scholarly journals 155 Polypharmacy Burden: How to Optimise, a Practical Approach

2019 ◽  
Vol 48 (Supplement_4) ◽  
pp. iv34-iv39
Author(s):  
Renukha Sellappans ◽  
Anand Prakash ◽  
Ahlam Sundus
Keyword(s):  
Drug Therapy ◽  
Medication Review ◽  
Older Persons ◽  
Adverse Drug Events ◽  
Healthcare Utilisation ◽  
Good Evidence ◽  
Clinical Indication ◽  
Practical Recommendation ◽  
The World ◽  
The Impact

Abstract Polypharmacy refers to the numerical value of medications used by a patient and is typically described as the concurrent use of five or more medications per day, but the definition is variable and there is no global consensus. Polypharmacy is unfortunate consequence of rapid advancement of medicine. Polypharmacy could be appropriate or problematic. Problematic polypharmacy can arise if the medicines are used without good evidence and in this situation risk of harm outweighs benefit. While there might be clinical indication for the medications to treat co-morbidities of a given patient, polypharmacy in older persons are associated with negative outcomes such as falls, adverse drug events and increased healthcare utilisation. This is mainly due to the physiological changes in this population which increases their risk of adverse drug events as well as the problems associated with remembering, managing and administering the medications appropriately. Hence, researchers and clinicians around the world have been actively looking at ways to reduce polypharmacy and optimise drug therapy in older persons to improve clinical, economic and social outcomes. To date, medication review by pharmacists in various settings has been the most researched and documented evidence in tackling this issue. Medication review refers to the structured evaluation of a patient’s medication with the aim to reach agreement with the patient about drug therapy, optimising the impact of medication, and minimising the number of drug-related problems. This session aims to summarise the available evidence on various types and outcomes of medication review with the aim to optimise polypharmacy among older persons around the world and provide a practical recommendation in tackling the phenomena.

scholarly journals Prevention of domestic violence is everyone’s personal deal!

2020 ◽  
Vol 1 (1) ◽  
pp. 287-293
Author(s):  
Olena Protsenko
Keyword(s):  
Domestic Violence ◽  
Partner Violence ◽  
Older Persons ◽  
Intimate Partner ◽  
Dating Relationships ◽  
Relationship Skills ◽  
The World ◽  
Psychological Assistance ◽  
National Police ◽  
The Impact

The article summarizes approaches to coercive measures that apply to persons who have committed domestic violence, as well as developing their own recommendations to address or reduce the severity of this problem in society. The existing and planned measures by the National Police of Ukraine on the impact on criminals practicing domestic violence are analyzed. Examples of the fight against domestic violence in the leading countries of the world are given. The need for a clear definition in the minds of citizens what exactly should be qualified as domestic violence is noted. It is recommended to conduct thematic lessons with the disclosure of such concepts as “mutual respect”, “mutual assistance”, “respectful attitude to women, as well as older persons”, “tolerant attitude to people with special needs” and others, which ultimately will help to grow mentally healthy nation. Programs that teach young people healthy relationship skills such as communication, effectively managing feelings, and problem-solving can prevent violence. These skills can stop violence in dating relationships before it occurs. The best way to put a lasting stop to domestic violence is for people to abstain from the practice of trying to control and mistreat those they love. To be able to achieve this goal, we need to teach our younger generation the significance of respecting their prospective partners through a courteous and healthy bond with our spouses and partners. There are several ways to boost the prevention of domestic violence in our community. A major strategy for preventing domestic violence, frequently referred to as intimate partner violence, is by boosting respectful and peaceful relationships. It is proposed to organize the work of a sufficient number of centers of social and psychological assistance available for victims, as well as free helplines that should work around the clock.

scholarly journals The Influence of Pharmacogenetics on the Clinical Relevance of Pharmacokinetic Drug–Drug Interactions: Drug–Gene, Drug–Gene–Gene and Drug–Drug–Gene Interactions

2021 ◽  
Vol 14 (5) ◽  
pp. 487
Author(s):  
Martina Hahn ◽  
Sibylle C. Roll
Keyword(s):  
Drug Therapy ◽  
Drug Interactions ◽  
Clinical Relevance ◽  
Adverse Drug Events ◽  
Current Evidence ◽  
Drug Event ◽  
Gene Interactions ◽  
Genetic Profile ◽  
The Impact ◽  
Pharmacokinetic Drug

