Mycobacterium tuberculosis - Still the Greatest Microbial Challenge in the World

1999 ◽  
Vol 10 (3) ◽  
pp. 133-133
Keyword(s):  
Mycobacterium Tuberculosis ◽  
The World ◽  
Microbial Challenge

scholarly journals GeneXpert MTB/RIF Assay for Rapid Identification of Mycobacterium Tuberculosis and Rifampicin Resistance Directly from Sputum Sample

2017 ◽  
Vol 7 (2) ◽  
pp. 86-89 ◽  
Author(s):  
Nourjahan Laskar ◽  
Md Akram Hossain ◽  
Jannatul Fardows ◽  
Mominur Rahman
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Sputum Sample ◽  
Rapid Identification ◽  
Rapid Diagnosis ◽  
World Health ◽  
Multi Drug Resistance ◽  
Drug Resistant ◽  
Resistant Tuberculosis ◽  
The World ◽  
Health Organization

Background: The World Health Organization has endorsed the use of molecular methods for the detection of tuberculosis (TB) and drug resistant TB as a rapid method. In Bangladesh, the Xpert MTB/RIF assay has been implemented into reference laboratories for diagnosis of TB and also MDR TB.Objective: Drug resistant tuberculosis has long been a common problem prevailing in our country. The present study focused on the rapid identification of Mycobacterium tuberculosis as well as drug resistance.Materials and Methods: Sputum samples from a total of 107 cases, assumed as multi-drug resistance tuberculosis, were studied through GeneXpert assay.Results: Out of 107 cases, 91 (85.05%) were detected having M. tuberculosis ? 64 (59.81%) were rifampicin sensitive and 27 (25.23%) were rifampicin resistant. The sensitivity and specificity of the GeneXpert are 87.64% and 75% respectively.Conclusion: GeneXpert assay can be considered for the rapid diagnosis of drug resistant tuberculosis.J Enam Med Col 2017; 7(2): 86-89

scholarly journals Update on TB Vaccine Pipeline

2020 ◽  
Vol 10 (7) ◽  
pp. 2632 ◽  
Author(s):  
Carlos Martin ◽  
Nacho Aguilo ◽  
Dessislava Marinova ◽  
Jesus Gonzalo-Asensio
Keyword(s):  
Drug Resistance ◽  
Clinical Trials ◽  
Mycobacterium Tuberculosis ◽  
Infectious Diseases ◽  
Significant Role ◽  
Causes Of Death ◽  
Multi Drug Resistance ◽  
Bacillus Calmette Guerin ◽  
The World

In addition to antibiotics, vaccination is considered among the most efficacious methods in the control and the potential eradication of infectious diseases. New safe and effective vaccines against tuberculosis (TB) could be a very important tool and are called to play a significant role in the fight against TB resistant to antimicrobials. Despite the extended use of the current TB vaccine Bacillus Calmette-Guérin (BCG), TB continues to be transmitted actively and continues to be one of the 10 most important causes of death in the world. In the last 20 years, different TB vaccines have entered clinical trials. In this paper, we review the current use of BCG and the diversity of vaccines in clinical trials and their possible indications. New TB vaccines capable of protecting against respiratory forms of the disease caused by sensitive or resistant Mycobacterium tuberculosis strains would be extremely useful tools helping to prevent the emergence of multi-drug resistance.

scholarly journals The World Health Organization excludes Mycobacterium tuberculosis from the 2017 priority pathogens list

2017 ◽  
Vol 107 (6) ◽  
pp. 466 ◽  
Author(s):  
Nesri Padayatchi ◽  
Sharana Mahomed ◽  
Max O’Donnell ◽  
Francesca Conradie ◽  
Kogieleum Naidoo
Keyword(s):  
Mycobacterium Tuberculosis ◽  
World Health Organization ◽  
World Health ◽  
The World ◽  
Health Organization

scholarly journals Tuberculosis: New Aspects of an Old Disease

2011 ◽  
Vol 2011 ◽  
pp. 1-13 ◽  
Author(s):  
Luisa Jordao ◽  
Otilia V. Vieira
Keyword(s):  
Public Health ◽  
Nitric Oxide ◽  
Infectious Disease ◽  
Innate Immunity ◽  
Mycobacterium Tuberculosis ◽  
Host Defense ◽  
Molecular Mechanisms ◽  
Nitric Oxide Production ◽  
Phagosome Maturation ◽  
The World

