Cognitive performance and subjective complaints before and after remission of major depression

2007 ◽  
Vol 12 (1) ◽  
pp. 25-45 ◽  
Author(s):  
Denise Lahr ◽  
Thomas Beblo ◽  
Wolfgang Hartje
2021 ◽  
Vol 14 (6) ◽  
pp. 582
Author(s):  
Monika Dominiak ◽  
Anna Z. Antosik-Wójcińska ◽  
Marcin Wojnar ◽  
Paweł Mierzejewski

Electroconvulsive therapy (ECT) remains the most effective therapy in treatment-resistant depression. However, the safety of ECT has been consistently questioned, particularly among elderly patients. We assessed the efficacy and safety of ECT in patients before and after 65 years old. The study was conducted between 2015 and 2018 and included 91 patients (61 under and 29 over 65 years old) with major depression undergoing ECT. The Hamilton Depression Rating Scale was used to evaluate efficacy. Cognitive functions were assessed using: MMSE, RAVLT, Trail Making Test, Stroop Test and Autobiographical Memory Interview-Short Form. ECT was more effective in older patients as compared to younger (p < 0.001). No serious adverse events were observed in either group. Increased blood pressure and arrhythmias were more common in the older compared to the younger group (p = 0.044 and p = 0.047, respectively), while disturbances of consciousness did not differ between groups (p = 0.820). Most of the cognitive functions remained unchanged compared to baseline, whereas the outcomes of MMSE, RAVLT and Stroop tests showed greater improvements in the older compared to the younger group (all p < 0.05). The decline in the retrieval consistency of autobiographical memory was more pronounced in the younger group (p = 0.024). ECT is a highly effective, safe and well-tolerated method of treating depression regardless of age.


2020 ◽  
Vol 18 (4) ◽  
pp. 507-523
Author(s):  
Ludmiła Zając-Lamparska

One of the most important determinants of successful aging is cognitive ability. Although cognitive decline is a well-documented phenomenon characteristic of aging, it is acknowledged that aging can also be related to cognitive neuroplasticity that allows one to compensate the decline and adapt to it. Cognitive neuroplasticity may be spontaneous or induced by external influences. An example of the former is compensatory brain activity in older adults, and the latter – improvement in cognitive functioning under the influence of cognitive training. Both the compensatory brain activity of older adults and the effectiveness of cognitive training in this age group have already been extensively studied. However, it has not yet been examined whether they can be linked. The article indicates theoretical and empirical premises for the possibility of influencing compensatory brain activity in older adults by cognitive training. In the most comprehensive way the phenomenon of compensatory brain activity in older adults is addressed by the STAC model – the Scaffolding Theory of Aging and Cognition, which also provides the theoretical grounds for the possible impact of cognitive training on compensatory brain activity. There are also empirical arguments in favour of such an impact, but they are quite limited in nature. The reason for this is the lack of research directly addressing the problem of the consistency of brain activity changes resulting from cognitive training with the assumptions of compensatory brain activity models, such as STAC. The theoretical grounds for the linkage of compensatory brain activity in older adults with the influence of cognitive training are clear. However, the analysis of the studies discussed in the article suggests that failing to embed the study design within the theoretical framework of compensatory brain activity in older adults may lead to the exclusion of factors important in drawing conclusions about this phenomenon. The following elements of the study design were identified as necessary to include: participation of young adults in the study as a reference group, usage of tasks in different difficulty levels during the measurement of brain activity and consideration of the relation between brain activity and cognitive performance, and comparison of brain activity in relation to cognitive performance before and after training in both, older and young adults.


2011 ◽  
Vol 26 (S2) ◽  
pp. 904-904
Author(s):  
F.D. Garcia ◽  
Q. Coquerel ◽  
E. Kiive ◽  
P. Déchelotte ◽  
J. Harro ◽  
...  

IntroductionAbnormal vasopressin (VP) and oxytocin (OT) signaling may contribute to the altered activity of the hypothalamo-pituitary-adrenal (HPA) axis in major depression; the underlying mechanisms remain uncertain.ObjectiveThis study characterized plasma levels and affinities of OT-and VP-reactive autoantibodies (autoAbs) with relation to disease severity and plasma cortisol response to physical exercise in patients with mild and moderate depression and healthy controls.MethodsPhysical exercise was used to elicit plasma cortisol response in 23 male depressive and 20 healthy subjects. All subjects were evaluated by the MADRS. Plasma levels VP-and OT-reactive IgG, IgA and IgM autoAbs were measured by ELISA, before and after the exercise, and affinity was measured by plasmon resonance.ResultsPlasma levels of OT-and VP-reactive total IgG autoAbs were lower in patients with moderate depression vs. controls and patients with mild depression. Both OT- and VP- free IgG autoAbs levels were negatively correlated with MADRS scores. Affinity values displayed 100 fold variability in both groups. Patients with moderate depression displayed blunted response of cortisol secretion to physical exercise. Baseline levels of VP total IgG and IgM autoAbs correlated negatively and of VP free IgG autoAbs correlated positively with plasma cortisol after physical exercise.ConclusionThese data show that changes of levels but not affinity of OT- and VP- reactive autoantibodies can be associated with the altered mood in subjects with moderate depression and that levels of VP-reactive autoAbs are associated with cortisol secretion.


