scholarly journals Associations of n-3, n-6 Fatty Acids Intakes and n-6:n-3 Ratio with the Risk of Depressive Symptoms: NHANES 2009–2016

Nutrients ◽  
2020 ◽  
Vol 12 (1) ◽  
pp. 240 ◽  
Author(s):  
Ronghui Zhang ◽  
Jing Sun ◽  
Yan Li ◽  
Dongfeng Zhang
Keyword(s):  
Fatty Acids ◽  
Depressive Symptoms ◽  
Fatty Acid ◽  
Cross Sectional Study ◽  
Fatty Acid Intake ◽  
Cross Sectional ◽  
Dietary Recall ◽  
Acid Intake ◽  
Patient Health ◽  
Using Data

Many studies have explored the association between n-3 fatty acids and depression, but research on the associations of n-6 fatty acids and n-6:n-3 ratio with depression is more scarce, and the results are controversial. Therefore, we conducted this cross-sectional study to explore the associations of n-3 and n-6 fatty acid intakes and n-6:n-3 ratio with the risk of depressive symptoms using data from National Health and Nutrition Examination Survey (NHANES) 2009–2016. Dietary data on n-3 and n-6 fatty acids were obtained through two 24-h dietary recall interviews, and were adjusted by energy. Depressive symptoms were measured by PHQ-9 (nine-item Patient Health Questionnaire). We applied logistic regression and restricted cubic spline models to assess the relationships of n-3 and n-6 fatty acids intake and n-6:n-3 ratio with the risk of depressive symptoms. A total of 17,431 individuals over 18 years old were enrolled in this study. In the multivariate-adjusted model 2, compared with the lowest category, the highest odd ratios (ORs) with 95% confidence intervals (CIs) for n-3 fatty acid intake and n-6:n-3 ratio were 0.71 (0.55–0.92) and 1.66 (1.10–2.50), and middle OR (95% CI) for n-6 fatty acid intake was 0.72 (0.56–0.92), respectively. Our study suggests that n-3 and n-6 fatty acids intake were inversely associated with the risk of depressive symptoms, while the n-6:n-3 ratio was positively associated with the risk of depressive symptoms.

scholarly journals Relationship between Dietary n-6 Fatty Acid Intake and Hypertension: Effect of Glycated Hemoglobin Levels

Nutrients ◽  
2018 ◽  
Vol 10 (12) ◽  
pp. 1825 ◽  
Author(s):  
Haruki Nakamura ◽  
Akinori Hara ◽  
Hiromasa Tsujiguchi ◽  
Thao Thi Thu Nguyen ◽  
Yasuhiro Kambayashi ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Fatty Acids ◽  
Fatty Acid ◽  
Confidence Interval ◽  
Odds Ratio ◽  
Glycated Hemoglobin ◽  
Cross Sectional Study ◽  
Fatty Acid Intake ◽  
Cross Sectional ◽  
Acid Intake

The relationship between dietary n-6 fatty acids and hypertension is not clear. The metabolic products of n-6 fatty acids include those that control blood pressure, such as prostaglandin and thromboxane, and that differ depending on the extent of glucose tolerance. This cross-sectional study investigated the association of dietary n-6 fatty acid intake on hypertension, and the effects of glycated hemoglobin (HbA1c) value in 633 Japanese subjects aged 40 years and older. Dietary intake was measured using a validated brief self-administered diet history questionnaire. We defined hypertension as the use of antihypertensive medication or a blood pressure of 140/90 mmHg. The prevalence of hypertension was 55.3%. A high n-6 fatty acids intake inversely correlated with hypertension in subjects with HbA1c values less than 6.5% (odds ratio, 0.857; 95% confidence interval, 0.744 to 0.987). On the contrary, in subjects with an HbA1c value of 6.5% or higher, the n-6 fatty acids intake was significantly associated with hypertension (odds ratio, 3.618; 95% confidence interval, 1.019 to 12.84). Regular dietary n-6 fatty acid intake may contribute to the prevention and treatment of hypertension in a healthy general population. By contrast, in subjects with diabetes, regular n-6 fatty acids intake may increase the risk of hypertension.

