scholarly journals The Feasibility of a Low Sodium Meal Plan for Residents of a Subsidized Senior Housing Facility: The SOTRUE Pilot Study

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 39-39
Author(s):  
Stephen Juraschek ◽  
Courtney Millar ◽  
Abby Foley ◽  
Misha Shtivelman ◽  
Virginia McNally ◽  
...  
Keyword(s):  
Pilot Study ◽  
Objective Measure ◽  
Mean Difference ◽  
Creatinine Ratio ◽  
Urine Sodium ◽  
Aging Research ◽  
Dietary Compliance ◽  
Low Sodium ◽  
Federal Department ◽  
Meal Plan

Abstract Objectives To determine the feasibility of a low sodium meal plan intervention aimed at reducing seated blood pressure (BP) in residents of a government-subsidized congregate, senior living facility. Methods The Satter House Trial of Reduced Sodium Meals (SOTRUE) was an individual-level, masked, randomized, controlled pilot study, testing the feasibility of administering a low versus typical sodium meal plan to adult residents of Jack Satter House, a section 202 congregate living facility in Revere, MA, subsidized by the Federal Department of Housing and Urban Development (HUD). Adults over age 60 years received 3 isocaloric meals with two snacks daily over a 14-day period. Both meal plans were equivalent in potassium and macronutrients, but differed in sodium density (<0.95 mg/kcal vs > 2 mg/kcal). The primary outcome was seated systolic BP (SBP) averaged over 2 visits (days 10 and 14) using an Omron HEM-907XL automated cuff. Our objective measure of compliance was morning urine sodium-creatinine ratio. Results We randomized 20 participants (95% women, 95% white, and mean age 78 +/− 8 years), beginning in October 7, 2019. Baseline characteristics were evenly distributed between groups. Dietary compliance was high (only 2 discontinued meals) and follow-up was 100% with the last participant ending November 4, 2019. Baseline SBP changed from 121 to 116 mm Hg on the typical sodium meal plan (N = 9; mean difference of −5 mm Hg; 95% CI: −18, 8) and 123 to 112 mm Hg on the low sodium meal plan (N = 11; mean difference of −11 mm Hg; 95% CI: −15.2, −7.7). Compared to the typical sodium meal plan, the low sodium meal plan non-significantly reduced SBP by 5 mm Hg (95% CI: −14, 4) and non-significantly reduced urine sodium-creatinine ratio (%-difference −36.0; 95% CI: −60.3, 3.4). Effects on SBP were greater in the subgroup using hypertension medications at baseline (−13 mm Hg; 95% CI: −26, −0) and changes in SBP from baseline were correlated with changes in urine sodium-creatinine ratio (Pearson's r = 0.31). Conclusions This trial represents an innovative, feasible, and practical approach to healthier eating by altering federally-mandated meal plans. A definitive study with a larger sample size is needed to establish the efficacy and safety of this approach in older adults who reside in section 202 housing. Funding Sources ISAC, Marcus Institute for Aging Research, Hebrew SeniorLife.

scholarly journals The Effects of a Low Sodium Meal Plan on Blood Pressure in Older Adults: The SOTRUE Randomized Feasibility Trial

Nutrients ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 964
Author(s):  
Stephen P. Juraschek ◽  
Courtney L. Millar ◽  
Abby Foley ◽  
Misha Shtivelman ◽  
Alegria Cohen ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Older Adults ◽  
Feasibility Trial ◽  
Creatinine Ratio ◽  
Urine Sodium ◽  
Double Blind ◽  
Sodium Diet ◽  
Low Sodium ◽  
Federal Department ◽  
Meal Plan

Reduced sodium meal plans are recommended by the Centers of Disease Control to lower blood pressure in older adults; however, this strategy has not been tested in a clinical trial. The Satter House Trial of Reduced Sodium Meals (SOTRUE) was an individual-level, double-blind, randomized controlled pilot study of adults living in a congregate living facility subsidized by the Federal Department of Housing and Urban Development (HUD). Adults over age 60 years ate 3 isocaloric meals with two snacks daily for 14 days. The meal plans differed in sodium density (<0.95 vs. >2 mg/kcal), but were equivalent in potassium and macronutrients. Seated systolic BP (SBP) was the primary outcome, while urine sodium-creatinine ratio was used to measure compliance. Twenty participants were randomized (95% women; 95% white; mean age 78 ± 8 years), beginning in 7 October 2019. Retention was 100% with the last participant ending 4 November 2019. Mean baseline SBP changed from 121 to 116 mmHg with the typical sodium diet (−5 mmHg; 95% CI: −18, 8) and from 123 to 112 mmHg with the low sodium diet (−11 mmHg; 95% CI: −15.2, −7.7). Compared to the typical sodium meal plan, the low sodium meal plan lowered SBP by 4.8 mmHg (95% CI: −14.4, 4.9; p = 0.31) and urine sodium-creatinine ratio by 36% (−36.0; 95% CI: −60.3, 3.4; p = 0.07), both non-significant. SOTRUE demonstrates the feasibility of sodium reduction in federally mandated meal plans. A longer and larger study is needed to establish the efficacy and safety of low sodium meals in older adults.

