scholarly journals Risk Factors for Venous Thromboembolism Among Reproductive Age Women

2016 ◽  
Vol 25 (1) ◽  
pp. 63-70 ◽  
Author(s):  
Carolyn L. Westhoff ◽  
Lara S. Yoon ◽  
Rosalind Tang ◽  
Vina Pulido ◽  
Andrew Eisenberger

2020 ◽  
Author(s):  
Irina Voevodina ◽  
Elena Maychuk ◽  
Olga Ivanova

Aims and objectives. Identify the priority features of the formation of the most significant diseases in women with the focus on the determination of disease markers and their development triggers. Materials and methods. 408 healthy women from the students and employees of The Moscow State University of Medicine and Dentistry named after A.I. Yevdokimov took part in the research. All the women completed a questionnaire, which was elaborated by the researchers. The survey contained questions designed to identify major risk factors for cardiovascular diseases and explore dietary and physical activity habits, bad habits and diseases, gynaecological status. Results. All the participants were divided into 4 groups. The 1st group included 157 female subjects under the age of 24; the 2nd was represented by 113 women above the age of 25 who reported pregnancy and birth in their case history; the 3rd group was formed by non-parous 74 women of the same age and the 4th one consisted of 64 postmenopausal women. Complaints of dyspnea and unpleasant feelings in the region of the heart which were not caused by physical exercise were found, for the most part (р=0,001), in the women of the fourth group (73 % opposed to 36 % of cases in the 1st group). 18.4% of the interviewed smoked and were mainly found in the groups of reproductive-age women. Worth noting that lack of physical activity was reported in the groups. Inactivity was found predominantly (48 %, р=0,001) in the volunteers of the 4th group. A third of the women from that group noted the symptoms of physical activity intolerance represented by dyspnea and weakness. 41,4 % of the female subjects (n=169) had chronic conditions: most of them were gastrointestinal diseases with the prevalence of gastritis (36,5 %). The analysis of the gynaecological status of the interviewed allowed to discover ovarian dysfunction in 26,8 % of the interviewed women. 52 % of the women from the 1st group suffered from premenstrual syndrome. 14,7 % of the interviewed had a premature birth. 11,7 % of the women had undergone C-section. Pregnancy complications were reported in 15,4 % of the interviewed; 11,4 % of the cases were pregnancy losses. 28 % of the representatives of the 4th group reported surgical menopause. This group demonstrates the proven (р=0,001) increase of body mass index, high arterial pressure, hot flushes, insomnia. Conclusion. The conducted research allowed discovering significant negative impacts of smoking, low physical activity, unhealthy diet, especially, in the group of reproductive-age women. Hormonal disorders, pathology in pregnant women found in the groups of young subjects as well as high rate of somatic diseases in healthy women require an in-depth study of the identified risk groups.



2013 ◽  
Vol 33 (4) ◽  
pp. 346-350 ◽  
Author(s):  
A. Karabulut ◽  
S. Ozkan ◽  
A. I. Bozkurt ◽  
T. Karahan ◽  
S. Kayan


2017 ◽  
Vol 34 (4) ◽  
pp. 327-331 ◽  
Author(s):  
Sunmie Kim ◽  
Jin Ju Kim ◽  
Min-Jeong Kim ◽  
Kyung Hee Han ◽  
Jung Ryeol Lee ◽  
...  


Blood ◽  
2006 ◽  
Vol 108 (11) ◽  
pp. 4100-4100
Author(s):  
Sarah Barsam ◽  
Catherine N. Bagot ◽  
Raj K. Patel ◽  
Paul S. Sidhu ◽  
Anthony Davies ◽  
...  

