scholarly journals Rapid Identification of Psychopharmacologic Agents in Cases of Drug Abuse

1972 ◽  
Vol 18 (5) ◽  
pp. 405-409 ◽  
Author(s):  
David Sohn ◽  
Julius Simon
Keyword(s):  
Gas Chromatography ◽  
Drug Abuse ◽  
Thin Layer ◽  
Thin Layer Chromatography ◽  
Drug Overdose ◽  
Rapid Identification ◽  
Suspected Drug ◽  
Toxic Agents ◽  
Layer Chromatography

Abstract When a patient is hospitalized in coma with suspected drug overdose, rapid identification of psychopharmacologic or toxic agents is essential. Methods for excluding other common toxic agents are indicated. Psychomimetic drugs that should be identified are enumerated. Screening by thin-layer chromatography is suggested as the method of choice, with confirmation or quantification by gas chromatography. Appropriate references to current methodology are appended.

Detection of pentazocine and tripelennamine in urine.

1981 ◽  
Vol 27 (1) ◽  
pp. 10-13 ◽  
Author(s):  
R W Reid ◽  
C M Gerbeck
Keyword(s):  
Gas Chromatography ◽  
Drug Abuse ◽  
Thin Layer ◽  
Thin Layer Chromatography ◽  
Chemical Ionization ◽  
Mass Spectrometric ◽  
Routine Screening ◽  
Ionization Mode ◽  
Layer Chromatography ◽  
Chromatographic Mass

Abstract Pentazocine and tripelennamine can be identified in urine as a part of routine screening for drug abuse. Pentazocine, pentazocine hydrate, and tripelennamine can be detected by thin-layer chromatography of chloroform/isopropanol extracts of heat- and acid-hydrolyzed urine. Gas chromatography is used for confirmation. Gas chromatographic/mass spectrometric studies (chemical ionization mode) show that such extracts contain major molecular (M+) ions of m/e 256, 286, and 304, indicating the presence of tripelennamine, pentazocine, and pentazocine hydrate, respectively.

Thin-layer chromatography and gas chromatography-mass spectrometry examination of shoe materials from patients with shoe dermatitis

2015 ◽  
Vol 72 (4) ◽  
pp. 248-252 ◽  
Author(s):  
Sri A. Febriana ◽  
Erik Zimerson ◽  
Cecilia Svedman ◽  
Winarto Haryadi ◽  
Pieter-Jan Coenraads ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Gas Chromatography ◽  
Thin Layer ◽  
Thin Layer Chromatography ◽  
Gas Chromatography Mass Spectrometry ◽  
Chromatography Mass Spectrometry ◽  
Layer Chromatography

Quantitative Determination of Vitamin E Isomers using Gas Chromatography, High Performance Liquid Chromatography and High Performance Thin Layer Chromatography

2017 ◽  
Vol 54 (3) ◽  
pp. 294
Author(s):  
Hari Ramakrishnan K. ◽  
Janaky Ranjithkumar
Keyword(s):  
Gas Chromatography ◽  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
Vitamin E ◽  
Thin Layer ◽  
Thin Layer Chromatography ◽  
High Performance ◽  
Highly Sensitive ◽  
Layer Chromatography

Vitamin E, the fat soluble vitamin is present naturally in some foods and added in food supplements, nutraceuticals etc due to its vital biological function as an antioxidant. Various methods are available for the analysis of vitamin E. Especially High Performance Liquid Chromatography (HPLC) and Gas Chromatography (GC) are exclusively used for the quantitative evaluation of vitamin E, which has also identified the four different isomeric forms of this vitamin. The rate of losses of this vitamin during food processing and analysis, in addition to their transient dynamics, presents complexities in developing a highly sensitive procedure for their separations. Though effective, HPLC instrument is expensive and comparatively cumbersome. In this prospective, the study was to evaluate the usefulness of High Performance Thin Layer Chromatography (HPTLC) in the analysis of vitamin E. There are methods available using Thin Layer Chromatography for its analysis, but they are not sensitive enough to identify the isomeric forms of vitamin E. In this HPTLC method, the different isomeric forms of vitamin E - α, β, γ and δ were identified. This technique shall be considered as an alternative to the other methods such as HPLC and GC.

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