scholarly journals P775 Evolution of inflammatory bowel disease research from a bird’s eye perspective: A text-mining analysis of publication trends and topics

2020 ◽  
Vol 14 (Supplement_1) ◽  
pp. S615-S615
Author(s):  
Y Barash ◽  
E Klan ◽  
N Tau ◽  
S Ben-Horin ◽  
A Levartovsky ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Text Mining ◽  
Bowel Disease ◽  
Research Effort ◽  
Annual Number ◽  
Free Text ◽  
Publication Rates ◽  
Inflammatory Bowel ◽  
Number Of Publications ◽  
Medical Therapeutics

Abstract Background There is an extensive and growing research effort in the field of inflammatory bowel diseases (IBD), with varying topics over the years. A comprehensive analysis of the trends in research and publications in IBD may help us grasp the gaps in knowledge and map out potential future areas of interest. Text-mining is the extraction of information from free text using computational methods. It can be applied to identify trends in a research field. The aim of our study was to create a map of IBD research of the last 25 years using text-mining techniques Methods We retrieved all available MEDLINE/PubMed annual datasets from 1992 to the end of 2017. We selected a set of relevant keywords from MeSH to include all papers relating to inflammatory bowel disease, Crohn’s disease and Ulcerative colitis. For each article we extracted the following data: article ID, title, journal, date of publication, abstract text, article type, keywords, citation frequency, and first author name and affiliation (from which we extracted the country of origin). We categorised the articles screening topics by using word combination and title match technique. We also scanned the topics in list of 100 papers (grouped by 5-year periods starting with 1992–1997) with the highest citation factor, i.e., the articles with the most citations from publish up to 2018. Results Between the years 1992 and 2017, 20,014 IBD-related publications appeared on PubMed. The annual number of publications increased almost 4-fold (from 354 in 1992 to 1361 in 2017). The USA had the highest number of papers (n = 3427/20,014, 17%) while Denmark and Israel had the highest rate of publications per population (for 2012–2017, 12 publications per 1 million in Israel and 17 in Denmark). The countries that achieved the most significant growth in publication rates were China, Egypt, Romania with growth rates of 0.0069, 0.0068 and 0.0062 respectively defined as the increase in articles per year normalised by the total amount of articles from that country. Out of 20014 papers, 5590 were successfully classified into 14 major topics. The topics that attracted the most publications over the years were medical therapeutics 1808/20014 (9% of articles from 1992 to 2017), followed by surgical treatment 1111/20014 (5.5%), endoscopy 637/20014 (3.2%) and genetics 552/20014 (2.7%), remaining stable through the study period. Conclusion There is a steady growth in the number of IBD-related publications. Although US is a world leader in the number of IBD publications overall, Denmark and Israel publish the most in relation to population size, while China, Romania and Egypt display the highest growth rate in the number of publications. Medical therapeutics is the most popular and best-cited topic.

Evolution of Inflammatory Bowel Disease Research From a Bird’s-Eye Perspective: A Text-Mining Analysis of Publication Trends and Topics

2020 ◽  
Author(s):  
Yiftach Barash ◽  
Eyal Klang ◽  
Noam Tau ◽  
Shomron Ben-Horin ◽  
Hussein Mahajna ◽  
...  
Keyword(s):  
United States ◽  
Inflammatory Bowel Disease ◽  
Surgical Treatment ◽  
Text Mining ◽  
Bowel Disease ◽  
The United States ◽  
Steady Increase ◽  
Inflammatory Bowel ◽  
Number Of Publications ◽  
Over Time

