Diorganotin(IV) Derivatives of Dipeptides Containing at Least One Essential Amino Acid Residue: Synthesis, Characteristic Spectral Data, Cardiovascular, and Anti‐inflammatory Activities

2004 ◽  
Vol 34 (10) ◽  
pp. 1689-1708 ◽  
Author(s):  
Mala Nath ◽  
Sandeep Pokharia ◽  
George Eng ◽  
Xueqing Song ◽  
Ashok Kumar
Keyword(s):  
Amino Acid ◽  
Spectral Data ◽  
Amino Acid Residue ◽  
Essential Amino Acid ◽  
Anti Inflammatory ◽  
Derivatives Of

scholarly journals Synthesis and Evaluation of Cyclic Acetals of Serine Hydroxylamine for Amide-Forming KAHA Ligations

Synthesis ◽  
2019 ◽  
Vol 51 (05) ◽  
pp. 1273-1283 ◽  
Author(s):  
Simon Baldauf ◽  
Jeffrey Bode
Keyword(s):  
Amino Acid ◽  
Amino Acid Residue ◽  
Amino Acid Residues ◽  
High Demand ◽  
Cyclic Acetals ◽  
Ligation Product ◽  
Canonical Amino Acid ◽  
The Stability ◽  
Peptide Segments ◽  
Derivatives Of

The α-ketoacid–hydroxylamine (KAHA) ligation allows the coupling of unprotected peptide segments. The most widely used variant employs a 5-membered cyclic hydroxylamine that forms a homoserine ester as the primary ligation product. While very effective, monomers that give canonical amino acid residues are in high demand. In order to preserve the stability and reactivity of cyclic hydroxylamines, but form a canonical amino acid residue upon ligation, we sought to prepare cyclic derivatives of serine hydroxylamine. An evaluation of several cyclization strategies led to cyclobutanone ketals as the leading structures. The preparation, stability, and amide-forming ligation of these serine-derived ketals are described.

Synthesis of ω-amino acid peptides related to leucine-enkephalin

1981 ◽  
Vol 34 (11) ◽  
pp. 2439 ◽  
Author(s):  
FHC Stewart
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Intramolecular Cyclization ◽  
Amino Acid Residue ◽  
Leucine Enkephalin ◽  
Derivatives Of

Syntheses are described of four peptides with modified leucine-enkephalin sequences in which the native glycylglycyl segment is replaced by an ω-amino acid residue. o-Nitrophenylthio-ω-amino acids were used as intermediates, and it was found that the derivatives of 4-aminobutyric and 5-amino-valeric acids undergo facile intramolecular cyclization under the influence of N,N'-dicyclohexylcarbodiimide.

A novel anti-inflammatory activity of mcIRBP from Momordica charantia is associated with the improvement of diabetic nephropathy

2022 ◽  
Author(s):  
Pei-Yung Liao ◽  
Hsin-Yi Lo ◽  
I-Chen Liu ◽  
Lun-Chien Lo ◽  
Chien-Yun Hsiang ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Amino Acid ◽  
Insulin Receptor ◽  
Amino Acid Residue ◽  
Trypsin Inhibitor ◽  
Momordica Charantia ◽  
Inflammatory Activity ◽  
Immune Disorder ◽  
Anti Inflammatory

Diabetic nephropathy is an inflammatory immune disorder accompanying diabetes. mcIRBP, the trypsin inhibitor of Momordica charantia, is an abundant 68-amino-acid-residue protein that interacts with the insulin receptor. Here the long-term...

Anti-inflammatory effect of l-cysteine (a semi-essential amino acid) on 5-FU-induced oral mucositis in hamsters

Amino Acids ◽  
2021 ◽  
Author(s):  
Khetyma Moreira Fonseca ◽  
Dionys Macda RodriguesCosta ◽  
Valderlon Freitas da Silva ◽  
Jelson Lina de Carvalho ◽  
Ana Patrícia Oliveira ◽  
...  
Keyword(s):  
Amino Acid ◽  
Oral Mucositis ◽  
Essential Amino Acid ◽  
Anti Inflammatory ◽  
Inflammatory Effect

Changes in the amino acid composition of grain during storage

2020 ◽  
Vol 29 (10) ◽  
pp. 60-65
Author(s):  
M.A. Yanova ◽  
◽  
I.V. Fedorovich ◽  
Keyword(s):  
Amino Acid ◽  
Amino Acid Composition ◽  
Acid Composition ◽  
Amino Acid Residue ◽  
Essential Amino Acid ◽  
Biological Value ◽  
Agricultural Enterprises ◽  
Low Level ◽  
Grain Crops ◽  
Low Rate

Samples of various grain crops (wheat, barley, oats) of agricultural enterprises of the Krasnoyarsk Territory in the central and western zones (LLC UCHHOZ MINDERLINSKOE "Sukhobuzimsky District, LLC ELEVATOR Uzhursky District, the composition of OJSC Iskra. It was determined that compared with wheat and barley oats are characterized by the highest content of the essential amino acid lysine, all crops have a low level of tryptophan. It was found that during storage of grain there was no significant change in the amino acid residue. acid composition, which indicates a low rate of the processes leading to a change in biological value. It was found that when storing grain in an elevator, the amino acid composition remains more valuable.

Design, synthesis and anti-inflammatory activity of 3-amino acid derivatives of ocotillol-type sapogenins

2020 ◽  
Vol 202 ◽  
pp. 112507 ◽  
Author(s):  
Gangqiang Yang ◽  
Meng Gao ◽  
Yixiao Sun ◽  
Conghui Wang ◽  
Xiaojuan Fang ◽  
...  
Keyword(s):  
Amino Acid ◽  
Inflammatory Activity ◽  
Amino Acid Derivatives ◽  
Design Synthesis ◽  
Anti Inflammatory ◽  
Derivatives Of

scholarly journals Molecular cloning of a cDNA and assignment of the C-terminal of sarcotoxin IA, a potent antibacterial protein of Sarcophaga peregrina

1986 ◽  
Vol 239 (3) ◽  
pp. 717-722 ◽  
Author(s):  
N Matsumoto ◽  
M Okada ◽  
H Takahashi ◽  
Q X Ming ◽  
Y Nakajima ◽  
...  
Keyword(s):  
Amino Acid ◽  
Amino Acid Residue ◽  
Amino Acid Sequences ◽  
Nucleotide Sequencing ◽  
Amino Acid Sequencing ◽  
Terminal Amino Acid ◽  
Sarcotoxin Ia ◽  
Terminal Amino ◽  
Synthetic Derivatives ◽  
Derivatives Of

A previous paper described the complete amino acid sequences of sarcotoxins IA, IB and IC, which are a group of potent antibacterial proteins with almost identical primary structures produced by Sarcophaga peregrina (fleshfly) larvae [Okada & Natori (1985) J. Biol. Chem. 260, 7174-7177]. The present paper describes the cDNA cloning and complete nucleotide sequencing of a cDNA clone for sarcotoxin IA. The C-terminal amino acid residue of sarcotoxin IA deduced from the nucleotide sequence was glycine, whereas it was found to be arginine by amino acid sequencing of purified sarcotoxin IA. Analysis of the elution profiles on h.p.l.c. of the synthetic derivatives of sarcotoxin IA showed that the C-terminal amino acid residue of authentic sarcotoxin IA is amidated arginine, which is probably produced by enzymic cleavage of terminal glycine.

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