Mango Intake Affects Skin Wrinkles in Postmenopausal Women

Abstract Objectives To investigate the effects of mango intake on skin wrinkles (SW) and skin carotenoids (C) in postmenopausal women. Methods A randomized, two-arm parallel study was conducted to assess 16 weeks (wk) of mango intake on SW development in the left and right lateral canthus (crow's feet) of healthy postmenopausal women, aged 50 to 70. Participants consumed either 85 g (0.5 cup) or 250 g (1.5 cup) of mangos, 4 times/wk. High-resolution facial images were captured at baseline, 8 wk, and 16 wk. SW were separated into three categories: Average (A), Fine (F), and Emerging (E) with indices of length (L), width (W) and severity (S). F lines were defined as medium contrast wrinkles, while E lines were low contrast wrinkles, both at a minimum length of 2.6 mm. The A SW was the mean contrast of all pixels of a SW. S was calculated as contrast multiplied by L. C values were measured with Raman spectroscopy and participants were separated into low baseline carotenoid (<383 nm; LBC) or high baseline carotenoid (>383 nm; HBC) groups. Participants started the study either in the Fall (Sep 1 – Nov 30) or Winter (Dec 1 – Feb 28) season. SW changes with mango intake were analyzed using One Way ANCOVA with the change in carotenoids, baseline BMI and season as covariates. Results Among women in the LBC group, SW L was differentially affected by mango intake, with an increase in L in the 250 g group compared to decreased L in the 85 g group (left AL: 8wk, P = 0.026 and 16 wk, P = 0.014; left FL: 8 wk, P = 0.009 and 16 wk, P = 0.048). These specific SW were not significantly changed in the HBC group. A positive correlation between C and left FS (r = 0.434, P = 0.027) was seen in 85 g group, while C was positively correlated with SW L and S with 250 g of intake. This includes left AL (r = 0.407, P = 0.039), left FS (r = 0.381, P = 0.054) and right ES (r = 0.479, P = 0.008). After 16 wk, women with LBC had a significant increase in C (P = 0.017) with 250 g compared to 85 g of mango intake. No changes in C were noted for the HBC group (P = 0.909). Conclusions Among women with baseline LBC, reduction in SW were observed with 85 g, but not 250 g, of mango intake. Confirmation of these results in a controlled dietary intervention trial are warranted. Funding Sources National Mango Board.

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Daily consumption of fermented soymilk helps to improve facial wrinkles in healthy postmenopausal women in a randomized, parallel-group, open-label trial

Functional Foods in Health and Disease ◽

10.31989/ffhd.v8i2.412 ◽

2018 ◽

Vol 8 (2) ◽

pp. 107 ◽

Cited By ~ 1

Author(s):

Mitsuyoshi Kano ◽

Kazuyoshi Haga ◽

Kouji Miyazaki ◽

Fumiyasu Ishikawa

Keyword(s):

Postmenopausal Women ◽

Maximum Depth ◽

Liquid Chromatography Mass Spectrometry ◽

Daily Consumption ◽

Open Label ◽

Facial Wrinkle ◽

Crow’S Feet ◽

Parallel Group ◽

Secondary Endpoints ◽

Open Label Trial

Background: Soymilk fermented by lactobacilli and/or bifidobacteria is attracting attention due to the excellent bioavailability of its isoflavones. We investigated the effects of fermented soymilk containing high amounts of isoflavone aglycones on facial wrinkles and urinary isoflavones in postmenopausal women in a randomized, parallel-group, open-label trial. Healthy Japanese women were randomly divided into active (n = 44, mean age 56.3 ± 0.5) or control (n = 44, mean age 56.1 ± 0.5) groups, who consumed or did not consume a bottle of soymilk fermented by Bifidobacterium breve strain Yakult and Lactobacillus mali for 8 weeks. Maximum depth of wrinkles around the crow’s feet area and other wrinkle parameters were evaluated as primary and secondary endpoints respectively at weeks 0, 4, and 8 during the consumption period. Urinary isoflavone levels were determined by liquid chromatography-mass spectrometry. Results: The active group demonstrated significant improvements in the maximum depth (p=0.015) and average depth (p=0.04) of wrinkles, and significantly elevated urinary isoflavones (daidzein, genistein, and glycitein; each p < 0.001) compared with the control during the consumption period. No serious adverse effects were recorded.Conclusion: These findings suggest that fermented soymilk taken daily may improve facial wrinkles and elevate urinary isoflavones in healthy postmenopausal women.Key words: postmenopausal women; isoflavone; fermented soymilk; phytoestrogen; facial wrinkle