scholarly journals Associations of Dietary ω-3, ω-6 Fatty Acids Consumption with Sleep Disorders and Sleep Duration among Adults

Nutrients ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 1475
Author(s):  
Jia Luo ◽  
Honghan Ge ◽  
Jing Sun ◽  
Kangyu Hao ◽  
Wenqin Yao ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Sleep Disorders ◽  
Sleep Duration ◽  
Cross Sectional Study ◽  
Fatty Acid Intake ◽  
Cross Sectional ◽  
Acid Intake ◽  
Acid Consumption ◽  
Normal Sleep

The relationship between ω-3 and ω-6 fatty acids consumption and sleep disorders or duration are controversial. Therefore, we used the data of the National Health and Nutrition Examination Survey 2007–2016 in this cross-sectional study to explore their relationships. ω-3 and ω-6 fatty acids consumption was assessed using two 24 h dietary recall interviews. Sleep disorders and sleep duration were based on self-reported data. Logistic regression models and restricted cubic spline analyses were used. Compared with tertile one, the odds ratios (ORs) and 95% confidence intervals (CIs) of sleep disorders for the second tertile of ω-6 fatty acid intake and the highest tertile of ω-6:ω-3 ratio were 1.30 (1.04–1.62) and 1.36 (1.08–1.70), respectively. Inverse U-shaped and linear dose–response relationships were observed between dietary ω-6 fatty acid intake and ω-6:ω-3 ratio and sleep disorders, respectively. In addition, ω-3 fatty acid consumption was adversely related to sleep disorders in men and the OR (95% CI) was 0.68 (0.49–0.95). Compared with normal sleep duration, ω-3 fatty acid consumption was negatively related to very short, short, and long sleep duration risk. The relative risk ratios (RRRs) were 0.53 (0.35–0.81), 0.79 (0.67–0.93), and 0.81 (068–0.98), respectively. The RRR of very short sleep for ω-6 fatty acid consumption was 0.57 (0.45–0.73). Our study indicates that ω-6 fatty acid consumption and the ω-6:ω-3 ratio are positively associated with the risk of sleep disorders, while the negative association between ω-3 fatty acids and sleep disorders may exist only in men. Furthermore, ω-3 and ω-6 fatty acid consumption are negatively related to the risk of non-normal sleep duration.

scholarly journals Relation between Dietary Omega-3 (n-3) and Omega-6 (n-3) Fatty Acid Intake and Depressive Symptoms in College Students of Central Mindanao University

2018 ◽  
Vol 3 (3) ◽  
Keyword(s):  
College Students ◽  
Depressive Symptoms ◽  
Fatty Acid ◽  
College Student ◽  
Fatty Acid Intake ◽  
Omega 3 ◽  
Cross Sectional ◽  
Hierarchical Logistic Regression ◽  
Acid Intake ◽  
Omega 6

This study aimed to determine the relationship between the intake of n-3 and n-6 fatty acids and the incidence of depression in college students. This study especially tested whether the association between the two was strong enough to be significant despite the effects of confounders found in college environment. A cross-sectional questionnaire survey was conducted to collect the different data from 201 college respondents for this study. Usual food intake recall (UFIR) was used to determine the n-3 and n-6 fatty acid intake; Beck Depression Inventory – II (BDI-II) for the ascertainment of depressive symptoms and a miscellaneous questionnaire for the determination of confounders. The study used the binary hierarchical logistic regression analysis to analyze the data. The results showed that there was significant relationship between n-3 and n-6 fatty acid intake and depressive symptoms in college students (x2 = 12.39, df = 1, p<.000). The n-3 and n-6 fatty acid intake variable strongly predicted the incidence of depressive symptoms in the hierarchical model (p<0.001, df =1) and that the association was independent from the influence of the confounders. The results also showed that a college student with adequate n-3 and n-6 fatty acid intake was 4.509 times more likely to have no depression than a college student with inadequate intake (95% C.I. = 1.857 to 10.949).

