scholarly journals The Impact of Blood Pressure and Visceral Adiposity on the Association of Serum Uric Acid With Albuminuria in Adults Without Full Metabolic Syndrome

2016 ◽  
pp. hpw098 ◽  
Author(s):  
Alena Krajcoviechova ◽  
Johanne Tremblay ◽  
Peter Wohlfahrt ◽  
Jan Bruthans ◽  
Muhmmad Ramzan Tahir ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Uric Acid ◽  
Serum Uric Acid ◽  
Visceral Adiposity ◽  
The Impact

scholarly journals Uric Acid: An Overlooked, Inexpensive Biomarker of Metabolic Syndrome (P10-068-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Maribel Barragan ◽  
Viridiana Luna ◽  
Juan Manuel Vargas-Morales ◽  
Celia Aradillas-Garcia ◽  
Margarita Teran-Garcia
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Uric Acid ◽  
Serum Uric Acid ◽  
San Luis ◽  
San Luis Potosi ◽  
Mexican Adults ◽  
Males And Females ◽  
San Luis Potosí

Abstract Objectives Elevated serum uric acid (HUA) levels have been shown to have a positive correlation with metabolic syndrome (MetS) risk factors. In countries where rates of MetS continue to increase, such as Mexico, it is important to identify reliable and inexpensive markers that will aid in predicting the development of MetS. Our aim was to evaluate the association between serum uric acid (UA) and MetS risk factors in young Mexican adults. Risk factors include glucose (GLU), systolic blood pressure (SBP), diastolic blood pressure (DBP), waist circumference (WC), triglycerides (TG), high-density lipoprotein (HDL), and body mass index (BMI). Methods Mexican college applicants involved in the Universities of San Luis Potosí and Illinois: Multidisciplinary Investigation on Obesity, Genetics and Socio-environment (UP AMIGOS) cohort (ages 18–25, n = 747, 56% female) underwent a health screening following an overnight fast. Fasting blood samples, anthropometric measurements, and blood pressure were collected. According to the literature, HUA levels are defined as ≥7 and ≥6 mg/dL for males and females, respectively. T-tests were conducted to compare mean differences of MetS risk components between individuals with and without HUA levels. Analyses were conducted separately by sex. Results The mean ± SD of UA was 5.73 ± 1.32 mg/dL and 4.39 ± 1.19 mg/dL for males and females, respectively. Males and females with HUA had significantly higher TG, and WC, and lower HDL (all P < 0.001). HUA was positively correlated with WC (R2 = 0.331, SBP (R2 = 0.151), DBP (R2 = 0.176), GLU (R2 = 0.863), TG (R2 = 0.424) and BMI (R2 = 0.363). In contrast, HDL was negatively correlated with HUA (R2 = -0.277), as hypothesized. All Pearson correlations were adjusted for age and sex and statistically significant (P < 0.05). Conclusions Serum UA has a strong correlation with MetS risk factors in young Mexican adults. Routine monitoring of serum UA could be utilized as an inexpensive early predictor of MetS, which would allow for early interventions to aid in preventing cardiovascular disease and type 2 diabetes. Funding Sources This study was funded by the University of Illinois at Urbana-Champaign and the USDA National Institute of Food and Agriculture, Hath Projects to M.T.-G. Funding was also provided by the Univerdidad Autonoma de San Luis Potosí to support C.A.-G.

P1684Elevated serum uric acid associated with hypertension in healthy individuals

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
C W Liu ◽  
Y W Wu ◽  
J J Hwang
Keyword(s):  
Blood Pressure ◽  
Uric Acid ◽  
Serum Uric Acid ◽  
Elevated Serum ◽  
Healthy Individuals ◽  
Incident Hypertension ◽  
Study Population ◽  
Definition Of ◽  
European Society Of Cardiology ◽  
The Impact