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Eating behaviors and weight loss outcomes in a 12-month randomized trial of diet and/or exercise intervention in postmenopausal women

International Journal of Behavioral Nutrition and Physical Activity ◽

10.1186/s12966-019-0887-1 ◽

2019 ◽

Vol 16 (1) ◽

Author(s):

Caitlin Mason ◽

Jean de Dieu Tapsoba ◽

Catherine Duggan ◽

Ching-Yun Wang ◽

Catherine M. Alfano ◽

...

Keyword(s):

Weight Loss ◽

Binge Eating ◽

Postmenopausal Women ◽

Eating Behavior ◽

Emotional Eating ◽

Eating Behaviors ◽

Dietary Intervention ◽

Restrained Eating ◽

Dietary Weight Loss ◽

Uncontrolled Eating

Abstract Background Certain eating behaviors are common among women with obesity. Whether these behaviors influence outcomes in weight loss programs, and whether such programs affect eating behaviors, is unclear. Methods Our aim was to examine the effect of baseline eating behaviors on intervention adherence and weight among postmenopausal women with overweight or obesity, and to assess intervention effects on eating behaviors. Four hundred and 39 women (BMI ≥25 kg/m2) were randomized to 12 months of: i) dietary weight loss with a 10% weight loss goal (‘diet’; n = 118); ii) moderate-to-vigorous intensity aerobic exercise for 225 mins/week (‘exercise’; n = 117); iii) combined dietary weight loss and exercise (‘diet + exercise’; n = 117); or iv) no-lifestyle change control (n = 87). At baseline and 12 months, restrained eating, uncontrolled eating, emotional eating and binge eating were measured by questionnaire; weight and body composition were assessed. The mean change in eating behavior scores and weight between baseline and 12 months in the diet, exercise, and diet + exercise arms were each compared to controls using the generalized estimating equation (GEE) modification of linear regression adjusted for age, baseline BMI, and race/ethnicity. Results Baseline restrained eating was positively associated with change in total calories and calories from fat during the dietary intervention but not with other measures of adherence. Higher baseline restrained eating was associated with greater 12-month reductions in weight, waist circumference, body fat and lean mass. Women randomized to dietary intervention had significant reductions in binge eating (− 23.7%, p = 0.005 vs. control), uncontrolled eating (− 24.3%, p < 0.001 vs. control), and emotional eating (− 31.7%, p < 0.001 vs. control) scores, and a significant increase in restrained eating (+ 60.6%, p < 0.001 vs. control); women randomized to diet + exercise reported less uncontrolled eating (− 26.0%, p < 0.001 vs. control) and emotional eating (− 22.0%, p = 0.004 vs. control), and increased restrained eating (+ 41.4%, p < 0.001 vs. control). Women randomized to exercise alone had no significant change in eating behavior scores compared to controls. Conclusions A dietary weight loss intervention helped women modify eating behaviors. Future research should investigate optimal behavioral weight loss interventions for women with both disordered eating and obesity. Trial registration NCT00470119 (https://clinicaltrials.gov). Retrospectively registered May 7, 2007.

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Effectiveness of rehabilitation in post-COVID compared with post-cardiosurgery patients. A single Center experience

European Journal of Preventive Cardiology ◽

10.1093/eurjpc/zwab061.385 ◽

2021 ◽

Vol 28 (Supplement_1) ◽

Author(s):

GQ Villani ◽

A Rosi ◽

D Corbellini ◽

V Schettino ◽

A Bosoni ◽

...

