scholarly journals Prediction of Lung Cancer using Ensemble Classifiers

2022 ◽  
Vol 2161 (1) ◽  
pp. 012007
Author(s):  
G Ashwin Shanbhag ◽  
K Anurag Prabhu ◽  
N V Subba Reddy ◽  
B Ashwath Rao

Abstract Carcinoma detection from CT scan images is extremely necessary for numerous diagnostic and healing applications. Because of the excessive amount of information in CT scan images and blurred boundaries, tumor segmentation and class are extremely laborious. The intention is to categorize carcinoma into benign and malignant categories. In MR pictures, the number of facts is a lot for interpreting and evaluating manually. Over the previous few years, carcinoma detection in CT has grown to be a rising evaluation space in the area of the scientific imaging system. Correct detection of length and site of lung cancer performs a vital position in the designation of carcinoma. In this paper, we introduce a novel carcinoma detection methodology that helps in predicting the carcinoma from the CT scanned images. The methodology has 4 different stages, pre-processing the image data, segmentation, extracting features, and classification stage to categorize the benign and malignant. This work makes use of extraordinary models for detecting carcinoma in a CT test via way of means of constructing an ensemble classifier. Techniques proposed in the paper helped us achieve an accuracy of 85% using Ensemble-Classifier which showcases that model has the capability of predicting the malignant cases correctly. The ensemble classifier consists of 5 machine learning models like SVM, LR, MLP, decision tree, and KNN. The inevitable parameters like accuracy, recall, and precision is calculated to determine the accurate results of the classifier.

Author(s):  
Zuherman Rustam ◽  
Aldi Purwanto ◽  
Sri Hartini ◽  
Glori Stephani Saragih

<span id="docs-internal-guid-94842888-7fff-2ae1-cd5c-026943b95b7f"><span>Cancer is one of the diseases with the highest mortality rate in the world. Cancer is a disease when abnormal cells grow out of control that can attack the body's organs side by side or spread to other organs. Lung cancer is a condition when malignant cells form in the lungs. To diagnose lung cancer can be done by taking x-ray images, CT scans, and lung tissue biopsy. In this modern era, technology is expected to help research in the field of health. Therefore, in this study feature extraction from CT images was used as data to classify lung cancer. We used CT scan image data from SPIE-AAPM Lung CT challenge 2015. Fuzzy C-Means and fuzzy kernel C-Means were used to classify the lung nodule from the patient into benign or malignant. Fuzzy C-Means is a soft clustering method that uses Euclidean distance to calculate the cluster center and membership matrix. Whereas fuzzy kernel C-Means uses kernel distance to calculate it. In addition, the support vector machine was used in another study to obtain 72% average AUC. Simulations were performed using different k-folds. The score showed fuzzy kernel C-Means had the highest accuracy of 74%, while fuzzy C-Means obtained 73% accuracy. </span></span>


2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Yipengchen Yin ◽  
Yongjing Li ◽  
Sheng Wang ◽  
Ziliang Dong ◽  
Chao Liang ◽  
...  

Abstract Background The recently developed biomimetic strategy is one of the mostly effective strategies for improving the theranostic efficacy of diverse nanomedicines, because nanoparticles coated with cell membranes can disguise as “self”, evade the surveillance of the immune system, and accumulate to the tumor sites actively. Results Herein, we utilized mesenchymal stem cell memabranes (MSCs) to coat polymethacrylic acid (PMAA) nanoparticles loaded with Fe(III) and cypate—an derivative of indocyanine green to fabricate Cyp-PMAA-Fe@MSCs, which featured high stability, desirable tumor-accumulation and intriguing photothermal conversion efficiency both in vitro and in vivo for the treatment of lung cancer. After intravenous administration of Cyp-PMAA-Fe@MSCs and Cyp-PMAA-Fe@RBCs (RBCs, red blood cell membranes) separately into tumor-bearing mice, the fluorescence signal in the MSCs group was 21% stronger than that in the RBCs group at the tumor sites in an in vivo fluorescence imaging system. Correspondingly, the T1-weighted magnetic resonance imaging (MRI) signal at the tumor site decreased 30% after intravenous injection of Cyp-PMAA-Fe@MSCs. Importantly, the constructed Cyp-PMAA-Fe@MSCs exhibited strong photothermal hyperthermia effect both in vitro and in vivo when exposed to 808 nm laser irradiation, thus it could be used for photothermal therapy. Furthermore, tumors on mice treated with phototermal therapy and radiotherapy shrank 32% more than those treated with only radiotherapy. Conclusions These results proved that Cyp-PMAA-Fe@MSCs could realize fluorescence/MRI bimodal imaging, while be used in phototermal-therapy-enhanced radiotherapy, providing desirable nanoplatforms for tumor diagnosis and precise treatment of non-small cell lung cancer.