Abstract Background Elevated serum uric acid (SUA) induces endothelial dysfunction and is associated with hypertension according to the traditional definition of hypertension. The impact of a divergent definition of hypertension between contemporary guidelines is unclear. Purpose We conducted the present study to investigate the association between SUA and new-onset hypertension according to contemporary blood pressure guidelines. Methods We enrolled 10,537 healthy individuals aged more than 30 years, who routinely underwent an annual health exam with office blood pressure records at our hospital in 2016; of them, 7,349 individuals repeated the exam in 2017. The individuals with hypertension at baseline were excluded, and the rest of the study population were divided into the European Society of Cardiology (ESC) cohort and the American College of Cardiology (ACC) cohort. According to the ESC guideline, hypertension was defined as office BP ≥140/90 mm Hg, whereas ACC guidelines defined hypertension as blood pressure ≥130/80 mm Hg. Hyperuricemia (HUA) is defined as an SUA level of ≥7 mg/dl in men and ≥6 mg/dl in women. Results The study population consisted of 6,378 individuals in the ESC cohort and 4,330 individuals in the ACC cohort. The HUA group was predominantly male and older than the normouricemic group and had a greater ratio of alcohol intake and histories of gout, and greater values of laboratory cardiometabolic biomarker values. The incidence of hypertension was 5.8% in the ESC cohort and 19% in the ACC cohort. Incident hypertension was significantly greater in the HUA vs. normouricemic group (8.6% vs. 4.7%, P<0.001 for ESC and 25.5% vs. 16.9%, P<0.001 for ACC). In multivariate logistic regression analyses, each increment of SUA was associated with increased risks of incident hypertension after age, gender, body mass index, blood pressure at baseline, fasting glucose were adjusted (OR: 1.160, 95% CI: 1.056–1.274, P=0.002 for ESC and OR: 1.120, 95% CI: 1.040–1.207, P=0.031 for ACC). Incidence of hypertension Conclusion Elevated SUA was associated with incident hypertension in healthy individuals from Taiwan regarding various contemporary blood pressure guidelines. Future studies might investigate the effect of urate-lowering therapy on lowering blood pressure. Acknowledgement/Funding TSGH 108-14

Abstract 3488: Hyperuricemia and the Risk of Isolated Hypertension among Young People without Cardiovascular and Metabolic Risk Factors: The CARDIA Study

Circulation ◽  
2007 ◽  
Vol 116 (suppl_16) ◽  
Author(s):  
Eswar Krishnan ◽  
Hyon K Choi ◽  
Lewis H Kuller ◽  
Kiang Liu
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Uric Acid ◽  
Cardiovascular Risk ◽  
Young People ◽  
Cardiovascular Risk Factors ◽  
Serum Uric Acid ◽  
The Metabolic Syndrome

PURPOSE: The association between higher serum uric acid (SUA) levels and hypertension in the context of the metabolic syndrome is well known. If such an association was causal, one would expect to demonstrate a link between hyperuricemia and incidence of isolated hypertension - a hypothesis that has not been tested so far. METHODS: We used the 15-year limited-access data from the prospective cohort study of Coronary Artery Risk Development in young adults (CARDIA), sponsored by the National Institutes of Health, to identify a group of non-smoking young people with normal blood pressure and free of insulin resistance, hyperlipidemia, obesity, and a family history of cardiovascular diseases. These young people aged between 18 and 30 years at baseline were followed-up for a period of 15 years by 6 study visits where all cardiovascular risk factors were reassessed. Incidence of JNC-7 hypertension was the outcome of interest in Cox proportional hazards models where age, gender, race, lipid levels, blood pressure, alcohol, body mass index, smoking and serum insulin levels (time-varying where appropriate) were the covariates. Baseline serum uric acid (continuous) was the independent variable of interest. A second set of Cox regression analyses was performed among the subgroup of these individuals who remained free of all cardiovascular risk factors (except for hypertension) over the 15-year follow up. RESULTS: Out of the 5113 CARDIA participants at baseline, 2057 subjects were free of cardiovascular risk factors at baseline and were available for evaluation at year 15. Over the follow-up period, 828 subjects developed hypertension. In multivariate Cox models, each mg/dl increase in serum uric acid was associated with a hazard ratio of 1.45 (1.09–1.91). In the second set of analyses, 753 were free of all cardiovascular risk factors at baseline and remained free of any of the components of the metabolic syndrome except hypertension (n = 122 incident cases of hypertension) were studied. In these analyses each mg/dl increasse in SUA was associated with a risk adjusted hazard ratio of 1.60 (95% CI 1.02–2.49). CONCLUSIONS: Unrelated to the other features of the metabolic syndrome, higher levels of SUA among young people predicts isolated hypertension.

