Autoantibodies reacting with vasopressin and oxytocin in relation to cortisol secretion in major depression

2011 ◽  
Vol 26 (S2) ◽  
pp. 904-904
Author(s):  
F.D. Garcia ◽  
Q. Coquerel ◽  
E. Kiive ◽  
P. Déchelotte ◽  
J. Harro ◽  
...  
Keyword(s):  
Major Depression ◽  
Physical Exercise ◽  
Plasma Levels ◽  
Plasma Cortisol ◽  
Cortisol Response ◽  
Cortisol Secretion ◽  
Mild Depression ◽  
Moderate Depression ◽  
Before And After ◽  
Underlying Mechanisms

IntroductionAbnormal vasopressin (VP) and oxytocin (OT) signaling may contribute to the altered activity of the hypothalamo-pituitary-adrenal (HPA) axis in major depression; the underlying mechanisms remain uncertain.ObjectiveThis study characterized plasma levels and affinities of OT-and VP-reactive autoantibodies (autoAbs) with relation to disease severity and plasma cortisol response to physical exercise in patients with mild and moderate depression and healthy controls.MethodsPhysical exercise was used to elicit plasma cortisol response in 23 male depressive and 20 healthy subjects. All subjects were evaluated by the MADRS. Plasma levels VP-and OT-reactive IgG, IgA and IgM autoAbs were measured by ELISA, before and after the exercise, and affinity was measured by plasmon resonance.ResultsPlasma levels of OT-and VP-reactive total IgG autoAbs were lower in patients with moderate depression vs. controls and patients with mild depression. Both OT- and VP- free IgG autoAbs levels were negatively correlated with MADRS scores. Affinity values displayed 100 fold variability in both groups. Patients with moderate depression displayed blunted response of cortisol secretion to physical exercise. Baseline levels of VP total IgG and IgM autoAbs correlated negatively and of VP free IgG autoAbs correlated positively with plasma cortisol after physical exercise.ConclusionThese data show that changes of levels but not affinity of OT- and VP- reactive autoantibodies can be associated with the altered mood in subjects with moderate depression and that levels of VP-reactive autoAbs are associated with cortisol secretion.

FC23-04 - Anti-neuropeptide y plasma immunoglobulins are distinctly associated with altered mood and appetite in depressive disorder

2011 ◽  
Vol 26 (S2) ◽  
pp. 1942-1942
Author(s):  
F.D. Garcia ◽  
Q. Coquerel ◽  
J.-C. do Rego ◽  
A. Cravezic ◽  
E. Kiive ◽  
...  
Keyword(s):  
Depressive Disorder ◽  
Neuropeptide Y ◽  
Plasma Levels ◽  
Forced Swim Test ◽  
Study Groups ◽  
Mild Depression ◽  
High Affinity ◽  
Swim Test ◽  
Moderate Depression ◽  
Immobility Time

IntroductionNeuropeptide Y(NPY) has potent antidepressant and orexigenic properties suggesting that altered NPY signaling can be relevant to etiology of altered mood and appetite commonly co-occurring in depressive disorder.ObjectiveStudy if plasma levels and affinities of anti-NPY immunoglobulins(autoAbs) are affected in depression.MethodsPlasma levels of NPY-reactive total/free IgG, IgM and IgA autoAbs were measured by ELISA in 14 patients with mild and in 9 patients with moderate depression and 20 controls. Affinity of autoAbs was assayed by the plasmon resonance. Depressant-like effect of human autoAbs was studied in mice using forced-swim test(FST) after IV injections of patients’ and controls’ IgG. Effects of affinity anti-NPY to antagonize NPY-induced antidepressant and orexigenic effects were studied in mice.ResultsPlasma levels of NPY total IgG autoAbs were lower in patients with moderate depression than in patients with mild depression and healthy controls. MADRS scores correlated negatively with levels of NPY free autoAbs but not with their affinity values were not significantly among study groups. Body mass index(BMI) correlated negatively with affinities of NPY IgG autoAbs. Immobility time in FST was increased by I.V. injection of IgG of patients and controls and correlated negatively with levels of NPY total IgG autoAbs. Low and high affinity NPY IgG autoAbs antagonized NPY-induced anti-immobility effect. Higher affinity autoAbs antagonized more NPY-induced food intake.ConclusionThese data suggest that changes of plasma levels of anti-NPY autoAbs are relevant to altered mood while changes of their affinity may be involved in altered appetite in depressive disorder.

