scholarly journals The Use of Beetroot as Natural Solutions for Reducing Inflammation - Case Studies from Thailand (P12-046-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Daniela Assimiti
Keyword(s):  
Biological Response ◽  
Complete Recovery ◽  
Bell’S Palsy ◽  
Normal Function ◽  
The Body ◽  
Recurrent Pain ◽  
Bell's Palsy ◽  
Body Tissues ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Abstract Objectives Introduction: Inflammation is a complex biological response of the body tissues to foreign particles or pathogens.Research shows that an alkaline state maintained by the cells is healthier while an acidic pH increases the risk for numerous problems including chronic inflammation. The usual adverse effects of the anti-inflammatory drugs, necessitate the search for novel compounds of herbal origin. Red beetroot (Beta vulgaris rubra), is a vegetable plant known to possess various beneficial properties and is considered as a promising therapeutic tool in a range of clinical pathologies associated with oxidative stress and inflammation due to the betalain pigments contained. The present study refers to three cases suggesting options in which beetroot might be used to handle in different situations of inflammation. Methods Case description: Raw beetroot was administered as a common, affordable, safe to use natural remedies and a possible alternative to the common pharmaceutical over-the-counter anti-inflammatory drugs. Its efficiency was evaluated in few particular situations involving inflammation, as : episodes of gingivitis and toothache, migraine headaches, or as part of a more elaborate plan to recover from Bell's palsy. All three cases are individuals in the age range 50–65. Results Eating raw beetroot and chewing thoroughly proved to be an efficient way to alleviate symptoms of gingivitis (probably linked to tooth infection). Gum inflammation was fully resolved within a week. In another case, it helped reduce deep pulsating headache and recurrent pain which prevented sleep as well as ease of the tension, thus headache was ameliorated within 30 min and good night rest could be resumed. Another challenge was given to help accelerate recovering from Bell's palsy condition (this time, under a more elaborate plan which included also vitamin B12 supplements and massage therapy) and the complete recovery and returning to normal function could be obtained within 8 weeks instead of 3–6 months. Conclusions Beetroot proved to be a potential highly effective anti-inflammatory remedy, easy accessible and safe to use. Further investigations would be essential in order to validate the bioactive components involved, its efficiency in other forms of inflammation and implications for clinical practice, as well as defining the best way to use it. Funding Sources No.

scholarly journals COMPLETE MANAGEMENT OF ARDITA (BELL’S PALSY) AS PER AYURVEDA CHIKITSA SUTRA – A CASE REPORT

2021 ◽  
Vol 09 (3) ◽  
pp. 650-656
Author(s):  
Ram Lakhan Meena ◽  
Santoshkumar Bhatted ◽  
Nilam Meena
Keyword(s):  
Case Report ◽  
Adverse Effects ◽  
Facial Nerve ◽  
Present Report ◽  
Complete Recovery ◽  
Bell’S Palsy ◽  
Bell's Palsy ◽  
Contemporary Science ◽  
The Face ◽  
Grading Scale

Bell’s palsy, also known as acute idiopathic lower motor neuron facial paralysis, is characterized by sud-den onset paralysis or weakness of the muscles to one side of the face controlled by the facial nerve. In contemporary science, administration of steroids is the treatment of choice for complete facial palsy. Cer-tain Panchakarma procedures and internal Ayurvedic medicines have been proved to be beneficial in the management of Ardita vata. The present report deals with a case of 62-year-old male patient diagnosed as Ardita vata was treated with various Panchakarma procedures like Nasya, Shirobasti, Kukkutanda Swedana, Dashmoola Ksheer Dhoom, Gandoosh and oral Ayurveda medicines. Criteria of assessment was based on the scoring of House-Brackmann Facial Nerve Grading scale. After completion of Ayurveda treatment, the patient Shown almost complete recovery without any adverse effects. This case is an evi-dence to demonstrate the effectiveness of Ayurveda treatment in case of Ardita vata (Bell’s palsy).