The impact of serum uric acid reduction on renal function and blood pressure in chronic kidney disease patients with hyperuricemia

2018 ◽  
Vol 22 (6) ◽  
pp. 1300-1308 ◽  
Author(s):  
Takayuki Tsuji ◽  
Kazuhisa Ohishi ◽  
Asumi Takeda ◽  
Daiki Goto ◽  
Taichi Sato ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Chronic Kidney Disease ◽  
Renal Function ◽  
Uric Acid ◽  
Kidney Disease ◽  
Serum Uric Acid ◽  
The Impact ◽  
Acid Reduction

scholarly journals Association between serum uric acid level and carotid atherosclerosis and metabolic syndrome in patients with type 2 diabetes mellitus

2021 ◽  
Author(s):  
wei li ◽  
Yan Wang ◽  
Shengrong Ouyang ◽  
Mengdi Li ◽  
Rui Liu ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Blood Pressure ◽  
Type 2 Diabetes ◽  
Metabolic Syndrome ◽  
Type 2 Diabetes Mellitus ◽  
Uric Acid ◽  
Serum Uric Acid ◽  
Carotid Atherosclerosis ◽  
Subclinical Atherosclerosis

Abstract Background Serum uric acid (SUA) is associated with many cardiovascular risk factors, such as metabolic syndrome (MetS) and subclinical atherosclerosis. However, the relationship of SUA with carotid atherosclerosis remains controversial. We aimed to investigate whether elevated SUA levels are associated with a high risk of carotid atherosclerosis and MetS in patients with type 2 diabetes mellitus (T2DM). Methods This cross-sectional study was performed with a sample of 1,947 hospitalized patients with T2DM. Carotid intima-media thickness (CIMT) and carotid artery plaques (CAP) were measured via Doppler ultrasound. Results Uric acid levels were negatively associated with HbA1C, eGFR, and HDL-C (all P < 0.001) and positively associated with WBC, BMI, ACR, creatinine, total cholesterol, triglycerides, LDL-C, systolic blood pressure, and diastolic blood pressure (all P < 0.001). After adjusting for multiple potential confounders, the risks were substantially higher for MetS in the highest quartile of SUA levels (odds ratio: 2.91, 95% confidence interval: 1.54–5.51, P = 0.003 for trend) than in the lowest quartile of SUA levels. Furthermore, a significant increase was observed in the prevalence of overweight/obesity, hypertension, and dyslipidemia across the SUA quartiles independent of confounders. However, no significant association was found between SUA quartile with the presence of carotid atherosclerosis. Conclusions In patients with T2DM, SUA levels were closely associated with MetS and its components but not with carotid atherosclerosis.

scholarly journals Association between serum uric acid level and carotid atherosclerosis and metabolic syndrome in patients with type 2 diabetes mellitus

2021 ◽  
Author(s):  
Wei Li ◽  
Yan Wang ◽  
Shengrong Ouyang ◽  
Mengdi Li ◽  
Rui Liu ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Blood Pressure ◽  
Type 2 Diabetes ◽  
Metabolic Syndrome ◽  
Type 2 Diabetes Mellitus ◽  
Uric Acid ◽  
Serum Uric Acid ◽  
Carotid Atherosclerosis ◽  
Subclinical Atherosclerosis

Abstract Background Serum uric acid (SUA) is associated with many cardiovascular risk factors, such as metabolic syndrome (MetS) and subclinical atherosclerosis. However, the relationship of SUA with carotid atherosclerosis remains controversial. We aimed to investigate whether elevated SUA levels are associated with a high risk of carotid atherosclerosis and MetS in patients with type 2 diabetes mellitus (T2DM). Methods This cross-sectional study was performed with a sample of 1,947 hospitalized patients with T2DM. Carotid intima-media thickness (CIMT) and carotid artery plaques (CAP) were measured via Doppler ultrasound. Results Uric acid levels were negatively associated with HbA1C, eGFR, and HDL-C (all P < 0.001) and positively associated with WBC, BMI, ACR, creatinine, total cholesterol, triglycerides, LDL-C, systolic blood pressure, and diastolic blood pressure (all P < 0.001). After adjusting for multiple potential confounders, the risks were substantially higher for MetS in the highest quartile of SUA levels (odds ratio: 2.91, 95% confidence interval: 1.54–5.51, P = 0.003 for trend) than in the lowest quartile of SUA levels. Furthermore, a significant increase was observed in the prevalence of overweight/obesity, hypertension, and dyslipidemia across the SUA quartiles independent of confounders. However, no significant association was found between SUA quartile with the presence of carotid atherosclerosis. Conclusions In patients with T2DM, SUA levels were closely associated with MetS and its components but not with carotid atherosclerosis.

scholarly journals Association between polymorphism at IGF-1 rs35767 gene locus and long-term decline in renal function: a Japanese retrospective longitudinal cohort study

