scholarly journals Anti-anxiety Activity Studies on Homoeopathic Formulations ofTurnera aphrodisiacaWard

2005 ◽  
Vol 2 (1) ◽  
pp. 117-119 ◽  
Author(s):  
Suresh Kumar ◽  
Anupam Sharma
Keyword(s):  
Elevated Plus Maze ◽  
Biological Effects ◽  
Anxiolytic Activity ◽  
Biologically Active ◽  
Active Constituent ◽  
Anxiety Neurosis ◽  
Plus Maze ◽  
Ethanol Extracts ◽  
Herbal Formulations ◽  
Bioactive Constituent

Turnera aphrodisiacaWard (Turneraceae) has been traditionally used for the treatment of anxiety neurosis, and as an aphrodisiac. Mother tinctures (85% ethanol extracts) ofT. aphrodisiacahave also been used for the treatment of central nervous system disorders. In the present investigation,T. aphrodisiacamother tinctures formulated by three reputed manufacturers of homoeopathic medicines (NLK, DWSG and SBL) were evaluated for their anxiolytic activity. Dried mother tinctures ofT. aphrodisiacawere subjected to anxiolytic activity evaluation at various doses, i.e. 50, 75, 100, 125 or 150 mg/kg p.o. in mice using elevated plus maze apparatus. Dried mother tinctures exhibited significant anxiolytic activity at 50 mg/kg (NLK), 75 mg/kg (DWSG) and 125 mg/kg (SBL), respectively, with reference to control as well as standard (diazepam, 2 mg/kg p.o.). Mother tinctures ofT. aphrodisiacaavailable in the market, have significant anxiolytic activity. Amongst the three mother tinctures ofT. aphrodisiacaanalyzed, the dry residue of NLK possesses the highest amount of anxiolytic constituent(s). To ensure uniformity and consistency of biological effects in herbal formulations, these should be standardized on the basis of bioactive markers. The authors are actively involved in isolating the bioactive constituent(s) fromT. aphrodisiacaso that the plant can be standardized on the basis of biologically active constituent(s).

scholarly journals The novel dipeptide ligand of TASP

2019 ◽  
Vol 484 (2) ◽  
pp. 228-232
Author(s):  
O. A. Deeva ◽  
A. S. Pantileev ◽  
I. V. Rybina ◽  
M. A. Yarkova ◽  
T. A. Gudasheva ◽  
...  
Keyword(s):  
Elevated Plus Maze ◽  
Open Field Test ◽  
Anxiolytic Activity ◽  
The Novel ◽  
Minimum Effective Dose ◽  
Elevated Plus Maze Test ◽  
Maze Test ◽  
Plus Maze ◽  
Order Of Magnitude ◽  
Preliminary Administration

Using the previously obtained first dipeptide ligand TSPO the N‑carbobenzoxy-L‑tryptophanyl-L‑isoleucine amide (GD‑23) as a basis, the new dipeptide was synthesized — the N‑phenylpropionyl–L‑tryptophanyl-L‑leucine amide (GD‑102). GD‑102 expressed anxiolytic activity in the open field test in BALB/c mice and in the elevated plus maze test in ICR mice. The minimum effective dose of GD‑102 was an order of magnitude lower than that of GD‑23. Preliminary administration of the TSPO selective antagonist, compound PK11195, completely blocked the anxiolytic activity of GD‑102, that indicated the participation of TSPO in the realization of the anxiolytic action GD‑102. The results were confirmed by molecular docking data.

scholarly journals Evaluation of antianxiety effect of cinnamaldehyde in swiss albino mice

2019 ◽  
Vol 9 (1) ◽  
pp. 85
Author(s):  
Ritesh Churihar ◽  
Sapna A. More ◽  
Pooja S. Mishra ◽  
Savita Vyas ◽  
Hemant Tanwani
Keyword(s):  
Elevated Plus Maze ◽  
Anxiolytic Effect ◽  
Volatile Oil ◽  
Antioxidant Property ◽  
Anxiolytic Activity ◽  
Protective Effects ◽  
Standard Drug ◽  
Group I ◽  
Plus Maze ◽  
Per Se

