scholarly journals Evaluation of hematological and urine parameters of Anoa (Bubalus Spp.) at Environment and Forestry Research and Development Institute of Manado (BP2LHK)

2021 ◽  
Vol 870 (1) ◽  
pp. 012014
Author(s):  
MZ Sinusi ◽  
EA Kajang ◽  
DID Arini ◽  
H Sonjaya ◽  
EW Ferial ◽  
...  
Keyword(s):  
Research And Development ◽  
Forestry Research ◽  
Development Institute

scholarly journals Identifikasi Faktor-Faktor Penumpukan Realisasi Anggaran Belanja Di Akhir Tahun (Studi Kasus Pada Balai Penelitian Dan Pengembangan Lingkungan Hidup Dan Kehutanan Manado)

2017 ◽  
Vol 8 (1) ◽  
Author(s):  
Nina Sudarwati ◽  
Herman Karamoy ◽  
Winston Pontoh
Keyword(s):  
Research And Development ◽  
Financial Management ◽  
Early Years ◽  
Fiscal Year ◽  
Government Programs ◽  
Budget Planning ◽  
National Budget ◽  
Forestry Research ◽  
Development Institute ◽  
S Curve

Abstract. Implementation of the budget is a very important stage in the realization of government programs that have been organized in the National budget. The implementation sometime found difficulties, including the realization of the budget tends to be low in the early years and accumulated at the end of the year. According to Rusqiayati (2014), ideally the realization of the government's budget follows the "S-curve" which is tends to be stable at the beginning of the year, then increased in the mid and stabilized towards the end of the fiscal year. This research aims to identify factors that causing the accumutaed of budget realization in the end of the year at Environment and Forestry Research and Development Institute of Manado. This study is a qualitative case study. The key informants in this research are  officers or employees directly involved in financial management, such as the Budget Authority (KPA), Committing Officer (CO), official signing of Warrant Pay (PPSPM), Treasurer, Assistant Treasurer, and Executive Technical Officer ( PTK).The results showed that  factors that causing the accumulated of budget realization in the end of the year at Environment and Forestry Research and Development Institute of Manado  were budget planning, budget execution, procurement of goods/services, and human resources. Keywords: Accumulation, Budget realization, Thematic Analysis Abstrak Pelaksanaan anggaran merupakan tahap yang sangat peting dalam merealisasikan program dan kegiatan pemerintah yang telah disusun dalam APBN. Dalam pelaksanaan mengalami berbagai kendala, diantaranya realisasi anggaran yang cenderung rendah di awal tahun dan menumpuk di akhir tahun. Menurut Rusqiayati (2014) idealnya, realisasi anggaran pemerintah mengikuti “Kurva S” yaitu cenderung stabil di awal tahun, kemudian meningkat pada pertengahan, dan kembali stabil menjelang akhir tahun anggaran. Penelitian ini bertujuan untuk mengidentifikasi faktor-faktor yang menyebabkan penumpukan realisasi anggaran di akhir tahun pada Balai Penelitian dan Pengembangan Lingkungan Hidup dan Kehutanan Manado. Penelitian ini menggunakan metode kualitatif studi kasus. Informan kunci penelitian ini adalah pejabat atau pegawai yang terlibat langsung dalam pengelolaan keuangan, seperti Kuasa Pengguna Anggaran (KPA), Pejabat Pembuat Komitmen (PPK), Pejabat Penandatangan Surat Perintah Bayar (PPSPM), Bendahara Pengeluaran, Pembantu Bendahara, dan Pelaksana Teknis Kegiatan (PTK). Hasil penelitian menunjukkan bahwa faktor-faktor yang menyebabkan penumpukan realisasi anggaran belanja di akhir tahun pada Balai Penelitian dan Pengembangan Lingkungan Hidup dan Kehutanan Manado yaitu perencanaan anggaran, pelaksanaan anggaran, pengadaan barang/jasa, dan sumber daya manusia. Kata Kunci : Penumpukan, Realisasi Anggaran Belanja, Analisis Tematik

scholarly journals Birds Species of Rallidae Family in Forestry and Environment Research and Development Institute of Manado

Jurnal Wasian ◽  
2016 ◽  
Vol 3 (1) ◽  
pp. 09
Author(s):  
Diah Irawati Dwi Arini
Keyword(s):  
Research And Development ◽  
Conservation Status ◽  
Bird Species ◽  
Wide Distribution ◽  
Good Prospect ◽  
Forestry Research ◽  
Development Institute ◽  
Environment Research ◽  
Research Institute