scholarly journals Effects of Delayed Sample Processing on Determination of Total and High Molecular Weight (HMW) Adiponectin in Serum and Plasma: A Pilot Study

2016 ◽  
Vol 8 (3) ◽  
pp. 19
Author(s):  
Choaping Ng ◽  
Felicity J Rose ◽  
Sahar Keshvari ◽  
Marina M Reeves ◽  
Goce Dimeski ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Pilot Study ◽  
High Molecular Weight ◽  
Accurate Determination ◽  
Mean Difference ◽  
Serum Samples ◽  
Blood Samples ◽  
Hmw Adiponectin ◽  
Total Adiponectin

<p>Adiponectin is a beneficial adipocyte-secreted hormone, which circulates in a variety of multimeric forms termed low and high molecular weight (LMW/HMW). Effectiveness of clinical therapeutic trials which target adiponectin rely on accurate determination of circulating total and HMW adiponectin levels but the accuracy may be influenced by variations in sample handling processes. The aim of this pilot study was to investigate the effects of delayed processing of blood samples on the concentration of total and HMW adiponectin.</p><p>Materials and Methods: Fasting blood samples were collected for analysis of total and HMW adiponectin concentrations in EDTA plasma and serum from eight healthy participants.  Samples were centrifuged post 15 min storage at 4<sup>o</sup>C as the comparative ‘ideal’ method or after up to 72 h of refrigerated storage or 6 h at room temperature. Total and HMW adiponectin concentrations were measured by ELISA.</p><p>Results: Under ideal handling conditions measurements of total and HMW adiponectin concentrations were significantly higher in serum than in plasma (mean difference: -1.3 µg/mL [95% CI: -1.6, -1.0], p&lt;0.001; and, -0.6 µg/mL [95% CI: -0.7, -0.5], p&lt;0.001, respectively).  Storage of blood samples at 4<sup>o</sup>C for 72 h resulted in significant reductions in concentration of total adiponectin in serum (mean difference: -1.4 µg/mL [95% CI: -2.0, -0.8], p=0.001) and HMW adiponectin in plasma (mean difference: -0.6 µg/mL [95%CI: -0.9, -0.2], p=0.007), compared with ideal conditions.  Further analysis of serum samples showed a significant decrease in total adiponectin concentration after 6 h storage at 4<sup>o</sup>C (mean difference: -1.4 µg/mL [95% CI: -2.0, -0.8], p=0.001) compared with ideal conditions.</p><p>Conclusions: Delayed processing of samples may have differential effects on the concentration of total and HMW adiponectin in serum or plasma. Larger studies are warranted for clinical intervention trials.</p>

scholarly journals Measuring Children’s Sodium and Potassium Intakes in New Zealand: A Pilot Study

Proceedings ◽  
2019 ◽  
Vol 8 (1) ◽  
pp. 14
Author(s):  
Helen Eyles ◽  
Neela Bhana ◽  
Sang Eun Lee ◽  
Carley Grimes ◽  
Rachael McLean ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
New Zealand ◽  
Pilot Study ◽  
High Potassium ◽  
Low Sodium ◽  
Sodium And Potassium

Background: Low sodium and high potassium intakes in childhood protect against rises in bloodpressure (BP) and risk of cardiovascular disease later in life [...]

scholarly journals Dietary electrolytes are related to mood

2008 ◽  
Vol 100 (5) ◽  
pp. 1038-1045 ◽  
Author(s):  
Susan J. Torres ◽  
Caryl A. Nowson ◽  
Anthony Worsley
Keyword(s):  
Disease Risk ◽  
Control Diet ◽  
High Potassium ◽  
Dietary Compliance ◽  
Low Sodium ◽  
High Calcium ◽  
Urinary Potassium ◽  
Hpa Axis Activity ◽  
The Relationship ◽  
Positive Effect