scholarly journals The association between triglyceride glucose index and depression: data from NHANES 2005–2018

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Yi-Yi Shi ◽  
Rui Zheng ◽  
Jie-Jie Cai ◽  
Song-Zan Qian
Keyword(s):  
Depressive Symptoms ◽  
Fasting Blood Glucose ◽  
Age Groups ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Logistic Regression Models ◽  
Tyg Index ◽  
Patient Health ◽  
Nationally Representative ◽  
Using Data

Abstract Background The association between triglyceride glucose (TyG) index and depression is unclear. We conducted this analysis to explore whether higher TyG index is associated with a higher odd of depression. Methods This was an observational study using data from the National Health and Nutrition Examination Survey (2005–2018), a cross-sectional and nationally representative database. Depression was assessed using the Patient Health Questionnaire-9 (PHQ-9). TyG index was calculated based on the equation as follows: ln [triglyceride (mg/dL) × fasting blood glucose (mg/dL)/2], and participants were divided into quartiles based on TyG index. Weighted multivariable logistic regression models were used to explore the relationship between the TyG index and depression. Results A total of 13,350 patients were included, involving 1001 (7.50%) individuals with depression. Higher TyG index is significantly associated with elevated depressive symptoms in U.S. adults. Multivariate-adjusted HRs for patients in the TyG index 4th quartile were higher for depression (OR = 1.46; 95% confidence interval (CI) 1.30, 1.64) compared with the 1st quartile of TyG index. Similar results were seen in men and women, across age groups, and baseline comorbidities. Conclusion In this large cross-sectional study, our result suggests that population with higher TyG index are significantly more likely to have depressive symptoms in U.S. adults.

scholarly journals Dietary fatty acid intake in hemodialysis patients and associations with circulating fatty acid profiles: A cross-sectional study

Nutrition ◽  
2019 ◽  
Vol 63-64 ◽  
pp. 14-21 ◽  
Author(s):  
Ban-Hock Khor ◽  
Sharmela Sahathevan ◽  
Ayesha Sualeheen ◽  
Mohammad Syafiq Md Ali ◽  
Sreelakshmi Sankara Narayanan ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Cross Sectional Study ◽  
Hemodialysis Patients ◽  
Dietary Fatty Acid ◽  
Fatty Acid Intake ◽  
Fatty Acid Profiles ◽  
Sectional Study ◽  
Cross Sectional ◽  
Acid Intake ◽  
Dietary Fatty Acid Intake

scholarly journals Cross-Sectional but Not Longitudinal Association Between n-3 Fatty Acid Intake and Depressive Symptoms: Results From the SU.VI.MAX 2 Study

2012 ◽  
Vol 175 (10) ◽  
pp. 979-987 ◽  
Author(s):  
E. Kesse-Guyot ◽  
M. Touvier ◽  
V. A. Andreeva ◽  
C. Jeandel ◽  
M. Ferry ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
Fatty Acid ◽  
Fatty Acid Intake ◽  
Cross Sectional ◽  
Acid Intake ◽  
Longitudinal Association

Omega-3 Levels and Nicotine Dependence: A Cross-Sectional Study and Clinical Trial

2015 ◽  
Vol 22 (3) ◽  
pp. 153-162 ◽  
Author(s):  
Juçara X. Zaparoli ◽  
Eduardo K. Sugawara ◽  
Altay A.L. de Souza ◽  
Sérgio Tufik ◽  
José Carlos F. Galduróz
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Fish Oil ◽  
Nicotine Dependence ◽  
Cross Sectional Study ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Double Blind ◽  
Cross Sectional ◽  
Omega 3 Fatty Acid

