The Association Between Age-Related Hearing Impairment and Metabolic Syndrome in Korean Women: 5-Year Follow-Up Observational Study

Purpose Longitudinal population-based cohort data were used to develop a standardized classification system for age-related hearing impairment using thresholds for frequencies (0.5–8 kHz) typically measured in cohort studies. Method Audiometric testing data collected in the Epidemiology of Hearing Loss Study from participants ( n = 1,369) with four visits (1993–1995, 1998–2000, 2003–2005, and 2009–2010) were included (10,952 audiograms). Cluster analyses (Wald's method) were used to identify audiometric patterns. Maximum allowable threshold values were defined for each cluster to create an ordered scale. Progression was defined as a two-step change. Results An eight-step scale was developed to capture audiogram shape and severity of hearing impairment. Of the 1,094 participants classified as having normal hearing based on a pure-tone average, only 25% ( n = 277) were classified as Level 1 (all thresholds ≤ 20 dB HL) on the new scale, whereas 17% ( n = 182) were Levels 4–6. During the 16-year follow-up, 64.9% of those at Level 1 progressed. There was little regression using this scale. Conclusions This is the first scale developed from population-based longitudinal cohort data to capture audiogram shape across time. This simple, standardized scale is easy to apply, reduces misclassification of normal hearing, and may be a useful method for identifying risk factors for early, preclinical, age-related changes in hearing.

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Association Between Dietary Variety Score and Metabolic Syndrome in Korean Women: A Prospective Cohort Study

Current Developments in Nutrition ◽

10.1093/cdn/nzaa061_040 ◽

2020 ◽

Vol 4 (Supplement_2) ◽

pp. 1412-1412

Author(s):

Dahye Han ◽

Jiyeon Kim ◽

Yoonjin Shin ◽

Yoonjin Lee ◽

Yangha Kim

Keyword(s):

Metabolic Syndrome ◽

Cohort Study ◽

Dietary Quality ◽

Korean Women ◽

Epidemiology Study ◽

Dietary Variety ◽

Follow Up Study ◽

Funding Sources ◽

High Triglyceride

Abstract Objectives Dietary variety is reported to be an indicator to assess dietary quality and reduces the risk of chronic diseases. This study was performed to investigate the association between dietary variety score (DVS) and the risk of developing metabolic syndrome (MS) in Korean women. Methods The data was obtained from the Ansan and Anseoneg Cohort Study which was a part of the Korean Genome and Epidemiology Study. Subjects were 2865 women aged 40–69 years without MS. DVS was defined by counting the number of different food items consumed during a day. When subjects consumed another food item, dietary variety scored 1. Based on the DVS from 0 to 85, subjects were classified into five groups. Results During the 12-years follow-up study, the cumulative incidence of MS was 38.0%. Subjects with higher DVS showed a decreased incidence of MS compared to those with lower DVS. In addition, higher DVS was associated with lower risk of developing MS [hazard ratio (HR) = 0.78, 95% CI: 0.63 – 0.97 for quintile 1 vs. quintile 5, p-trend = 0.008] after adjustment for potential cofounders. Of MS components, high abdominal obesity (HR = 0.82, 95% CI: 0.69 – 0.98, p-trend = 0.004), high blood pressure (HR = 0.79, 95% CI: 0.64 – 0.97, p-trend = 0.014) and high triglyceride (HR = 0.73, 95% CI: 0.57 – 0.92, p -trend = 0.041) were prospectively associated with DVS. Conclusions These results suggested that eating various foods may reduce the risk of MS in Korean women. Funding Sources None.

