scholarly journals P650 A trend to higher adoption of mesalazine suppository use for UC patients in 15 European countries

2021 ◽  
Vol 15 (Supplement_1) ◽  
pp. S581-S582
Author(s):  
L Mackenzie-Smith ◽  
H Wüthrich ◽  
R Laoun
Keyword(s):  
Czech Republic ◽  
Data Exchange ◽  
Fold Increase ◽  
European Countries ◽  
Geographical Differences ◽  
Clear Trend ◽  
Parallel Import ◽  
Maximum Daily Dose ◽  
Daily Dose ◽  
Full Analysis

Abstract Background In a previous abstract (ECCO 2014), we showed geographical differences between European countries in the use of 5ASA suppositories. The updated ECCO guidelines published in 2016 reiterated the importance of mesalazine suppositories in patients with ulcerative colitis: A mesalamine 1-g suppository once daily is the preferred initial treatment for mild or moderately active proctitis, mesalamine foam or enemas are an alternative, but suppositories deliver the drug more effectively to the rectum and are better tolerated [Statement 11A]. We wanted to look at the changes in mesalazine suppositories use and compare it to 2012. Methods We collected the data of suppositories consumption from April 2019 until March 2020 from IMS, the prevalence of UC in 2019 from the Global Health Data Exchange and the estimation of the population for 15 European countries (Czech Republic, Denmark, Estonia, Finland, France, Greece, Germany, Ireland, Latvia, Lithuania, Norway, Portugal, Spain, Sweden and the United Kingdom) from the Eurostat database. For comparison purposes, we assumed that all the patients could receive a 1000 mg daily dose of mesalazine suppository. Results The aggregate sales data from IMS show that 26979 kg of mesalazine suppository were consumed during the full year in 15 European countries. If we exclude Spain from the analysis, 23096 kg were consumed by 14 countries and this is a 1.6-fold increase in comparison to 2012. Assuming a cut-off of 33% of UC patients receiving the maximum daily dose of 1000 mg, 4 countries showed high use of mesalazine suppositories above that cut off: Greece, Ireland, Spain and Portugal. Except for Ireland, those 3 other countries are from Southern Europe. In addition when we compare the data from 2019 to 2012, we see a clear increase in the use of mesalazine suppository in the 14 countries. All countries showed an increase in suppository use that is above 50% except for Czech Republic, Denmark, France and Sweden. The increase in those countries was less pronounced. Sweden and Norway had the lowest rate of suppository use compared to the other countries. Conclusion Despite all the uncertainty around the UC prevalence and parallel import (due to price difference between the different European countries), there is a clear trend toward a higher use of suppositories in all the European countries. A full analysis of the topical use of mesalazine (suppository, foam and enema) would be interesting to evaluate more accurately the adherence to the ECCO guidelines in clinical practice.

INTERNATIONAL GRANT COOPERATION AS A TOOL FOR THE DEVELOPMENT OF PROFESSIONAL COMPETENCIES OF UNIVERSITY TEACHERS

2018 ◽  
pp. 4-8
Author(s):  
Milan Chmura
Keyword(s):  
Higher Education ◽  
Czech Republic ◽  
Professional Education ◽  
European Countries ◽  
International Project ◽  
The Czech Republic ◽  
University Teachers ◽  
Quality Of Higher Education ◽  
Education And Development

The education and development of university teachers have its justifcation and its importance is signifcant not only in the Czech Republic but also abroad. This study provides an analysis of further professional education of university teachers in the Czech Republic and in selected European countries. Subsequently, it presents an international project with participants from the Czech Republic, Ukraine, Slovakia and Poland, which, ultimately, plays a role in the improvement of the quality of higher education.