Abstract The relationship between uterine leiomyomata (fibroids) and venous thromboembolism (VTE) is poorly characterised. Fibroids are smooth muscle cell tumours of the uterus; occuring in approximately 40% of women of reproductive age, they are twice as prevalent in women from African compared to Caucasian origin. It is assumed that massive leiomyomata (palpable beyond the level of the umbilicus) cause deep vein thrombosis as a consequence of a direct compressive effect on pelvic veins but this explanation may be insufficient. Other hypotheses for the thrombogenic nature of leiomyomata include the abnormal expression of type 1 basic FGF receptor, increased expression of thrombospondin 1 and nitrogen oxide synthase, abnormal oestrogen regulation and fibroid-induced polycythaemia. We describe the cases of seven women (mean age 41 yrs, range 29–46yrs) with VTE presumed secondary to massive fibroids. The majority of women (86%) were of African or Carribbean origin. Massive uterine leiomyomata were demonstrated in each patient by transvaginal ultrasound scanning. All cases had objectively confirmed (duplex ultrasound) symptomatic DVT, and two had CT-confirmed symptomatic pulmonary embolism (PE) at presentation. Direct venous compression by massive fibroids was demonstrated in only one case using magnetic resonance imaging (MRI)(case 1). Interestingly the two cases with left sided proximal DVT (cases 2 and 5) revealed right-sided lateral and posterior uterine wall fibroids. Data on known acquired risk factors for VTE was recorded for each patient. Thrombophilia screening was performed in all cases at least four weeks following cessation of anticoagulation. Venous compression alone failed to explain six of the cases, where fibroids were not positionally related to the site of DVT. Of these, only one had significant additional risk factors for VTE (case 3). Whereas extrinsic compression of the pelvic veins may contribute to venous stasis and DVT formation in some cases, our findings suggest that it is unlikely that this is the only pathogenic mechanism. In conclusion, we suggest that the occurrence of VTE in women with massive fibroids is unlikely to be due solely to mechanical compression of the pelvic veins. It is possible that biological growth factors produced by the leiomyomata may trigger VTE formation and that oestrogen may have an independent growth promoting effect on both VTE and leiomyomata. Further research is required to characterise the prothrombotic state in these women. Patient Characteristics Ethnicity Site DVT D-dimer(mcg/l) Thrombophilia Risk Factors Fibroid Site Fibroid Size (mm) 1 Caribbean Left Proximal 1563 No No Left lateral wall 147 × 134 × 102 2 Caribbean Left Proximal 481 No No Posterior and right lateral wall and fundus 99 × 94 × 79 3 Caucasian Left Distal 969 Yes Flight, Previous DVT Posterior wall and fundus 89 × 77 4 African Right Proximal/PE 1883 No No Posterior wall 350 × 300 × 250 5 African Left Proximal 6152 No No Posterior and right lateral wall 136 × 124 × 124 6 African Right Proximal/PE N/A No No Multiple, widespread 60 × 58 × 73 7 Caribbean Right Proximal 2503 No No Right lateral wall 130×116



Physiology ◽  
2017 ◽  
Vol 32 (5) ◽  
pp. 357-366 ◽  
Author(s):  
Licy L. Yanes Cardozo ◽  
Damian G. Romero ◽  
Jane F. Reckelhoff

Polycystic ovary syndrome (PCOS) is the most common endocrine disorder that affects reproductive-age women. Hyperandrogenemia is present in a significant fraction (~80%) of women with PCOS. Increased prevalence of cardiometabolic risk factors is frequently observed in PCOS women. The present review aims to highlight the key role of androgens in mediating the negative cardiometabolic profile observed in PCOS women.





Flebologiia ◽  
2018 ◽  
Vol 12 (3) ◽  
pp. 101 ◽  
Author(s):  
M. G. Nikolaeva ◽  
K. A. Momot ◽  
N. N. Yasafova ◽  
A. P. Momot ◽  
N. G. Khorev


2008 ◽  
Vol 46 (12) ◽  
pp. 1913-1920 ◽  
Author(s):  
Johnstone J. Kumwenda ◽  
Bonus Makanani ◽  
Frank Taulo ◽  
Chiwawa Nkhoma ◽  
George Kafulafula ◽  
...  


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