Bridging the gap: A geroscience primer for neuroscientists with potential collaborative applications

2021 ◽  
Author(s):  
Jessica M Hoffman ◽  
Caesar M Hernandez ◽  
Abbi R Hernandez ◽  
Jennifer L Bizon ◽  
Sara N Burke ◽  
...  
Keyword(s):  
Neurodegenerative Diseases ◽  
Disease Diagnosis ◽  
The State ◽  
Reproducible Research ◽  
Collaborative Effort ◽  
Important Impact ◽  
Collaborative Applications ◽  
The Many ◽  
Biology Of Aging

Abstract While neurodegenerative diseases can strike at any age, the majority of afflicted individuals are diagnosed at older ages. Due to the important impact of age in disease diagnosis, the field of neuroscience could greatly benefit from the many of the theories and ideas from the biology of aging – now commonly referred as geroscience. As discussed in our complementary perspective on the topic, there is often a “silo-ing” between geroscientists who work on understanding the mechanisms underlying aging and neuroscientists who are studying neurodegenerative diseases. While there have been some strong collaborations between the biology of aging and neuroscientists, there is still great potential for enhanced collaborative effort between the two fields. To this end, here, we review the state of the geroscience field, discuss how neuroscience could benefit from thinking from a geroscience perspective, and close with a brief discussion on some of the “missing links” between geroscience and neuroscience and how to remedy them. Notably, we have a corresponding, concurrent review from the neuroscience perspective. Our overall goal is to “bridge the gap” between geroscience and neuroscience such that more efficient, reproducible research with translational potential can be conducted.

The Constitutional Principle of Accountability: A Study of Contemporary South African Case Law

2018 ◽  
Vol 33 (1) ◽  
Author(s):  
Chuks Okpaluba
Keyword(s):  
Judicial Review ◽  
Police Officers ◽  
Public Procurement ◽  
Case Law ◽  
The State ◽  
Constitutional Principle ◽  
Starting Point ◽  
The Law ◽  
Constitutional Right ◽  
The Many

‘Accountability’ is one of the democratic values entrenched in the Constitution of South Africa, 1996. It is a value recognised throughout the Constitution and imposed upon the law-making organs of state, the Executive, the Judiciary and all public functionaries. This constitutional imperative is given pride of place among the other founding values: equality before the law, the rule of law and the supremacy of the Constitution. This study therefore sets out to investigate how the courts have grappled with the interpretation and application of the principle of accountability, the starting point being the relationship between accountability and judicial review. Therefore, in the exercise of its judicial review power, a court may enquire whether the failure of a public functionary to comply with a constitutional duty of accountability renders the decision made illegal, irrational or unreasonable. One of the many facets of the principle of accountability upon which this article dwells is to ascertain how the courts have deployed that expression in making the state and its agencies liable for the delictual wrongs committed against an individual in vindication of a breach of the individual’s constitutional right in the course of performing a public duty. Here, accountability and breach of public duty; the liability of the state for detaining illegal immigrants contrary to the prescripts of the law; the vicarious liability of the state for the criminal acts of the police and other law-enforcement officers (as in police rape cases and misuse of official firearms by police officers), and the liability of the state for delictual conduct in the context of public procurement are discussed. Having carefully analysed the available case law, this article concludes that no public functionary can brush aside the duty of accountability wherever it is imposed without being in breach of a vital constitutional mandate. Further, it is the constitutional duty of the courts, when called upon, to declare such act or conduct an infringement of the Constitution.

State-Sponsored Inequality

2017 ◽  
Author(s):  
Shuang Chen
Keyword(s):  
Qing Dynasty ◽  
Social Stratification ◽  
Social Hierarchy ◽  
The State ◽  
Structural Inequality ◽  
Political Hierarchy ◽  
History Of ◽  
Agrarian Societies ◽  
Stratification System ◽  
The Many