Non-steroidal anti-inflammatory drugs for the prevention of post-endoscopic retrograde cholangiography pancreatitis Short title: Post-ERCP pancreatitis prevention

2020 ◽  
Vol 1 (1) ◽  
Author(s):  
Mirghani HO
Keyword(s):  
Diclofenac Sodium ◽  
Route Of Administration ◽  
The Body ◽  
Endoscopic Retrograde ◽  
Randomized Controlled Studies ◽  
Conflicting Objectives ◽  
The Usa ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Background: Post-endoscopic retrograde cholangiopancreatography pancreatitis (PEP) is a serious disease. The role of nonsteroidal anti-inflammatory drugs (NSAIDs) in the prevention of PEP is conflicting. Objectives: This review aimed to assess the preventive role of NSAIDs in PEP with special emphasis on the dose and route of administration. Methods: We searched PubMed and Google Scholar for relevant observational studies published in English during the period from January 2010 to January 2020. The terms post-ERCP pancreatitis, diclofenac sodium, indomethacin, NSAIDs, dose, route of administration were used. Results: Of the 179 identified, 19 full texts were screened and included in the review. Ten studies were from Europe, seven from Asia and two were published in the USA, the studies showed that NSAIDs were effective in preventing PEP when used rectally or intramuscularly, higher doses are more efficacious and the combination with stents was not superior, careful patients selection is needed in particular regarding the body mass index. Conclusion: NSAIDs were effective in PEP prevention; however, the evidence is weak due to the observational nature and the different methods used in the included studies. Randomized controlled studies are needed to solve the issue.

scholarly journals Association of Patients’ Characteristics with Acupuncture Treatment Outcomes in Treating Bell’s Palsy: Results from a Randomised Controlled Trial

2019 ◽  
Vol 2019 ◽  
pp. 1-7
Author(s):  
Xianjun Xiao ◽  
Qianhua Zheng ◽  
Yunzhou Shi ◽  
Leixiao Zhang ◽  
Ling Zhao ◽  
...  
Keyword(s):  
Acupuncture Treatment ◽  
Controlled Trial ◽  
Secondary Analysis ◽  
Complete Recovery ◽  
Bell’S Palsy ◽  
Acute Stage ◽  
Chorda Tympani ◽  
Bell's Palsy ◽  
Significant Difference ◽  
Multicenter Randomized Controlled Trial

Background. Acupuncture has been found to be effective for treating Bell’s palsy (BP). However, which class of BP patients will have a better response to acupuncture remains uncertain and requires investigation. Methods. We performed a secondary analysis of a multicenter, randomized, controlled trial. BP patients were randomly divided into five acupuncture treatment groups. The degree of facial nerve recovery was assessed according to the House–Brackmann grading system (HB grade). Grade I was defined as complete recovery (CR), and grades II–VI were defined as incomplete recovery (IR). The relevant patient characteristics were collected and compared between CR and IR groups by univariate and logistic regression analyses. Results. Eight-hundred twenty-six subjects were analyzed. Among these, 698 (85%) subjects had a good prognosis. No significant difference in the effectiveness of the five treatments was observed (all P>0.05). The likelihood of IR increased by 2.2% with each one-year increase in age (odds ratio (OR) 1.022, 95% confidence interval (CI) 1.005–1.038; P=0.009). The likelihood of IR increased by 9% with each kg/m2 increase in BMI (OR 1.090, 95% CI 1.019–1.165; P=0.012). The likelihood of IR at the recovery stage was higher than that at the acute stage (OR 7.996, 95% CI 4.570–13.991; P<0.001), and the likelihood of IR of patients with lesions at or above the chorda tympani was higher than that of patients with lesions below the chorda tympani (OR 1.989, 95% CI 1.256–3.150; P=0.003). The likelihood of IR increased by 281.7% with each unit increase in the HB grade (OR 2.817, 95% CI 2.113–3.756; P<0.001). Conclusions. Younger patients at the acute stage of the disease with low BMIs, low initial HB grades, and lesions below the chorda tympani were more likely to respond to acupuncture.

