P4459The influence of the polymorphism BUD13-ZNF259 rs964184 on coronary disease according to age

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
A Pereira ◽  
M Mendonca ◽  
J A Sousa ◽  
F Mendonca ◽  
M Neto ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Tyrosine Kinase ◽  
Coronary Disease ◽  
Age Groups ◽  
Significant Risk ◽  
Cellular Level ◽  
Dominant Model ◽  
Coronary Patients ◽  
The Impact ◽  
Cad Risk

Abstract A recent GWAS study found a significant association between the BUD13-ZNF259 rs964184 polymorphism, dyslipidemia and the onset of coronary disease (CAD). This variant encoding zinc finger protein (ZPR1) interacts with the receptor tyrosine kinase at cellular level, increasing oxidative stress, inflammatory response and atherogenesis. There are no studies of the effect of this variant on the Portuguese population. Objective Investigate the association of BUD13-ZNF259 rs964184 with dyslipidemia and its impact on CAD risk. Evaluate its impact in different age groups of our population. Methods A case-control study was performed with 3050 subjects (1619 coronary patients with 53.3±8 years; 78.9% male and 1431 controls with 52.8±8 years; 76.6% male) from the GENEMACOR study population. Traditional risk factors (smoking, dyslipidemia, diabetes, family history, hypertension, body mass index, alcohol consumption, physical inactivity) and others considered new, such as creatinine clearance, pulse wave velocity, homocysteine, fibrinogen, lipoprotein (a), APOB and PCR (hs) were investigated. BUD13-ZNF259 variant was genotyped and analyzed using the dominant model (CG + GG vs. CC). Bivariate and multivariate analyzes (logistic regression) were used to estimate the ORs and 95% CI, after adjusting for potential confounding factors, in 3 different age groups (<45; 45–55; >55). Results BUD13-ZNF259 polymorphism presented an independent and significant risk of CAD (OR=1.58; 95% CI: 1.07–2.32; p=0.019) only in the group of young coronary patients <45 years (n=482 patients), as well as dyslipidemia (OR=2.04; 95% CI: 1.26–3.31; p=0.003). After binary logistic regression entering with the interaction between dyslipidemia and the dominant model ZNF259 (CG + GG vs. CC), we verified an association with CAD risk (OR= 1.78; 95% CI: 1.08–2.95; p=0.025). Conclusion BUD13-ZNF259 rs964184 variant showed a significant risk for the onset of CAD in the young population (<45 years). The impact of the interaction of ZPR1 protein with tyrosine kinase (Syk) at the cellular level seems to be more relevant in young patients. This aspect may represent a possible prophylactic and therapeutic target, especially in coronary disease in young people.

scholarly journals Trends in Poliovirus Seroprevalence in Kano State, Northern Nigeria

2018 ◽  
Vol 67 (suppl_1) ◽  
pp. S103-S109
Author(s):  
Harish Verma ◽  
Zubairu Iliyasu ◽  
Kehinde T Craig ◽  
Natalie A Molodecky ◽  
Utibeabasi Urua ◽  
...  
Keyword(s):  
Old Age ◽  
Age Groups ◽  
Significant Risk ◽  
Immunization Coverage ◽  
Neutralizing Antibody ◽  
Age Group ◽  
Parental Consent ◽  
Population Immunity ◽  
Antibody Titres ◽  
The Impact