The book explores the social economic processes of inequality produced by differential state entitlements. Drawing on uniquely rich source materials from central and local archives, the book provides an unprecedented, comprehensive view of the creation of a socio-economic and political hierarchy under the Eight Banners in the Qing dynasty in what is now Shuangcheng County, Heilongjiang province. Shuangcheng was settled by bannermen from urban Beijing and elsewhere in rural Manchuria in the nineteenth century. The state classified the immigrants into distinct categories, each associated with differentiated land entitlements. By reconstructing the history of settlement and land distribution in this county, the book shows that patterns of wealth stratification and the underlying social hierarchy were not merely imposed by the state from the top-down but created and reinforced by local people through practices on the ground. In the course of pursuing their own interests, settlers internalized the distinctions created by the state through its system of unequal land entitlements. The tensions built into the unequal land entitlements therefore shaped the identities of immigrant groups, and this social hierarchy persisted after the fall of the Qing in 1911. The book offers an in-depth understanding of the key factors that contributed to social stratification in agrarian societies in the nineteenth- and early twentieth-century China. Moreover, it also sheds light on the many parallels between the stratification system in Qing-dynasty Shuangcheng and the structural inequality in contemporary China.

Introduction

2018 ◽  
Author(s):  
Graeme D. Ruxton ◽  
William L. Allen ◽  
Thomas N. Sherratt ◽  
Michael P. Speed
Keyword(s):  
Evolutionary Ecology ◽  
The State ◽  
Warning Signals ◽  
The Many

In 2004, the first edition of ‘Avoiding Attack: The Evolutionary Ecology of Crypsis, Warning Signals, and Mimicry’ by Ruxton et al. was published. The book aimed to provide a systematic and up-to-date review and synthesis of widespread anti-predator defences. In it, we focussed on sensorially mediated defences and the many factors that underpin these adaptations, aiming to set out the state-of-understanding in the fascinating world of anti-predator adaptations, and highlight which topics within the field seem most ripe for further investigation....

scholarly journals Is There a Brain Microbiome?

2021 ◽  
Vol 16 ◽  
pp. 263310552110187
Author(s):  
Christopher D Link
Keyword(s):  
Animal Models ◽  
Human Brain ◽  
Neurodegenerative Diseases ◽  
Ground Truth ◽  
Healthy Human ◽  
Strong Motivation ◽  
The Many ◽  
The Brain

Numerous studies have identified microbial sequences or epitopes in pathological and non-pathological human brain samples. It has not been resolved if these observations are artifactual, or truly represent population of the brain by microbes. Given the tempting speculation that resident microbes could play a role in the many neuropsychiatric and neurodegenerative diseases that currently lack clear etiologies, there is a strong motivation to determine the “ground truth” of microbial existence in living brains. Here I argue that the evidence for the presence of microbes in diseased brains is quite strong, but a compelling demonstration of resident microbes in the healthy human brain remains to be done. Dedicated animal models studies may be required to determine if there is indeed a “brain microbiome.”

scholarly journals Molecular and cellular pathways contributing to brain aging

2021 ◽  
Vol 17 (1) ◽  
Author(s):  
Aliabbas Zia ◽  
Ali Mohammad Pourbagher-Shahri ◽  
Tahereh Farkhondeh ◽  
Saeed Samarghandian
Keyword(s):  
Neurodegenerative Diseases ◽  
Neurodegenerative Disorders ◽  
Brain Aging ◽  
Neuroprotective Effect ◽  
Ros Generation ◽  
Brain Health ◽  
Cellular Pathways ◽  
Aging Mechanisms ◽  
Oxidatively Modified ◽  
Biology Of Aging

AbstractAging is the leading risk factor for several age-associated diseases such as neurodegenerative diseases. Understanding the biology of aging mechanisms is essential to the pursuit of brain health. In this regard, brain aging is defined by a gradual decrease in neurophysiological functions, impaired adaptive neuroplasticity, dysregulation of neuronal Ca2+ homeostasis, neuroinflammation, and oxidatively modified molecules and organelles. Numerous pathways lead to brain aging, including increased oxidative stress, inflammation, disturbances in energy metabolism such as deregulated autophagy, mitochondrial dysfunction, and IGF-1, mTOR, ROS, AMPK, SIRTs, and p53 as central modulators of the metabolic control, connecting aging to the pathways, which lead to neurodegenerative disorders. Also, calorie restriction (CR), physical exercise, and mental activities can extend lifespan and increase nervous system resistance to age-associated neurodegenerative diseases. The neuroprotective effect of CR involves increased protection against ROS generation, maintenance of cellular Ca2+ homeostasis, and inhibition of apoptosis. The recent evidence about the modem molecular and cellular methods in neurobiology to brain aging is exhibiting a significant potential in brain cells for adaptation to aging and resistance to neurodegenerative disorders.