scholarly journals The drug likeness analysis of anti-inflammatory clerodane diterpenoids

2020 ◽  
Vol 15 (1) ◽  
Author(s):  
Zheling Feng ◽  
Jun Cao ◽  
Qingwen Zhang ◽  
Ligen Lin
Keyword(s):  
Marine Sponges ◽  
The Body ◽  
Low Grade ◽  
Active Defense ◽  
Inflammatory Drugs ◽  
Clerodane Diterpenoids ◽  
Anti Inflammatory ◽  
External Stimuli

AbstractInflammation is an active defense response of the body against external stimuli. Long term low-grade inflammation has been considered as a deteriorated factor for aging, cancer, neurodegeneration and metabolic disorders. The clinically used glucocorticoids and non-steroidal anti-inflammatory drugs are not suitable for chronic inflammation. Therefore, it’s urgent to discover and develop new effective and safe drugs to attenuate inflammation. Clerodane diterpenoids, a class of bicyclic diterpenoids, are widely distributed in plants of the Labiatae, Euphorbiaceae and Verbenaceae families, as well as fungi, bacteria, and marine sponges. Dozens of anti-inflammatory clerodane diterpenoids have been identified on different assays, both in vitro and in vivo. In the current review, the up-to-date research progresses of anti-inflammatory clerodane diterpenoids were summarized, and their druglikeness was analyzed, which provided the possibility for further development of anti-inflammatory drugs.

Pathogenesis of Bell's Palsy

1977 ◽  
Vol 86 (4) ◽  
pp. 549-558 ◽  
Author(s):  
Ruth Gussen
Keyword(s):  
Facial Nerve ◽  
Complete Recovery ◽  
Bell’S Palsy ◽  
Facial Canal ◽  
Chorda Tympani ◽  
Bell's Palsy ◽  
Nerve Branch ◽  
Collagen Formation ◽  
Myelin Sheaths ◽  
Metabolic Exchange

The pathogenesis of Bell's palsy is presented as retrograde epineurial compression edema with ischemia of the facial nerve. Although the etiology is unknown, an attractive theory is vasospasm, from any cause, along any facial nerve branch, with the chorda tympani, perhaps, the usual primary involvement. Retrograde vascular distension and edema, within the epineurium of the bony facial canal, compresses the nerve from outside its perineurial sheath. The compression force may be mild or severe, resulting in varying degrees of reversible or irreversible ischemic degeneration of myelin sheaths and axons, with varying degrees of cellular reaction to myelin breakdown. The edema may be resorbed, leaving reversible or irreversible nerve damage, or may stimulate collagen formation within the epineurium, with persisting fibrous compression (entrapment) neuropathy of the facial nerve. This concept is consistent with the varying results of Bell's palsy, and depends on the severity and duration of edema, and whether fibrosis occurs within the epineurium of the facial canal. Epineurial fibrosis also results in disturbance of metabolic exchange through the epineurial-permeurial-endoneurial tissues, and may ultimately result in obliteration of vascular drainage. Two temporal bone cases of Bell's palsy, one occurring ten years before death, with residual paralysis. and one two years before death, with clinical recovery, are added to the previously described four cases in the literature, three of early Bell's palsy, and one of remote palsy with almost complete recovery.