Abstract Background Kano state has been a protracted reservoir of poliovirus in Nigeria. Immunity trends have been monitored through seroprevalence surveys since 2011. The survey in 2015 was, in addition, intended to assess the impact of use of inactivated poliovirus vaccine (IPV). Methods It was a health facility based seroprevalence survey. Eligible children aged 6-9, 12-15 and 19-22 months of age brought to the paediatrics outpatient department of Murtala Mohammad Specialist Hospital between 19 October and 6 November 2015, were screened for eligibility. Eligible children were enrolled after parental consent, history taken, physical examination conducted, and a blood sample collected to test for neutralizing antibody titres against the three poliovirus serotypes. Results Overall, 365 results were available in the three age groups. In the 6-9-month-old age group, the seroprevalence was 73% (95% confidence interval [CI] 64-80%), 83% (95% CI 75-88%), and 66% (95% CI 57-73%) for serotypes 1, 2, and 3, respectively. In the 12-15- and 19-22-month-old age groups, seroprevalence was higher but still remained <90% across serotypes. Seroprevalence to serotypes 1 and 3 in 2015 was similar to 2014; however, for serotype 2 there was a significant improvement. IPV received in supplemental immunization activities was found to be a significant predictor of seropositivity among 6-9-month-old infants for serotypes 1 and 2. Conclusions Seroprevalence for serotypes 1 and 3 remains low (<80%) in 6-9-month-olds. This poses a significant risk for poliovirus spread if reintroduced into the population. Efforts to strengthen immunization coverage are imperative to secure and sustain high population immunity.

scholarly journals The impact of diabetes on multiple avoidable admissions: a cross-sectional study

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Joana Seringa ◽  
Ana Patrícia Marques ◽  
Bruno Moita ◽  
Cátia Gaspar ◽  
João Filipe Raposo ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Age Groups ◽  
Health Care Expenditures ◽  
Cross Sectional Study ◽  
Health Concern ◽  
Diabetes Diagnosis ◽  
Cross Sectional ◽  
Younger Adults ◽  
Logistic Regression Models ◽  
The Impact

Abstract Background Multiple admissions for ambulatory care sensitive conditions (ACSC) are responsible for an important proportion of health care expenditures. Diabetes is one of the conditions consensually classified as an ACSC being considered a major public health concern. The aim of this study was to analyse the impact of diabetes on the occurrence of multiple admissions for ACSC. Methods We analysed inpatient data of all public Portuguese NHS hospitals from 2013 to 2015 on multiple admissions for ACSC among adults aged 18 or older. Multiple ACSC users were identified if they had two or more admissions for any ACSC during the period of analysis. Two logistic regression models were computed. A baseline model where a logistic regression was performed to assess the association between multiple admissions and the presence of diabetes, adjusting for age and sex. A full model to test if diabetes had no constant association with multiple admissions by any ACSC across age groups. Results Among 301,334 ACSC admissions, 144,209 (47.9%) were classified as multiple admissions and from those, 59,436 had diabetes diagnosis, which corresponded to 23,692 patients. Patients with diabetes were 1.49 times (p < 0,001) more likely to be admitted multiple times for any ACSC than patients without diabetes. Younger adults with diabetes (18–39 years old) were more likely to become multiple users. Conclusion Diabetes increases the risk of multiple admissions for ACSC, especially in younger adults. Diabetes presence is associated with a higher resource utilization, which highlights the need for the implementation of adequate management of chronic diseases policies.

scholarly journals Associations between probable anxiety and mood disorder and measures of alcohol and cannabis use in young, middle-aged and older adults.

2019 ◽  
Vol 1 (2) ◽  
pp. 9-19
Author(s):  
Robert E. Mann ◽  
Wah Lap Cheung ◽  
Gina Stoduto ◽  
Christine M. Wickens ◽  
Anca R. Ialomiteanu ◽  
...  
Keyword(s):  
Older Adults ◽  
Logistic Regression ◽  
General Health Questionnaire ◽  
Age Groups ◽  
Alcohol Problems ◽  
Cannabis Use ◽  
Religious Service Attendance ◽  
Middle Aged ◽  
Cross Sectional ◽  
The Impact

