A-54 The Relationship between Age and MMSE Performance Amongst Individuals with Heart Failure

2021 ◽  
Vol 36 (6) ◽  
pp. 1096-1096
Author(s):  
Natasha Nemanim ◽  
Nicholas Lackey ◽  
Eric J Connors ◽  
Alexander O Hauson ◽  
Anna Pollard ◽  
...  
Keyword(s):  
Heart Failure ◽  
Meta Analysis ◽  
Included Study ◽  
Effect Sizes ◽  
Medium Effect ◽  
Future Research ◽  
Global Cognition ◽  
Meta Regression ◽  
K 12 ◽  
The Impact

Abstract Objective A previous meta-analysis assessing the impact of heart failure (HF) on cognition found the HF group performed more poorly than the healthy control (HC) on global cognition measures. The study observed a medium effect and moderate heterogeneity when using the Mini-Mental Status Examination (MMSE) to measure HF’s impact on global cognition. The current meta-regression explores whether the mean age of the HF group moderates performance on the MMSE when comparing HF patients to HC. Data Selection Two researchers independently searched eight databases, extracted data, and calculated effect sizes as part of a larger study. Inclusion criteria were: (a) adults with a diagnosis of HF, (b) comparison of HF patients to HC, and (c) adequate data to calculate effect sizes. Articles were excluded if patients had other types of organ failure, the article was not available in English, or there was a risk of sample overlap with another included study. Twelve articles (HF n = 1166 and HC n = 1948) were included. The unrestricted maximum likelihood computational model was used for the meta-regression. Data Synthesis Studies included in the meta-regression evidenced a statistically significant medium effect size estimate with moderate heterogeneity (k = 12, g = 0.671, p < 0.001, I2 = 80.91%). The meta-regression was statistically significant (slope = −0.023, p = 0.0022, Qmodel = 5.26, df = 1, p = 0.022). Conclusions Individuals with HF performed more poorly on the MMSE than HC. Larger effect sizes on the MMSE were observed in studies with participants who were younger compared to studies with participants who were older. Future research should continue to delineate the impact of age on global cognition in individuals with HF.

A-53 The Relationship between Age and TMT-A Performance in Patients with Heart Failure

2021 ◽  
Vol 36 (6) ◽  
pp. 1095-1095
Author(s):  
Nicholas S Lackey ◽  
Natasha Nemanim ◽  
Alexander O Hauson ◽  
Eric J Connors ◽  
Anna Pollard ◽  
...  
Keyword(s):  
Heart Failure ◽  
Effect Size ◽  
Significant Proportion ◽  
Effect Sizes ◽  
Medium Effect ◽  
Future Research ◽  
Medium Effect Size ◽  
Meta Regression ◽  
The Impact ◽  
The Relationship

Abstract Objective A previous meta-analysis utilized the Trail Making Test A (TMT-A) to measure the impact of heart failure (HF) on attention. A near medium effect size with moderate heterogeneity was observed, the HF group performed worse than healthy controls (HC). This study explores if the age of the HF group moderates differences in the performance of individuals with HF versus HC on TMT-A. Data Selection Two researchers searched eight databases, extracted data, and calculated effect sizes as part of a larger study. Inclusion criteria were: (a) adults with HF (New York Heart Association severity II or higher), (b) comparison to a HC group, (c) standardized neuropsychological/cognitive testing, and (d) adequate data to calculate effect sizes. Exclusion criteria were: (a) participants had other types of major organ failure, (b) the article was not in English, or (c) there was a risk of sample overlap with another included study. A total of six articles were included in this sub-study (Total HF n = 602 and HC n = 342). The unrestricted maximum likelihood computational model was used for the meta-regression. Data Synthesis Studies included in the meta-regression evidenced a statistically significant medium effect size estimate with moderate heterogeneity (k = 6, g = 0.636, p < 0.001, I2 = 56.85%). The meta-regression was statistically significant (slope = −0.0515, p = 0.0016, Qmodel = 9.86, df = 1, p = 0.0016). Conclusions Individuals with HF performed worse on the TMT-A than HC. Age accounted for a significant proportion of the observed heterogeneity in the meta-regression. Future research should examine the relationship of age on cognition in individuals with HF.

scholarly journals Compensatory Interventions for Cognitive Impairments in Psychosis: A Systematic Review and Meta-Analysis

