Food Seasoning Spices Mixture Improves Glucose Metabolism and Lipid Profile in Fructose-Fed Hyperinsulinemic Rats

Objective. Kisspeptin, a puberty control neuropeptide, has been discovered to have an additional role in metabolism and glucose homeostasis regulation. This study aimed to determine the association of serum kisspeptin with metabolic parameters and glucose metabolism in obese children. Design, Patients and Measurements. A cross-sectional study of 270 obese children was conducted. All children underwent an oral glucose tolerance test and had serum kisspeptin, glycated hemoglobin (HbA1c), and lipid profile measurements. Body fat mass was assessed by bioelectrical impedance analysis. Serum kisspeptin levels of both prepubertal and pubertal children with two HbA1c ranges, <5.7% (normal range) and 5.7–6.4% (prediabetes range), were analyzed and correlated with metabolic parameters and glucose metabolism status. Results. The median (IQR) serum kisspeptin level of only pubertal (not prepubertal) children with prediabetes HbA1c was higher than those with normal HbA1c (53.2 (33.9, 69.8) and 37.8 (29.6, 67.5) pg/mL; p = 0.015 , respectively). There were no differences in serum kisspeptin levels among children with different glucose metabolism status. During pubertal progression, serum kisspeptin reached the highest level at Tanner stage II only in obese boys. Additionally, there was a positive correlation between serum kisspeptin and HbA1c after adjusting for puberty (β = 12.87; p = 0.001 ). No correlations between serum kisspeptin and insulin sensitivity indices, insulin secretion indices, lipid profile, blood glucose, as well as percentage of body fat were demonstrated. Conclusions. Serum kisspeptin levels in pubertal obese children with prediabetes HbA1c were greater than those with normal HbA1c. Serum kisspeptin was positively associated with HbA1c, but not with glucose metabolism status.

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AVE8134, a novel potent PPARα agonist, improves lipid profile and glucose metabolism in dyslipidemic mice and type 2 diabetic rats

Acta Pharmacologica Sinica ◽

10.1038/aps.2011.165 ◽

2012 ◽

Vol 33 (1) ◽

pp. 82-90 ◽

Cited By ~ 30

Author(s):

Hans Ludwig Schäfer ◽

Wolfgang Linz ◽

Eugen Falk ◽

Maike Glien ◽

Heiner Glombik ◽

...

Keyword(s):

Glucose Metabolism ◽

Lipid Profile ◽

Diabetic Rats ◽

Type 2 Diabetic ◽

Pparα Agonist

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Effects of retinoid therapy on insulin sensitivity, lipid profile and circulating adipocytokines

Acta Endocrinologica ◽

10.1530/eje.1.02057 ◽

2006 ◽

Vol 154 (1) ◽

pp. 83-86 ◽

Cited By ~ 47

Author(s):

S Corbetta ◽

R Angioni ◽

A Cattaneo ◽

P Beck-Peccoz ◽

A Spada

Keyword(s):