Keyword(s):

Barthel Index ◽

Rehabilitation Program ◽

Walking Test ◽

Rehabilitative Treatment ◽

Funding Sources ◽

Single Center Experience ◽

Clinical Complexity ◽

Significant Disability ◽

Group A ◽

Group B

Abstract Funding Acknowledgements Type of funding sources: None. The COVID 19 disease is frequently associated with significant disability related to intensive care unit-acquired weakness, decontitioning, myopathies and neuropathies. However there are no data on the results of a specific rehabilitative treatment in this group of patients. The aim of our work was to evaluate the effectiveness f a personalized rehabilitative therapy in group of post-COVID patients (A, 47 patients, average age 65.3± 11.6 y, 27 M,) comparing the results with a group of post-cardiosurgical patients COVID 19 negative (B, 47 patients, average age 63.5± 10.3 y, 29 M) evaluating the degree of clinical complexity (Rehabilitation Complexity Scale, RCS-E V13) and the degree of autonomy recovery (Six-minute walking test SMWT, Barthel Index, BI) pre and post-treatment. In Group A patients the Rehabilitation program is associated with a significant improvement in autonomy recovery (BI admission 29.7 ± 20 vs discharge 72.7 ± 28.6 p <0.005, SMWT admission 146 ± 25 vs 318 ± 18 m, p <0.005) and in clinical complexity (RCS admission 10.9 ± 1.1 vs discharge 5.3, p< 0.05) Conclusions Post-COVID patients show a greater loss of autonomy than post-cardiosurgery patients. Rehabilitative treatment has proven effective in ensuring adequate functional recovery with similar results to those obtained in the population of cardiological subjects COVID 19 negative. Group A vs Group B Group A Group B p pre-rehabilitation hospital stay (days) 31 ± 5 8 ± 2 0.005 RCS admission 10.9 ± 1.1 11.6 ± 1.2 ns BI admission 29.7 ± 20 47.7 ± 19 0.05 SMWT admission (m) 146 ± 25 255 ± 18 0.05 Rehabilitation duration (days) 29.7 ± 12.8 29.6 ± 10.1 ns RCS discharge 5.3 ± 2 6.5 ± 2 ns BI discharge 72.7 ± 28 71.5 ± 22.5 ns SMWT discharge (m) 385 ± 18 410 ± 25 ns RCS rehabilitation complexity scale, BI: Barthel Index, SMWT: six-minute walking test

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Lower Eyelid and Midfacial Rejuvenation

Surgery of the Eyelid, Lacrimal System, and Orbit ◽

10.1093/oso/9780195340211.003.0035 ◽

2011 ◽

Author(s):

Chun Cheng Lin Yang ◽

Richard L. Anderson

Keyword(s):

Lower Eyelid ◽

Fat Pad ◽

Tear Trough ◽

Aesthetic Unit ◽

Lateral Canthus ◽

Age Related ◽

Crow’S Feet ◽

The Face ◽

The Aesthetic ◽

The Individual

Over the past two and a half decades, techniques for midfacial rejuvenation have evolved. Midfacial rejuvenation has gained significant popularity among many aesthetic surgeons, including the ophthalmic plastic surgeon. Yet rejuvenation of the midface remains a challenge for the aesthetic surgeon who seeks facial harmony. A variety of techniques and approaches are available, yet no single approach is ideal for all patients. It is clear that the age-related anatomic alterations that cause patients to seek rejuvenation vary from patient to patient, and that many patients have more than one anatomic alteration that must be addressed to rejuvenate the lower lid. The surgeon must address the individual needs of each patient for optimal results. It has also become clear that the lower eyelid and midface form a continuum that needs to be addressed in its entirety for optimal rejuvenation. To achieve this, the surgeon must understand the basic concepts important to lower eyelid and midface rejuvenation, which include an understanding of eyelid and midfacial anatomy, an understanding of aging changes of the lower eyelid and midface, and surgical approaches and nonincisional options. A full understanding of aging changes in the lower eyelid and midface is essential to successfully address midfacial rejuvenation. A harmonious facial appearance consists of a balanced relationship among all tissues of the face. With age, disturbance of this harmony among midfacial tissues occurs. The aging process of the midface encompasses the lower eyelid, malar fat pad and associated structures, melolabial fold, and lateral perioral region. Hester describes four important features of midfacial aging: (1) baring of the inferior orbital rim with creation of a hollow valley at the junction of the lower eyelid and cheek; (2) descent of the malar fat pad, with loss of malar prominence; (3) deepening of the tear trough; and (4) exaggeration of the nasolabial fold. The midface represents a crucial aesthetic unit of the face. It is bordered by structures that play major roles in the overall appearances of the face. The lower eyelid and tear trough toward the nose and the lateral canthus and crow’s feet at the superior lateral aspect frame the midface superiorly.