Abstract Background and aim Inflammatory bowel disease (IBD) research is extensive and increasing, with topics varying and shifting foci over time. A comprehensive analysis of the trends in IBD publications may help us grasp knowledge gaps and map future areas of interest. The aim of our study was to create a map of IBD research for the last 25 years using computational text-mining techniques. Methods We retrieved all available MEDLINE/PubMed annual datasets between 1992 and 2016. We categorized article characteristics by using word combination and title match techniques. We also assigned country of origin for each article from the first author’s affiliation. Results During the study period, 18,653 publications that appeared on PubMed were classified as IBD-related. The annual number of publications increased almost 4-fold (354 to 1361) during the study period. The United States had the highest total number of publications (n = 3179/16,358, 19.4%) and Denmark, Sweden, and Israel had the highest rate of publications per capita. There were 7986 articles successfully assigned with a main subject. Therapeutics, surgical treatment, and endoscopy were the 3 leading topics, with n = 2432/7986 (30%), 1707/7986 (21%), and 981/7986 (12%), respectively. When analyzing trends in topics over time, we found an increase in the proportion of articles on imaging (2.2% in 1992-1996 to 8% in 2012-2016) and a decrease in the proportion of articles on surgical treatment (30% in 1992-1996 to 19% in 2012-2016). Conclusions There is steady increase in the number of IBD-related publications. Although the United States is a world leader in the number of IBD publications, Denmark, Sweden, and Israel publish the most per population size. Medical therapeutics is the most popular topic, yet there is a steady increase in publications devoted to imaging and monitoring.

scholarly journals Incidence and Prevalence Trends of Pediatric Inflammatory Bowel Disease in the Daegu-Kyungpook Province From 2017 to 2020

2022 ◽  
Vol 9 ◽  
Author(s):  
Jae Young Choe ◽  
Sujin Choi ◽  
Ki Hwan Song ◽  
Hyo-Jeong Jang ◽  
Kwang-Hae Choi ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Children And Adolescents ◽  
Bowel Disease ◽  
Population Based ◽  
Annual Number ◽  
Number Of Children ◽  
Pediatric Inflammatory Bowel Disease ◽  
Prevalence Trends ◽  
Inflammatory Bowel ◽  
Pediatric Ibd

Background and Aim: There is paucity of data regarding the epidemiology of pediatric IBD in Asia compared to that of Western countries. We aimed to investigate the incidence and prevalence trends of pediatric inflammatory bowel disease (IBD) in the Daegu-Kyungpook province of South Korea from 2017 to 2020.Methods: This study was a multicenter, retrospective study conducted in eight IBD referral centers located in the Daegu-Kyungpook province. Children and adolescents of ≤18 years who were initially diagnosed with IBD between 2017 and 2020 were included. The annual number of children and adolescents newly diagnosed with IBD and the annual resident population of children and adolescents ≤18 years of age in the Daegu-Kyungpook province were investigated to calculate the annual incidence and prevalence in the region.Results: A total 304 children and adolescents that had been diagnosed with IBD were included in this study. Among these patients, 71.4% had been diagnosed with Crohn's disease (CD), and 28.6% with ulcerative colitis (UC). The population based annual incidences of IBD from 2017 to 2020 were each 7.24, 6.82, 10.27, and 13.33 per 100,000, respectively (P for trend <0.001), 4.48, 5.26, 7.39, and 9.8 per 100,000, respectively, for CD (P for trend <0.001), and 2.76, 1.56, 2.88, and 3.53 per 100,000, respectively, for UC (P for trend = 0.174).Conclusion: Pediatric IBD, especially CD has significantly increased recently in the Daegu-Kyungpook province. Epidemiology studies from other regions of Asia are required to better elucidate this trend of increase in Asia.

scholarly journals Analysis of publications on paratuberculosis from 1995 to 2009 with emphasis on the period from 2005 to 2009

2010 ◽  
Vol 55 (No. 2) ◽  
pp. 43-54 ◽  
Author(s):  
M. Kaevska ◽  
K. Hruska
Keyword(s):  
Inflammatory Bowel Disease ◽  
Crohn’S Disease ◽  
Mycobacterium Avium ◽  
Bowel Disease ◽  
Web Of Science ◽  
Descriptive Data ◽  
Funding Agencies ◽  
Inflammatory Bowel ◽  
Number Of Publications ◽  
The Web

The importance of paratuberculosis, an infectious bowel disease of ruminants, and Crohn’s disease, a type of inflammatory bowel disease in humans with suspected links with <I>Mycobacterium avium</I> subsp. <I>paratuberculosis</I>, is evident from the steadily increasing number of publications on these topics. Data from the Web of Science databases were analysed by authors, institutions, countries and funding agencies, involved in research. A summary of the descriptive data for the most frequently cited publications are presented here.

scholarly journals Thromboprophylaxis for Hospitalized Patients with Inflammatory Bowel Disease—Are We There Yet?