This study examined the associations of cannabis use, alcohol use and alcohol problems with probable anxiety and mood disorders (AMD) in young, middle-aged and older adults. Method: Data are based on the CAMH Monitor, an ongoing cross-sectional telephone survey of Ontario adults aged 18 years and older. For the purposes of the current study, a merged dataset from the years 2001 through 2009 inclusive was separated into three individual datasets: 18-34 year olds (n=4,211), 35-54 year olds (n=7,874), and 55 years of age and older (n=6,778). The survey included the 12-item version of the General Health Questionnaire, which provides a measure of probable AMD for the general population. Logistic regression analyses examined the odds of probable AMD in three age groups associated with alcohol measures (number of drinks per day and alcohol problems (AUDIT 8+)) and cannabis use, while controlling for self-reported physical health, religious service attendance, and demographic factors. Due to listwise deletion, the logistic regression models were based on reduced samples. Results: Lifetime cannabis use and past year cannabis use predicted probable AMD in young and middle-aged adults, but only lifetime cannabis use predicted probable AMD among older adults. Alcohol problems predicted probable AMD among middle aged and older adults, but not among younger adults. No consistent link between recent alcohol consumption and probable AMD was observed. Conclusion: These analyses suggest that the impact of alcohol and cannabis use and problems on probable AMD may differ across age groups.

scholarly journals Relationship between early proteinuria and long term outcome of kidney transplanted patients from different decades of donor age

2019 ◽  
Author(s):  
Davide Diena ◽  
Maria Messina ◽  
Consuelo De Biase ◽  
Fabrizio Fop ◽  
Edoardo Scardino ◽  
...  
Keyword(s):  
Graft Survival ◽  
Age Groups ◽  
Graft Function ◽  
Significant Risk ◽  
Low Grade ◽  
Donor Age ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Post Transplant ◽  
The Impact

Abstract Background Proteinuria after kidney transplantation portends a worse graft survival. However the magnitude of proteinuria related to patient and graft survival and its correlation with donor and recipient characteristics are poorly explored. Methods This study investigated the impact of post transplant proteinuria in the first year in 1127 kidney transplants analyzing the impact of different donor ages. Proteinuria cut off was set at 0.5 g/day. Results Transplants with proteinuria > 0.5 g/day correlated with poor graft and patient outcome in all donor age groups. In addition, 6-month-1-year proteinuria increase was significantly associated with graft outcome, especially with donors > 60 years old (p < 0.05; Odd Ratio 1.8). 1-year graft function (eGFR < or ≥44 ml/min) had similar impact to proteinuria (≥ 0.5 g/day) on graft failure (HR 2.77 vs HR 2.46). Low-grade proteinuria (0.2-0.5 g/day) demonstrated a trend for worse graft survival with increasing donor age. Also in kidney-paired analysis proteinuria ≥ 0.5 effect was more significant with donors >50 years old (OR 2.3). Conclusions Post-transplant proteinuria was increasingly harmful with older donor age. Proteinuria ≥ 0.5 g/day correlates with worse outcomes in all transplanted patients. Prognostic value of proteinuria and eGFR for graft and patient survival was comparable and these two variables remain significant risk factors even in a multivariate model that take into consideration the most important clinical variables (donor age, rejection, delayed graft function and cytomegalovirus viremia among others).

Epidemiology and risk factors for varicose veins among older people: cross-sectional population study in the UK

2010 ◽  
Vol 25 (5) ◽  
pp. 236-240 ◽  
Author(s):  
A Clark ◽  
I Harvey ◽  
F G R Fowkes
Keyword(s):  
Risk Factors ◽  
Logistic Regression ◽  
Varicose Veins ◽  
Age Groups ◽  
Significant Risk ◽  
P Value ◽  
Cross Sectional ◽  
Vein Thrombosis ◽  
History Of ◽  
The Uk