Drug interactions are a well-known cause of adverse drug events, and drug interaction databases can help the clinician to recognize and avoid such interactions and their adverse events. However, not every interaction leads to an adverse drug event. This is because the clinical relevance of drug–drug interactions also depends on the genetic profile of the patient. If inhibitors or inducers of drug metabolising enzymes (e.g., CYP and UGT) are added to the drug therapy, phenoconcversion can occur. This leads to a genetic phenotype that mismatches the observable phenotype. Drug–drug–gene and drug–gene–gene interactions influence the toxicity and/or ineffectivness of the drug therapy. To date, there have been limited published studies on the impact of genetic variations on drug–drug interactions. This review discusses the current evidence of drug–drug–gene interactions, as well as drug–gene–gene interactions. Phenoconversion is explained, the and methods to calculate the phenotypes are described. Clinical recommendations are given regarding the integratation of the PGx results in the assessment of the relevance of drug interactions in the future.

The impact of functional limitations on disability and the moderating effects of psychological attributes in community-dwelling older persons

1998 ◽  
Author(s):  
G. I. J. M. Kempen ◽  
M. J. G. van Heuvelen ◽  
E. van Sonderen ◽  
R. H. S. van den Brink ◽  
A. C. Kooijman ◽  
...  
Keyword(s):  
Older Persons ◽  
Functional Limitations ◽  
Community Dwelling ◽  
Moderating Effects ◽  
Psychological Attributes ◽  
The Impact

Exploring the World Trade Organisation's Trade and Environment/Public Health Jurisprudence as a Model for Incorporating a Trade–Labour Linkage into the Organisation's Multilateral Trade Regime: Should African Countries Accept a Policy Shift?

2017 ◽  
Vol 25 (1) ◽  
pp. 47-65
Author(s):  
Tapiwa V. Warikandwa ◽  
Patrick C. Osode
Keyword(s):  
Public Health ◽  
Developing Countries ◽  
World Trade ◽  
African Countries ◽  
Trade Regime ◽  
Multilateral Trade ◽  
Appellate Body ◽  
The World ◽  
Labour Standards ◽  
The Impact

The incorporation of a trade-labour (standards) linkage into the multilateral trade regime of the World Trade Organisation (WTO) has been persistently opposed by developing countries, including those in Africa, on the grounds that it has the potential to weaken their competitive advantage. For that reason, low levels of compliance with core labour standards have been viewed as acceptable by African countries. However, with the impact of WTO agreements growing increasingly broader and deeper for the weaker and vulnerable economies of developing countries, the jurisprudence developed by the WTO Panels and Appellate Body regarding a trade-environment/public health linkage has the potential to address the concerns of developing countries regarding the potential negative effects of a trade-labour linkage. This article argues that the pertinent WTO Panel and Appellate Body decisions could advance the prospects of establishing a linkage of global trade participation to labour standards without any harm befalling developing countries.

Modernism, Empiricism, and Rationalism

2016 ◽  
Vol 46 (1) ◽  
pp. 38-47
Author(s):  
Geoffrey Squires
Keyword(s):  
Twentieth Century ◽  
The Other ◽  
Modern Poetry ◽  
Philosophical Perspective ◽  
Irish Poetry ◽  
Dimensional Spectrum ◽  
Culture History ◽  
The World ◽  
The Impact ◽  
Rule Out

Modernism is usually defined historically as the composite movement at the beginning of the twentieth century which led to a radical break with what had gone before in literature and the other arts. Given the problems of the continuing use of the concept to cover subsequent writing, this essay proposes an alternative, philosophical perspective which explores the impact of rationalism (what we bring to the world) on the prevailing empiricism (what we take from the world) of modern poetry, which leads to a concern with consciousness rather than experience. This in turn involves a re-conceptualisation of the lyric or narrative I, of language itself as a phenomenon, and of other poetic themes such as nature, culture, history, and art. Against the background of the dominant empiricism of modern Irish poetry as presented in Crotty's anthology, the essay explores these ideas in terms of a small number of poets who may be considered modernist in various ways. This does not rule out modernist elements in some other poets and the initial distinction between a poetics of experience and one of consciousness is better seen as a multi-dimensional spectrum that requires further, more detailed analysis than is possible here.

