scholarly journals Reasons why unscreened patients with cervical cancer present with advanced stage disease

2013 ◽  
Vol 5 (1) ◽  
pp. 16-20 ◽  
Author(s):  
L C Snyman ◽  
U Herbst
Keyword(s):  
Cervical Cancer ◽  
Advanced Stage ◽  
Stage Disease

scholarly journals Socio-demographic, reproductive and clinical profile of women diagnosed with cervical cancer in a tertiary care center in middle Kerala

2017 ◽  
Vol 4 (6) ◽  
pp. 2112
Author(s):  
Neha E. L. ◽  
Nishi Roshini Kondakasseril
Keyword(s):  
Health Care ◽  
Cervical Cancer ◽  
Health Education ◽  
Late Stage ◽  
Rural Population ◽  
Clinical Presentation ◽  
Tertiary Care ◽  
Advanced Stage ◽  
Stage Disease ◽  
Late Stage Disease

Background: Cervical cancer is a major health problem in rural India. Barriers to cervical cancer control in our country include a lack of awareness of the disease because of illiteracy, poverty, lack of health education and screening programme. The aim of the study was the clinical profile of women diagnosed with cervical carcinoma in a tertiary care centre in the middle part of Kerala in South India.Methods: This prospective observational study was conducted in the Department of Obstetrics and Gynecology, Government medical college Thrissur for a period of two years from January 2014 to December 2016. The characteristics of patient (age, age at menarche and at marriage, parity, reproductive history, place of residence, income, education status, contraception, screening details, clinical presentation and tumor histopathology and stage were obtained. Data was entered in Excel and analysed.Results: Among7224 new patients seeking care from the department, 104 new cases of carcinoma of uterine cervix were identified (0.71%). Mean age was 58.3±8.4 years. 79% women were from rural area. 73% were illiterate, 88.5% belonged to below poverty line (BPL). Post-menopausal bleeding was the commonest clinical presentation (78.8%). Squamous cell carcinoma was the commonest histologic type (88.5%). 50% had first coitus before age of twenty. 94.3% were not aware of any screening procedures and its importance. 67.31% of cases presented in the advanced stage (stage 2B-1V). 75.81% of late stage disease patients were rural population. 96.77% of late stage disease patients were from below poverty line.Conclusions: Carcinoma cervix is more in the low socioeconomic class and rural elderly presented at an advanced stage. Ignorance about the disease and the lack of awareness of the risk factors, need and availability of screening programmes at low cost in Government health care systems was noteworthy. Government health care policies, health education, effective cancer prevention strategies and early cancer detection programmes are yet to reach the outskirts of rural population in Kerala.

Mo1621 - Association Between Time to Colonoscopy after a Positive Guaiac Fecal Test Result and Risk of Colorectal Cancer and Advanced Stage Disease at Diagnosis

2018 ◽  
Vol 154 (6) ◽  
pp. S-772-S-773
Author(s):  
Amani Beshara ◽  
Doron Comaneshter ◽  
Iris Dotan ◽  
Yaron Niv ◽  
Alexander Vilkin ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Advanced Stage ◽  
Stage Disease ◽  
Test Result

scholarly journals Surgical candidacy and treatment uptake among women with cervical cancer at public referral hospitals in Kampala, Uganda

2020 ◽  
Author(s):  
Megan L Swanson ◽  
Miriam Nakalembe ◽  
Lee-may Chen ◽  
Stefanie M Ueda ◽  
Jane Namugga ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Early Stage ◽  
Locally Advanced ◽  
Phone Call ◽  
Treatment Recommendation ◽  
Advanced Stage ◽  
Multivariate Statistical ◽  
Recommended Treatment ◽  
Treatment Uptake ◽  
Referral Hospitals

AbstractPurposeCervical cancer is the most common malignancy among women in Uganda. Most present with advanced disease, when hysterectomy is not possible and cure is less likely. This study reports the proportion recommended for hysterectomy and associated factors, recommended treatments by stage, and treatment uptake.MethodsWe conducted a prospective study among patients seeking care for cervical cancer at public referral hospitals in Uganda. In-person surveys were followed by a phone call. Descriptive and multivariate statistical analyses examined associations between predictors and outcomes.ResultsAmong 268 participants, 76% were diagnosed at an advanced stage (IIB-IVB). In total, 12% were recommended for hysterectomy. In adjusted analysis, living within 15 kilometers of Kampala (OR 3.10, 95% CI 1.20-8.03) and prior screening (OR 2.89, 95% CI 1.22-6.83) were significantly associated with surgical candidacy. Radiotherapy availability was not significantly associated with treatment recommendations for early-stage (IA-IIA) disease, but was associated with recommended treatment modality (chemo-radiation versus primary chemotherapy) for locally advanced stage (IIB-IIIB). Most (67%) had started treatment. No demographic or health factor, treatment recommendation, or radiation availability was associated with treatment initiation. Among those recommended for hysterectomy, 55% underwent surgery. Among those who had initiated treatment, 82% started the modality that was actually recommended.ConclusionWomen presented to public referral centers in Kampala with mostly advanced-stage cervical cancer and few were recommended for surgery. Lack of access to radiation did not significantly increase the proportion of early-stage cancers recommended for hysterectomy.

