Role of low-density lipoproteins in atherogenesis and development of coronary heart disease
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Abstract There is a strong association between increased blood concentrations of low-density lipoprotein (LDL) and severity of coronary atherosclerosis. Multiple mechanisms affect hypercholesterolemia, e.g., diet, aging, hormones, and genetics. LDL receptors apparently are also important--through down-regulation, defects in structure, or decreased numbers--as are changes in LDL binding characteristics caused by alterations in apolipoprotein B content or structure. Current concepts of LDL metabolism are extensively reviewed, including the role of modified or oxidized LDL in atherogenesis.
1979 ◽
Vol 83
(3)
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pp. 588-594
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2005 ◽
Vol 35
(3)
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pp. 531-545
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2019 ◽
Vol 26
(9)
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pp. 1512-1524
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2005 ◽
Vol 12
(1)
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pp. 68-75
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1993 ◽
Vol 4
(5)
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pp. 373-381
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1979 ◽
Vol 10
(2)
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pp. 173-178
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