scholarly journals Physicochemical characterization and antioxidant properties of cerium oxide nanoparticles

2018 ◽  
Vol 1115 ◽  
pp. 032094 ◽  
Author(s):  
R A Vazirov ◽  
S Y Sokovnin ◽  
V G Ilves ◽  
I N Bazhukova ◽  
N Pizurova ◽  
...  
Keyword(s):  
Cerium Oxide ◽  
Antioxidant Properties ◽  
Physicochemical Characterization ◽  
Cerium Oxide Nanoparticles ◽  
Oxide Nanoparticles

Characterizing the phosphatase mimetic activity of cerium oxide nanoparticles and distinguishing its active site from that for catalase mimetic activity using anionic inhibitors

2017 ◽  
Vol 4 (8) ◽  
pp. 1742-1749 ◽  
Author(s):  
A. Dhall ◽  
A. Burns ◽  
J. Dowding ◽  
S. Das ◽  
S. Seal ◽  
...  
Keyword(s):  
Cell Culture ◽  
Cerium Oxide ◽  
Active Site ◽  
Animal Studies ◽  
Antioxidant Properties ◽  
Reactive Oxygen ◽  
Cerium Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Nitrogen Species

Cerium oxide nanoparticles (CeNPs) are potent reactive oxygen and nitrogen species scavengers and demonstrate beneficial antioxidant properties in both cell culture and animal studies.

scholarly journals Synthesis, physicochemical characterization, antifungal activity and toxicological features of cerium oxide nanoparticles

2021 ◽  
Vol 14 (1) ◽  
pp. 102888
Author(s):  
Isabela A.P. Farias ◽  
Carlos C.L. Santos ◽  
Aline L. Xavier ◽  
Tatianne M. Batista ◽  
Yuri M. Nascimento ◽  
...  
Keyword(s):  
Antifungal Activity ◽  
Cerium Oxide ◽  
Physicochemical Characterization ◽  
Cerium Oxide Nanoparticles ◽  
Oxide Nanoparticles

scholarly journals Cerium Oxide Nanoparticles: A Brief Review of Their Synthesis Methods and Biomedical Applications

Antioxidants ◽  
2018 ◽  
Vol 7 (8) ◽  
pp. 97 ◽  
Author(s):  
Atul Dhall ◽  
William Self
Keyword(s):  
Cerium Oxide ◽  
Biomedical Applications ◽  
Antioxidant Properties ◽  
Cerium Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Synthesis Methods ◽  
Ros Scavenging ◽  
Corona Formation

Cerium oxide nanoparticles (CeNPs) exhibit antioxidant properties both in vitro and in vivo. This is due to the self-regeneration of their surface, which is based on redox-cycling between 3+ and 4+ states for cerium, in response to their immediate environment. Additionally, oxygen vacancies in the lattice structure allow for alternating between CeO2 and CeO2−x during redox reactions. Research to identify and characterize the biomedical applications of CeNPs has been heavily focused on investigating their use in treating diseases that are characterized by higher levels of reactive oxygen species (ROS). Although the bio-mimetic activities of CeNPs have been extensively studied in vitro, in vivo interactions and associated protein corona formation are not well understood. This review describes: (1) the methods of synthesis for CeNPs, including the recent green synthesis methods that offer enhanced biocompatibility and a need for establishing a reference CeNP material for consistency across studies; (2) their enzyme-mimetic activities, with a focus on their antioxidant activities; and, (3) recent experimental evidence that demonstrates their ROS scavenging abilities and their potential use in personalized medicine.

scholarly journals Cerium Oxide Nanoparticles Protect against Oxidant Injury and Interfere with Oxidative Mediated Kinase Signaling in Human-Derived Hepatocytes

2019 ◽  
Vol 20 (23) ◽  
pp. 5959 ◽  
Author(s):  
Silvia Carvajal ◽  
Meritxell Perramón ◽  
Gregori Casals ◽  
Denise Oró ◽  
Jordi Ribera ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cell Viability ◽  
Cerium Oxide ◽  
Antioxidant Properties ◽  
Cerium Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Oxidant Injury ◽  
Ros Scavenging ◽  
Alcoholic Fatty Liver ◽  
The Impact