scholarly journals Gynecological malignancies at tertiary care hospital, Pakistan: A five-year review

2021 ◽  
Vol 37 (3) ◽  
Author(s):  
Tayyiba Wasim ◽  
Javeria Mushtaq ◽  
Ahmad Zunair Wasim ◽  
Gul e Raana
Keyword(s):  
Risk Factors ◽  
Ovarian Cancer ◽  
Cervical Cancer ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Care Hospital ◽  
Advanced Stage ◽  
Gynecological Malignancy ◽  
Abdominal Symptoms ◽  
Gynecological Malignancies

Background & Objective: Gynecological malignancies are important cause of female morbidity and mortality. They pose significant burden on health resources in low middle-income countries. Data on presentation and risk factors can help in early identification and reduce this burden. Our objective was to evaluate frequency, stage of presentation and risk factors of gynecological malignancies in a tertiary care setting. Methods: It was cross sectional study done in Gynecology Department, Services Institute of Medical Sciences, Services Hospital, Lahore from January 2015- December 2019. The records of the patients were retrospectively reviewed to include all cases of gynecologic malignancies. Demographic information, frequency, risk factors, symptoms, grade and stage of tumor was collected. Results: There were 122 patients diagnosed with gynecological malignancy during the study period. Ovarian cancer was seen in 60 (49.18%) patients followed by cervical cancer in 29(23.7%), endometrial cancer 27(22.1%) and vulva 06(4.9%). Mean age for all cancers was 51±12.7 to 55±9.3 except cervical cancer which was seen in 43±8.9 years. Patients with ovarian cancer had significantly more hypertension and diabetes (p<0.05). Heavy menstrual bleeding and postmenopausal bleeding was significantly seen in patients of endometrial and cervical cancer (p<0.05). Abdominal symptoms of pain, mass and distension were seen in patients with ovarian cancer (p<0.05). Majority patients presented in advanced stage. Among ovarian cancer, 52/60(86.6%) were epithelial in origin while 25(86.2%) cervical cancer and all vulva cancers were squamous cell carcinoma. Conclusion: Ovarian cancer was commonest gynecological malignancy followed by cervical cancer. Late presentation with advanced stage was seen in majority of all cancers. doi: https://doi.org/10.12669/pjms.37.3.3596 How to cite this:Wasim T, Mushtaq J, Wasim AZ, Gul-e-Raana. Gynecological malignancies at tertiary care hospital, Pakistan: A five-year review. Pak J Med Sci. 2021;37(3):---------. doi: https://doi.org/10.12669/pjms.37.3.3596 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

scholarly journals Collision Tumors of the Cervix – A Case Series: Its Clinical Significance in the Management of an Early Stage Disease

2018 ◽  
Vol 52 (6) ◽  
Author(s):  
Jimmy A. Billod ◽  
Efren J. Domingo
Keyword(s):  
Cervical Cancer ◽  
Recent Literature ◽  
Early Stage ◽  
Case Series ◽  
Response To Treatment ◽  
Clinicopathologic Features ◽  
Early Stage Disease ◽  
Collision Tumors ◽  
Stage Disease ◽  
Histologic Types

Majority of cervical cancer are squamous cell carcinoma and adenocarcinoma. The co-existence of two histologic types is rare. This article presents three cases of collision tumors of the cervix within a 10-year review. All underwent radical hysterectomy for an early stage disease. Likewise, it aims to review clinicopathologic features, management, response to treatment and prognosis of these types of tumor in the light of recent literature.

scholarly journals Novel Indications of Epigenetic Therapy in Ovarian Cancer

2021 ◽  
Author(s):  
Courtney Griffiths ◽  
Michelle Bilbao ◽  
Lauren Krill ◽  
Olga Ostrovsky
Keyword(s):  
Gene Expression ◽  
Ovarian Cancer ◽  
Early Diagnosis ◽  
Gynecologic Cancer ◽  
Epigenetic Modifications ◽  
Epigenetic Therapy ◽  
Intratumor Heterogeneity ◽  
Survival Outcomes ◽  
Advanced Stage ◽  
Stage Disease

Early diagnosis and intervention are some of the longstanding challenges associated with ovarian cancer, which is the leading cause of gynecologic cancer mortality. While the majority of patients who present with advanced stage disease at time of diagnosis will initially respond to traditional combination platinum and taxane-based chemotherapy in conjunction with cytoreductive surgery, approximately 70% will ultimately recur due to chemoresistance within the first two years. Intratumor heterogeneity is proposed to be a leading factor in the development of chemoresistance and resultant poorer outcomes for those with recurrent or advanced stage disease. Both inherent and acquired mechanisms of chemoresistance are postulated to be a result of alterations in gene expression, also known as epigenetic modifications. Therefore, epigenetic therapy is a pivotal avenue which allows for reversal of chemoresistance in cancer through the targeting of aberrant mutations. In this chapter, we discuss how these epigenetic modifications prove to be promising targets in cancer therapy leading to heightened drug sensitivity and improved patient survival outcomes.

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