Background: High oxidative stress, which is caused by smoking, can alter omega-3 fatty acid concentrations. Since omega-3 fatty acids play a role in dopaminergic neurotransmission related to dependence, it is important to understand their effects on nicotine dependence. Methods: This research comprised 2 studies. The first one consisted of a cross-sectional evaluation, in which the levels of the most important omega-3 fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), were compared between smokers and non-smokers in a sample of 171 individuals; of them, 120 were smokers and 51 were non-smokers. The other study was a clinical, double-blind, randomized, placebo controlled, in which 63 smokers received daily treatment with capsules of fish oil (a source of omega-3/3 g/day) or mineral oil (used as placebo, also 3 g/day), taken 3 times a day for 90 days. Each fish oil capsules contained approximately 210.99 mg EPA and 129.84 mg of DHA. The outcome was evaluated by means of psychometric and biological measures as well as self-reports of tobacco use. The evaluations were carried out at the beginning of treatment and once a month thereafter (total of 4 times). Outcomes: The omega-3 fatty acid lipid profile showed that smokers present lower concentrations of DHA. After treatment, the omega-3 group showed a significant reduction in their levels of dependence. Interpretation: Smokers showed lower peripheral levels of omega-3, and treatment with the most important omega-3 fatty acids brought about a reduction in nicotine dependence.

scholarly journals Modeled replacement of traditional soybean and canola oil with high-oleic varieties increases monounsaturated fatty acid and reduces both saturated fatty acid and polyunsaturated fatty acid intake in the US adult population

2018 ◽  
Vol 108 (3) ◽  
pp. 594-602 ◽  
Author(s):  
Susan K Raatz ◽  
Zach Conrad ◽  
Lisa Jahns ◽  
Martha A Belury ◽  
Matthew J Picklo
Keyword(s):  
At Risk ◽  
Fatty Acids ◽  
Fatty Acid ◽  
Canola Oil ◽  
Food Sources ◽  
Fatty Acid Intake ◽  
High Oleic ◽  
Acid Intake ◽  
The Us ◽  
Age And Sex

ABSTRACT BACKGROUND High-oleic (HO) seed oils are being introduced as replacements for trans fatty acid (TFA)–containing fats and oils. Negative health effects associated with TFAs led to their removal from the US Generally Recognized As Safe list. HO oils formulated for use in food production may result in changes in fatty acid intake at population levels. Objectives The purposes of this study were to 1) identify major food sources of soybean oil (SO) and canola oil (CO), 2) estimate effects of replacing SO and CO with HO varieties on fatty acid intake overall and by age and sex strata, and 3) compare predicted intakes with the Dietary Reference Intakes and Adequate Intakes (AIs) for the essential fatty acids (EFAs) α-linolenic acid (ALA) and linoleic acid (LA). Design Food and nutrient intakes from NHANES waves 2007–2008, 2009–2010, 2011–2012, and 2013–2014 in 21,029 individuals aged ≥20 y were used to model dietary changes. We estimated the intake of fatty acid with the replacement of HO-SO and HO-CO for commodity SO and CO at 10%, 25%, and 50% and evaluated the potential for meeting the AI at these levels. RESULTS Each modeling scenario decreased saturated fatty acids (SFAs), although intakes remained greater than recommended for all age and sex groups. Models of all levels increased the intake of total monounsaturated fatty acids (MUFAs), especially oleic acid, and decreased the intake of total polyunsaturated fatty acids (PUFAs), particularly LA and ALA. Replacement of traditional with HO oils at 25–50% places specific adult age and sex groups at risk of not meeting the AI for LA and ALA. Conclusions The replacement of traditional oils with HO varieties will increase MUFA intake and reduce both SFA and PUFA intakes, including EFAs, and may place specific age and sex groups at risk of inadequate LA and ALA intake.

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