Postdexamethason intact and multisequentia ACTH in melancholia

1991 ◽  
Vol 3 (1) ◽  
pp. 8-13
Author(s):  
M. Maes ◽  
C. Vandervorst ◽  
E. Suy ◽  
M. Martin ◽  
B. Minner ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Plasma Levels ◽  
Clinical Relevance ◽  
Plasma Cortisol ◽  
Adrenocorticotropic Hormone ◽  
Severity Of Illness ◽  
Dexamethasone Suppression Test ◽  
Before And After ◽  
Suppression Test ◽  
Dexamethasone Suppression

SummaryThe dexamethasone suppression test has been carried out in 111 depressed inpatients. Fasting, 8 a.m. plasma levels of Cortisol and adrenocorticotropic hormone (ACTH) were determined before and after administration of 1 mg dexamethasone. In 64 subjects multisequential (1-17,1-24,1-39) ACTH, and in 47 subjects intact (1-39) ACTH has been determined. Patients with melancholia exhibited significantly higher postdexamethasone Cortisol and intact ACTH values as compared with minor and simple major depressives. Severity of illness was significantly and positively related to postdexamethasone intact ACTH - but not to multisequential ACTH. Cortisol nonsuppressors showed higher postdexamethasone (only intact) ACTH values than Cortisol suppressors. Both postdexamethasone ACTH values were significantly and positively related with the postdexamethasone Cortisol values. We have established that Cortisol nonsuppression during melancholia is determined by an augmented escape of ACTH from suppression by dexamethasone. Intact ACTH showed the most significant clinical relevance for depression and Cortisol nonsuppression. In the clinical practice we advize the use of postdexamethasone intact ACTH in stead of plasma Cortisol or multisequential ACTH.

Effects of neuroleptic treatment on cortisol and 3-methoxy-4-hydroxyphenylethyl glycol levels in blood

1995 ◽  
Vol 144 (3) ◽  
pp. 425-429 ◽  
Author(s):  
G Wik
Keyword(s):  
Drug Treatment ◽  
Plasma Cortisol ◽  
Neuroleptic Drug ◽  
Cortisol Secretion ◽  
Healthy Controls ◽  
Neuroleptic Treatment ◽  
Before And After ◽  
Cortisol Levels

Abstract Plasma cortisol and serum 3-methoxy-4-hydroxyphenylethyl glycol (MHPG) were determined before and after 5–6 weeks of neuroleptic treatment in patients with schizophrenia. Following drug treatment both plasma cortisol and serum MHPG levels in patients decreased and plasma cortisol levels were also lower than in unmedicated healthy controls. Indications of a relationship between the reduction of cortisol and MHPG levels were found. The data show that neuroleptic drug treatment inhibits cortisol secretion. It is speculated that this inhibition could be related to reduced noradrenergic activity. Journal of Endocrinology (1995) 144, 425–429

scholarly journals TINGKAT DEPRESI PADA IBU POSTPARTUM DI PUSKESMAS MOROKREMBANGAN SURABAYA

2017 ◽  
Vol 5 (1) ◽  
pp. 43
Author(s):  
Sisilia Indriasari W
Keyword(s):  
Major Depression ◽  
Total Population ◽  
Mild Depression ◽  
Keywords Depression ◽  
Descriptive Research ◽  
Moderate Depression ◽  
Prevention And Treatment ◽  
Mother And Child ◽  
Research Population ◽  
Depression Level

ABSTRAKDepresi postpartum adalah depresi setelah melahirkan yang berlangsung selama berbulan-bulan dan kadang mereka tidak menyadari bahwa yang sedang dialaminya merupakan penyakit. Kelahiran dan kehadiran seorang bayi seharusnya mendatangkan kebahagiaan tersendiri bagi pasangan suami istri. Tidak semua ibu merasa gembira dengan kelahiran mereka, misalnya ibu mengungkapkan tidak bisa tidur dengan nyenyak dan mengalami penurunan berat badan. Penelitian ini bertujuan  untuk mengidentifikasi gambaran tingkat depresi ibu postpartum di Puskesmas. Desain penelitian ini adalah penelitian deskriptif dengan variabel  tingkat depresi pada ibu postpartum. Populasi terjangkau dari penelitian ini adalah 64 ibu yang datang memeriksakan diri ke Puskesmas dan terdiri dari 55 responden. Hasil penelitian tingkat depresi ibu postpartum dari 55 responden adalah 53%  mengalami depresi ringan, 33% tidak mengalami depresi, 9% mengalami depresi berat dan 5% mengalami depresi sedang maka, diharapkan Puskesmas Morokrembangan bagian KIA untuk memberikan penyuluhan mengenai pencegahan dan penanganan depresi setelah melahirkan pada kelas ibu hamil. Kata-kata kunci : depresi, postpartum ABSTRACTPostpartum depression is an after birth depression lasting for months and sometimes it is an unrealized disease. The birth of a baby should bring in special happiness for mothers. But, they are not ready due to the unwell sleep and weigh loss. This research identified the description of postpartum women’s depression level at Puskesmas. This was a descriptive research with depression level as the variable. The available research population of was 64 mothers coming to Puskesmas to check themselves and total population was 55 respondents. The data were collected using enclosed questionnaire. The results showed that 53 % experienced mild depression, 33 % had no depression, 9% had major depression and 5 % experienced moderate depression, The mothers’ depression level at Puskesmas arranged from moderate to severe. The Mother and Child was expected to provide education on the prevention and treatment of postpartum depression in pregnant women’s class. Keywords: depression, postpartum