Background: Cinnamon is one of the best known spices used as an herbal medicine. Cinnamaldehyde (CNM) the volatile oil, which was present in the essential oil of the bark, is the important constituents of cinnamon. Cinnamon has been investigated for its various effects like peptic ulcer protection, antioxidant property, inhibition of tau aggregation, anti-inflammatory activity, effect on cardiovascular system, anti-nociceptive activity, hepato-protective effects, hypolipidemic and antidiabetic activites. The present study was aimed to evaluate the anxiolytic effect of CNM per se and its interaction with diazepam in swiss albino mice.Methods: Anxiolytic activity was evaluated by elevated plus maze method. A group of 36 healthy mice of either sex weighing 20-30 grams were divided at random into six groups (n=6). CNM and diazepam were dissolved in tween twenty 20% to maintain uniformity of the solvent and given orally. Group I was given twenty 20% (10 ml/kg, p.o.), group II diazepam (0.5 mg/kg, p.o.), group III diazepam (1 mg/kg, p.o.), group IV cinnamaldehyde (100 mg/kg, p.o.), group V cinnamaldehyde (200 mg/kg, p.o.), group VI cinnamaldehyde and diazepam (100 mg/kg and 0.5 mg/kg, p.o.).Results: Cinnamaldehyde per se showed no anxiolytic effect at any dose (p<0.05). The standard drug diazepam has shown significant anxiolytic activity on elevated plus maze. Whereas combination of diazepam 0.5 mg/kg and cinnamaldehyde 100 mg/kg showed significant increase in the time spent in open arms as compared to all groups (p<0.05).Conclusions: CNM per se did not show any effect on anxiety but enhanced the action of diazepam when co-administered.

scholarly journals ANTIANXIETY EFFECT OF ETHANOLIC EXTRACT OF FRUITS OF LIMONIA ACIDISSIMA IN SWISS ALBINO MICE

2021 ◽  
Vol 6 (8) ◽  
pp. 104-117
Author(s):  
Chouhan Vaishali ◽  
Sujane Sandhya ◽  
Bapna Rajendra ◽  
Pyathi Asharani
Keyword(s):  
Elevated Plus Maze ◽  
Treatment Options ◽  
Ethanolic Extract ◽  
Anxiolytic Effect ◽  
Ethanol Extract ◽  
Active Constituent ◽  
Swiss Albino Mice ◽  
Plus Maze ◽  
Albino Mice ◽  
Limonia Acidissima

Anxiety disorder is one of the most common mental ailments exhibited by human. It is characterized by motor tension, sympathetic hyperactivity and apprehension and vigilance syndromes. A part from very few chemical remedies available like benzodiazepine and serotonin modulators, not much treatment options are at hand that safely and effectively alleviate anxiety. The ethanol extract of the fruits of plant Limonia acidissima was evaluated for its anti-anxiety activity in swiss albino mice at dose 200mg/kg and 400mg/kg body weight. Anti-anxiety was assessed by using elevated plus maze (EPM) and light and dark model methods. The ethanolic extract exhibit anxiolytic effect in experimental mice. So it is supports the use of Limonia acidissima as anxiolytic agents. Further investigation should be made to elucidate the active constituent of responsible for the activity.

scholarly journals Anxiolytic activity of aerial part hydroethanolic extract of Allium ascalonicum Linn. (Liliaceae) in mice

2012 ◽  
Vol 2 (11) ◽  
pp. 448 ◽  
Author(s):  
Abidemi J. Akindele ◽  
Hakeem A. Sanni ◽  
Pamela C. Edeh
Keyword(s):  
Social Interaction ◽  
Open Field ◽  
Aerial Part ◽  
Elevated Plus Maze ◽  
Anxiolytic Activity ◽  
Elevated Plus Maze Test ◽  
Plus Maze ◽  
Hole Board ◽  
Hole Board Test ◽  
Hydroethanolic Extract