Background There are many hypotheses concerning risk factors for the development of varicose veins based mostly on pathophysiological plausibility. Population studies have been carried out mostly on the middle aged with relatively few on elderly populations. Objectives To investigate epidemiological risk factors for varicose veins in an elderly population in the UK. Methods The South Wales Skin Cancer study – an examination survey undertaken between 1988 and 1991 of a random sample ( n = 792) drawn from all patients aged 60 and over registered with a general practitioner in South Glamorgan. Exposure variables were obtained from a structured administered questionnaire combined with clinical examination. Unadjusted and adjusted odds ratios were estimated using logistic regression. Results The response rate was 71% with an average age of 71 years (range 60–97). The age-adjusted prevalence of trunk varices was 63.2% (95% confidence interval [CI] 57.9–68.4%) in men and 57.0% (95% CI 50.6–63.4%) in women. In a multiple logistic regression the significant risk factors for varicose veins were increasing age ( P value = 0.001), obesity (odds ratio [OR] 3.28, 95% CI 1.25–8.63, P = 0.042), self-reported history of deep vein thrombosis (DVT) (OR 3.19, 1.16–8.78, P = 0.024) and history of hypertension (OR 0.58, 0.38–0.89, P = 0.013). The results for gender suggested that women were at greater risk than men, but this was not statistically significant (OR 1.53, 0.99–2.38, P = 0.056). Conclusion Trunk varices occur very commonly in older age groups with increasing age, obesity and possibly female sex as risk factors. Associations found with DVT and hypertension were based on history alone and must be interpreted with caution.

Abstract 17276: Impact of Cardiovascular Comorbidities on COVID-19 Infection Risk

Circulation ◽  
2020 ◽  
Vol 142 (Suppl_3) ◽  
Author(s):  
David Tofovic ◽  
Minji Seok ◽  
Logan S Schwarzman ◽  
Sreenivas Konda ◽  
Noreen T Nazir
Keyword(s):  
Risk Factors ◽  
Cohort Analysis ◽  
Age Groups ◽  
Significant Risk ◽  
Significant Risk Factor ◽  
Age Group ◽  
Cvd Risk Factors ◽  
Cvd Risk ◽  
Patient Demographics ◽  
The Impact

Introduction: A disproportionate amount of COVID-19 infections has occurred in minority populations and in individuals with comorbid disease. We sought to evaluate the impact of patient demographics, cardiovascular disease (CVD), and known CVD risk factors on the incidence of COVID-19 infection. Methods: Between April 1st to May 1st, 2020, 844 adult patients (mean age 51.4±17.7 years, mean BMI 29.6±8.3, 50% male) admitted for any reason and tested for COVID-19 based on CDC criteria were studied in this large, metropolitan, single-center retrospective cohort analysis. Bivariate and multivariate analysis between patient demographics, CVD, and CVD risk factors with COVID-19 were evaluated. The nonlinear effects of age on COVID-19 test results were further analyzed. Results: Prevalence of COVID-19 was 21.7%. African Americans, Latinos, and Caucasian were 463(55%), 216(25%), 165(20%) respectively. Unadjusted, diabetes mellitus (DM) was significantly related with the COVID-19 positivity (OR 1.83, 95% CI 1.30-2.58, P=0.0005), but age adjusted DM was insignificant (OR 1.35, 95% CI 0.93-1.97, P=0.12). Similar results were found with other CVD risk factors (see Tables 1,2). Stratified analysis by age groups (18-40 years, ≥40 years), DM in the younger age group was the most significant risk factor for the COVID-19 positivity (OR 4.52, 95% CI 1.95-10.52, P=0.0002) but not in older inpatients (OR 1.23, 95% CI 0.85-1.81, P=0.2763). In the older age group, Latinos were significantly higher risk for COVID-19 compared to Caucasian (OR 2.27, 95% CI 1.26-4.07, P=0.005). Conclusions: Increased resources for testing in younger individuals with DM and the Hispanic population may be merited.

Transfusion Transmission of GB Virus Type C (HGV) In a Cohort of HIV Infected Patients

Blood ◽  
2010 ◽  
Vol 116 (21) ◽  
pp. 3341-3341
Author(s):  
Farnaz Vahidnia ◽  
Maya Petersen ◽  
George Rutherford ◽  
Michael Busch ◽  
Susan Assmann ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Virus Type ◽  
Conflicts Of Interest ◽  
Significant Risk ◽  
Hiv Viral Load ◽  
Total Blood ◽  
Logistic Regression Models ◽  
Blood Institute ◽  
Type C ◽  
The Impact