This study aims to determine species and conservation status of Rallidae family in Forestry and Environment Research and Development Institute of Manado; also the prospect of its development. This study may provide a source of data and information on the diversity of certain bird species. Observations conducted in June 2015 included the species of birds in Rallidae family found around the Forestry and Environment Research and Development Institute of Manado. Data were analyzed descriptively in the forms of figures and tables. Results showed that there were three species within this family found in Manado Forestry Research Institute. Those were isabelline bush-hen (Amaurornis isabellina), buff-banded rail (Gallirallus philippensis), and Barred Rail (Gallirallus torquatus). All three species are not protected in Indonesia and IUCN categorized them as Least Concern (LC). Isabelline bush-hen is endemic to the island of Sulawesi, while buff-banded rail and barred rail have a wide distribution. Weris has a good prospect to be domesticated.

scholarly journals Quantitative PK/PD Prediction of the Efficacious and Safe Dose Ranges of the LMP7 Inhibitor M3258 for Phase I Application in Relapsed/Refractory Multiple Myeloma Patients

Blood ◽  
2019 ◽  
Vol 134 (Supplement_1) ◽  
pp. 5582-5582
Author(s):  
Florian Lignet ◽  
Christina Esdar ◽  
Manja Friese-Hamim ◽  
Andreas Becker ◽  
Elise Drouin ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Research And Development ◽  
Phase I ◽  
Dose Escalation ◽  
Single Agent ◽  
Proteasome Inhibitors ◽  
Refractory Multiple Myeloma ◽  
Oral Application ◽  
Development Institute ◽  
Safe Dose

M3258 is an orally bioavailable, potent, selective, reversible inhibitor of the large multifunctional peptidase 7 (LMP7, β5i, PSMB8) proteolytic subunit of the immunoproteasome; a crucial component of the cellular protein degradation machinery, which is highly expressed in malignant hematopoietic cells including multiple myeloma. M3258 was previously shown to deliver strong in vivo preclinical efficacy in multiple myeloma xenograft models, as well as a more benign non-clinical safety profile compared to approved pan-proteasome inhibitors, exemplified by a lack of effects on the central and peripheral nervous systems and cardiac and respiratory organs. Here we describe preclinical PK/PD and PK/efficacy modelling which led to a prediction of the PK profile, and the efficacious and safe dose ranges of M3258 in human which were used to guide the design of the phase I dose-escalation trial of M3258 in >3 line relapsed/refractory multiple myeloma (RRMM) patients. Mouse, rat, dog and monkey PK, plasma protein binding and intrinsic clearance data were used to estimate a half-life of approximately 6 hours for M3258 in human. The human total clearance and volume of distribution for M3258 were predicted to be 0.033 L/h/kg and 0.28 L/kg, respectively, whilst oral bioavailability was estimated to be above 80%. LMP7 proteolytic activity was assessed as a PD readout in human multiple myeloma tumor cells xenografted to mice as well as in dog peripheral blood mononuclear cells (PBMCs). A strong PK/PD relationship was observed for M3258 across both species. LMP7 inhibition by M3258 also correlated strongly with anti-tumor efficacy in multiple myeloma xenografts, with maximal efficacy observed at M3258 exposure delivering sustained inhibition of tumor LMP7 activity. Quantitative PK/PD/efficacy modeling predicted the biologically efficacious dose (BED) of M3258 upon oral application to be between 10 - 90 mg daily in human. By incorporating data from nonclinical safety studies, these data suggest an attractive human PK profile of M3258, enabling oral application, as well as an improved human therapeutic index compared to approved pan-proteasome inhibitors. M3258 is being investigated in a phase I, first-in-man, 2-part, open label clinical study designed to determine the safety, tolerability, PK, PD and early signs of efficacy of M3258 as a single agent (dose-escalation) and co-administered with dexamethasone (dose-expansion) in participants with RRMM whose disease has progressed following > 3 prior lines of therapy and for whom no effective standard therapy exists. Integration of these data will guide the selection of the BED for potential further clinical development of M3258. Disclosures Lignet: Merck Healthcare KGaA: Employment. Esdar:Merck Healthcare KGaA: Employment. Friese-Hamim:Merck Healthcare KGaA: Employment. Becker:Merck Healthcare KGaA: Employment, Other: Holding shares with a value below 1000-USD. Drouin:EMD Serono Research and Development Institute: Employment. El Bawab:Merck Healthcare KGaA: Employment. Goodstal:EMD Serono Research and Development Institute: Employment. Gimmi:Merck Healthcare KGaA: Employment. Haselmayer:Merck Healthcare KGaA: Employment. Jährling:Merck Healthcare KGaA: Employment. Sanderson:Merck Healthcare KGaA: Employment. Sloot:Merck Healthcare KGaA: Employment. Stinchi:Merck Healthcare KGaA: Employment. Victor:Merck Healthcare KGaA: Employment. Walter:Merck Healthcare KGaA: Employment. Rohdich:Merck Healthcare KGaA: Employment.