Outcome of Treatment with Valacyclovir and Prednisone in Patients with Bell's Palsy

2003 ◽  
Vol 112 (3) ◽  
pp. 197-201 ◽  
Author(s):  
Sara Axelsson ◽  
Sven Lindberg ◽  
Anna Stjernquist-Desatnik
Keyword(s):  
Treatment Group ◽  
Medical Treatment ◽  
Antiviral Drug ◽  
Complete Recovery ◽  
Bell’S Palsy ◽  
Adult Patients ◽  
University Hospital ◽  
Control Group ◽  
Type I ◽  
Bell's Palsy

Idiopathic facial paralysis, or Bell's palsy, shows a nonepidemic pattern that might indicate reactivation of a latent microorganism such as herpes simplex type I as a causative agent. Thirty percent of patients with Bell's palsy given no treatment will not recover completely, and 5% will have severe sequelae. The aim of this study was to find out whether treatment with an antiviral drug in combination with corticosteroids is more effective than no medical treatment at all in patients with Bell's palsy. Fifty-six consecutive adult patients attending the otorhinolaryngology department of the University Hospital of Lund from 1997 to 1999 were treated with 1 g of valacyclovir hydrochloride 3 times per day for 7 days and 50 mg of prednisone daily for 5 days, with the dose being reduced by 10 mg daily for the next 5 days. Fifty-six adult patients with Bell's palsy attending the same department between 1995 and 1996 who were given no medical treatment were studied retrospectively and used as the control group. Forty-nine patients (87.5%) in the treatment group recovered completely, as compared with 38 patients (68%) in the control group (p <.05). One patient (1.8%) in the treatment group displayed severe sequelae, defined as a House-Brackmann score of IV or worse, as compared with 10 of 56 patients (18%) in the control group (p <.01). Among patients over 60 years old, 10 of 10 in the treatment group had complete recovery, as compared with 5 of 12 patients in the control group (p <.01). The present study showed a significantly better outcome in patients with Bell's palsy treated with valacyclovir and prednisone as compared with patients given no medical treatment. This difference in outcome was especially pronounced among elderly patients.

scholarly journals Role of Neuromuscular Electrical Stimulation in Bell’s Palsy: A Case Study of Three Patients

2021 ◽  
Vol 6 (4) ◽  
pp. 235-241
Author(s):  
Nasrin Bharti
Keyword(s):  
Electrical Stimulation ◽  
Neuromuscular Electrical Stimulation ◽  
Complete Recovery ◽  
Daily Basis ◽  
Bell’S Palsy ◽  
Bell's Palsy ◽  
Early Management ◽  
The Face ◽  
Conventional Physiotherapy

Bell's palsy is an idiopathic, unilateral facial paralysis, caused by a malfunction anywhere along the facial nerve's peripheral portion, from the pons distally. Bell's palsy is treated by removing the cause of nerve injury, strengthening the face muscles, and restoring facial function. Physical therapy in the form of neuromuscular electrical stimulation (NMES), massage and facial exercises is used as adjuvant to hasten recovery. The aim of this study is to access of role of neuromuscular electrical stimulation (NMES) treatment in Bell’s palsy patients. A detailed neurological assessment of three patients was done with emphasis on facial muscles and severity of paralysis was graded according to House Brackmann scale (HBS). Conventional physiotherapy was given in the form of electrical stimulation, facial massage, exercises and functional re-education on a daily basis. Patients were assessed at weekly and 1months after the treatment. They experienced complete recovery within 1month follow-up, no recurrence was observed and all patients have normal facial movement. Physiotherapy in the form of NMES and facial exercises has a effective role in the early management of Bell’s palsy. Keywords: Bell’s palsy; neuromuscular electrical stimulation; House Brackmann scale; physiotherapy.

Synthesis and Evaluation of Glycyrrhetic Acid-aromatic Hybrids as Anti-inflammatory Agents

2020 ◽  
Vol 16 (6) ◽  
pp. 715-723
Author(s):  
Zhi Chen ◽  
Shi-Chao Chen ◽  
Bo Li ◽  
Yong-An Yang ◽  
Jing Zhang
Keyword(s):  
Biological Response ◽  
Glycyrrhetic Acid ◽  
X Ray Diffraction ◽  
X Ray ◽  
New Class ◽  
Structure Activity ◽  
Body Tissues ◽  
Ic50 Values ◽  
Anti Inflammatory ◽  
Sar Study