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Kosuke Honda ◽  
Satoru Kuriyama ◽  
Kimiyoshi Ichida ◽  
Tomoko Nakano ◽  
Naoki Sugano ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Renal Function ◽  
Uric Acid ◽  
Cohort Study ◽  
Serum Uric Acid Level ◽  
Human Growth ◽  
Longitudinal Cohort Study ◽  
Longitudinal Cohort

Abstract Background Insulin-like growth factor-1 (IGF-1) acts on glucose and protein metabolism and human growth and also influences blood pressure and renal function. This study investigated whether the single-nucleotide polymorphism of IGF-1, rs35767, plays a role in metabolic syndrome indicators, including blood pressure, glucose metabolism, uric acid levels, and renal function. Methods In this retrospective longitudinal cohort study, blood samples from 1506 Japanese individuals were collected and used for genotyping for variant rs35767: T > C in the IGF-1 upstream promoter. Data were analyzed to identify associations between IGF-1 genotypes and patient biochemical parameters, including the components of metabolic syndrome and the long-term change in renal function. Results The cohort rs35767 genotypes included 650 CC carriers (43.2%), 687 TC carriers (45.6%), and 169 TT carriers (11.2%). Multiple regression analysis revealed no association between IGF-1 genotype and blood pressure, glycated hemoglobin level, and serum uric acid level. However, in females, blood pressure was negatively correlated with the TT genotype. Longitudinal observation revealed that the decline in eGFR over 10 years was greater in TT (− 18.51 ± 1.04 mL/min/1.73m2) than in CC carriers (− 16.38 ± 0.52 mL/min/1.73m2; P < 0.05). Conclusion The present study suggests that renal function declines faster in individuals with the TT genotype at the IGF-1 rs35767 locus than in those with the CC genotype, suggesting that the TT genotype is associated with the long-term chronological decline in renal function.

Association of Serum Uric Acid and Metabolic Syndrome Among Health Personnel from a Public Hospital in Peru

Metabolism ◽  
2021 ◽  
Vol 116 ◽  
pp. 154669
Author(s):  
Brenda Galindo Yllu ◽  
Ricardo Rojas Humpire ◽  
Carlos Toro Huamanchumo ◽  
Rosmery Gutierrez Ajañlcriña ◽  
Anderson Soriano Moreno
Keyword(s):  
Metabolic Syndrome ◽  
Uric Acid ◽  
Serum Uric Acid ◽  
Health Personnel ◽  
Public Hospital

scholarly journals Melatonin and diet-induced metabolic syndrome in rats: impact on the hypophysial-testicular axis

2013 ◽  
Vol 16 (2) ◽  
Author(s):  
Pablo A. Scacchi Bernasconi ◽  
Nancy P. Cardoso ◽  
Roxana Reynoso ◽  
Pablo Scacchi ◽  
Daniel P. Cardinali
Keyword(s):  
Metabolic Syndrome ◽  
Body Weight ◽  
Uric Acid ◽  
Plasma Levels ◽  
Density Lipoprotein ◽  
The Body ◽  
High Fat ◽  
Testosterone Secretion ◽  
Diet Manipulation ◽  
The Impact

AbstractCombinations of fructose- and fat-rich diets in experimental animals can model the human metabolic syndrome (MS). In rats, the increase in blood pressure (BP) after diet manipulation is sex related and highly dependent on testosterone secretion. However, the extent of the impact of diet on rodent hypophysial-testicular axis remains undefined. In the present study, rats drinking a 10% fructose solution or fed a high-fat (35%) diet for 10 weeks had higher plasma levels of luteinizing hormone (LH) and lower plasma levels of testosterone, without significant changes in circulating follicle-stimulating hormone or the weight of most reproductive organs. Diet manipulation brought about a significant increase in body weight, systolic BP, area under the curve (AUC) of glycemia after an intraperitoneal glucose tolerance test (IPGTT), and plasma low-density lipoprotein cholesterol, cholesterol, triglycerides, and uric acid levels. The concomitant administration of melatonin (25 μg/mL of drinking water) normalized the abnormally high LH levels but did not affect the inhibited testosterone secretion found in fructose- or high-fat-fed rats. Rather, melatonin per se inhibited testosterone secretion. Melatonin significantly blunted the body weight and systolic BP increase, the increase in the AUC of glycemia after an IPGTT, and the changes in circulating lipid profile and uric acid found in both MS models. The results are compatible with a primary inhibition of testicular function in diet-induced MS in rats and with the partial effectiveness of melatonin to counteract the metabolic but not the testicular sequelae of rodent MS.

Sign in / Sign up

Export Citation Format

Share Document