2020 ◽  
Vol 46 (4) ◽  
pp. 869-883 ◽  
Author(s):  
Kelly Allott ◽  
Kristi van-der-EL ◽  
Shayden Bryce ◽  
Emma M Parrish ◽  
Susan R McGurk ◽  
...  
Keyword(s):  
Systematic Review ◽  
Psychiatric Symptoms ◽  
Meta Analysis ◽  
Risk Of Bias ◽  
Effect Sizes ◽  
Medium Effect ◽  
Post Intervention ◽  
Psychosocial Disability ◽  
The Impact

Abstract Objective Cognitive compensatory interventions aim to alleviate psychosocial disability by targeting functioning directly using aids and strategies, thereby minimizing the impact of cognitive impairment. The aim was to conduct a systematic review and meta-analysis of cognitive compensatory interventions for psychosis by examining the effects on functioning and symptoms, and exploring whether intervention factors, study design, and age influenced effect sizes. Methods Electronic databases (Ovid Medline, PsychINFO) were searched up to October 2018. Records obtained through electronic and manual searches were screened independently by two reviewers according to selection criteria. Data were extracted to calculate estimated effects (Hedge’s g) of treatment on functioning and symptoms at post-intervention and follow-up. Study quality was assessed using Cochrane Collaboration’s risk of bias tool. Results Twenty-six studies, from 25 independent randomized controlled trials (RCTs) were included in the meta-analysis (1654 participants, mean age = 38.9 years, 64% male). Meta-analysis revealed a medium effect of compensatory interventions on functioning compared to control conditions (Hedge’s g = 0.46, 95% CI = 0.33, 0.60, P < .001), with evidence of relative durability at follow-up (Hedge’s g = 0.36, 95% CI = 0.19, 0.54, P < .001). Analysis also revealed small significant effects of cognitive compensatory treatment on negative, positive, and general psychiatric symptoms, but not depressive symptoms. Estimated effects did not significantly vary according to treatment factors (ie, compensatory approach, dosage), delivery method (ie, individual/group), age, or risk of bias. Longer treatment length was associated with larger effect sizes for functioning outcomes. No evidence of publication bias was identified. Conclusion Cognitive compensatory interventions are associated with robust, durable improvements in functioning in people with psychotic illnesses.

scholarly journals The Impact of Mindfulness-Based Programmes on Self-Compassion in Nonclinical Populations: a Systematic Review and Meta-Analysis

Mindfulness ◽  
2020 ◽  
Vol 12 (1) ◽  
pp. 29-52
Author(s):  
Hannah L. Golden ◽  
Jane Vosper ◽  
Jessica Kingston ◽  
Lyn Ellett
Keyword(s):  
Publication Bias ◽  
Meta Analysis ◽  
Small Sample ◽  
Medium Effect ◽  
Future Research ◽  
Significant Heterogeneity ◽  
Self Compassion ◽  
Small Sample Sizes ◽  
Randomised Controlled ◽  
The Impact

Abstract Objectives Self-compassion has been proposed as a mechanism of change in mindfulness-based programmes (MBPs). The current study systematically reviewed the evidence for the effect of MBPs on self-compassion, in randomised controlled trials addressing broad mental health outcomes (depression, anxiety and stress) in nonclinical populations, and statistically synthesisesd these findings in a meta-analysis. Methods Three databases were systematically searched, and pre-post programme between group effect sizes (Hedges g) were calculated and synthesised using meta-analytic procedures. Correlation between change in self-compassion and distress (r) was also assessed. Moderator analyses were conducted and publication bias was assessed. Results Twenty-six studies met inclusion criteria (n = 598). A significant medium effect of pre-post change on self-compassion was found for MBPs compared to control conditions (g = 0.60, 95% CI = 0.41 to 0.80, p < 0.001). There was significant heterogeneity in the study sample, and no differences found for any of the moderators tested. There was no strong evidence for publication bias. Meta-analysis of correlation between change in self-compassion and distress was underpowered and found no significant effect. The improvement in self-compassion following MBI was not always consistent with improvements in depression or anxiety. Conclusions The results suggest that MBPs can increase self-compassion in nonclinical populations, though the moderators of this effect remain unknown. Methodological limitations include small sample sizes, over-reliance on wait-list control conditions and limitations in how self-compassion is measured. Theoretical and clinical implications of the review, and future research directions, are also discussed.

scholarly journals Is Internationalization Beneficial to Innovation? Evidence from a Meta-analysis

