Moderate and vigorous physical activity levels are associated with circulating CD34+ progenitor cells which are predictive of all-cause and cardiovascular mortality

Abstract Funding Acknowledgements Type of funding sources: Public Institution(s). Main funding source(s): Edinburgh Napier University Research Excellence Grant Background Circulating progenitor cells (CPCs) play an important role in vascular repair and may influence cardiovascular (CV) health and longevity. Physical activity is known to promote vascular health and may do so by modulating CPC counts. Purpose The primary aims of this study were to evaluate the association of CPCs with mortality and explore the association between physical activity (PA) and CPCs. Methods We studied 1,751 individuals from the Framingham Offspring cohort (66 ± 9 years, 54% female). CPCs (CD34+, CD34 + CD133+, CD34 + CD133 + KDR+) were measured from blood samples by flow cytometry. Multivariable cox regression analyses were performed to investigate the relationship of CPCs with future CV event, mortality, and all-cause mortality. Multivariate regression analyses were performed to determine the relationship between self-reported PA and CPC counts. Results Following adjustment for standard risk factors, there was an inverse association between CD34+ CPCs and all-cause mortality (hazard ratio (HR) per unit increase in CD34+, 0.79; 95% CI 0.64 – 0.98). CD34 + CD133+ CPCs were inversely associated with CV mortality (HR 0.63, 95% CI 0.44 – 0.91, P = 0.013). Associations of CD34+ and CD34 + CD133+ with mortality were strongest in participants with pre-existing CVD. PA was associated with CD34+ CPCs only in CVD participants. This relationship was maintained after adjustment for confounding variables. Conclusions Higher number of CD34+ and CD34+ CD133+ CPCs were inversely associated with all-cause and CV mortality. These associations were strongest in participants already diagnosed with CVD. PA is independently associated with CD34+ CPCs in individuals with CVD only, suggestive of greater benefit for this population group.

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Circulating CD34+ Progenitor Cells are Predictive of All-Cause and Cardiovascular Mortality and are Influenced by Physical Activity.

10.1101/2020.06.24.20139220 ◽

2020 ◽

Author(s):

David Muggeridge ◽

Jennifer Dodd ◽

Mark D. Ross

Keyword(s):

Physical Activity ◽

Progenitor Cells ◽

Cox Regression ◽

Population Group ◽

Inverse Association ◽

Regression Analyses ◽

Confounding Variables ◽

All Cause Mortality ◽

Unit Increase ◽

Relationship Of

AbstractBackgroundCirculating progenitor cells (CPCs) play an important role in vascular repair and may influence cardiovascular (CV) health and longevity. Exercise is known to modulate these cells via mobilization from the bone marrow. The primary aims of this study were to evaluate the association of CPCs with mortality and explore the association between physical activity (PA) and CPCs.DesignWe studied 1,751 individuals from the Framingham Offspring cohort (66 ± 9 years [40-92 years], 54% female). CPCs (CD34+, CD34+CD133+, CD34+CD133+KDR+) were measured in participants using flow cytometry. Multivariable cox regression analyses were performed to investigate relationship of CPCs with future CV event, CV mortality and all-cause mortality. Multivariate regression analyses were performed to determine the relationship between self-reported PA and CPC counts.ResultsFollowing adjustment for standard risk factors, there was an inverse association between CD34+ CPCs and all-cause mortality (hazard ratio (HR) per unit increase in CD34+, 0.79; 95% CI 0.64 – 0.98, P=0.036). CD34+CD133+ CPCs were inversely associated with CV mortality (HR 0.63, 95% CI 0.44 – 0.91, P=0.013). Associations of CD34+ and CD34+CD133+ with mortality were strongest in participants with pre-existing CVD. PA was associated with CD34+ CPCs only in CVD participants. This relationship was maintained after adjustment for confounding variables.ConclusionsHigher number of CD34+ and CD34+ CD133+ CPCs were inversely associated with all-cause and CV mortality. These associations were strongest in participants already diagnosed with CVD. PA is independently associated with CD34+ CPCs in individuals with CVD only, suggestive of greater benefit for this population group.