Adrenocortical Responsiveness during Courses of Electro-convulsive Therapy

1969 ◽  
Vol 115 (522) ◽  
pp. 575-580 ◽  
Author(s):  
A. Elithorn ◽  
P. K. Bridges ◽  
J. R. Hodges ◽  
M. T. Jones
Keyword(s):  
Plasma Cortisol ◽  
Close Similarity ◽  
Cortisol Response ◽  
Convulsive Therapy ◽  
Adrenocortical Activity ◽  
Depressed Patients ◽  
Before And After ◽  
Schizophrenic Patients ◽  
Cortisol Levels ◽  
Electro Convulsive Therapy

In a previous paper (Hodges, Jones, Elithorn and Bridges, 1964) we reported on adrenocortical activity in depressed and schizophrenic patients as revealed by plasma cortisol levels before and after electro-convulsive therapy (E.C.T.). Close similarity was found between the two groups except for three depressed patients who appeared to show considerably higher cortisol levels after the treatment than did the remaining subjects. The patients were examined at random different treatments during the whole treatment course and it appeared possible, both that the observed cortisol response to E.C.T. might depend partly on which treatment of the series in a whole course was under examination, and also that the response of the illness to therapy might be a significant factor. It was therefore decided to observe in a number of subjects the response to successive treatments throughout courses of E.C.T.

Psychological stress and cortisol secretion in anhedonic alcoholic men

2003 ◽  
Vol 18 (8) ◽  
pp. 415-417 ◽  
Author(s):  
D. Marra ◽  
D. Warot ◽  
I. Berlin ◽  
E. Hispard ◽  
S. Dally
Keyword(s):  
Psychological Stress ◽  
Plasma Cortisol ◽  
Experimental Situation ◽  
Cortisol Response ◽  
Cortisol Secretion ◽  
Healthy Controls

AbstractWe investigated plasma cortisol in a psychological stress paradigm in seven weaned anhedonic alcoholics in comparison with seven age-matched healthy controls. Alcoholics had significantly higher mean plasma cortisol at baseline and no increase following a psychological stress paradigm. Anhedonic alcoholics judged the experimental situation less agreeable than controls. Anhedonic alcoholics may have blunted cortisol response to psychological stress.

scholarly journals Psychoemotional status in patients with duodenal ulcer disease complicated by suband decompensated stenosis

2020 ◽  
pp. 38-44
Author(s):  
N. V. Korochanskaya ◽  
V. M. Durleshter ◽  
A. A. Serdyuk
Keyword(s):  
Duodenal Ulcer ◽  
Surgical Removal ◽  
Adaptive Responses ◽  
Adherence To Treatment ◽  
Mild Depression ◽  
Ulcer Disease ◽  
Russian Version ◽  
Psychological Diagnosis ◽  
Moderate Depression ◽  
Before And After

The aim of the study was to assess the influence of the types of attitudes to disease and depression on adherence to treatment of patients with duodenal ulcer.Material and methods: Adherence to treatment was evaluated in 43 patients with sub- and decompensated scar-ulcerative stenosis aged from 21 to 74 years old (the average age being 47,5±26,5 years old), who underwent surgical removal of stenosis in the amount of duodenoplasty. The compliance of duodenal ulcer patients was assessed on the basis of the questionnaire developed by us. Assessment of the level of depression in patients was carried out using the Russian version of the Beck questionnaire (BDI). The method “type of attitude to disease” was used for psychological diagnosis of the types of attitude to the disease, the method being developed in the laboratory of clinical psychology of the Institute named after V. M. Bekhterev.Results: all 43 patients according to the degree of adherence to treatment were divided into 2 groups: compliant (20 patients) and non-compliant (23 people); also the types of attitudes to the disease and the level of depression were assessed. It was found that adaptive types of attitude to the disease were found in 51.2% of patients. Adaptive responses to illness provide overall adaptive behavior due to the adequate assessment of patients’ condition, or due to the obsessive desire for active employment, which is typical for ergopathic type of attitude to the disease, or due to the negation of everything associated with the disease with anosognosic type of the relation to disease. In «non-compliant» patients, in comparison with “compliant” ones, both before and after the surgery, statistically significant differences in the severity of the diagnosed depressive disorder were revealed. For «non-compliant” patients significantly more often mild depression and moderate depression were revealed, requiring the reception of psychopharmacological drugs.