Abstract Abstract 3341 Background: GB virus type C (GBV-C) infection is common with 3–5% rates of viremia in blood donors and a much higher prevalence in HIV infected patients. GBV-C is transmitted by sexual or blood exposure. Although infection may persist, most immune competent individuals clear viremia within 2 years. Few data describe the clinical course of acute GBV-C infection following transfusion in HIV infected patients. We estimated risk of GBV-C RNA acquisition following transfusion. Methods: We used a limited access database from the National Heart Lung and Blood Institute from the Viral Activation Transfusion Study (VATS). A RCT of leukoreduced (LR) vs. non-LR transfusion, VATS collected blood samples from U.S. HIV infected transfusion naïve patients. GBV-C RNA in pre- and post transfusion samples was tested after completion of VATS. GBV-C RNA acquisition up to 120 days post-transfusion was examined in 294 patients who were GBV-C RNA and antibody negative before transfusion. Discrete hazard of GBV-C RNA acquisition as a function of cumulative units transfused was estimated using pooled logistic regression. Results: GBV-C RNA was detected in 22 (7.5%) of 294 subjects within 120 days following first transfusion. Viremia was detected within the first 30 days in 12 (4.1%) subjects and between 31 and 120 days in 10 (3.4%) subjects. Median (IQR) follow-up duration and total blood units transfused for subjects who acquired GBV-C RNA or stayed negative were: 88.5 (80-108) and 77.5 (32-100) days; and 4 (2-7) and 4 (2-6) units, respectively (Table 1). Discrete hazard of GBV-C RNA acquisition increased with each additional unit transfused (OR=1.09, 95% CI=1.06, 1.11) (Table 2). In pooled logistic regression models, lower baseline HIV viral load and use of antiretroviral therapy (ART) predicted subsequent GBV-C RNA acquisition after controlling for units of blood transfused. Leukoreduction status was not associated with GBV-C transmission. Conclusion: Blood transfusion is associated with significant risk of GBV-C acquisition in HIV infected patients. Establishing evidence for transfusion transmission of GBV-C will allow additional studies on the impact of acute acquisition on the course of HIV infection in co-infected patients. Disclosures: No relevant conflicts of interest to declare.

scholarly journals Relationship between early proteinuria and long term outcome of kidney transplanted patients from different decades of donor age

2019 ◽  
Author(s):  
Davide Diena ◽  
Maria Messina ◽  
Consuelo De Biase ◽  
Fabrizio Fop ◽  
Edoardo Scardino ◽  
...  
Keyword(s):  
Graft Survival ◽  
Age Groups ◽  
Graft Function ◽  
Significant Risk ◽  
Low Grade ◽  
Donor Age ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Post Transplant ◽  
The Impact

Abstract Background Proteinuria after kidney transplantation portends a worse graft survival. However the magnitude of proteinuria related to patient and graft survival and its correlation with donor and recipient characteristics are poorly explored. Methods This study investigated the impact of post transplant proteinuria in the first year in 1127 kidney transplants analyzing the impact of different donor ages. Proteinuria cut off was set at 0.5 g/day. Results Transplants with proteinuria > 0.5 g/day correlated with poor graft and patient outcome in all donor age groups. In addition, 6-month-1-year proteinuria increase was significantly associated with graft outcome, especially with donors > 60 years old (p < 0.05; Odd Ratio 1.8). 1-year graft function (eGFR < or ≥44 ml/min) had similar impact to proteinuria (≥ 0.5 g/day) on graft failure (HR 2.77 vs HR 2.46). Low-grade proteinuria (0.2-0.5 g/day) demonstrated a trend for worse graft survival with increasing donor age. Also in kidney-paired analysis proteinuria ≥ 0.5 effect was more significant with donors >50 years old (OR 2.3). Conclusions Post-transplant proteinuria was increasingly harmful with older donor age. Proteinuria ≥ 0.5 g/day correlates with worse outcomes in all transplanted patients. Prognostic value of proteinuria and eGFR for graft and patient survival was comparable and these two variables remain significant risk factors even in a multivariate model that take into consideration the most important clinical variables (donor age, rejection, delayed graft function and cytomegalovirus viremia among others).