scholarly journals Industrial Utilization of Grasses

2003 ◽  
pp. 131-134
Author(s):  
Zsolt Janowszky
Keyword(s):  
Research And Development ◽  
Environmental Protection ◽  
Agricultural Research ◽  
Paper Industry ◽  
Breeding Programme ◽  
Development Institute ◽  
Industrial Utilization ◽  
Agricultural Research And Development

The Agricultural Research and Development Institute P.U.C., Szarvas – realizing the importance of using the biomass in a number of ways – was one of the first in Europe, who began the breeding of grasses suitable for industrial utilization. The possible areas of using the energygrass – which could be called industrial grass – are the following:– Energetical use– Paper industry use– Utilization as an industrial fibrematerial– Use for feedingThe aim of the breeding programme: developing the kinds of grass, which yields big drymaterial mass and suitable for industrial utilization. These kind of grass, taking soil-utilization, economicality and environmental protection, offer and ensure new marketing perspectives and employment facilities for the disadvantageous areas.

scholarly journals eleksi Dini Hibrida F1 Mangga Produktif dan Berwarna Merah Berdasarkan Aktivitas Enzim Esterase dan Kandungan Antosianin

2013 ◽  
Vol 22 (3) ◽  
pp. 217
Author(s):  
Muhammad Jawal Anwarudinsyah ◽  
Sukartini Sukartini ◽  
Diah Sunarwati ◽  
Rebin Rebin ◽  
Nono Sutrisno
Keyword(s):  
Enzyme Activity ◽  
Research And Development ◽  
Skin Color ◽  
Early Selection ◽  
Anthocyanin Content ◽  
Tropical Fruits ◽  
Development Institute ◽  
Hybrid Number ◽  
Selection Of ◽  
Research Institute

ABSTRAK. Arumanis 143 merupakan varietas mangga unggul nasional yang memiliki kualitas buah cukup baik dan sudah dikenal di pasar, tetapi tingkat produktivitasnya masih rendah dan kulit buah tetap berwarna hijau walaupun sudah masak. Persilangan antara mangga Arumanis dengan varietas yang lebih produktif dan berwarna merah merupakan salah satu cara untuk memperbaiki produktivitas dan mengubah warna menjadi merah. Penelitian dilakukan mulai Januari sampai dengan Desember 2006 di Laboratorium Balai Penelitian Tanaman Buah Tropika Solok dan Balai Besar Penelitian dan Pengembangan Pascapanen Pertanian  untuk menyeleksi secara dini karakter produktif dan warna merah pada kulit buah terhadap 19 semaian hibrida F1 hasil persilangan antara induk Arumanis 143 dengan mangga-mangga Cukurgondang melalui analisis aktivitas enzim esterase dan kandungan antosianin. Hasil penelitian menunjukkan bahwa dari 19 semaian hibrida F1 ada empat semaian yang produktivitasnya lebih rendah dan 15 semaian yang produktivitasnya lebih tinggi dari tetua induk Arumanis 143. Dari 15 semaian ada lima semaian yang sangat produktif karena aktivitas enzim esterasenya lebih tinggi daripada standar (tetua paling produktif yaitu Keith), sehingga dapat dijadikan sebagai kandidat varietas mangga Arumanis yang produktif. Kelima semaian tersebut  berasal dari persilangan  nomor 25, 33, 35, 47, dan 50. Hasil analisis kandungan antosianin menunjukkan bahwa hampir seluruh semaian hibrida F1 memiliki kandungan antosianin lebih tinggi dari induk Arumanis 143, tetapi yang memiliki kandungan antosianin lebih tinggi dari standar (Apel dan Khirsapati Maldah) ada empat semaian, yaitu hibrida dari persilangan nomor 20, 25, 44, dan 48. Keempat  semaian tersebut selanjutnya dikategorikan sebagai kandidat varietas mangga Arumanis yang kulit buahnya berpotensi berwarna merah. Khusus semaian hibrida F1 dari persilangan no 25 selain lebih produktif juga kulit buahnya berpotensi berwarna merah.<br /><br />ABSTRACT. Jawal, M Anwarudin Syah, Sukartini, Sunarwati, D, Rebin, and Sutrisno, N 2012. The Early Selection of Mango Hybrids which Productive and  Red Skin Fruit by Activity of Esterase Enzymes and Anthocyanin Content. The Arumanis 143 is a national superior mango cultivar which have a good quality and marketable, but the low productivity and green of skin fruit. The hybridization of Arumanis 143 cultivar with the productive cultivars and red skin mango is a method to improved the productivity and change the skin color to red on Arumanis cultivar. Early selection on productivity character and red skin color of mango based on esterase enzyme activity and anthocyanin content on hybrid F1 seedling by crossing Arumanis 143 with the productive cultivars and red skin mango. The research was conducted at Laboratory of Indonesian Tropical Fruits Research Institute Solok and Postharvest Research and Development Institute Bogor from January to December 2006. The objective of the research was to early selection of productivity character and red skin color of mango on 19 hybrids F1 by activities of esterase enzyme and anthocyanin content. The results analysis of  esterase enzyme activity showed that there were five seedlings hybrids F1 which activity of esterase enzyme higher than standard (Keith) i.e. hybrid number 25, 33, 35, 47, and 50. Those five seedlings hybrid can be determined as productive candidate of Arumanis mango cultivars. The results analysis of anthocyanin content showed that there were four seedlings hybrids F1 which anthocyanin content higher than standard (Apel and Khirsapati Maldah) i.e. hybrid number 20, 25, 44, and 48. The four seedlings hybrid can be determined as red skin of mango candidate of Arumanis cultivars. The seedlings number 25 have high of esterase enzyme activity and anthocyanin content, thus could be determined as Arumanis cultivars which productive and red skin mango.<br /><br />