Mathematics ◽  
2021 ◽  
Vol 9 (13) ◽  
pp. 1457
Author(s):  
Muazzam Maqsood ◽  
Sadaf Yasmin ◽  
Irfan Mehmood ◽  
Maryam Bukhari ◽  
Mucheol Kim

A typical growth of cells inside tissue is normally known as a nodular entity. Lung nodule segmentation from computed tomography (CT) images becomes crucial for early lung cancer diagnosis. An issue that pertains to the segmentation of lung nodules is homogenous modular variants. The resemblance among nodules as well as among neighboring regions is very challenging to deal with. Here, we propose an end-to-end U-Net-based segmentation framework named DA-Net for efficient lung nodule segmentation. This method extracts rich features by integrating compactly and densely linked rich convolutional blocks merged with Atrous convolutions blocks to broaden the view of filters without dropping loss and coverage data. We first extract the lung’s ROI images from the whole CT scan slices using standard image processing operations and k-means clustering. This reduces the search space of the model to only lungs where the nodules are present instead of the whole CT scan slice. The evaluation of the suggested model was performed through utilizing the LIDC-IDRI dataset. According to the results, we found that DA-Net showed good performance, achieving an 81% Dice score value and 71.6% IOU score.


Lung ◽  
2012 ◽  
Vol 190 (6) ◽  
pp. 621-628 ◽  
Author(s):  
M. Pallin ◽  
S. Walsh ◽  
M. F. O’Driscoll ◽  
C. Murray ◽  
A. Cahalane ◽  
...  

2021 ◽  
Author(s):  
Andres Gonzalez ◽  
Zoya Heidari ◽  
Olivier Lopez

Abstract Depositional mechanisms of sediments and post-depositional process often cause spatial variation and heterogeneity in rock fabric, which can impact the directional dependency of petrophysical, electrical, and mechanical properties. Quantification of the directional dependency of the aforementioned properties is fundamental for the appropriate characterization of hydrocarbon-bearing reservoirs. Anisotropy quantification can be accomplished through numerical simulations of physical phenomena such as fluid flow, gas diffusion, and electric current conduction in porous media using multi-scale image data. Typically, the outcome of these simulations is a transport property (e.g., permeability). However, it is also possible to quantify the tortuosity of the media used as simulation domain, which is a fundamental descriptor of the microstructure of the rock. The objectives of this paper are (a) to quantify tortuosity anisotropy of porous media using multi-scale image data (i.e., whole-core CT-scan and micro-CT-scan image stacks) through simulation of electrical potential distribution, diffusion, and fluid flow, and (b) to compare electrical, diffusional, and hydraulic tortuosity. First, we pre-process the images (i.e., CT-scan images) to remove non-rock material visual elements (e.g., core barrel). Then, we perform image analysis to identify different phases in the raw images. Then, we proceed with the numerical simulations of electric potential distribution. The simulation results are utilized as inputs for a streamline algorithm and subsequent direction-dependent electrical tortuosity estimation. Next, we conduct numerical simulation of diffusion using a random walk algorithm. The distance covered by each walker in each cartesian direction is used to compute the direction-dependent diffusional tortuosity. Finally, we conduct fluid-flow simulations to obtain the velocity distribution and compute the direction-dependent hydraulic tortuosity. The simulations are conducted in the most continuous phase of the segmented whole-core CT-scan image stacks and in the segmented pore-space of the micro-CT-scan image stacks. Finally, the direction-dependent tortuosity values obtained with each technique are employed to assess the anisotropy of the evaluated samples. We tested the introduced workflow on dual energy whole-core CT-scan images and on smaller scale micro-CT-scan images. The whole-core CT-scan images were obtained from a siliciclastic depth interval, composed mainly by spiculites. Micro-CT-scan images we obtained from Berea Sandstone and Austin Chalk formations. We observed numerical differences in the estimates of direction-dependent electrical, diffusional, and hydraulic tortuosity for both types of image data employed. The highest numerical differences were observed when comparing electrical and hydraulic tortuosity with diffusional tortuosity. The observed differences were significant specially in anisotropic samples. The documented comparison provides useful insight in the selection process of techniques for estimation of tortuosity. The use of core-scale image data in the proposed workflow provides semi-continuous estimates of tortuosity and tortuosity anisotropy which is typically not attainable when using pore-scale images. Additionally, the semi-continuous nature of the tortuosity and tortuosity anisotropy estimates in whole-core CT-scan image data provides an excellent tool for the selection of core plugs coring locations.


Haigan ◽  
1987 ◽  
Vol 27 (2) ◽  
pp. 149-154 ◽  
Author(s):  
Chojiro Yamashita ◽  
Noriaki Tsubota ◽  
Ryuta Aogauchi ◽  
Koichi Yoshikawa ◽  
Noboru Ishii ◽  
...  

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