2020 ◽  
Vol 9 (9) ◽  
pp. 2753
Author(s):  
Asaf Levartovsky ◽  
Yiftach Barash ◽  
Shomron Ben-Horin ◽  
Bella Ungar ◽  
Eyal Klang ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Medical Center ◽  
Hospitalized Patients ◽  
Data Repository ◽  
Free Text ◽  
Post Discharge ◽  
Inflammatory Bowel ◽  
Ed Visits

Patients with inflammatory bowel disease (IBD) have a high risk of venous thromboembolism (VTE) events in both hospitalized patients and outpatients. Although thromboprophylaxis is recommended for hospitalized patients with IBD, implementation is not universal, especially for non IBD-related hospitalizations. Our objective was to present VTE and thromboprophylaxis adherence rates among hospitalized patients with IBD. An electronic data repository was created of all patients with IBD who visited the emergency department (ED) of our tertiary medical center between 2012 and 2018. The data included tabular variables and free-text physician records. We searched the data for VTE events, using ICD10 coding. Overall, there were 7009 ED visits of 2405 patients with IBD, 1556 (64.7%) with Crohn’s disease (CD) and 849 (35.3%) with ulcerative colitis (UC). Thromboprophylaxis was administered in 463 hospitalizations (12.4% of IBD-related and 10.9% of non IBD-related hospitalizations, p = 0.13). Nineteen VTEs were diagnosed in the ED and seventeen were diagnosed during hospitalization (11 non IBD-related and 6 IBD-related hospitalizations, 0.6% and 0.28% respectively, p = 0.12). One patient died during hospitalization and an additional two in the 90 days post-discharge from hospitalization (unrelated to VTEs). In conclusion, thromboprophylaxis rates in hospitalized patients with IBD are low, despite possible implications and established guidelines. Thromboprophylaxis should be implemented in patients with IBD hospitalized for all indications.

P221 Thromboembolic events in hospitalised patients with inflammatory bowel disease – a large tertiary hospital experience

2020 ◽  
Vol 14 (Supplement_1) ◽  
pp. S253-S253
Author(s):  
A Levartovsky ◽  
Y Barash ◽  
S Ben-Horin ◽  
B Ungar ◽  
E Klang ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Tertiary Hospital ◽  
Data Repository ◽  
Free Text ◽  
Vte Prophylaxis ◽  
Vein Thrombosis ◽  
Hospitalised Patients ◽  
Related Hospitalisation ◽  
Inflammatory Bowel

Abstract Background Patients with inflammatory bowel disease (IBD) have a greater risk of venous thromboembolism (VTE) events compared with the general population especially during flares, in both hospitalised and ambulatory patients. Although VTE prophylaxis (thromboprophylaxis) is recommended in hospitalised IBD patients, the implementation is not universal, especially for non-IBD-related hospitalisations. In this study, we aimed to present the rates of VTEs and thromboprophylaxis among hospitalised IBD patients. Methods We created an electronic data repository of all IBD patients who visited the emergency department (ED) of our tertiary medical centre between 2012 and 2018. Data included tabular demographic and clinical variables (reason for referral, VTEs, clinical characteristics, hospitalisation, lab results, treatment and outcome) as well as free-text physician records. For this study, we searched the data repository for VTE cases, using ICD10 coding. Results Overall, there were 7009 ED visits of 2405 patients with IBD, 1556 (64.7%) Crohn's disease and 849 (35.3%) Ulcerative colitis patients. Thromboprophylaxis was administered in 463 hospitalisations (12.4% of IBD-related and 10.9% of non-IBD-related hospitalisations). 1.5% of patients (36/2405) who visited the ED had a new VTE. Thirty patients were diagnosed with a deep vein thrombosis (DVT), two patients with a pulmonary embolism (PE) and six additional patients were diagnosed with both a DVT and PE in the same hospitalisation. Eleven patients had a VTE during a non-IBD-related hospitalisation and six patients during an IBD-related hospitalisation (0.6% vs. 0.3%, respectively, pv = 0.12). Five patients (29.4%) developed VTEs after receiving thromboprophylaxis during hospitalisation. The majority (72.7%) of VTEs diagnosed during a non-IBD-related hospitalisation did not have additional thrombosis-related risk factors. One patient died during hospitalisation and two more patients died in the upcoming 30 days (unrelated to VTEs). Conclusion The rate of thromboprophylaxis in hospitalised IBD patients is low, despite posing life-threatening implications. Thromboprophylaxis should be implemented in IBD patients hospitalised for all indications.