Dehydration, but not vasopressin infusion, enhances the adrenocortical responses of sheep to corticotropin-releasing hormone or restraint

1991 ◽  
Vol 125 (5) ◽  
pp. 556-562 ◽  
Author(s):  
S. G. Matthews ◽  
R. F. Parrott
Keyword(s):  
Plasma Cortisol ◽  
Jugular Vein ◽  
Experimental Period ◽  
Cortisol Response ◽  
Cortisol Secretion ◽  
Blood Samples ◽  
Pretreatment Period ◽  
Cortisol Responses ◽  
Adrenocortical Responses ◽  
Saline Vehicle

Abstract. Two experiments were carried out using adult castrated sheep prepared with jugular vein catheters. In Experiment 1, sheep (N=8) were injected iv with saline vehicle, vehicle + 15 or 30 μg oCRH, or subjected to 120 min mild physical stress (restraint), following a 48 h period during which water was freely available or withheld. Blood samples were taken for 30 min before and 120 min after oCRH injection, and before and during restraint, and the plasma analysed for AVP and cortisol content. Levels of AVP increased by over 500% after dehydration, but were unaffected by oCRH or restraint. In contrast, plasma cortisol was unchanged after dehydration, but increased after oCRH and restraint. Moreover, these cortisol responses were significantly greater when the sheep were dehydrated. In Experiment 2, euhydrated sheep (N =6) were infused iv with saline vehicle or vehicle + AVP for a 5-h pretreatment period, followed by a 2-h experimental period in which the animals were injected with 15 μg oCRH or subjected to 120 min restraint, as in Experiment 1. Blood samples were taken throughout the experiment from a contralateral catheter and the plasma analysed for AVP and cortisol content. The AVP infusion produced plasma levels of the hormone approximately twice those seen after 48 h dehydration in Experiment 1, but did not affect cortisol secretion. Furthermore, the cortisol response to oCRH, or restraint, was not enhanced by the AVP infusion. These results suggest that pituitary responsiveness to exogenous or endogenous CRH (restraint stress) may be enhanced in sheep by dehydration through a mechanism that does not involve an adrenal or pituitary action of circulating AVP.

scholarly journals Depression Level Of Adolescent In Banyuwangi Based On Gender Using Beck Depression Inventory-II

2020 ◽  
Vol 11 (2) ◽  
pp. 105-111
Author(s):  
Ary's Kusumaayu Purwoningrum
Keyword(s):  
High Schools ◽  
Major Depression ◽  
Beck Depression Inventory ◽  
Male Students ◽  
Age Group ◽  
Mild Depression ◽  
Organization Management ◽  
Moderate Depression ◽  
Depression Level ◽  
Vocational High Schools

Depression can interfere with the mood that affects a person's feelings, thinking ability, and completing daily activities. Symptoms of depression include prolonged sadness and loss of interest in doing activities that are usually done, followed by a decrease in the ability to carry out activities. Based on data from WHO in 2015, the proportion of the global population experiencing depression is estimated at 4.4%. Meanwhile, based on a survey from Riskesdas in 2018 showed that depression began to occur in the 15-24 year age group with a prevalence of 6.2%. Adolescents are an age group that is vulnerable to depression. This study aims to determine the level of depression in students of OSIS management of vocational high schools (SMK) in Banyuwangi based on gender using BDI-II (Beck Depression Inventory-II). This research is a descriptive type of research with a quantitative approach using a total population of 51 people of the student organization management of vocational high schools (SMK) in Banyuwangi. The questionnaire used is BDI-II (Beck Depression Inventory-II) which consists of 21 statements. The respondents' answers were categorized into 4 levels of depression categories, namely no depression, mild depression, moderate depression and major depression. Male students who did not depression were 41.7%, mild depression were 16.6%, moderate depression were 41.7%, and major depression were 0%. The female students who did not depression were 56.4%,  mild depression were 35.9%, moderate depression were 7.7%, and major depression were 0%. Depression is more common in women than men

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