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Polypill therapy and frailty in elderly: Time to stop treating everything

Asian Journal of Medical Sciences ◽

10.3126/ajms.v12i4.33182 ◽

2021 ◽

Vol 12 (4) ◽

pp. 39-42

Author(s):

Sunil Kumar ◽

Parth Godhiwala ◽

Amrutha Garikapati ◽

Shraddha Jain

Keyword(s):

Observational Study ◽

Elderly Patients ◽

Prospective Observational Study ◽

Related Condition ◽

Medicine Department ◽

Risk Of Death ◽

Age Related ◽

One Year ◽

The Impact

Background: Frailty is a reversible age-related condition of increased vulnerability and risk of death or unplanned hospitalization. Frailty and polypill therapy are common in elderly, although little is known about the impact, they may have on each other. Aims and Objective: The study was a prospective observational study, designed with an aim to observe the six-month and one-year outcomes of elderly patients on polypill therapy. Material and Methods: Three hundred forty-two patients aged more than 60 years on polypill treatment were enrolled in this study, which were on regular follow up in our rural hospital at geriatric units of medicine department. Results: At the end of one year, 38.1% were in severe frailty (FIRE >0.7) category, out of which death happened at the end of one year were 41.6%. 47.6% required repeated hospitalisations that were on polypill therapy. Conclusions: A reduction of polypill therapy could be a cautious strategy to prevent and manage frailty. Further research is needed to confirm the possible benefits of reducing polypill in the development, reversion or delay of frailty.

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Observations of the Morphological Evolution of Neuronal Intranuclear Rods in the Human Substantia Nigra Across the Age Spectrum

American Journal of Clinical Pathology ◽

10.1093/ajcp/aqz114.001 ◽

2019 ◽

Vol 152 (Supplement_1) ◽

pp. S76-S76

Author(s):

Osama Khan ◽

Mario Capitano ◽

Susan Fan ◽

John Woulfe

Keyword(s):

Observational Study ◽

Middle Ages ◽

Morphological Evolution ◽

Age Groups ◽

Distinct Type ◽

Elderly Subjects ◽

Cellular Mechanisms ◽

Age Related ◽

Shed Light

Abstract Objectives Parkinson’s disease (PD) is a neurodegenerative disease characterized by a depletion of dopaminergic neurons in the substansia nigra (SN). Loss of SN neurons occurs at a rate of up to 10% per decade in nonpathological aging. Other age-related changes in nigral neurons include accumulation of intranuclear inclusions called Marinesco bodies (MBs). MBs have been shown to associate with a distinct type of neuronal intranuclear body called the intranuclear rod (INR). At what point in the aging process INRs develop, and when they give rise to MBs, are questions that remain unanswered. In this observational study, we set out to determine whether SN INRs display changes in their morphology across the human age spectrum. Methods The laboratory information system was searched for hospital and forensic autopsies conducted from 2010-2017 that had midbrain sections taken. Ten slides were cut from each of 11 age groups from ages ranging from 1 month to 80 years of age. Sections were immunostained with glucocorticoid receptor (GR) to identify INRs. Results There was a progressive age-associated transition in INR morphology from long, linear intranuclear structures in the youngest age groups (infants), to shorter linear structures at middle ages, culminating in small, dot-like juxtanucleolar structures in elderly subjects. A proportion of short INRs displayed contact with MBs in the middle age groups. Conclusion We demonstrated a striking progressive, age-dependent alteration in INR morphology. These results suggest that INRs give rise to MBs in the SN during middle ages. As a follow-up of this preliminary observational study, quantitative analysis of INR frequency and size is currently being performed in our lab. Ultimately, we plan to expand our cases for the creation of a human SN tissue microarray, which we hope will shed light on the cellular mechanisms of neuronal ageing and degeneration in the SN.

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Diet quality indices and risk of metabolic syndrome among postmenopausal women of Mexican ethnic descent in the Women’s Health Initiative Observational Study

Nutrition and Healthy Aging ◽

10.3233/nha-190076 ◽

2020 ◽

Vol 5 (4) ◽

pp. 261-272

Author(s):

Margarita Santiago-Torres ◽

Zaixing Shi ◽

Lesley F. Tinker ◽

Johanna W. Lampe ◽

Matthew A. Allison ◽

...

