scholarly journals Cross-Sectional but Not Longitudinal Association Between n-3 Fatty Acid Intake and Depressive Symptoms: Results From the SU.VI.MAX 2 Study

2012 ◽  
Vol 175 (10) ◽  
pp. 979-987 ◽  
Author(s):  
E. Kesse-Guyot ◽  
M. Touvier ◽  
V. A. Andreeva ◽  
C. Jeandel ◽  
M. Ferry ◽  
...  

This study aimed to determine the relationship between the intake of n-3 and n-6 fatty acids and the incidence of depression in college students. This study especially tested whether the association between the two was strong enough to be significant despite the effects of confounders found in college environment. A cross-sectional questionnaire survey was conducted to collect the different data from 201 college respondents for this study. Usual food intake recall (UFIR) was used to determine the n-3 and n-6 fatty acid intake; Beck Depression Inventory – II (BDI-II) for the ascertainment of depressive symptoms and a miscellaneous questionnaire for the determination of confounders. The study used the binary hierarchical logistic regression analysis to analyze the data. The results showed that there was significant relationship between n-3 and n-6 fatty acid intake and depressive symptoms in college students (x2 = 12.39, df = 1, p<.000). The n-3 and n-6 fatty acid intake variable strongly predicted the incidence of depressive symptoms in the hierarchical model (p<0.001, df =1) and that the association was independent from the influence of the confounders. The results also showed that a college student with adequate n-3 and n-6 fatty acid intake was 4.509 times more likely to have no depression than a college student with inadequate intake (95% C.I. = 1.857 to 10.949).


Nutrients ◽  
2020 ◽  
Vol 12 (1) ◽  
pp. 240 ◽  
Author(s):  
Ronghui Zhang ◽  
Jing Sun ◽  
Yan Li ◽  
Dongfeng Zhang

Many studies have explored the association between n-3 fatty acids and depression, but research on the associations of n-6 fatty acids and n-6:n-3 ratio with depression is more scarce, and the results are controversial. Therefore, we conducted this cross-sectional study to explore the associations of n-3 and n-6 fatty acid intakes and n-6:n-3 ratio with the risk of depressive symptoms using data from National Health and Nutrition Examination Survey (NHANES) 2009–2016. Dietary data on n-3 and n-6 fatty acids were obtained through two 24-h dietary recall interviews, and were adjusted by energy. Depressive symptoms were measured by PHQ-9 (nine-item Patient Health Questionnaire). We applied logistic regression and restricted cubic spline models to assess the relationships of n-3 and n-6 fatty acids intake and n-6:n-3 ratio with the risk of depressive symptoms. A total of 17,431 individuals over 18 years old were enrolled in this study. In the multivariate-adjusted model 2, compared with the lowest category, the highest odd ratios (ORs) with 95% confidence intervals (CIs) for n-3 fatty acid intake and n-6:n-3 ratio were 0.71 (0.55–0.92) and 1.66 (1.10–2.50), and middle OR (95% CI) for n-6 fatty acid intake was 0.72 (0.56–0.92), respectively. Our study suggests that n-3 and n-6 fatty acids intake were inversely associated with the risk of depressive symptoms, while the n-6:n-3 ratio was positively associated with the risk of depressive symptoms.


Nutrients ◽  
2018 ◽  
Vol 10 (12) ◽  
pp. 1825 ◽  
Author(s):  
Haruki Nakamura ◽  
Akinori Hara ◽  
Hiromasa Tsujiguchi ◽  
Thao Thi Thu Nguyen ◽  
Yasuhiro Kambayashi ◽  
...  

The relationship between dietary n-6 fatty acids and hypertension is not clear. The metabolic products of n-6 fatty acids include those that control blood pressure, such as prostaglandin and thromboxane, and that differ depending on the extent of glucose tolerance. This cross-sectional study investigated the association of dietary n-6 fatty acid intake on hypertension, and the effects of glycated hemoglobin (HbA1c) value in 633 Japanese subjects aged 40 years and older. Dietary intake was measured using a validated brief self-administered diet history questionnaire. We defined hypertension as the use of antihypertensive medication or a blood pressure of 140/90 mmHg. The prevalence of hypertension was 55.3%. A high n-6 fatty acids intake inversely correlated with hypertension in subjects with HbA1c values less than 6.5% (odds ratio, 0.857; 95% confidence interval, 0.744 to 0.987). On the contrary, in subjects with an HbA1c value of 6.5% or higher, the n-6 fatty acids intake was significantly associated with hypertension (odds ratio, 3.618; 95% confidence interval, 1.019 to 12.84). Regular dietary n-6 fatty acid intake may contribute to the prevention and treatment of hypertension in a healthy general population. By contrast, in subjects with diabetes, regular n-6 fatty acids intake may increase the risk of hypertension.


PEDIATRICS ◽  
2010 ◽  
Vol 126 (3) ◽  
pp. e623-e630 ◽  
Author(s):  
K. Murakami ◽  
Y. Miyake ◽  
S. Sasaki ◽  
K. Tanaka ◽  
M. Arakawa

Epidemiology ◽  
2009 ◽  
Vol 20 (4) ◽  
pp. 598-603 ◽  
Author(s):  
Jean Golding ◽  
Colin Steer ◽  
Pauline Emmett ◽  
John M. Davis ◽  
Joseph R. Hibbeln

Nutrients ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 1475
Author(s):  
Jia Luo ◽  
Honghan Ge ◽  
Jing Sun ◽  
Kangyu Hao ◽  
Wenqin Yao ◽  
...  

The relationship between ω-3 and ω-6 fatty acids consumption and sleep disorders or duration are controversial. Therefore, we used the data of the National Health and Nutrition Examination Survey 2007–2016 in this cross-sectional study to explore their relationships. ω-3 and ω-6 fatty acids consumption was assessed using two 24 h dietary recall interviews. Sleep disorders and sleep duration were based on self-reported data. Logistic regression models and restricted cubic spline analyses were used. Compared with tertile one, the odds ratios (ORs) and 95% confidence intervals (CIs) of sleep disorders for the second tertile of ω-6 fatty acid intake and the highest tertile of ω-6:ω-3 ratio were 1.30 (1.04–1.62) and 1.36 (1.08–1.70), respectively. Inverse U-shaped and linear dose–response relationships were observed between dietary ω-6 fatty acid intake and ω-6:ω-3 ratio and sleep disorders, respectively. In addition, ω-3 fatty acid consumption was adversely related to sleep disorders in men and the OR (95% CI) was 0.68 (0.49–0.95). Compared with normal sleep duration, ω-3 fatty acid consumption was negatively related to very short, short, and long sleep duration risk. The relative risk ratios (RRRs) were 0.53 (0.35–0.81), 0.79 (0.67–0.93), and 0.81 (068–0.98), respectively. The RRR of very short sleep for ω-6 fatty acid consumption was 0.57 (0.45–0.73). Our study indicates that ω-6 fatty acid consumption and the ω-6:ω-3 ratio are positively associated with the risk of sleep disorders, while the negative association between ω-3 fatty acids and sleep disorders may exist only in men. Furthermore, ω-3 and ω-6 fatty acid consumption are negatively related to the risk of non-normal sleep duration.


Nutrition ◽  
2019 ◽  
Vol 63-64 ◽  
pp. 14-21 ◽  
Author(s):  
Ban-Hock Khor ◽  
Sharmela Sahathevan ◽  
Ayesha Sualeheen ◽  
Mohammad Syafiq Md Ali ◽  
Sreelakshmi Sankara Narayanan ◽  
...  

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