scholarly journals Management of Inflammatory Bowel Disease Patients With Clinical Care Pathways Reduces Emergency Department Utilization

2020 ◽  
Vol 2 (4) ◽  
Author(s):  
Ellina Lytvyak ◽  
Reed T Sutton ◽  
Levinus A Dieleman ◽  
Farhad Peerani ◽  
Richard N Fedorak ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Emergency Department ◽  
Bowel Disease ◽  
Negative Binomial ◽  
Clinical Care ◽  
Emergency Department Utilization ◽  
Annual Number ◽  
Care Pathways ◽  
Inflammatory Bowel ◽  
Ed Visits

Abstract Background Standardizing care through pathways has the potential to reduce emergency department (ED) utilization. We developed and evaluated inflammatory bowel disease (IBD) care pathways for that purpose. Methods Over 2014–2016, IBD patients were retrospectively stratified into those managed and not managed by pathways. Patient data were extracted, and negative binomial regression used to predict the annual number of ED visits. Results There was a difference of 30.7 ED visits/100 patients between managed and nonmanaged at 12 months (P &lt; 0.001). The incidence rate ratio of total ED visits occurring annually was 0.750 (P = 0.008). Conclusions Management with IBD care pathways reduces ED utilization.

scholarly journals Risk Factors of Urothelial Cancer in Inflammatory Bowel Disease

2021 ◽  
Vol 10 (15) ◽  
pp. 3257
Author(s):  
Gian Paolo Caviglia ◽  
Giorgio Martini ◽  
Angelo Armandi ◽  
Chiara Rosso ◽  
Marta Vernero ◽  
...  
Keyword(s):  
Risk Factors ◽  
Inflammatory Bowel Disease ◽  
General Population ◽  
Bowel Disease ◽  
Urothelial Cancer ◽  
Increased Risk ◽  
History Of ◽  
Inflammatory Bowel ◽  
Number Of Publications

Extraintestinal cancers are important complications in patients with inflammatory bowel disease (IBD). A limited number of publications are available regarding the association between IBD and urothelial cancer. The primary outcome of our study was the comparison of the prevalence of urothelial cancer in patients with IBD with respect to the prevalence in the general population. Secondary outcomes were the assessment of risk factors for the onset of urothelial cancer in IBD. In a retrospective study we examined the medical records of all patients with a confirmed diagnosis of IBD followed in our clinic between 1978 and 2021. For each of the patients with identified urothelial cancer, more than ten patients without cancer were analyzed. Furthermore, 5739 patients with IBD were analyzed and 24 patients diagnosed with urothelial cancer were identified. The incidence of urothelial cancer, compared with the incidence in the general population, was not significantly different (0.42% vs. 0.42%; p = 0.98). Twenty-three cases were then compared (1 case was discarded due to lack of follow-up data) against 250 controls. During the multivariate analysis, smoking (odds ratio, OR = 8.15; 95% confidence interval, CI = 1.76–37.63; p = 0.007) and male sex (OR = 4.04; 95% CI = 1.29–12.66; p = 0.016) were found as risk factors. In conclusion, patients with IBD have a similar risk of developing urothelial cancer compared to the general population, but males with a history of smoking are at increased risk.

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