16th and 17th Workshops of the International Association of Vegetation Science Working Group for the European Vegetation Survey (Rome, Italy, 22-26 March 2007; Brno, Czech Republic, 1-5 May 2008)

2008 ◽  
pp. 131-133
Author(s):  
T. M. Lysenko ◽  
Yu. A. Semenishchenkov
Keyword(s):  
Czech Republic ◽  
Working Group ◽  
International Association ◽  
Botanical Garden ◽  
European Countries ◽  
Vegetation Survey ◽  
Vegetation Science ◽  
The University ◽  
Science Working

22-26 March 2007 in Rome (Italy), in the Botanical garden of the University «La Sapienza» hosted the 16th meeting of the Working group «Review of the Vegetation of Europe» of the International Association of Vegetation Science (IAVS). These meetings are held every spring in one of the European countries and dedicated to various topics.

scholarly journals Investigator Initiated Clinical Trials (IICTs): A Systematic Search in Registries to Compare the Czech Republic and Portugal in Terms of Funding Policies and Scientific Outcomes

2021 ◽  
Author(s):  
C. Madeira ◽  
L. Hořavová ◽  
F. dos Santos ◽  
J. R. Batuca ◽  
K. Nebeska ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Czech Republic ◽  
Clinical Research ◽  
Systematic Search ◽  
European Countries ◽  
The Czech Republic ◽  
Research Outcomes ◽  
Funding Policies ◽  
Funding Agencies ◽  
First Time

Abstract Objectives Clinical trials provide one of the highest levels of evidence to support medical practice. Investigator initiated clinical trials (IICTs) answer relevant questions in clinical practice that may not be addressed by industry. For the first time, two European Countries are compared in terms of IICTs, respective funders and publications, envisaging to inspire others to use similar indicators to assess clinical research outcomes. Methods A retrospective systematic search of registered IICTs from 2004 to 2017, using four clinical trials registries was carried out in two European countries with similar population, GDP, HDI and medical schools but with different governmental models to fund clinical research. Each IICT was screened for sponsors, funders, type of intervention and associated publications, once completed. Results IICTs involving the Czech Republic and Portugal were n = 439 (42% with hospitals as sponsors) and n = 328 (47% with universities as sponsors), respectively. The Czech Republic and Portuguese funding agencies supported respectively 61 and 27 IICTs. Among these, trials with medicinal products represent 52% in Czech Republic and 4% in Portugal. In the first, a higher percentage of IICTs’ publications in high impact factor journals with national investigators as authors was observed, when compared to Portugal (75% vs 15%). Conclusion The better performance in clinical research by Czech Republic might be related to the existence of specific and periodic funding for clinical research, although further data are still needed to confirm this relationship. In upcoming years, the indicators used herein might be useful to tracking clinical research outcomes in these and other European countries.

A Mistrustful Society?

2020 ◽  
Vol 10 (2) ◽  
pp. 52-71
Author(s):  
Nicole Horáková
Keyword(s):  
Czech Republic ◽  
Empirical Data ◽  
European Countries ◽  
Eastern European ◽  
The Czech Republic ◽  
State Institutions ◽  
Government Institutions ◽  
European Values ◽  
European Values Study ◽  
Eastern European Countries

The level of trust in politicians also in government institutions is taken as an indicator of the state of society in general. Various studies have shown that the population of the Central Eastern European countries, and especially the citizens of the Czech Republic, lack trust in state institutions and democratic structures. The trust of the Czech population in government institutions is, compared to other (Western) European countries, at a relatively low level. This article aims to discuss different factors that are currently influencing this lack of trust: the historical, cultural, and institutional. The empirical data for this article is based on the European Values Study and Czech surveys of public opinion concerning trust in government institutions.

A Comparative Analysis of the Power of Selected European Countries. The Economic Determinants

2021 ◽  
Vol 37 (37) ◽  
pp. 22-42
Author(s):  
Alicja Paluch ◽  
Henryk Spustek
Keyword(s):  
Czech Republic ◽  
Comparative Analysis ◽  
European Countries ◽  
Economic Power ◽  
Strongly Correlated ◽  
The Czech Republic ◽  
Independent Variables ◽  
Economic Sphere ◽  
National Power