Mechanisms of liver damage in COVID-19

2020 ◽  
Vol 1 (19) ◽  
pp. 39-46
Author(s):  
T. V. Pinchuk ◽  
N. V. Orlova ◽  
T. G. Suranova ◽  
T. I. Bonkalo
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Transplantation ◽  
Risk Factor ◽  
Liver Disease ◽  
Liver Function ◽  
Liver Damage ◽  
The World ◽  
Coronavirus Infection ◽  
The Impact ◽  
Analyze Data

At the end of 2019, a new coronavirus (SARS-CoV-2) was discovered in China, causing the coronavirus infection COVID-19. The ongoing COVID-19 pandemic poses a major challenge to health systems around the world. There is still little information on how infection affects liver function and the significance of pre-existing liver disease as a risk factor for infection and severe COVID-19. In addition, some drugs used to treat the new coronavirus infection are hepatotoxic. In this article, we analyze data on the impact of COVID-19 on liver function, as well as on the course and outcome of COVID-19 in patients with liver disease, including hepatocellular carcinoma, or those on immunosuppressive therapy after liver transplantation.

Introduction

2017 ◽  
Author(s):  
George E. Dutton
Keyword(s):  
Nineteenth Century ◽  
Vantage Point ◽  
15Th Century ◽  
The World ◽  
Catholic Mission ◽  
Historical Moment ◽  
The Impact ◽  
Main Figure

This chapter introduces the book’s main figure and situates him within the historical moment from which he emerges. It shows the degree to which global geographies shaped the European Catholic mission project. It describes the impact of the Padroado system that divided the world for evangelism between the Spanish and Portuguese crowns in the 15th century. It also argues that European clerics were drawing lines on Asian lands even before colonial regimes were established in the nineteenth century, suggesting that these earlier mapping projects were also extremely significant in shaping the lives of people in Asia. I argue for the value of telling this story from the vantage point of a Vietnamese Catholic, and thus restoring agency to a population often obscured by the lives of European missionaries.

ANALISIS DETERMINAN KUALITAS LINGKUNGAN PERIODE 1999-2013

2016 ◽  
Vol 21 (1) ◽  
pp. 9-20
Author(s):  
Ersalina Tang
Keyword(s):  
Foreign Direct Investment ◽  
Energy Consumption ◽  
Gross Domestic Product ◽  
Co2 Emissions ◽  
Direct Investment ◽  
Meat Consumption ◽  
Domestic Product ◽  
World Data ◽  
The World ◽  
The Impact

The purpose of this study is to analyze the impact of Foreign Direct Investment, Gross Domestic Product, Energy Consumption, Electric Consumption, and Meat Consumption on CO2 emissions of 41 countries in the world using panel data from 1999 to 2013. After analyzing 41 countries in the world data, furthermore 17 countries in Asia was analyzed with the same period. This study utilized quantitative approach with Ordinary Least Square (OLS) regression method. The results of 41 countries in the world data indicates that Foreign Direct Investment, Gross Domestic Product, Energy Consumption, and Meat Consumption significantlyaffect Environmental Qualities which measured by CO2 emissions. Whilst the results of 17 countries in Asia data implies that Foreign Direct Investment, Energy Consumption, and Electric Consumption significantlyaffect Environmental Qualities. However, Gross Domestic Product and Meat Consumption does not affect Environmental Qualities.

The Process of Globalization and Its Impact on Media

2016 ◽  
Vol 1 (4) ◽  
pp. 150
Author(s):  
Veton Zejnullahi
Keyword(s):  
New Technology ◽  
World Order ◽  
Modern Society ◽  
Media Access ◽  
Four Corners ◽  
The World ◽  
The Media ◽  
The Republic ◽  
Human Eyes ◽  
The Impact

The process of globalization, which many times is considered as new world order is affecting all spheres of modern society but also the media. In this paper specifically we will see the impact of globalization because we see changing the media access to global problems in general being listed on these processes. We will see that the greatest difficulties will have small media as such because the process is moving in the direction of creating mega media which thanks to new technology are reaching to deliver news and information at the time of their occurrence through choked the small media. So it is fair to conclude that the rapid economic development and especially the technology have made the world seem "too small" to the human eyes, because for real-time we will communicate with the world with the only one Internet connection, and also all the information are take for the development of events in the four corners of the world and direct from the places when the events happen. Even Albanian space has not left out of this process because the media in the Republic of Albania and the Republic of Kosovo are adapted to the new conditions under the influence of the globalization process. This fact is proven powerful through creating new television packages, written the websites and newspapers in their possession.

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