2021 ◽  
Author(s):  
Sasa Ding ◽  
Frank McDonald ◽  
Yingqi Wei
Keyword(s):  
Research Design ◽  
Meta Analysis ◽  
Effect Sizes ◽  
Future Research ◽  
Causal Inferences ◽  
Analytical Review ◽  
Key Aspects ◽  
The Impact ◽  
Design Factors

AbstractThis paper conducts a meta-analytical review to examine the impact of internationalization on innovation, with particular attention to the role of research design factors that may confound causal inferences. The existing literature is examined (1) to determine the average effect of internationalization on innovation and (2) to assess how variations in key aspects of research design has affected results. Analysis of 99 studies reveals that the effects of internationalization on innovation are diverse but are generally positive, albeit the effect sizes are mostly small to moderate. The inferred magnitude of such effects is influenced by research design factors and that country-context matters. The results suggest that internationalization measurements, data characteristics and statistical artifacts affect the variations in effect sizes. We conclude with a discussion of opportunities and challenges in future research on the internationalization-innovation nexus.

scholarly journals The role of lifetime stressors in adult fibromyalgia: systematic review and meta-analysis of case-control studies

2021 ◽  
Vol 51 (2) ◽  
pp. 177-193
Author(s):  
Nia Kaleycheva ◽  
Alexis E. Cullen ◽  
Robyn Evans ◽  
Tirril Harris ◽  
Timothy Nicholson ◽  
...  
Keyword(s):  
Physical Abuse ◽  
Emotional Abuse ◽  
Meta Analysis ◽  
Full Range ◽  
Stressful Events ◽  
Effect Sizes ◽  
Study Quality ◽  
Case Control Studies ◽  
Meta Regression ◽  
The Impact

AbstractBackgroundFibromyalgia is a chronic condition characterised by widespread musculoskeletal pain. Although accumulating evidence suggests that exposure to stressful events increases the risk for this complex disorder, this is the first meta-analysis to compare the impact of a full range of lifetime stressors (e.g. physical trauma through to emotional neglect) on adult fibromyalgia.MethodsThis review was performed in accordance with PRISMA guidelines. Random-effects models examined associations between different stressor exposures and fibromyalgia status with meta-regression investigating the effects of publication year and study quality on effect sizes.ResultsNineteen studies were included in the meta-analysis. Significant associations with fibromyalgia status were observed for all six exposure types examined: odds ratios (OR) were highest for physical abuse (OR 3.23, 95% confidence interval 1.99–5.23) and total abuse (3.06, 1.71–5.46); intermediate for sexual abuse (2.65, 1.85–3.79) and smaller for medical trauma (1.80, 1.19–2.71), other lifetime stressors (1.70, 1.31–2.20), and emotional abuse (1.52, 1.27–1.81). Results were not significantly changed when childhood, as opposed to adult, exposures were used in studies that reported both. Meta-regression analyses demonstrated no effect of publication year or study quality on effect sizes.ConclusionsThis study confirmed a significant association between stressor exposure and adult fibromyalgia with the strongest associations observed for physical abuse. Limitations related to current available literature were identified; we provide several suggestions for how these can be addressed in future studies. Stressors are likely to be one of many risk factors for fibromyalgia which we argue is best approached from a biopsychosocial perspective.

The Impact of Theory in HPV Vaccination Promotion Research: A Systematic Review and Meta-Analysis

2021 ◽  
pp. 089011712110125
Author(s):  
Xizhu Xiao ◽  
Danielle Ka Lai Lee ◽  
Rachel Min Wong ◽  
Porismita Borah
Keyword(s):  
Systematic Review ◽  
Data Extraction ◽  
Meta Analysis ◽  
Hpv Vaccination ◽  
Future Research ◽  
Comprehensive Overview ◽  
Promotional Strategies ◽  
K 12 ◽  
Theory Use ◽  
The Impact