Background: : Inflammation is a biological response of body tissues to harmful stimuli, so it is desirable to search for novel anti-inflammatory agents with improved pharmaceutical profiles and reduced adverse effects. Objective: : This study was to explore natural anti-inflammatory agents and improve therapeutic application of glycyrrhetic acid (GA) through molecular hybridization with active aromatics. Methods: : Fourteen novel GA-aromatic hybrids were synthesized and evaluated for their antiinflammatory activities by inhibiting LPS-induced nitric oxide (NO) release in RAW264.7 cells. The synthesized compounds were characterized by single-crystal X-ray diffraction, 1H NMR, 13C NMR and HRMS. Result: : The structure-activity relationship (SAR) study indicated that compounds with styryl displayed better NO inhibitory activity. Among them, compounds 2a and 3c exhibited the most promising activity with IC50 values of 9.93 μM and 12.25 μM, respectively. In addition, X-ray singlecrystal diffraction data for compounds 2e and 3c showed that the absolute configuration of GA skeleton was consistent with that of natural 18 β-glycyrrhetic acid. Conclusion: : The results showed that GA-aromatic hybrids were a new class of anti-inflammatory agents and this study provided useful information on further optimization.

Bell's palsy

2021 ◽  
Vol 14 (12) ◽  
pp. 733-741
Author(s):  
Frith Cull ◽  
Holli Coleman
Keyword(s):  
Facial Nerve ◽  
Complete Recovery ◽  
Rapid Onset ◽  
Bell’S Palsy ◽  
Bell's Palsy ◽  
Ocular Complications ◽  
The United Kingdom ◽  
Common Diagnosis ◽  
Nerve Paresis ◽  
And Function

Bell's palsy is the term given to an idiopathic lower motor neurone facial nerve paresis or paralysis. It is of rapid onset, almost always unilateral, and may be associated with facial or retro-auricular pain or otalgia. It is the most common diagnosis associated with facial nerve palsy; a GP will see a case approximately every 2 years in practice in the United Kingdom. Early diagnosis and steroid treatment increase the likelihood of full recovery, whereas ocular complications can be prevented by lubricants and lid taping. Over 70% of patients recover within a year. Options to improve facial appearance and function, in those who do not experience a complete recovery, include surgery.

scholarly journals Bell’s Palsy: Symptoms Preceding and Accompanying the Facial Paresis

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Daniele De Seta ◽  
Patrizia Mancini ◽  
Antonio Minni ◽  
Luca Prosperini ◽  
Elio De Seta ◽  
...  
Keyword(s):  
Facial Pain ◽  
Early Period ◽  
Complete Recovery ◽  
Bell’S Palsy ◽  
Dry Mouth ◽  
Bell's Palsy ◽  
Facial Paresis ◽  
Maximum Delay ◽  
Severe Grade ◽  
Nervus Intermedius

This individual prospective cohort study aims to report and analyze the symptoms preceding and accompanying the facial paresis in Bell’s palsy (BP). Two hundred sixty-nine patients affected by BP with a maximum delay of 48 hours from the onset were enrolled in the study. The evolution of the facial paresis expressed as House-Brackmann grade in the first 10 days and its correlation with symptoms were analyzed. At the onset, 136 patients presented postauricular pain, 114 were affected by dry eye, and 94 reported dysgeusia. Dry mouth was present in 54 patients (19.7%), facial pain, hyperlacrimation, aural fullness, and hyperacusis represented a smaller percentage of the reported symptoms. After 10 days, 39.9% of the group had a severe paresis while 10.2% reached a complete recovery. Dry mouth at the onset was correlated with severe grade of palsy and was prognostic for poor recovery in the early period. These outcomes lead to the deduction that the nervus intermedius plays an important role in the presentation of the BP and it might be responsible for most of the accompanying symptomatology of the paresis. Our findings could be of important interest to early address a BP patient to further examinations and subsequent therapy.

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