Dietary therapies are routinely recommended to reduce disease risk; however, there is concern they may adversely affect mood. We compared the effect on mood of a low-sodium, high-potassium diet (LNAHK) and a high-calcium diet (HC) with a moderate-sodium, high-potassium, high-calcium Dietary Approaches to Stop Hypertension (DASH)-type diet (OD). We also assessed the relationship between dietary electrolytes and cortisol, a stress hormone and marker of hypothalamic–pituitary–adrenal (HPA) axis activity. In a crossover design, subjects were randomized to two diets for 4 weeks, the OD and either LNAHK or HC, each preceded by a 2-week control diet (CD). Dietary compliance was assessed by 24 h urine collections. Mood was measured weekly by the Profile of Mood States (POMS). Saliva samples were collected to measure cortisol. The change in mood between the preceding CD and the test diet (LNAHK or HC) was compared with the change between the CD and OD. Of the thirty-eight women and fifty-six men (mean age 56·3 (sem 9·8) years) that completed the OD, forty-three completed the LNAHK and forty-eight the HC. There was a greater improvement in depression, tension, vigour and the POMS global score for the LNAHK diet compared to OD (P < 0·05). Higher cortisol levels were weakly associated with greater vigour, lower fatigue, and higher levels of urinary potassium and magnesium (r 0·1–0·2, P < 0·05 for all). In conclusion, a LNAHK diet appeared to have a positive effect on overall mood.

scholarly journals Startle responses in Duchenne muscular dystrophy: a novel biomarker of brain dystrophin deficiency

2021 ◽  
Author(s):  
Kate Maresh ◽  
Andriani Papageorgiou ◽  
Deborah Ridout ◽  
Neil A. Harrison ◽  
William Mandy ◽  
...  
Keyword(s):  
Duchenne Muscular Dystrophy ◽  
Muscular Dystrophy ◽  
Objective Measure ◽  
Mean Difference ◽  
Extinction Phase ◽  
Variable Degree ◽  
Neuropsychological Measures ◽  
Increased Risk ◽  
Dystrophin Deficiency ◽  
Conditioned Responses

AbstractDuchenne muscular dystrophy (DMD) is characterised by loss of dystrophin in muscle. Patients affected by DMD also have variable degree of intellectual disability and neurobehavioural co-morbidities. In contrast to muscle, in which a single full-length isoform (Dp427) is produced, multiple dystrophin isoforms are produced in the brain, and their deficiency accounts for the variability of CNS manifestations, with increased risk of comorbidities in patients carrying mutations affecting the 3’ end of gene, disrupting the shorter Dp140 and Dp71 isoforms. The mdx mouse model of DMD lacks Dp427 in muscle and CNS and exhibits exaggerated startle responses to threat, linked to the deficiency of dystrophin in limbic structures such as the amygdala, which normalise with postnatal brain dystrophin-restoration therapies. A pathological startle response is not a recognised feature of DMD, and its characterisation has implications for improved clinical management and translational research.To investigate startle responses in DMD, we used a novel fear-conditioning task in an observational study of 56 males aged 7-12 years (31 DMD, mean age 9.7±1.8 years; 25 Controls, mean age 9.6±1.4 years). Trials of two neutral visual stimuli were presented to participants: one ‘safe’ cue presented alone; one ‘threat’ cue paired with an aversive noise to enable conditioning of physiological startle responses (skin conductance response, SCR; heart rate, HR). Retention of conditioned physiological responses was subsequently tested with presentation of both cues without the aversive noise in an ‘extinction’ phase. Primary outcomes were the magnitude of the initial unconditioned SCR and HR change responses to the aversive ‘threat’ and acquisition and retention of conditioned responses after conditioning. Secondary outcomes were neuropsychological measures and genotype associations.The initial (unconditioned) mean SCR to threat was greater in DMD than Controls (Mean difference 3.0 µS (95% CI 1.0, 5.1), P=.004), associated with a significant threat-induced bradycardia only in the DMD group (mean difference -5.6 bpm (95% CI 0.51, 16.9); P=.04). DMD participants found the task more aversive than Controls, consequently early termination during the extinction phase occurred in 26% of the DMD group (vs. 0% Controls; P=.007).This study provides the first evidence that boys with DMD show increased unconditioned startle responses to threat, similar to the mdx mouse phenotype that also responds to brain dystrophin restoration. Our study provides new insights into the neurobiology underlying the complex neuropsychiatric co-morbidities in DMD and defines an objective measure of this CNS phenotype, which will be valuable for future CNS-targeted dystrophin-restoration studies.

scholarly journals A pilot study on efficacy and safety of a new salt substitute with very low sodium among hypertension patients on regular treatment

Medicine ◽  
2020 ◽  
Vol 99 (8) ◽  
pp. e19263 ◽  
Author(s):  
Lihong Mu ◽  
Chenglong Li ◽  
Ting Liu ◽  
Wuxiang Xie ◽  
Ge Li ◽  
...  
Keyword(s):  
Pilot Study ◽  
Efficacy And Safety ◽  
Regular Treatment ◽  
Low Sodium ◽  
Salt Substitute

scholarly journals The Feasibility of Using Computrition Software for Nutrition Research