Keyword(s):

Metabolic Syndrome ◽

Waist Circumference ◽

Observational Study ◽

Postmenopausal Women ◽

Mediterranean Diet ◽

Diet Quality ◽

Hdl Cholesterol ◽

Quality Indices ◽

Health Initiative

BACKGROUND: The prevalence of metabolic syndrome is higher among minority populations, including individuals of Mexican ethnic descent. Whether alignment to healthy dietary patterns is associated with lower risk of metabolic syndrome in this population is largely unknown. OBJECTIVE: To prospectively evaluate the associations between a priori diet quality scores and risk of metabolic syndrome and its components among postmenopausal women of Mexican ethnic descent. METHODS: A total of 334 women of Mexican ethnic descent who participated in the Women’s Health Initiative (WHI) observational study without metabolic syndrome or diabetes at baseline (1993–1998) were included. Baseline diets were scored with the Alternate Mediterranean Diet (aMED), the Dietary Approaches to Stop Hypertension (DASH), the Healthy Eating Index (HEI-2010), the Mediterranean Diet Score (MDS), and the traditional Mexican Diet (MexD) score. Multivariable linear and logistic regression models were used to test the associations between baseline diet quality and risk of metabolic syndrome and its individual components at follow-up (2012-2013). RESULTS: Approximately 16% of women met the criteria for metabolic syndrome at follow-up. None of the diet quality indices were associated with risk of metabolic syndrome. However, higher vs lower DASH scores were associated with lower waist circumference (85.2 vs 88.0 cm) and glucose concentrations (90.0 vs 95.1 mg/dL), and higher HDL cholesterol (62.6 vs 59.0 mg/dL), while higher vs lower HEI-2010 scores were associated with lower waist circumference (83.9 vs 88.1 cm), triglycerides (103 vs 117 mg/dL) and glucose concentrations (89.5 vs 94.4 mg/dL), and higher HDL cholesterol levels (63.9 vs 58.5 mg/dL). CONCLUSIONS: Diet quality was not associated with risk of metabolic syndrome in this population. However, the results suggest that alignment to DASH and HEI-2010 recommendations may be beneficial for reducing some individual components of metabolic syndrome among postmenopausal women of Mexican descent.

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Metabolic syndrome and cardiovascular disease after haematopoietic cell transplantation (HCT) in adults: an EBMT cross-sectional non-interventional study

Bone Marrow Transplantation ◽

10.1038/s41409-021-01414-7 ◽

2021 ◽

Author(s):

D. M. Greenfield ◽

N. Salooja ◽

C. Peczynski ◽

S. van der Werf ◽

H. Schoemans ◽

...

Keyword(s):

Cardiovascular Disease ◽

Metabolic Syndrome ◽

Cardiovascular Risk ◽

Cell Transplantation ◽

Interventional Study ◽

Cross Sectional ◽

Haematopoietic Cell ◽

Age Related ◽

Randomised Controlled

AbstractMetabolic syndrome (MetS) is associated with cardiovascular disease in the general population and is also a potential cardiovascular risk factor in survivors of haematopoietic cell transplantation (HCT). We report an EBMT cross-sectional, multi-centre, non-interventional study of 453 adult HCT patients surviving a minimum of 2 years post-transplant attending routine follow-up HCT and/or late effects clinics in 9 centres. The overall prevalence of MetS was 37.5% rising to 53% in patients >50 years of age at follow-up. There were no differences in rates of MetS between autologous and allogeneic HCT survivors, nor any association with graft-versus-host disease (GvHD) or current immunosuppressant therapy. Notably, there was a significantly higher occurrence of cardiovascular events (CVE, defined as cerebrovascular accident, coronary heart disease or peripheral vascular disease) in those with MetS than in those without MetS (26.7% versus 9%, p < 0.001, OR 3.69, 95% CI 2.09–6.54, p < 0.001), and, as expected, MetS and CVE were age-related. Unexpectedly, CVE were associated with occurrence of second malignancy. Screening for and management of MetS should be integrated within routine HCT long-term follow-up care for both allogeneic and autologous HCT survivors. Further research is warranted, including randomised controlled trials of interventional strategies and mechanistic studies of cardiovascular risk in HCT survivors.

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