Objective: Numerous studies examined HPV vaccination promotional strategies. However, an overview of theory use, a synthesis of strategies’ effectiveness and an examination of the moderating influence of theory are absent. Data Source: We retrieved studies from Academic Search Complete, Business Source Complete, PubMed, PsycINFO, Web of Science, CMMC, CINAHL, and MEDLINE. Study Inclusion and Exclusion Criteria: 1) peer-reviewed articles written in English, 2) experimental or quasi-experimental, 3) measure HPV vaccination-related outcomes, 4) had to contain a control condition and report statistics necessary for conversion (for meta-analysis only). Data Extraction: 70 and 30 studies were included for the systematic review and meta-analysis respectively. Data Synthesis: Four major categories were coded: study information, theory use, type of theory, and outcomes. Two independent coders coded the sample (Cohen’s Kappa ranged from .8 to 1). Results: Most of the studies were based in the U.S. (77%, k = 54) with convenient samples (80%, k = 56), targeted toward females (46%, k = 32), and around a quarter did not employ any theories (47%, k = 33). Among theory-driven studies, the most commonly used were Framing (22%, k = 19), Health Belief Model (HBM; 13%, k = 12), and Narrative (7%, k = 6). Among controlled studies, promotional strategies were significantly more effective compared to the control (r+ = .25, p < .001). Strategies guided by the information, motivation, behavioral skills model (IMB) were more effective (r+ = .75, p < .001) than studies guided by framing theory (r+ = −.23, p < .001), HBM (r+ = .01, p < .001), and other theories (r+ = .11, p < .001). Conclusion: This review contributes to HPV vaccination promotion literature by offering a comprehensive overview of promotional strategies and practical suggestions for future research and practices.

scholarly journals Vagally mediated heart rate variability in headache patients—a systematic review and meta-analysis

Cephalalgia ◽  
2015 ◽  
Vol 36 (3) ◽  
pp. 265-278 ◽  
Author(s):  
Julian Koenig ◽  
DeWayne P Williams ◽  
Andrew H Kemp ◽  
Julian F Thayer
Keyword(s):  
Systematic Review ◽  
Heart Rate ◽  
Heart Rate Variability ◽  
Effect Size ◽  
Meta Analysis ◽  
Medium Effect ◽  
Future Research ◽  
Vagal Activity ◽  
Headache Disorders ◽  
The Impact

Objective Vagal nerve activity—indexed by heart rate variability (HRV)—has been linked to altered pain processing and inflammation, both of which may underpin headache disorders and lead to cardiovascular disease (CVD). Here we examined the evidence for differences in parasympathetic (vagal) activity indexed by time- and frequency-domain measures of HRV in patients with headache disorders compared to healthy controls (HCs). Methods A systematic review and meta-analysis was conducted on studies investigating group differences in vagally mediated HRV (vmHRV) including time- (root-mean-square of successive R-R-interval differences (RMSSD)) and frequency- (high-frequency HRV) domain measures. Studies eligible for inclusion were identified by a systematic search of the literature, based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. Results Seven studies reporting a total of 10 comparisons of patients with headache disorders (HF-HRV n = 67, RMSSD n = 122) and HCs (HF-HRV n = 64, RMSSD n = 125) were eligible for inclusion. Random-effects meta-analysis revealed a significant main effect on RMSSD ( Z = 2.03, p = 0.04; Hedges’ g = −0.63; 95% CI (−1.24, –0.02); k = 6) and similar pooled effect size estimates for HF-HRV when breathing was controlled ( g = −0.30; 95% CI (−0.69; 0.10)) but not when breathing was not controlled ( g = 0.02; 95% CI (−0.69; 0.74)). Controlling for breathing had no effect on RMSSD. Conclusion vmHRV is reduced in patients with headache disorders, findings associated with a medium effect size. Suggestions for future research in this area are provided, emphasizing a need to investigate the impact of headache disorders and commonly comorbid conditions—including mental disorders—as well as the investigation of the risk for CVD in migraine in particular. We further emphasize the need for large-scale studies to investigate HRV as a mechanism mediating the association of migraine and CVD.

scholarly journals Adventure therapy effects on self-concept – A meta-analysis

2017 ◽  
Author(s):  
Corinna Fleischer ◽  
Philipp Doebler ◽  
Paul - Christian Bürkner ◽  
Heinz Holling
Keyword(s):  
Locus Of Control ◽  
Self Efficacy ◽  
Meta Analysis ◽  
Self Esteem ◽  
Effect Sizes ◽  
Self Concept ◽  
Future Research ◽  
Adventure Therapy ◽  
Concept Change ◽  
The Impact