scholarly journals Meta-analysis of FOXP3 gene rs3761548 and rs2232365 polymorphism and multiple sclerosis susceptibility

2019 ◽  
Author(s):  
Yijian Zhang ◽  
Junxin Zhang ◽  
Hao Liu ◽  
Fan He ◽  
Angela Chen ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Gene Polymorphism ◽  
Meta Analysis ◽  
Significant Risk ◽  
Recessive Model ◽  
Dominant Model ◽  
Foxp3 Gene ◽  
The Central Nervous System ◽  
The Impact ◽  
Strength Of Association

Abstract Background: Multiple sclerosis (MS) is a common autoimmune disease of the central nervous system (CNS), and is associated with genetic factors. FOXP3 gene polymorphism has been reported as the risk factor for MS, however, previous studies have showed conflicting results. The purpose of this study is to investigate the impact of FOXP3 gene polymorphism on the MS susceptibility through a meta-analysis. Methods: Pubmed, Embase, library of Cochrane, and Web of Science were used to search the eligible articles up to 1 Oct 2018. The odds ratio (ORs) and its 95 % confidence intervals (CI) were used to evaluate the strength of association. Allele model, homozygote model, heterozygote model, dominant model, and recessive model were used to evaluate the association between FOXP3 gene polymorphism and MS. Results: A total of 5 studies contained 1276 MS patients and 1447 controls (for rs3761548) and 600 MS patients and 640 controls (for rs2232365) were enrolled in this meta-analysis. The association showed significant differences in allele and dominant model for rs3761548 polymorphism. In addition, a clear tendency to significance was detected in homozygote and recessive model for rs3761548 (p = 0.052). Subgroup analysis indicated a significant risk of MS in all genotype models but heterozygotes in Asians. Conclusion: FOXP3 gene polymorphism rs3761548 was associated with a higher MS risk, especially in Asians. This conclusion needs to be validated in more large samples and multiracial studies. Keywords: FOXP3 gene, single nucleotide polymorphism, multiple sclerosis, meta-analysis.

scholarly journals Relationship between early proteinuria and long term outcome of kidney transplanted patients from different decades of donor age

2019 ◽  
Author(s):  
Davide Diena ◽  
Maria Messina ◽  
Consuelo De Biase ◽  
Fabrizio Fop ◽  
Edoardo Scardino ◽  
...  
Keyword(s):  
Graft Survival ◽  
Age Groups ◽  
Graft Function ◽  
Significant Risk ◽  
Low Grade ◽  
Donor Age ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Post Transplant ◽  
The Impact

Abstract Background Proteinuria after kidney transplantation portends a worse graft survival. However the magnitude of proteinuria related to patient and graft survival and its correlation with donor and recipient characteristics are poorly explored. Methods This study investigated the impact of post transplant proteinuria in the first year in 1127 kidney transplants analyzing the impact of different donor ages. Proteinuria cut off was set at 0.5 g/day. Results Transplants with proteinuria > 0.5 g/day correlated with poor graft and patient outcome in all donor age groups. In addition, 6-month-1-year proteinuria increase was significantly associated with graft outcome, especially with donors > 60 years old (p < 0.05; Odd Ratio 1.8). 1-year graft function (eGFR < or ≥44 ml/min) had similar impact to proteinuria (≥ 0.5 g/day) on graft failure (HR 2.77 vs HR 2.46). Low-grade proteinuria (0.2-0.5 g/day) demonstrated a trend for worse graft survival with increasing donor age. Also in kidney-paired analysis proteinuria ≥ 0.5 effect was more significant with donors >50 years old (OR 2.3). Conclusions Post-transplant proteinuria was increasingly harmful with older donor age. Proteinuria ≥ 0.5 g/day correlates with worse outcomes in all transplanted patients. Prognostic value of proteinuria and eGFR for graft and patient survival was comparable and these two variables remain significant risk factors even in a multivariate model that take into consideration the most important clinical variables (donor age, rejection, delayed graft function and cytomegalovirus viremia among others).

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