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Can a simple measure of vigorous physical activity predict future mortality? Results from the OXCHECK study

Public Health Nutrition ◽

10.1079/phn2003548 ◽

2004 ◽

Vol 7 (4) ◽

pp. 557-562 ◽

Cited By ~ 14

Author(s):

Melvyn Hillsdon ◽

Margaret Thorogood ◽

Mike Murphy ◽

Lesley Jones

Keyword(s):

Physical Activity ◽

Cox Regression ◽

Vigorous Physical Activity ◽

Previous History ◽

Self Report ◽

Moderate Intensity ◽

Risk Of Death ◽

All Cause Mortality ◽

Intensity Physical Activity

AbstractBackground:As epidemiological studies have become more complex, demands for short, easily administered measures of risk factors have increased. This study investigates whether such a measure of physical activity is associated with the risk of death from all causes and death from specific causes.Methods:A prospective follow-up study of 11 090 men and women, aged 35–64 years, recruited from five UK general practices who responded to a postal questionnaire in 1989. Self-reported frequency of vigorous-intensity physical activity and data on confounding factors were collected at baseline survey. Death notifications up to 31 December 2001 were provided by the Office for National Statistics. The relative risk (and 95% confidence interval) of dying associated with each level of exposure to physical activity was estimated by the hazard ratio in a series of Cox regression models.Results:After > 10 years' follow-up there were 825 deaths among the 10 522 subjects with no previous history of angina or myocardial infarction. Participation in vigorous exercise was associated with a significantly lower risk of all-cause mortality. Similar associations were found for ischaemic heart disease and cancer mortality, although the relationships were not significant at the 5% level.Conclusions:Simple measures of self-reported vigorous physical activity are associated with the risk of future mortality, at least all-cause mortality in a somewhat selected group. Interpretation of the finding should be treated with caution due to the reliance on self-report and the possibility that residual confounding may underlie the associations. Because moderate-intensity physical activity is also beneficial to health, short physical activity questionnaires should include measures of such physical activity in the future.

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Evaluating Motivational Interviewing and Habit Formation to Enhance the Effect of Activity Trackers on Healthy Adults’ Activity Levels: Randomized Intervention (Preprint)

10.2196/preprints.10988 ◽

2018 ◽

Author(s):

Laura D Ellingson ◽

Jeni E Lansing ◽

Kathryn J DeShaw ◽

Karissa L Peyer ◽

Yang Bai ◽

...

Keyword(s):

Physical Activity ◽

Behavior Change ◽

Motivational Interviewing ◽

Vigorous Physical Activity ◽

Healthy Adults ◽

Activity Levels ◽

Regression Analyses ◽

Sedentary Behaviors ◽

Wear Time ◽

Activity Trackers

BACKGROUND While widely used and endorsed, there is limited evidence supporting the benefits of activity trackers for increasing physical activity; these devices may be more effective when combined with additional strategies that promote sustained behavior change like motivational interviewing (MI) and habit development. OBJECTIVE This study aims to determine the utility of wearable activity trackers alone or in combination with these behavior change strategies for promoting improvements in active and sedentary behaviors. METHODS A sample of 91 adults (48/91 female, 53%) was randomized to receive a Fitbit Charge alone or in combination with MI and habit education for 12 weeks. Active and sedentary behaviors were assessed pre and post using research-grade activity monitors (ActiGraph and activPAL), and the development of habits surrounding the use of the trackers was assessed postintervention with the Self-Reported Habit Index. During the intervention, Fitbit wear time and activity levels were monitored with the activity trackers. Linear regression analyses were used to determine the influence of the trial on outcomes of physical activity and sedentary time. The influence of habits was examined using correlation coefficients relating habits of tracker use (wearing the tracker and checking data on the tracker and associated app) to Fitbit wear time and activity levels during the intervention and at follow-up. RESULTS Regression analyses revealed no significant differences by group in any of the primary outcomes (all P>.05). However, personal characteristics, including lower baseline activity levels (beta=–.49, P=.01) and lack of previous experience with pedometers (beta=–.23, P=.03) were predictive of greater improvements in moderate and vigorous physical activity. Furthermore, for individuals with higher activity levels at the baseline, MI and habit education were more effective for maintaining these activity levels when compared with receiving a Fitbit alone (eg, small increase of ~48 steps/day, d=0.01, vs large decrease of ~1830 steps/day, d=0.95). Finally, habit development was significantly related to steps/day during (r=.30, P=.004) and following the intervention (r=.27, P=.03). CONCLUSIONS This study suggests that activity trackers may have beneficial effects on physical activity in healthy adults, but benefits vary based on individual factors. Furthermore, this study highlights the importance of habit development surrounding the wear and use of activity trackers and the associated software to promote increases in physical activity. CLINICALTRIAL ClinicalTrials.gov NCT03837366; https://clinicaltrials.gov/ct2/show/NCT03837366

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Activity Patterns and Correlates among Youth: Differences by Weight Status

Pediatric Exercise Science ◽

10.1123/pes.14.4.418 ◽

2002 ◽

Vol 14 (4) ◽

pp. 418-431 ◽

Cited By ~ 35

Author(s):

Wendell C. Taylor ◽

James F. Sallis ◽

Marsha Dowda ◽

Patty S. Freedson ◽

Karen Eason ◽

...

