCF was compared with other containers of KETO (KETO/SBA-15) and commercial tablets. Conclusion: The best model to fit experimental data was Ritger-Peppas equation. Other models used in this work could not properly explain the controlled drug release of this material. The predominant release of KETO from MCF was non-Fickian diffusion.

scholarly journals Magnetic hyperthermia controlled drug release in the GI tract: solving the problem of detection

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Joseph C. Bear ◽  
P. Stephen Patrick ◽  
Alfred Casson ◽  
Paul Southern ◽  
Fang-Yu Lin ◽  
...  
Keyword(s):  
Drug Release ◽  
Controlled Drug Release ◽  
Magnetic Hyperthermia ◽  
Gi Tract

Improvement of Medication Adherence and Controlled Drug Release by Optimized Acetaminophen Formulation

2021 ◽  
Author(s):  
Suyoung Been ◽  
Jeongmin Choi ◽  
Young Hun Lee ◽  
Pil Yun Kim ◽  
Won Kyung Kim ◽  
...  
Keyword(s):  
Medication Adherence ◽  
Drug Release ◽  
Controlled Drug Release
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