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Factors Predicting the Response to a Vitamin D-Fortified Milk in Healthy Postmenopausal Women

Nutrients ◽

10.3390/nu11112641 ◽

2019 ◽

Vol 11 (11) ◽

pp. 2641 ◽

Cited By ~ 1

Author(s):

Rebeca Reyes-Garcia ◽

Antonia Garcia-Martin ◽

Santiago Palacios ◽

Nancy Salas ◽

Nicolas Mendoza ◽

...

Keyword(s):

Body Mass Index ◽

Vitamin D ◽

Postmenopausal Women ◽

Body Mass ◽

Body Fat ◽

Dietary Intervention ◽

The Body ◽

Hydroxyvitamin D ◽

Percentage Of Body Fat ◽

Fortified Milk

Background: Milk products fortified with vitamin D may constitute an alternative to pharmacological supplements for reaching the optimal levels of serum 25-hydroxyvitamin D [25(OH)D]. Our aim was to analyze the response of serum 25(OH)D and its predictive factors in postmenopausal healthy women after a dietary intervention with a milk fortified with vitamin D and calcium. Methods: We designed a prospective study including 305 healthy postmenopausal women who consumed a fortified milk with calcium (900 mg/500 mL) and vitamin D3 (600 IU/500 mL) daily for 24 months. Results: The 25(OH)D concentrations at 24 months were correlated to weight, to body mass index, to the percentage of fat, triglycerides and to baseline 25(OH)D levels. We found significant differences in the levels of 25(OH)D at 24 months according to baseline 25(OH)D levels (p < 0.001) and body mass index (p = 0.019) expressed at quartiles. Multivariate analysis showed an association between levels of 25(OH)D after the intervention and at baseline 25(OH)D (Beta = 0.47, p < 0.001) and percentage of body fat (Beta = −0.227, p = 0.049), regardless of the body mass index. Conclusions: In healthy postmenopausal women, the improvement in 25(OH)D after an intervention with a fortified milk for 24 months depends mainly on the baseline levels of serum 25(OH)D and on the percentage of body fat.

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Associations between the proportion of fat-free mass loss during weight loss, changes in appetite, and subsequent weight change: results from a randomized 2-stage dietary intervention trial

American Journal of Clinical Nutrition ◽

10.1093/ajcn/nqz331 ◽

2020 ◽

Vol 111 (3) ◽

pp. 536-544 ◽

Cited By ~ 3

Author(s):

Jake Turicchi ◽

Ruairi O'Driscoll ◽

Graham Finlayson ◽

Cristiana Duarte ◽

Mark Hopkins ◽

...

Keyword(s):