2021 ◽  
Author(s):  
◽  
James Sullivan

<p>Tubular Daylighting Devices are used to bring daylight into deep-plan spaces, and meet sustainability goals. However, they are expensive, and justification for their use lies in hypothesised benefits they can provide in areas such as well-being and productivity. Yet, there is very little research into the effects of Tubular Daylighting Devices. The broader daylighting literature suggests that benefits to satisfaction, mood, and performance are possible — though research into the benefits of daylight is still not conclusive.  Therefore, a before and after study was carried out in a windowless computer room in the university to compare how the students responded under TDDs versus typical electric lighting. Their cognitive performance, change in mood, average sleepiness, and perceptions of the room and lighting were measured.  TDDs significantly increased ratings of room attractiveness and brightness, and had no more perceived glare than the electric lighting. Ratings of lighting quality were on a par with both typical electric lighting and good modern lighting. They were also just as effective on overcast days as sunny. No effects were found on performance or sleepiness, and mood results were inconclusive.  Overall, it is suggested that TDDs can be considered to be on a par with good modern lighting, and superior to typical existing lighting. Note, however, that it is possible that effects in rooms with windows could differ from those found here. Further research should use longer exposures and larger sample sizes if they wish to find performance effects.</p>


2006 ◽  
Vol 15 (5) ◽  
pp. 471-478 ◽  
Author(s):  
Gilles Dupuis ◽  
Elaine Kennedy ◽  
Ruth Lindquist ◽  
Franca B. Barton ◽  
Michael L. Terrin ◽  
...  

• Background Some studies have indicated a decline in patients’ cognitive performance after coronary artery bypass graft surgery. • Objective To evaluate cognitive performance before and after coronary artery bypass graft surgery. • Methods Patients’ cognitive performance before and after coronary artery bypass graft surgery was evaluated in a prospective observational multicenter study in 5 academic medical centers. A total of 242 men and 123 women were evaluated before surgery; 333 men and 216 women, 5 to 11 months after surgery (197 men and 99 women were evaluated both before and after surgery). Verbal ability, attention/concentration, logical/verbal and visual memory, and facial recognition were measured. Data on demographic, medical, and psychosocial characteristics also were collected. • ResultsAfter surgery, patients’ overall performance improved (P &lt; .001) for attention/concentration, verbal fluency, and logical/verbal memory. Patients with more education (high school or greater) performed better on each test (P &lt; .001) than did patients with less education. No strong effects of sex or age on cognitive performance were observed before or after surgery, and no important differences in sex, age, or education were associated with changes in scores from before to after surgery. • Conclusion On average, cognitive performance improved rather than declined after coronary artery bypass graft surgery. The improvements were consistent across sex, age, and education.


2020 ◽  
Vol 274 ◽  
pp. 813-818
Author(s):  
André Ponsoni ◽  
Laura Damiani Branco ◽  
Charles Cotrena ◽  
Flávio Milman Shansis ◽  
Rochele Paz Fonseca

2019 ◽  
Vol 46 (2) ◽  
pp. E14 ◽  
Author(s):  
Bradley Kolb ◽  
Hassan Fadel ◽  
Gary Rajah ◽  
Hamidreza Saber ◽  
Ali Luqman ◽  
...  

OBJECTIVESteno-occlusive diseases of the cerebral vasculature have been associated with cognitive decline. The authors performed a systematic review of the existing literature on intracranial steno-occlusive disease, including intracranial atherosclerosis and moyamoya disease (MMD), to determine the extent and quality of evidence for the effect of revascularization on cognitive performance.METHODSA systematic search of PubMed/MEDLINE, the Thomson Reuters Web of Science Core Collection, and the KCI Korean Journal Database was performed to identify randomized controlled trials (RCTs) in the English-language literature and observational studies that compared cognitive outcomes before and after revascularization in patients with steno-occlusive disease of the intracranial vasculature, from which data were extracted and analyzed.RESULTSNine papers were included, consisting of 2 RCTs and 7 observational cohort studies. Results from 2 randomized trials including 142 patients with symptomatic intracranial atherosclerotic steno-occlusion found no additional benefit to revascularization when added to maximal medical therapy. The certainty in the results of these trials was limited by concerns for bias and indirectness. Results from 7 observational trials including 282 patients found some cognitive benefit for revascularization for symptomatic atherosclerotic steno-occlusion and for steno-occlusion related to MMD in children. The certainty of these conclusions was low to very low, due to both inherent limitations in observational studies for inferring causality and concerns for added risk of bias and indirectness in some studies.CONCLUSIONSThe effects of revascularization on cognitive performance in intracranial steno-occlusive disease remain uncertain due to limitations in existing studies. More well-designed randomized trials and observational studies are needed to determine if revascularization can arrest or reverse cognitive decline in these patients.


2006 ◽  
Vol 22 (2) ◽  
pp. 107-112 ◽  
Author(s):  
Akiko Fujita ◽  
Shutaro Nakaaki ◽  
Kazuhisa Segawa ◽  
Hideki Azuma ◽  
Kiyoe Sato ◽  
...  

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