Insulin Sensitivity ◽

Glucose Metabolism ◽

Lipid Profile ◽

Oral Treatment ◽

Density Lipoprotein ◽

Hdl Cholesterol ◽

Glucose And Lipid Metabolism ◽

Cholesterol Levels

Objective: In vitro and in vivo models indicate that all-trans retinoic acids influence glucose and lipid metabolism. We aimed to evaluate the effects of chronic treatment with acitretin, an all-trans retinoic acid, on glucose metabolism, lipid profile and adiponectin and resistin levels. Design: Ten normoglycemic, normolipemic patients affected with psoriasis vulgaris were studied before and after 1 and 3 months of oral treatment with 35 μg of acitretin. Methods: Glucose metabolism, lipid profile, and adiponectin and resistin levels were evaluated in basal conditions and after acitretin treatment. Ten healthy subjects matched for age, body mass index (BMI) and insulin sensitivity were studied as controls. Results: One-month acitretin treatment reduced psoriasis activity, insulin sensitivity, evaluated as QUICKI values (0.364 ± 0.034 versus 0.329 ± 0.051; P < 0.05) and HOMA-IR index (1.53 ± 0.73 versus 2.59 ± 1.41; P < 0.05), and high-density lipoprotein (HDL)-cholesterol levels (45.2 ± 11.7 versus 39.4 ± 10.4 mg/dl; P = 0.01). The impairment in glucose and lipid homeostasis was transient and not associated to BMI variations. Adiponectin levels did not change during the treatment, while resistin levels, which were higher in untreated patients than in controls (9.4 ± 4.4 versus 6.2 ± 2.1 ng/ml; P = 0.05), fell within the normal range after 1 and 3 months of therapy. The normalization of resistin levels occurred without significant changes in circulating tumor necrosis factor α (TNFα) levels, which persisted elevated throughout the treatment. Conclusions: Treatment with a low dose of acitretin induced a mild, transient reduction of insulin sensitivity and HDL-cholesterol levels that was not related to modifications of adiponectin, resistin and TNFα levels. Although the role of resistin in humans remains elusive, the levels of this adipocytokine seem to be affected, at least in part, by retinoids.

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Comparison of two dose regimens of growth hormone (GH) with different target IGF-1 levels on glucose metabolism, lipid profile, cardiovascular function and anthropometric parameters in gh-deficient adults

Growth Hormone & IGF Research ◽

10.1016/j.ghir.2012.04.002 ◽

2012 ◽

Vol 22 (3-4) ◽

pp. 116-121 ◽

Cited By ~ 2

Author(s):

Maria Claudia Peixoto Cenci ◽

Débora Vieira Soares ◽

Luciana Diniz Carneiro Spina ◽

Rosane Resende de Lima Oliveira Brasil ◽

Priscila Marise Lobo ◽

...

Keyword(s):

Growth Hormone ◽

Glucose Metabolism ◽

Lipid Profile ◽

Cardiovascular Function ◽

Anthropometric Parameters

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Fructose Consumption in the Development of Obesity and the Effects of Different Protocols of Physical Exercise on the Hepatic Metabolism

10.20944/preprints201702.0103.v1 ◽

2017 ◽

Author(s):

Rodrigo M. Pereira ◽

José Diego Botezelli ◽

Kellen Cristina Da Cruz Rodrigues ◽

Dennys Esper Cintra ◽

José Rodrigo Pauli ◽

...

Keyword(s):

Insulin Resistance ◽

Glucose Metabolism ◽

Physical Exercise ◽

Inflammatory Response ◽

Lipid Profile ◽

Redox State ◽

Liver Lipid ◽

Hepatic Metabolism ◽

Exercise Protocol ◽

Markers Of Inflammation

Fructose consumption has been growing exponentially and, concomitant with this, the increase in the incidence of obesity and associated complications has followed the same behavior. Studies indicate that fructose may be a carbohydrate with greater obesogenic potential than other sugars. In this context, the liver seems to be a key organ for understanding the deleterious health effects promoted by fructose consumption. Fructose promotes complications in glucose metabolism, accumulation of triacylglycerol in the hepatocytes and alterations in the lipid profile, which, associated with an inflammatory response and alterations in the redox state, will imply a systemic picture of insulin resistance. However, physical exercise has been indicated for the treatment of several chronic diseases. In this review, we show how each exercise protocol (aerobic, strength or a combination of both) promote improvements in the obesogenic state created by fructose consumption as an improvement in the serum and liver lipid profile (HDL increase and decrease TG and LDL levels) and a reduction of markers of inflammation caused by an excess of fructose. Therefore, it is concluded that the practice of aerobic physical exercise, strength or a combination of both is essential for attenuating the complications developed by the consumption of fructose.