Weight Loss ◽

Body Composition ◽

Energy Balance ◽

Weight Regain ◽

Dietary Intervention ◽

Body Weight Loss ◽

Weight Loss Maintenance ◽

Fat Free Mass ◽

Weight Outcomes ◽

Dietary Intervention Trial

ABSTRACT Background Dynamic changes in body composition which occur during weight loss may have an influential role on subsequent energy balance behaviors and weight. Objectives The aim of this article is to consider the effect of proportionate changes in body composition during weight loss on subsequent changes in appetite and weight outcomes at 26 wk in individuals engaged in a weight loss maintenance intervention. Methods A subgroup of the Diet, Obesity, and Genes (DiOGenes) study (n = 209) was recruited from 3 European countries. Participants underwent an 8-wk low-calorie diet (LCD) resulting in ≥8% body weight loss, during which changes in body composition (by DXA) and appetite (by visual analog scale appetite perceptions in response to a fixed test meal) were measured. Participants were randomly assigned into 5 weight loss maintenance diets based on protein and glycemic index content and followed up for 26 wk. We investigated associations between proportionate fat-free mass (FFM) loss (%FFML) during weight loss and 1) weight outcomes at 26 wk and 2) changes in appetite perceptions. Results During the LCD, participants lost a mean ± SD of 11.2 ± 3.5 kg, of which 30.4% was FFM. After adjustment, there was a tendency for %FFML to predict weight regain in the whole group (β: 0.041; 95% CI: −0.001, 0.08; P = 0.055), which was significant in men (β: 0.09; 95% CI: 0.02, 0.15; P = 0.009) but not women (β: 0.01; 95% CI: −0.04, 0.07; P = 0.69). Associations between %FFML and change in appetite perceptions during weight loss were inconsistent. The strongest observations were in men for hunger (r = 0.69, P = 0.002) and desire to eat (r = 0.61, P = 0.009), with some tendencies in the whole group and no associations in women. Conclusions Our results suggest that composition of weight loss may have functional importance for energy balance regulation, with greater losses of FFM potentially being associated with increased weight regain and appetite. This trial was registered at clinicaltrials.gov as NCT00390637.

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Fragility Vertebral Compression Fractures in Postmenopausal Women: The Role of a Fracture Liaison Service Program

The American Surgeon ◽

10.1177/0003134820933254 ◽

2020 ◽

pp. 000313482093325

Author(s):

Avery Jackson ◽

Tarik Wasfie ◽

Caramarie Brock ◽

Stefanija Galovska ◽

Melany Smalley ◽

...

Keyword(s):

Vitamin D ◽

Postmenopausal Women ◽

Fragility Fractures ◽

Fracture Liaison Service ◽

Vertebral Compression Fractures ◽

Compression Fractures ◽

Vitamin D Levels ◽

Group A ◽

Group B ◽

Fracture Liaison

Background As the aging population increases in the United States, so has the prevalence of osteoporosis (10.2 million adults aged 50 years and older in 2010). Programs to manage the increased incidence of fragility fractures in such patients particularly the postmenopausal women are the priority. Programs such as the Fracture Liaison Service (FLS) might be the answer. Methods Data of 256 postmenopausal women with vertebral compression fractures treated with vertebroplasty between 2012 and 2017 were divided into 2 groups. Group A were patients seen between 2012 and 2014 before the establishment of the FLS program at the clinic. Group B were patients seen between 2015 and 2017 who presented to the FLS program in our clinic. Data collected included demographics, refracture rates, dual-energy X-ray absorptiometry (DEXA) scan T-scores, fracture risk score (FRAX), serum calcium and vitamin D levels, and comorbid conditions. Results There were 103 female patients with a mean age of 79.75 years (standard deviation [SD] ± 10.86) in group A, while group B had 153 patients with a mean age of 75.66 years (SD ± 10.78). There was no significant difference in the DEXA scan T-scores, FRAX scores, and mean serum calcium and vitamin D levels; however, there was a significant reduction in the refracture rate for vertebral compression fractures ( P = .003). Conclusion FLS programs, when implemented, will have a beneficial effect in reducing refracture rates of postmenopausal women with osteoporotic fragility fractures.

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The Prebiotic Inulin Beneficially Alters the Gut Microbiome and Associated Metabolites in an APOE4 Mouse Model (P08-133-19)

Current Developments in Nutrition ◽

10.1093/cdn/nzz044.p08-133-19 ◽

2019 ◽

Vol 3 (Supplement_1) ◽

Author(s):

Lucille Yanckello ◽

Jared Hoffman ◽

Ishita Parikh ◽

Jessie Hoffman ◽

Stefan Green ◽

...