Background: Allium ascalonicum Linn. (Liliaceae) is a mildly aromatic annual herb used to flavor food. Ethnobotanical survey revealed application of A. ascalonicumin the treatment of central nervous system (CNS) disorders.  Objective: To investigate the anxiolytic activity of aerial part hydroethanolic extract of A. ascalonicum. Methods: The hole-board, elevated plus maze, light/dark exploration, open field and social interaction tests were used in this study. Groups of mice were treated orally with distilled water (10 ml/kg), diazepam (1 mg/kg), and A. ascalonicum (50-400 mg/kg). Evaluations were done 1 h post-treatment and the duration of observation was mostly 5 min. In the hole-board test, mice were observed for number/duration of head dips and number of sectional crossings. In the elevated plus maze test, the time spent in the open/closed arms and the number of entries by mice were observed. In the light/dark exploration test, the latency of entry into the dark box, time spent in the light and dark compartments, number of rearing and assisted rearing were determined. In respect of the open field test, observations were made for the number of rearing, assisted rearing, and sectional crossings. In the social interaction test, pairs of mice were observed for number of interactions including sniffing, following, and partner grooming. Results: In the hole-board test, A. ascalonicum significantly (p<0.05, 0.01) increased the number/duration of head dips and number of sectional crossings. In the elevated plus maze test, A. ascalonicum significantly (p<0.05) increased the number of entries into the open arm with corresponding reduction in number of entries into the closed arm. In the light/dark exploration test, A. ascalonicum significantly (p<0.05, 0.01) increased the latency of entry into the dark box, time spent in the light box, and number of rearing and assisted rearing. In respect of the open field test, A. ascalonicum significantly (p<0.05, 0.01) increased the number of sectional crossings and rearing. Considering the social interaction test, A. ascalonicum significantly (p<0.05) increased the number of interactions. Peak anti-anxiety effects were mostly observed at the dose of 100 mg/kg. Conclusion: The aerial part hydroethanolic extract of Allium ascalonicum possesses anxiolytic properties. Keywords: Allium ascalonicum, Liliaceae, anxiolytic activity, medicinal plants, traditional medicine.

GABA and 5-HT Receptor Mediated Anxiolytic Effect of Essential Oil of Ferula sumbul Hook. Roots

2020 ◽  
Vol 10 (3) ◽  
pp. 262-271
Author(s):  
Sonali Batra ◽  
Ashwani Kumar ◽  
Anupam Sharma
Keyword(s):  
Essential Oil ◽  
Receptor Antagonist ◽  
Open Field ◽  
Gaba Receptors ◽  
Elevated Plus Maze ◽  
Anxiolytic Effect ◽  
Anxiolytic Activity ◽  
Ms Analysis ◽  
Significant Reversal ◽  
Plus Maze

Background: Ferula sumbul Hook. (Umbelliferae) roots have been traditionally used as sedative in nervous disorders. Objective: The present study identifies the components of essential oil of F. sumbul roots (EOFS) using GC-MS analysis and further evaluates mechanism-based anxiolytic potential of oil. Materials and Methods: EOFS was extracted using Clevenger apparatus, and was screened for anxiolytic activity using an elevated plus maze model. A battery of models was subsequently used to confirm the anxiolytic potential of EOFS. Further, benzodiazepine (BZD) receptor antagonist flumazenil and pentylenetetrazole (PTZ) were used for investigating the possible involvement of GABA receptors. Results: GC-MS analysis of EOFS revealed the presence of 32 components comprising triterpenoids and their derivatives. The oil exhibited significant anxiolytic activity at 50 μl/kg in various models like the elevated plus maze, light/dark, mirror chamber, open-field and mCPP-induced anxiety. The observation that anxiolytic effect of EOFS was completely blocked by benzodiazepine (BZD) receptor antagonist flumazenil, and partially by pentylenetetrazole, clearly demonstrates that anxiolytic activity of the oil is mediated mainly through BZD site on GABA receptors. Further, a significant reversal of mCPP induced anxiety by EOFS strongly indicates the possible involvement of 5-HT receptors in mediating anxiolytic activity of the oil. Conclusion: Results of the present study clearly demonstrates the anxiolytic potential of EOFS and, thus, validates the traditional relevance of the plant. This is the first report not only on multi-model based antianxiety activity of EOFS but also on the possible antianxiety mechanism of the oil.