scholarly journals Pengembangan mobile learning berbasis android sebagai media pembelajaran organisasi arsitektur komputer

2019 ◽  
Vol 6 (2) ◽  
pp. 137-147
Author(s):  
Aminda Dewi Sutiasih ◽  
Renny Permata Saputri
Keyword(s):  
Research And Development ◽  
Computer Architecture ◽  
Instructional Development ◽  
Mobile Learning ◽  
Learning Process ◽  
Learning System ◽  
Average Value ◽  
Development Institute ◽  
Learning Development ◽  
The University

Optimalisasi penggunaan smartphone dalam proses pembelajaran masih rendah. Maka sangat diperlukan merancang suatu proses pembelajaran dengan mengoptimalkan penggunaan smartphone. Penelitian ini bertujuan merancang proses pembelajaran menggunakan smartphone dengan sistem mobile learning berbasis android terhadap mata kuliah Organisasi Arsitektur Komputer di perguruan tinggi. Model yang digunakan adalah Instructional Development Institute (IDI) dalam metode Research and Development (R&D). Hasil penelitian ini menunjukkan bahwa mobile learning untuk matakuliah organisasi arsitektur komputer ini valid untuk dimanfaatkan sebagai media pendukung pembelajaran, sesuai dengan hasil uji validitas yang dilakukan dengan pakar media serta pakar materi didapatkan hasil dari Perhitungan validasi materi yaitu validator 1 (0,91), validator 2 (0,95) dan validasi desain yaitu validator 1 (0,9), validator 2 (0,89) , yang termasuk  kategori  valid. Hasil uji kepraktisan terhadap media pembelajaran mobile learning berbasis android berdasar respon dosen adalah pada nilai rata-rata 92%, dan berdasar respon mahasiswa adalah pada nilai rata-rata 87,61% yang termasuk kategori sangat praktis. Untuk uji efektifitas yang diujikan ke mahasiswa didapatkan hasil untuk kelas kontrol sebesar 74,56% dan eksperimen sebesar 82,25%.  Sehingga penggunaan mobile learning berbasis Android ini valid, praktis dan efektif untuk dapat digunakan pada mata kuliah organisasi arsitektur komputer di Universitas Putera Indonesia YPTK Padang.Kata kunci: Mobile learning, organisasi arsitektur komputer, research and development Android-based mobile learning development as a learning media for computer architecture organization AbstractOptimizing the use of smartphones in the learning process is still low. So it is very necessary to design a learning process by optimizing the use of smartphones. This study aims to design the learning process using a smartphone with an Android-based mobile learning system for Computer Architecture Organization courses in universities. The model used is the Instructional Development Institute (IDI) in the Research and Development (R&D) method. The results of this study indicate that mobile learning for computer architecture organization courses is valid to be used as a learning support media, in accordance with the results of the validity test conducted with media experts and material experts obtained from the Calculation of material validation namely validator 1 (0.91), validator 2 (0.95) and design validation, namely validator 1 (0.9), validator 2 (0.89), which is included in the valid category. The results of practicality tests on Android-based mobile learning media based on lecturer responses are at an average value of 92%, and based on student responses is at an average value of 87.61% which is included in the very practical category. For the effectiveness test that is tested on students, the results for the control class were 74.56% and experiments were 82.25%. So that the use of Android-based mobile learning is valid, practical and effective to be used in computer architecture organization courses at the University of Putera Indonesia YPTK Padang.Keywords: computer architecture organization, mobile learning, research and development

Sign in / Sign up

Export Citation Format

Share Document