Keyword(s):

Gut Microbiota ◽

Gut Microbiome ◽

Dietary Intervention ◽

Disease Risk ◽

Short Chain Fatty Acids ◽

Apoe4 Allele ◽

Funding Sources ◽

Tryptophan Metabolites ◽

Host Metabolism ◽

Microbiota Diversity

Abstract Objectives The APOE4 allele is a genetic risk factor for certain diseases, due in part to alterations in lipid and glucose metabolism. The gut microbiota is also known to impact metabolic and can be beneficially modulated by prebiotics. Prebiotics are fermented into metabolites by the gut microbiota. These metabolites act as gut-brain axis components. However, the interaction of the APOE4 allele, gut microbiota, and prebiotics are unknown. The goal of the study was to use prebiotic diet to restore the gut microbiome of mice with human APOE4 (E4FAD) genes. We hypothesized that the microbial compositions of E4 mice fed inulin, compared to control fed, will correlate to metabolites being produced by the microbiome that confer benefit to host metabolism. Methods At 3 months of age the E4FAD mice were fed for 4 months with either control or inulin diet. We used 16S rRNA sequencing to determine gut microbiota diversity and species variations; non-targeted UPLC-MS/MS and GC-MS analysis was used to determine metabolic profiles of blood. Results The inulin fed mice showed a more beneficial microbial taxa profile than those mice that were control fed. Control mice showed higher levels of dimethylglycine, choline, creatine and the polyamine spermine. Higher levels of spermine, specifically, correlate to higher levels of the Proteobacteria which has been implicated in GI disorders. E4 inulin fed mice showed higher levels of bile acids, short chain fatty acids and metabolites involved in energy, increased levels of tryptophan metabolites and robust increases in sphingomyelins. Specifically in E4 inulin fed mice we saw increases in certain genera of bacteria, all of which have been implicated in being beneficial to the composition of the microbiome and producing one or more of the above mentioned metabolites. Conclusions We believe the disparities of microbial metabolite production between E4 inulin fed mice and E4 control fed mice can be attributed to differences in certain taxa that produce these metabolites, and that higher levels of these taxa are due to the dietary intervention of inulin. Despite the APOE4 allele increasing one's risk for certain diseases, we believe that beneficially modulating the gut microbiota may be one way to enhance host metabolism and decrease disease risk over time. Funding Sources NIH/NIDDK T323048107792, NIH/NIA R01AG054459, NIEHS/NIH P42ES007380. Supporting Tables, Images and/or Graphs

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Protein and Omega-3 Polyunsaturated Fatty Acid Supplementation for 16 Weeks Improves Sleep and Mood States in Postmenopausal Women

Current Developments in Nutrition ◽

10.1093/cdn/nzaa040_009 ◽

2020 ◽

Vol 4 (Supplement_2) ◽

pp. 9-9

Author(s):

Jamie Baum ◽

Aubree Hawley ◽

Caroline Baughn ◽

Sam Walker ◽

Angela Tacinelli ◽

...

Keyword(s):

Body Composition ◽

Sleep Quality ◽

Postmenopausal Women ◽

Dietary Intervention ◽

Sleep Time ◽

Protein Isolate ◽

Mood States ◽

Current Evidence ◽

Omega 3 ◽

Wrist Actigraphy

Abstract Objectives Body composition shifts as we age, resulting in loss of skeletal muscle mass with an increase in fat mass, which is linked to disruptions in sleep-wake rhythms and mood disturbance. Current evidence suggests protein and omega-3 polyunsaturated fatty acids (O3FA) individually augment sleep quality and attenuate depression, but a concomitant effect is yet to be determined. The objective of this study was to determine the effect of protein and O3FA supplementation on regulation of sleep and mood states in postmenopausal women. Methods Overweight, postmenopausal women (60.6 ± 9.0 years; BMI: 28.1 ± 6.9) participated in this randomized, controlled, single-blinded, 16 wk dietary intervention. Participants were allocated to 1 of 5 groups: 1) control, no INT (n = 6); 2) whey protein isolate (PRO; 25 g/d; n = 4); 3) O3FA (DHA/EPA; 4.3 g/d; n = 10); 4) PRO + soy bean oil (4.3 g/d) placebo (n = 6), and 5) PRO + O3FA (n = 8). Sleep (via Pittsburgh Sleep Quality Index Global Sleeping Score; PSQI GSS) and total mood disturbances; (TMD; via Profile of Mood States (POMS)) including six affect states of depression, fatigue, anger, tension, confusion, and vigor subscales were assessed at 0, 4, 8, 12, and 16 wks. Sleep was measured at 0, 8, and 16 wk via wrist Actigraphy. Body composition was measured via DXA at 0 and 16 wk. Data were analyzed using two-way ANOVA to assess the relationship between diet, sleep, and mood states over time. Results Overall, all interventions improved PSQI GSS (P < 0.05) by 16 wks. There was a trend for all interventions to improve sleep efficiency (P = 0.06), with no effect on total sleep time. All interventions improved TMD (P < 0.05) and vigor (P < 0.001), with a trend on depression (P = 0.06). PRO, O3FA, and O3FA + PRO significantly improved vigor at 12-wks (P < 0.01). PRO alone significantly improved vigor at 16 wk (P < 0.001) compared to CON. There was no significant effect of intervention on body composition. However, PRO, O3FA, and PRO + O3FA had a positive (564.7 ± 681.4 g) and the CON had a negative (−171.0 ± 991.6) net change of total lean mass at 16 wks. Conclusions This pilot study suggests that PRO, O3FA, and PRO + O3FA have potential to improve sleep and mood in overweight, postmenopausal women. Additional research is needed to determine the long-term individual and concomitant effect of PRO and O3FA on sleep and mood states. NCT0303041. Funding Sources Arkansas Biosciences Institute.