scholarly journals Anxiolytic activity of hydro-alcohol extract of Trema guineensis and its effect on behavioral activities of mice

2020 ◽  
Vol 9 (8) ◽  
pp. 1186
Author(s):  
Bakou Niangoran Francois ◽  
Kpahe Ziehi Fidele ◽  
Horo Yodanatchio Jules ◽  
Atayi Eugene
Keyword(s):  
Anxiety Disorders ◽  
Therapeutic Agent ◽  
Elevated Plus Maze ◽  
Ethanolic Extract ◽  
Anxiolytic Activity ◽  
Alcohol Extract ◽  
Plus Maze ◽  
Hole Board ◽  
Behavioral Activities

Background: Objective was to study the anxiolytic activity of hydro ethanolic extract of Trema guineensis.Methods: Male swiss albino mice were used. Hydro ethanolic extract of Trema guineensis was administered in the doses of 5, 10 and 20 mg/kg IP hole board (HB), open field (OF), elevated plus maze (EPM) tests were used for determination of anxiolytic activity.Results: The hydro ethanolic extract of Trema guineensis significantly increased the number and duration of head poking in HB test. The extract also significantly increased the time spent and the number of entries in open arm in EPM. In OFT, the extract showed significant increase in number of rearing, assisted rearing and the squares crossed.Conclusions: In the present study, Trema guineensis exhibited anxiolytic activity which might be attributed to its phytoconstituents like alkaloid, steroid and triterpenes. Since Trema guineensis is ubiquitous and abundantly grown, it could be a fairly economical therapeutic agent for management of anxiety disorders.

scholarly journals Influence of meadowsweet ordinary (Filipendula vulgaris) extract on behavior in models of anxiety

2010 ◽  
Vol 9 (6) ◽  
pp. 93-98 ◽  
Author(s):  
A. V. Kaygorodtsev
Keyword(s):  
Open Field ◽  
Elevated Plus Maze ◽  
Emotional Reaction ◽  
Plus Maze ◽  
Influence Of Water ◽  
Albino Mice ◽  
Ethanol Extracts

Influence of water and water-ethanol extracts of meadowsweet ordinary on behavior of albino mice in anxiety models is studied. Anxiolytic action of extracts estimated on animals behavior in an elevated plus-maze, an «open field» and in the test of emotional reaction. It was defined that water and 95% water-ethanol extracts of meadowsweet ordinary render the most expressed anxiolytic action and surpass in activity an valerian extract.

scholarly journals Evaluation of Anxiolytic Activity of Pulsatilla nigricans L. in Wistar Rats by using Elevated Plus Maze and Hole Board Paradigms

2020 ◽  
Vol 52 (3) ◽  
Author(s):  
Rafia Sadaf ◽  
Ishrat Younus ◽  
Sidra Maqbool ◽  
Talha Bin Fayyaz ◽  
Sarah Jameel Khan ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Elevated Plus Maze ◽  
Anxiolytic Activity ◽  
Plus Maze ◽  
Hole Board

Anxiolytic effects of fractions obtained from Passiflora incarnata L. in the elevated plus maze in mice

Planta Medica ◽  
2010 ◽  
Vol 76 (12) ◽  
Author(s):  
C Sampath ◽  
M Holbik ◽  
L Krenn ◽  
V Butterweck
Keyword(s):  
Elevated Plus Maze ◽  
Plus Maze ◽  
Passiflora Incarnata
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