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The Splenectomy Effects on Lipid Profile and Glucose Metabolism in the Major Thalassemia Patients

Journal of Nutrition and Food Security ◽

10.18502/jnfs.v6i1.5300 ◽

2021 ◽

Author(s):

Zohreh Sajadi Hezaveh ◽

Mahsa Hadidi ◽

Farzad Shidfar

Keyword(s):

Physical Activity ◽

Glucose Metabolism ◽

Lipid Profile ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Lipoprotein Cholesterol ◽

Beta Thalassemia ◽

Oral Glucose ◽

Low Density ◽

Low Density Lipoprotein Cholesterol

Background: Splenectomy is a common treatment for beta thalassemia. It not only eliminates many complications by reducing the need for blood transfusion, but also causes new complications that threaten the patients' health. The aim of this study was to determine if splenectomy could alter the lipid profile and glucose metabolism in beta thalassemia major patients. Methods: In this case-control study, 41 splenectomized and 42 non-splenectomized eligible beta thalassemia patients were selected from Zafar Thalassemia Clinic, Tehran, Iran. Anthropometric, demographic, and biochemical data were collected using standard methods. Physical activity and food intake were measured using International Physical Activity Questionnaire (IPAQ) and food frequency questionnaires (FFQ), respectively. Results: Demographic characteristics and dietary intake were not significantly different between the two groups. However, triglyceride (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), very low density lipoprotein cholesterol (VLDL-C), TC/HDL-C, LDL-C/TG, and LDL-C/HDL-C ratios were significantly higher, but HDL-C was significantly lower in splenectomized patients (P < 0.05). Furthermore, fasting blood glucose (P < 0.39) and oral glucose tolerance test (P < 0.53) did not significantly differ between the two groups. Conclusions: Reduced activity of the reticuloendothelial system and reduced removal of cholesterol might be the reason for higher plasma lipid profile and greater risk of cardiovascular diseases in splenectomized patients. On the other hand, glucose metabolism was not affected by splenectomy in adult patients. To clarify this relationship, prospective studies are suggested.

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Lipid Profile and Blood Glucose Level of Hypertensive Population in Rural Regions of West China.

10.21203/rs.3.rs-136355/v1 ◽

2020 ◽

Author(s):

Lihong Fan ◽

Xiaojing Hu ◽

You Li ◽

Tiao Bai ◽

Longfei Pan ◽

...

Keyword(s):

Blood Glucose ◽

Glucose Metabolism ◽

Blood Glucose Level ◽

Lipid Profile ◽

Glucose Level ◽

Rural Regions ◽

Hypertensive Patients ◽

West China ◽

Abnormal Glucose Metabolism ◽

Hypertensive Population

Abstract Background: In rural regions of West China, there was almost no intervention on dyslipidemias and abnormal glucose metabolism of individuals with hypertension because of no literature reporting the lipid profile or blood glucose of these patients. This study was designed to investigate the lipid profile and blood glucose level of the hypertensive population in these regions. Methods: A cross-sectional community survey was carried out in Xunyi county of Shaanxi province in West China. The study enrolled 1425 hypertensive patients. The lipid profile and blood glucose levels were assessed. Diet and physical activity were also investigated by questionnaire. Results: 54% of the population had dyslipidemias. The hypercholesterolemia (hyper-TC) and hypertriglyceridemia (hyper-TG) were the main dyslipidemias (hyper-TC:25%; hyper-TG: 33% ). The prevalence of abnormal glucose metabolism was 37%. 16% of the population had hyperglycemia. Despite of low-fat intake, the diet was unbalanced by excess salt consumption and seriously insufficient intake of vegetables, fruits and protein. Conclusion: Dyslipidemias and abnormal glucose metabolism were common in the hypertensive patients in rural areas of West China. They were needed to be invented to reduce the risks of atherosclerotic cardiovascular diseases of hypertensive patients in these regions. Unbalanced diet here may be needed to be modified.

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