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Diet Intervention Alleviates Pruritus by Reducing Intestinal Inflammation to Improve Skin Health in Dogs (P09-001-19)

Current Developments in Nutrition ◽

10.1093/cdn/nzz033.p09-001-19 ◽

2019 ◽

Vol 3 (Supplement_1) ◽

Cited By ~ 1

Author(s):

Dayakar Badri ◽

Dennis Jewell ◽

Kiran Panickar

Keyword(s):

Dietary Intervention ◽

Intestinal Inflammation ◽

Fecal Calprotectin ◽

Major Protein ◽

Total Dietary Fiber ◽

Feeding Study ◽

Funding Sources ◽

Inflammatory Status ◽

Control Food ◽

The Mean

Abstract Objectives Pruritus is the most common reason for dog visits to veterinarians for dermatological diagnosis. Here we hypothesize that dietary intervention alleviates pruritus by reducing intestinal inflammation to improve skin health. Methods Control food (CF) and Test food (TF) were formulated to meet or exceed AAFCO nutritional recommendations. Difference between the foods was inclusion of grains in TF. Both foods had similar macronutrient levels (fat: 15.33% ± 1.73, protein: 16.57% ± 0.35, carbohydrate: 53.16% ± 1.15, crude fiber: 2.1% ± 0.1, total dietary fiber: 9.5% ± 0.3, moisture: 7.35% ± 0.08 and ash: 5.49% ± 0.05). A feeding study was performed with 15 derm disorder dogs (DD) and pair-matched 15 healthy dogs (HD). All dogs were pre-fed with maintenance food for 28 days and then randomized into 2 groups based on their age, gender and disease condition. A feeding study was performed using a cross-over design without a washout period and each phase was fed for 42 days. Fecal and blood samples were collected and assessment of skin symptoms was conducted by a veterinarian for all dogs at all phases of the study. Results DD increased the response rate 14.29% for pruritus reduction when fed TF compared with CF. Also, DD fed with TF decreased the mean level of fecal calprotectin (FC) (57.914 ng/g SE ± 52.26) compared with CF (129.09 ng/g SE ± 54.10). However, HD fed with TF showed no decrease in the mean level of FC (36.40 ng/g SE ± 6.49) compared with CF (33.68 ng/g SE ± 6.49). Number of DD that responded by decreasing FC levels increased to 42.86% fed with TF compared with CF. FC is a major protein released from neutrophils during the period of active inflammatory status and DD fed with TF increased the mean level of neutrophils count (4.28 k/µl SE ± 0.34) compared with CF (3.85 k/µl SE ± 0.34). However, HD fed with TF did not show any increase in the mean level of neutrophils count (3.97 k/µl SE ± 0.21) compared with CF (3.77 k/µl SE ± 0.22). Our results suggest that a decrease in FC levels with TF, likely indicating a reduction in the inflammatory status in the gut, was due to the addition of grains in TF. Conclusions TF intervention alleviates pruritus by reducing intestinal inflammation to improve skin health in dogs. Funding Sources This study was funded by Hill's Pet Nutrition, Inc.

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