Purpose: Self-concept change has been proposed as a key driver of behavioral change through adventure therapy (Hans, 2000). Through exploratory moderator analysis we tried to identify process variables that influence the effect of adventure therapy on self-concept to contribute to a deeper understanding of why and when adventure therapy works. Methods: This meta-analysis includes thirty studies (53 effect sizes, 1802 subjects) that report effects of adventure therapy programs on three constructs concerning self-concept: locus of control, self-efficacy, and self-esteem. Participants were either at risk or in treatment for behavioral or mental health issues. Results: Short-term effect sizes of the impact of adventure therapy on self-concept were moderate for both uncontrolled effects (g = 0.51) and controlled effects (g = 0.56). There was no evidence for a difference between the effects on locus of control, self-efficacy or self-esteem. The revealed high heterogeneity of effect sizes could not be explained by any of the examined moderating variables. The follow-up effects confirmed a lasting self-concept change. No publication bias was found, but limitations and alternative explanations of the results are discussed. Conclusions: Future research needs to focus on psychological processes involved in adventure therapy and strive towards high methodological quality.

scholarly journals Influence of receptor selectivity on benefits from SGLT2 inhibitors in patients with heart failure: a systematic review and head-to-head comparative efficacy network meta-analysis

2021 ◽  
Author(s):  
Tobias Täger ◽  
Lutz Frankenstein ◽  
Dan Atar ◽  
Stefan Agewall ◽  
Norbert Frey ◽  
...  
Keyword(s):  
Heart Failure ◽  
Meta Analysis ◽  
Comparative Efficacy ◽  
Receptor Selectivity ◽  
Sodium Glucose Cotransporter ◽  
Significant Difference ◽  
Patients With Heart Failure ◽  
All Cause Mortality ◽  
Meta Regression ◽  
The Impact

Abstract Background Receptor selectivity of sodium-glucose cotransporter-2 inhibitors (SGLT2i) varies greatly between agents. The overall improvement of cardiovascular (CV) outcomes in heart failure (HF) patients varies between trials. We, therefore, evaluated the comparative efficacy of individual SGLT2i and the influence of their respective receptor selectivity thereon. Methods We identified randomized controlled trials investigating the use of SGLT2i in patients with HF—either as the target cohort or as a subgroup of it. Comparators included placebo or any other active treatment. The primary endpoint was the composite of hospitalization for HF or CV death. Secondary outcomes included all-cause mortality, CV mortality, hospitalization for HF, worsening renal function (RF), and the composite of worsening RF or CV death. Evidence was synthesized using network meta-analysis. In addition, the impact of receptor selectivity on outcomes was analysed using meta-regression. Results We identified 18,265 patients included in 22 trials. Compared to placebo, selective and non-selective SGLT2i improved fatal and non-fatal HF events. Head-to-head comparisons suggest superior efficacy with sotagliflozin as compared to dapagliflozin, empagliflozin or ertugliflozin. No significant difference was found between canagliflozin and sotagliflozin. Meta-regression analyses show a decreasing benefit on HF events with increasing receptor selectivity of SGLT2i. In contrast, receptor selectivity did not affect mortality and renal endpoints and no significant difference between individual SGLT2i was noted. Conclusion Our data point towards a class-effect of SGLT2i on mortality and renal outcomes. However, non-selective SGLT2i such as sotagliflozin may be superior to highly selective SGLT2i in terms of HF outcomes.

The Effects of Multi-Domain Interventions on Cognition: A Systematic Review

2021 ◽  
pp. 019394592110322
Author(s):  
Sangwoo Ahn ◽  
Jae Woo Chung ◽  
Monica K. Crane ◽  
David R. Bassett ◽  
Joel G. Anderson
Keyword(s):  
Physical Activity ◽  
Cognitive Training ◽  
Cardiovascular Health ◽  
Preventive Measure ◽  
Included Study ◽  
Effect Sizes ◽  
Future Research ◽  
Beneficial Effects ◽  
Global Cognition ◽  
Clinically Significant

This review aimed to evaluate the effects of multi-domain interventions on cognition among individuals without dementia. Multi-domain interventions refer to those combining any single preventive measure such as physical activity, cognitive training, and/or nutrition to prevent dementia. Seventeen studies were included (n = 10,056 total participants; mean age = 73 years), eight of which were rated as strong in quality while the other nine showed moderate quality. The standardized mean difference (SMD; d) was used to calculate the effect size for each included study. Multi-domain interventions consisting of physical activity, cognitive training, cardioprotective nutrition, and/or cardiovascular health education exerted beneficial effects on global cognition, episodic memory, and/or executive function with very small to moderate effect sizes (0.16–0.77). Nurses may consider combining these components to potentially stave off dementia. Future research is warranted to identify the optimal multi-domain intervention components that can induce clinically significant beneficial effects on cognition.

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