Keyword(s):

Physical Activity ◽

Family Support ◽

Weight Status ◽

Vigorous Physical Activity ◽

Activity Patterns ◽

Activity Levels ◽

Regression Analyses ◽

Twelfth Graders ◽

Physical Activity Levels ◽

Significant Factors

The purposes of the study were to assess differences in physical activity levels and correlates of physical activity among overweight (‡ 85 th percentile of body mass index for their sex and age) and non-overweight (< 85th percentile) youth. The sample included 509 seventh through twelfth graders. Activity was measured by a 7-day, 46-item activity checklist. Overweight girls were more sedentary than non-overweight girls (p < .03), and non-overweight girls engaged in more vigorous physical activity than overweight girls (p < .03). For boys, there were no significant differences in activity. The regression analyses for vigorous activity yielded the largest total R2’s (R2 = .49 for overweight and R2 = .27 for non-overweight.) The significant factor for overweight youth was greater athletic coordination (p < .01). For non-overweight youth, the significant factors were greater family support (p < .05), greater peer support (p < .001), fewer barriers (p < .03), and greater athletic coordination (p < .01). Correlates of physical activity vary by weight status of young people.

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Cardiovascular or mortality risk of controlled hypertension and importance of physical activity

Heart ◽

10.1136/heartjnl-2020-318193 ◽

2021 ◽

pp. heartjnl-2020-318193

Author(s):

Sehoon Park ◽

Kyungdo Han ◽

Soojin Lee ◽

Yaerim Kim ◽

Yeonhee Lee ◽

...

Keyword(s):

Physical Activity ◽

Blood Pressure ◽

Cox Regression ◽

Vigorous Physical Activity ◽

Study Groups ◽

Adverse Outcomes ◽

Uncontrolled Hypertension ◽

Cox Regression Analysis ◽

Cerebrovascular Events ◽

All Cause Mortality

ObjectiveTo investigate the risk of major adverse cardiac and cerebrovascular events (MACCEs) and all-cause death of patients with controlled hypertension and suggest the benefits of physical activity in their prognosis.MethodsPeople aged 40–69 years from the prospective UK Biobank cohort (UKB, n=220 026) and the retrospective Korean National Health Insurance Service cohort (KNHIS, n=3 593 202) were included in this observational cohort study, excluding those with previous cerebrocardiovascular diseases or hypertension without treatment. The study groups were stratified into normotension, controlled hypertension (patients with hypertension with systolic blood pressure <140 mm Hg and diastolic blood pressure <90 mm Hg) and uncontrolled hypertension groups. The outcomes were MACCEs and all-cause mortality, analysed by Cox regression analysis.ResultsWe included 161 405/18 844/39 777 and 3 122 890/383 828/86 484 individuals with normotension/controlled hypertension/uncontrolled hypertension state from the UKB and KNHIS cohorts, respectively. The controlled hypertension group showed significantly higher risk of MACCEs (UKB: adjusted HR 1.73 (95% CI 1.55 to 1.92); KNHIS: 1.46 (95% CI 1.43 to 1.49)) and all-cause mortality (UKB: adjusted HR 1.28 (95% CI 1.18 to 1.39); KNHIS: 1.29 (95% CI 1.26 to 1.32)) than individuals with normotension. The controlled hypertension group not involved in any moderate or moderate-to-vigorous physical activity showed high risk of adverse outcomes, which was comparable with or even higher than the risk of patients with uncontrolled hypertension who were engaged in physical activity.ConclusionsControlled hypertension is associated with residual risks of adverse outcomes. Clinicians may encourage physical activity for patients with controlled hypertension, not being reassured by their achieved target blood pressure values.