Tuberculosis is an ancient infectious disease that remains a threat for public health around the world. Although the etiological agent as well as tuberculosis pathogenesis is well known, the molecular mechanisms underlying the host defense to the bacilli remain elusive. In this paper we focus on the innate immunity of this disease reviewing well-established and consensual mechanisms likeMycobacterium tuberculosisinterference with phagosome maturation, less consensual mechanism like nitric oxide production, and new mechanisms, such as mycobacteria translocation to the cytosol, autophagy, and apoptosis/necrosis proposed mainly during the last decade.

scholarly journals The Impact of Transcriptomics on the Fight against Tuberculosis: Focus on Biomarkers, BCG Vaccination, and Immunotherapy

2011 ◽  
Vol 2011 ◽  
pp. 1-6 ◽  
Author(s):  
Carlos Rodrigo Zárate-Bladés ◽  
Celio Lopes Silva ◽  
Geraldo A. Passos
Keyword(s):  
Mycobacterium Tuberculosis ◽  
High Throughput ◽  
Basic Research ◽  
World Population ◽  
Biological Phenomenon ◽  
Bcg Vaccination ◽  
The World ◽  
Global Vision ◽  
Key Issues ◽  
The Impact

In 1882 Robert Koch identifiedMycobacterium tuberculosisas the causative agent of tuberculosis (TB), a disease as ancient as humanity. Although there has been more than 125 years of scientific effort aimed at understanding the disease, serious problems in TB persist that contribute to the estimated 1/3 of the world population infected with this pathogen. Nonetheless, during the first decade of the 21st century, there were new advances in the fight against TB. The development of high-throughput technologies is one of the major contributors to this advance, because it allows for a global vision of the biological phenomenon. This paper analyzes how transcriptomics are supporting the translation of basic research into therapies by resolving three key issues in the fight against TB: (a) the discovery of biomarkers, (b) the explanation of the variability of protection conferred by BCG vaccination, and (c) the development of new immunotherapeutic strategies to treat TB.

scholarly journals Transformative tools for tackling tuberculosis

2015 ◽  
Vol 212 (11) ◽  
pp. 1759-1769 ◽  
Author(s):  
Jennifer L. Gardiner ◽  
Christopher L. Karp
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Host Response ◽  
Control Strategies ◽  
Disease Development ◽  
Diagnostic Biomarkers ◽  
Human Host ◽  
Current State ◽  
Highly Sensitive ◽  
The World ◽  
Total Body

The world is in need of more effective approaches to controlling tuberculosis. The development of improved control strategies has been hampered by deficiencies in the tools available for detecting Mycobacterium tuberculosis and defining the dynamic consequences of the interaction of M. tuberculosis with its human host. Key needs include a highly sensitive, specific nonsputum diagnostic; biomarkers predictive of responses to therapy; correlates of risk for disease development; and host response–independent markers of M. tuberculosis infection. Tools able to sensitively detect and quantify total body M. tuberculosis burden might well be transformative across many needed use cases. Here, we review the current state of the field, paying particular attention to needed changes in experimental paradigms that would facilitate the discovery, validation, and development of such tools.

scholarly journals MODELLING THE NUMBER OF NEW PULMONARY TUBERCULOSIS CASES WITH GEOGRAPHICALLY WEIGHTED NEGATIVE BINOMIAL REGRESSION METHOD

2018 ◽  
Vol 2 (2) ◽  
pp. 77-92
Author(s):  
Tsuraya Mumtaz ◽  
Agung Priyo Utomo
Keyword(s):  
Diabetes Mellitus ◽  
Infectious Disease ◽  
Developing Countries ◽  
Mycobacterium Tuberculosis ◽  
Negative Binomial ◽  
Negative Binomial Regression ◽  
Regression Method ◽  
Pulmonary Tb ◽  
Binomial Regression ◽  
The World

Tuberculosis (TB) is an infectious disease caused by Mycobacterium Tuberculosis. Untill now, TB is still one of the main problems in many countries, especially developing countries. Indonesia ranked second as the country with the highest TB cases in the world in 2015, where most cases were found in Java. This study was conducted to model the number of new pulmonary TB cases in Java by considering the spatial aspects using Geographically Weighted Negative Binomial Regression (GWNBR). GWNBR method was chosen  because the data used in this study are overdispered. The result showed that the population density and percentage of healty homes were not significantly influential in each region. While the number of puskesmas, the percentage of smokers, the percentage of good PHBS, the percentage of diabetes mellitus, and the percentage of less IMT were significant in some regions. In general, the GWNBR model was better for modelling the number of new pulmonary TB cases than negative binomial regression and GWPR.

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