Cerium oxide nanoparticles (CeO2NPs) possess powerful antioxidant properties, thus emerging as a potential therapeutic tool in non-alcoholic fatty liver disease (NAFLD) progression, which is characterized by a high presence of reactive oxygen species (ROS). The aim of this study was to elucidate whether CeO2NPs can prevent or attenuate oxidant injury in the hepatic human cell line HepG2 and to investigate the mechanisms involved in this phenomenon. The effect of CeO2NPs on cell viability and ROS scavenging was determined, the differential expression of pro-inflammatory and oxidative stress-related genes was analyzed, and a proteomic analysis was performed to assess the impact of CeO2NPs on cell phosphorylation in human hepatic cells under oxidative stress conditions. CeO2NPs did not modify HepG2 cell viability in basal conditions but reduced H2O2- and lipopolysaccharide (LPS)-induced cell death and prevented H2O2-induced overexpression of MPO, PTGS1 and iNOS. Phosphoproteomic analysis showed that CeO2NPs reverted the H2O2-mediated increase in the phosphorylation of peptides related to cellular proliferation, stress response, and gene transcription regulation, and interfered with H2O2 effects on mTOR, MAPK/ERK, CK2A1 and PKACA signaling pathways. In conclusion, CeO2NPs protect HepG2 cells from cell-induced oxidative damage, reducing ROS generation and inflammatory gene expression as well as regulation of kinase-driven cell survival pathways.

scholarly journals Cerium Oxide Nanoparticles Alleviate Hepatic Fibrosis Phenotypes In Vitro

2021 ◽  
Vol 22 (21) ◽  
pp. 11777
Author(s):  
Adrian Boey ◽  
Shu Qing Leong ◽  
Sayali Bhave ◽  
Han Kiat Ho
Keyword(s):  
Cerium Oxide ◽  
Hepatic Fibrosis ◽  
Metallic Nanoparticles ◽  
Stellate Cell ◽  
Antioxidant Properties ◽  
Unintended Consequences ◽  
Cerium Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Cellular Interactions ◽  
Body Tissues

Exposure to metallic nanoparticles (NPs) can result in inadvertent NP accumulation in body tissues. While their subsequent cellular interactions can lead to unintended consequences and are generally regarded as detrimental for health, they can on occasion mediate biologically beneficial effects. Among NPs, cerium oxide nanoparticles (CeO2 NP) possess strong antioxidant properties and have shown to alleviate certain pathological conditions. Herein, we show that the presence of cubic 25 nm CeO2 NP was able to reduce TGF-β-mediated activation in the cultured hepatic stellate cell line LX2 by reducing oxidative stress levels and TGF-β-mediated signalling. These cells displayed reduced classical liver fibrosis phenotypes, such as diminished fibrogenesis, altered matrix degradation, decreased cell motility, modified contractability and potentially lowered autophagy. These findings demonstrate that CeO2 NP may be able to ameliorate hepatic fibrosis and suggest a possible therapeutic pathway for an otherwise difficult-to-treat condition.

Polyacrylic Acid Modified Cerium Oxide Nanoparticles: Synthesis and Characterization as a Peroxidase Mimic for Non-Enzymatic H2O2 Sensor

2020 ◽  
Vol 16 (5) ◽  
pp. 816-828
Author(s):  
Gurdeep Rattu ◽  
Nishtha Khansili ◽  
Prayaga M. Krishna
Keyword(s):  
Hydrogen Peroxide ◽  
Cerium Oxide ◽  
Polyacrylic Acid ◽  
Spectroscopic Analysis ◽  
Cerium Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Peroxidase Mimic ◽  
Ft Ir ◽  
H2o2 Sensing ◽  
Fluorescence Spectrometer

Background: Cerium oxide nanoparticles (nanoceria) are efficient free-radical scavengers due to their dual valence state and thus exhibit optical and catalytic properties. Therefore, the main purpose of this work was to understand the peroxidase mimic activity of polymer-stabilized nanoceria for enzyme-less H2O2 sensing by fluorescence spectrometer. Objective: This research revealed the development of fluorescence hydrogen peroxide nanosensor based on the peroxidase-like activity of polyacrylic acid stabilized nanoceria (PAA-CeO2 Nps). Methods: PAA-CeO2 Nps were synthesized by simple cross-linking reaction at a low temperature and characterized by XRD, SEM, Zeta potential, TGA, FT-IR and UV-VIS spectroscopic analysis. H2O2 sensing was performed by a fluorescence spectrometer. Results:: The synthesized polymer nanocomposite was characterized by XRD, SEM, TGA, FT-IR and UV-VIS spectroscopic analysis. The XRD diffraction patterns confirmed the polycrystalline nature and SEM micrograph showed nanoparticles having hexagonal symmetry and crystallite size of 32 nm. The broad peak of Ce–O bond appeared at 508 cm-1. UV-VIS measurements revealed a welldefined absorbance peak around 315 nm and an optical band-gap of 3.17 eV. As synthesized PAACeO2 Nps effectively catalysed the decomposition of hydrogen peroxide (H2O2) into hydroxyl radicals. Then terephthalic acid was oxidized by hydroxyl radical to form a highly fluorescent product. Under optimized conditions, the linear range for determination of hydrogen peroxide was 0.01 - 0.2 mM with a limit of detection (LOD) of 1.2 μM. Conclusion: The proposed method is ideally suited for the sensing of H2O2 at a low cost and this detection system enabled the sensing of analytes (sugars), which can enzymatically generate hydrogen peroxide.

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