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Physical Activity Amount and Cognitive Impairment in Korean Elderly Population

Brain Sciences ◽

10.3390/brainsci10110804 ◽

2020 ◽

Vol 10 (11) ◽

pp. 804

Author(s):

Seung-Taek Lim ◽

Yung Zoon Jung ◽

Takao Akama ◽

Eunjae Lee

Keyword(s):

Physical Activity ◽

Cognitive Function ◽

Short Form ◽

Vigorous Physical Activity ◽

Activity Levels ◽

Elderly Adults ◽

Dementia Screening ◽

Elderly Koreans ◽

Korean Elderly ◽

The Relationship

The relationship between physical activity amount and cognitive function in elderly Koreans has received little attention. This study therefore aimed to understand the independent and common link between cognitive function and physical activity levels among elderly Korean adults. This study recruited a total of 2746 elderly adults (1348 males and 1398 females). All participants were assessed for cognitive functioning using the Korean Dementia Screening Questionnaire Cognition (KDSQ-C). The computerized Korean version short form of the International Physical Activity Questionnaire (IPAQ) used in this study was entirely based on the long, self-administered, usual week-long IPAQ found in the IPAQ manual of operation. In the unadjusted model, elderly adults who met the recommended level of moderate-to-vigorous physical activity were more likely to have a sufficient level of cognitive function. Hemoglobin, creatinine, cholesterol (TC), triglycerides (TG), LDL-C, and HDL-C differed significantly between groups. A negative correlation was found between KDSQ-C score and the moderate-to-vigorous physical activity (MVPA) amount per week. Physical activity amount is associated with cognition function in Korean elderly adults. Increasing physical activity may improve hemoglobin and creatinine and be involved in improving serum lipid profiles in elderly adults. Thus, physical activity has been suggesting as a useful tool to reduce the risk of cognitive function associated with aging.

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Comparison of quantity and quality of muscle as clinical prognostic markers in patients undergoing carotid endarterectomy

British Journal of Radiology ◽

10.1259/bjr.20200136 ◽

2020 ◽

Vol 93 (1111) ◽

pp. 20200136

Author(s):

Mohammed Abdul Waduud ◽

Awais Ul-Hassan ◽

Talha Naveed ◽

Pratik Adusumilli ◽

Thomas Alexander Slater ◽

...

Keyword(s):

Carotid Endarterectomy ◽

Cox Regression ◽

Clinical Care ◽

Muscle Quality ◽

Regression Analyses ◽

Muscle Area ◽

Pearson’S Correlation ◽

All Cause Mortality ◽

Pearson's Correlation ◽

The Relationship

Objective: The measurement of muscle area is routinely utilised in determining sarcopaenia in clinical research. However, this simple measure fails to factor in age-related morphometric changes in muscle quality such as myosteatosis. The aims of this study were to: firstly investigate the relationship between the masseter area (quantity) and density (quality), and secondly compare the prognostic clinical relevance of each parameter. Methods: Cross-sectional CT head scans were reviewed for patients undergoing carotid endarterectomy. The masseter was manually delineated and the total masseter area (TMA) and the total masseter density (TMD) calculated. Measurements of the TMA were standardised against the cranial circumference. Observer variability in measurements were assessed using Bland–Altman plots. The relationship between TMA and TMD were evaluated using Pearson’s correlation and linear regression analyses. The prognostic value of TMA and TMD were assessed using receiver operator curves and cox-regression analyses. Results: In total, 149 patients who had undergone routine CT scans prior to a carotid endarterectomy were included in this study. No significant observer variations were observed in measuring the TMA, TMD and cranium circumference. There was a significant positive correlation between standardised TMA and TMD (Pearson’s correlation 0.426, p < 0.001, adjusted R-squared 17.6%). The area under the curve for standardised TMA in predicting all-cause mortality at 30 days, 1 year and 4 years were higher when compared to TMD. Standardised TMA was only predictive of post-operative overall all-cause mortality (adjusted hazard ratio 0.38, 95% confidence interval 0.15–0.97, p = 0.043). Conclusion: We demonstrate a strong relationship between muscle size and density. However, the utilisation of muscle area is likely to be limited in routine clinical care. Advances in knowledge: Our study supports the utilisation of muscle area in clinical sarcopaenia research. We did not observe any additional prognostic advantage in quantifying muscle density.