The ever-increasing need for in-depth analysis and quantification of the national power, in particular ‘hard’ and ‘soft’ power-generating factors as well as difficulties in identifying a comprehensive and effective method for scientific determination of the national power, have given rise to research in the indicated scientific issues within this article. The presented considerations aim to define the assumptions for a descriptive sub-model that would enable a comparison of Poland’s power in the economic sphere (which is a component of the non-military sphere) with the power of selected European countries. The research hypothesis is that, among the variety of descriptive variables in the economic sphere of the national power, there is a subset of mutually independent variables, at the same time strongly correlated with the national power, which make it possible to define assumptions for the sub-model of the national power. The steps of the research procedure were carried out using the method of system analysis (multi-criteria comparative analysis) and statistical analysis. The research activities undertaken have shown that the factors that are strongly correlated with the national power in the economic area of the European countries adopted for the analysis are: dynamics of industrial production, private sector credit flows and economic freedom index. The comparative analysis carried out demonstrates that the greatest increase in the economic power in the analysed period took place in Germany (0.68). Slightly smaller growth was recorded in the Czech Republic (0.62) and Poland (0.60), while the lowest value of increase was in Romania (0.23). The conducted qualitative comparative analysis of the economic power of selected European countries allowed to conclude that the independent variables identified are crucial for the formation of the economic power of the analysed countries. At the same time, a fairly strong position of the Czech Republic and Poland in relation to the economic power of Germany was found. The performed quantification of the economic power of the European countries provides a basis for the correct determination of changes in the power distribution of political units, assessment of the power and resources held by the state.

A Grave Case of Morphia and Cocaine Habit [Considérations sur un cas grave de morphi-cocaïnomanie]. (Prog. Méd., May 12th, 1900.) Sollier, P

1901 ◽  
Vol 47 (198) ◽  
pp. 603-603
Author(s):  
W. C. Sullivan
Keyword(s):  
Subcutaneous Tissue ◽  
Abdominal Region ◽  
Maximum Daily Dose ◽  
Daily Dose

The patient was a medical man, æt. 40; the morphia habit dated back ten years, the maximum daily dose being 3 grammes; the cocaine habit was more recent. When the case came under Sollier's treatment the intoxication was profound; the patient was emaciated; there was diffuse induration of the subcutaneous tissue, and there were numerous ulcers in the abdominal region where the patient injected the drugs; the urine contained albumen, and severe uræmic symptoms had appeared; the hæmoglobin was reduced to 4·5 per cent., and was shown by the spectroscope to be very imperfectly oxidised. The author specially indicates this blood-state, as he considers that the symptoms of collapse on the withdrawal of morphia are due to asphyxia.

scholarly journals Unusual Occurrence of Salmonella Mikawasima in 2012–2013 in the Czech Republic: Part of a Multistate Outbreak?

2014 ◽  
Vol 63 (3) ◽  
pp. 355-357 ◽  
Author(s):  
PETRA MYŠKOVÁ ◽  
RENÁTA KARPÍŠKOVÁ
Keyword(s):  
Czech Republic ◽  
Antimicrobial Susceptibility ◽  
Susceptibility Testing ◽  
Antimicrobial Susceptibility Testing ◽  
European Countries ◽  
Quinolone Resistance ◽  
Environmental Isolates ◽  
The Czech Republic ◽  
Unusual Occurrence ◽  
Microbial Agents

An increased number of cases of salmonellosis caused by the rare serotype Mikawasima was noted in the years 2012 and 2013 in the Czech Republic. A potential on-going outbreak caused by this serotype in European countries has also been reported. Altogether 14 human and 1 environmental isolates from the year 2012 and 11 human isolates from the year 2013 from different locations of the Czech Republic were sent to our laboratory for typing. Macrorestriction analysis together with antimicrobial susceptibility testing and PCR for ESBL and plasmid-mediated quinolone resistance detection were performed to compare our isolates. Twenty-one isolates created two very similar clusters and 5 isolates had different profiles. Twenty-five isolates were fully susceptible to all agents used. One isolate showed resistance to 12 microbial agents and possessed blaTEM, blaSHV, blaOXA, blaCTX-M and qnrB genes.

scholarly journals Increase in hepatitis A cases in the Czech Republic in 2008 – an update

2009 ◽  
Vol 14 (3) ◽  
Author(s):  
J Cástková ◽  
C Beneš
Keyword(s):  
Czech Republic ◽  
General Population ◽  
Drug Users ◽  
Hepatitis A ◽  
Fold Increase ◽  
Injecting Drug Users ◽  
Annual Number ◽  
The Czech Republic ◽  
Parenteral Transmission ◽  
Increased Susceptibility

In 2008, 1,616 cases of hepatitis A were reported in the Czech Republic, more than a 10-fold increase compared with the annual number of cases registered in 2003-2007. The infection was initially associated with injecting drug users, most probably by person-to-person contact or parenteral transmission, and in the second half of the year continued to spread among the general population with increased susceptibility.

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