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 1177-1177
Author(s):  
Courtney Millar ◽  
Alegria Cohen ◽  
Stephen Juraschek ◽  
Abby Foley ◽  
Misha Shtivelman ◽  
...  
Keyword(s):  
Pilot Study ◽  
Small Sample ◽  
Urinary Sodium ◽  
Nutrition Intervention ◽  
Calorie Intake ◽  
Double Blind ◽  
Sodium Diet ◽  
Low Sodium Diet ◽  
Low Sodium ◽  
Nutrition Research

Abstract Objectives Computrition is a food service software utilized by dieticians in clinical settings to create recipes, design menus, and scale the menus to larger quantities, yet it is underutilized in the research setting. The objective was to determine the practicality of administering two meal plans (low sodium vs typical sodium) designed with Computrition in a double-blind, randomized pilot study in older adult residents of a congregate housing facility. Methods This pilot study included 19 females and 1 male aged ≥65y residing at Jack Satter House, Revere, MA. Participants were randomized to low sodium or typical sodium meals (&lt;0.95 or &gt;2 mg/kcal), designed with Computrition. A base 7-day meal plan (with breakfast, lunch, dinner, and two snacks) was generated. Recipes entered in Computrition were modified to reach three calorie levels (1750, 2000, 2250 kcal/d) and two sodium densities, while keeping potassium levels constant at ∼3500 mg/d. Finally, Computrition labels were generated to execute meals while maintaining blinding. To determine efficacy of these meal plans, compliance was evaluated by comparing change in urinary sodium (mmol/L) over 2-weeks between low sodium vs. typical sodium groups. These comparisons were also assessed in sub-groups by calorie intake (≤1750 kcal/d, n = 12 and ≥2000 kcal/d, n = 8). Results Mean age was 77 ± 6y and calorie intake was 1849 kcal (low sodium group, n = 11) and 80 ± 9y and 1785 kcal (typical sodium group, n = 9). Over 2-weeks, urinary sodium decreased by −30.6 mmol/L in the low sodium diet, compared to 2.4 mmol/L in the typical sodium diet (P = 0.003). In those consuming ≤ 1750 kcal/d on the low sodium diet, urinary sodium decreased non-significantly by −18.3 mmol/L, compared to −2.3 mmol/L in the typical sodium diet (P = 0.16). In those consuming ≥2000 kcal/d on the low sodium diet, urinary sodium decreased non-significantly by −22.0 mmol/L, compared to no change in the typical sodium diet (P = 0.26). Conclusions In this study, two sodium meal plans designed using Computrition altered urinary sodium over 2 weeks. Similar trends in reduction were seen in the sub-groups by calorie intake, although results were not significant due to small sample sizes. Future work should evaluate testing and standardization of this software for a multi-site nutrition intervention study. Funding Sources ISAC, Marcus Institute, Hebrew SeniorLife.

ePS4.09 Spot urine sodium/creatinine ratio in cystic fibrosis patients and its relation to nutritional status

2020 ◽  
Vol 19 ◽  
pp. S48
Author(s):  
I. Bambir ◽  
A. Ladic ◽  
L. Omerza ◽  
I. Markelic ◽  
A. Vukic Dugac ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Nutritional Status ◽  
Creatinine Ratio ◽  
Urine Sodium ◽  
Spot Urine

scholarly journals The Feasibility of Using Computrition Software for Nutrition Research—A Pilot Study

Nutrients ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 329
Author(s):  
Courtney L. Millar ◽  
Alegria Cohen ◽  
Stephen P. Juraschek ◽  
Abby Foley ◽  
Misha Shtivelman ◽  
...  
Keyword(s):  
Older Adults ◽  
Pilot Study ◽  
Future Studies ◽  
Nutrition Research ◽  
Meal Plan ◽  
Post Hoc

We evaluated the feasibility of using Computrition to design and implement a low vs. typical sodium meal plan intervention for older adults. Dietitians used Computrition to design a 7-day meal plan with three caloric levels (≤1750, 2000, ≥2250 kcals/day) and two sodium densities (low = 0.9 mg/kcal; n = 11 or typical = 2 mg/kcal; n = 9). Feasibility was determined by post-hoc definitions of effectiveness, sodium compliance, palatability of diet, sustainability, and safety. Given the low number of participants in one of the three calorie groups, the higher calorie groups were combined. Thus, comparisons are between low vs. typical meal plans at two calorie levels (≤1750 or ≥2000 kcals/day). Overall, regardless of the calorie group, the meal plans created with Computrition were effective in reaching the targeted sodium density and were safe for participants. Furthermore, individuals appeared to be equally compliant and reported similar palatability across meal plans. However, one of the three criteria for the sustainability definition was not met. In conclusion, we successfully used Computrition to design low and typical sodium meal plans that were effective, compliable, and safe. Future studies of older adults in similar settings should focus on improving the palatability of the meal plans and scaling this protocol to larger studies in older adults.

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