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Physical Activity and Depressive Symptoms in American Adolescents

Journal of Sport and Exercise Psychology ◽

10.1123/jsep.29.4.534 ◽

2007 ◽

Vol 29 (4) ◽

pp. 534-543 ◽

Cited By ~ 22

Author(s):

Laura N. Desha ◽

Jenny M. Ziviani ◽

Jan M. Nicholson ◽

Graham Martin ◽

Ross E. Darnell

Keyword(s):

Physical Activity ◽

Depressive Symptoms ◽

Depressive Symptomatology ◽

Vigorous Physical Activity ◽

Panel Study ◽

Regression Analyses ◽

Income Dynamics ◽

Physical Activity Guidelines ◽

Second Child ◽

The Relationship

This study employed ordinal logistic regression analyses to investigate the relationship between American adolescents’ participation in physical activity and depressive symptomatology. Data were drawn from the second Child Development Supplement to the Panel Study of Income Dynamics (CDS II), which was conducted over 2002-2003. Fewer than 60% of adolescents were found to accumulate 60 min of moderate-to-vigorous physical activity (MVPA) outside of school hours on week or weekend days. Accumulated duration of MVPA was not, however, significantly associated with severity of depressive symptoms for either gender. Males who were not involved in sporting clubs or lessons were more likely than males who were highly involved to experience greater severity of depressive symptoms (OR = 3.24, CI = 1.33, 7.87). Results highlight gender variability in the psychosocial correlates of sporting participation and prompt further investigation of the relevance of current physical activity guidelines for mental health in adolescence.

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Comparison of accelerometer-derived physical activity levels between individuals with and without cancer: a UK Biobank study

Future Oncology ◽

10.2217/fon-2019-0443 ◽

2019 ◽

Vol 15 (33) ◽

pp. 3763-3774 ◽

Cited By ~ 1

Author(s):

Laura McDonald ◽

Mustafa Oguz ◽

Robert Carroll ◽

Pratik Thakkar ◽

Fei Yang ◽

...

Keyword(s):

Physical Activity ◽

Cox Regression ◽

Activity Levels ◽

Uk Biobank ◽

Cancer Group ◽

All Cause Mortality ◽

History Of ◽

The Difference ◽

The Uk ◽

History Of Cancer

Aim: To identify the difference in physical activity (PA) levels between individuals with and without cancer, and to estimate all-cause mortality associated with this difference. Methods: Current cancer, cancer survivor and cancer-free groups were identified from the UK Biobank. We used multivariate and Cox regression to estimate PA differences and association of PA with all-cause mortality. Results: Compared with the cancer-free individuals, participants in the two cancer groups had fewer minutes in moderate-to-vigorous PA per day in adjusted analyses. The PA difference was associated with higher mortality in the current cancer group. Conclusion: Patients with a history of cancer were less active than those without cancer, and PA is associated with increased mortality. PA improvement strategies in cancer patients must be explored.

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Abstract 172: Baseline Physical Activity and Clinical Outcomes in Patients with Diabetes Mellitus and Stable Ischemic Heart Disease: Analysis From BARI-2D Trial.

Circulation Cardiovascular Quality and Outcomes ◽

10.1161/circoutcomes.8.suppl_2.172 ◽

2015 ◽

Vol 8 (suppl_2) ◽

Author(s):

Lynda Otalvaro Orozco ◽

Abdulla Damluji ◽

Christopher Hawk ◽

George Marzouka ◽

Italo Novoa ◽

...

Keyword(s):

Physical Activity ◽

Cox Regression ◽

Activity Levels ◽

Cox Regression Analysis ◽

Strenuous Activity ◽

All Cause Mortality ◽

Strenuous Physical Activity ◽

Sedentary Life ◽

Sedentary Life Style ◽

Baseline Physical Activity

Introduction: We aimed to evaluate the differences in clinical outcomes among patients with DM and coronary heart disease according to their baseline physical activity status. Methods: We evaluated 2,343 patients with CHD and DM who underwent either prompt revascularization (PR) and intensive medical therapy (IMT) or IMT alone in the Bypass Angioplasty Revascularization Investigation 2 Diabetes (BARI 2D) trial. Patients were categorized according to their baseline physical activity status to sedentary, mild physical activity or moderate/strenuous activity. Primary end points were all cause mortality. Cox Regression analysis was used to evaluate the effects of baseline physical activity on all-cause-mortality. Results: Of 2,343 patients, 858 (37%) were able to achieve moderate/strenuous physical activity prior to randomization. Patients with sedentary life style and mild physical activity at baseline had worse survival compared to those with higher activity levels (Figure). In a Cox regression analysis, in patients randomized to IMT alone, there were no differences in mortality across physical activity levels. In the PR arm, sedentary and mild physical activity carried high risk of mortality compared to strenuous activity levels. Furthermore, patients in the low physical activity categories carried an increased risk of death if they were randomized to the insulin sensitizing arm of the trial. Conclusions: In this study, patients with DM and CHD, moderate/strenuous physical activity at baseline had improved survival compared to mild physical activity or sedentary life-style.

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