scholarly journals Genetic and Transcriptomic Biomarkers in Neurodegenerative Diseases: Current Situation and the Road Ahead

Cells ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 1030
Author(s):  
Julie Lake ◽  
Catherine S. Storm ◽  
Mary B. Makarious ◽  
Sara Bandres-Ciga
Keyword(s):  
Neurodegenerative Diseases ◽  
Large Scale ◽  
Disease Diagnosis ◽  
Open Science ◽  
Future Directions ◽  
The Road ◽  
Current State ◽  
Molecular Complexity ◽  
Science Framework ◽  
Lateral Sclerosis

Neurodegenerative diseases are etiologically and clinically heterogeneous conditions, often reflecting a spectrum of disease rather than well-defined disorders. The underlying molecular complexity of these diseases has made the discovery and validation of useful biomarkers challenging. The search of characteristic genetic and transcriptomic indicators for preclinical disease diagnosis, prognosis, or subtyping is an area of ongoing effort and interest. The next generation of biomarker studies holds promise by implementing meaningful longitudinal and multi-modal approaches in large scale biobank and healthcare system scale datasets. This work will only be possible in an open science framework. This review summarizes the current state of genetic and transcriptomic biomarkers in Parkinson’s disease, Alzheimer’s disease, and amyotrophic lateral sclerosis, providing a comprehensive landscape of recent literature and future directions.

scholarly journals Designing of Nanomaterials-Based Enzymatic Biosensors: Synthesis, Properties, and Applications

Electrochem ◽  
2021 ◽  
Vol 2 (1) ◽  
pp. 149-184
Author(s):  
Francisco T. T. Cavalcante ◽  
Italo R. R. de A. Falcão ◽  
José E. da S. Souza ◽  
Thales G. Rocha ◽  
Isamayra G. de Sousa ◽  
...  
Keyword(s):  
Enzyme Immobilization ◽  
State Of The Art ◽  
Volume Ratio ◽  
The State ◽  
Future Research ◽  
Synthesis Properties ◽  
Signal Response ◽  
Enzymatic Biosensors ◽  
The Many ◽  
Biological Entities

Among the many biological entities employed in the development of biosensors, enzymes have attracted the most attention. Nanotechnology has been fostering excellent prospects in the development of enzymatic biosensors, since enzyme immobilization onto conductive nanostructures can improve characteristics that are crucial in biosensor transduction, such as surface-to-volume ratio, signal response, selectivity, sensitivity, conductivity, and biocatalytic activity, among others. These and other advantages of nanomaterial-based enzymatic biosensors are discussed in this work via the compilation of several reports on their applications in different industrial segments. To provide detailed insights into the state of the art of this technology, all the relevant concepts around the topic are discussed, including the properties of enzymes, the mechanisms involved in their immobilization, and the application of different enzyme-derived biosensors and nanomaterials. Finally, there is a discussion around the pressing challenges in this technology, which will be useful for guiding the development of future research in the area.

Step It Up and Go

2020 ◽  
Author(s):  
David Menconi
Keyword(s):  
Working Class ◽  
Popular Music ◽  
Hip Hop ◽  
The State ◽  
College Town ◽  
American Idol ◽  
Recorded Music ◽  
American Popular Music ◽  
The Many ◽  
Nina Simone

This book is a love letter to the artists, scenes, and sounds defining North Carolina’s extraordinary contributions to American popular music. David Menconi spent three decades immersed in the state’s music, where traditions run deep but the energy expands in countless directions. Menconi shows how working-class roots and rebellion tie North Carolina’s Piedmont blues, jazz, and bluegrass to beach music, rock, hip-hop, and more. From mill towns and mountain coves to college-town clubs and the stage of American Idol, Blind Boy Fuller and Doc Watson to Nina Simone and Superchunk, Step It Up and Go celebrates homegrown music just as essential to the state as barbecue and basketball. Spanning a century of history from the dawn of recorded music to the present, and with sidebars and photos that help reveal the many-splendored glory of North Carolina’s sonic landscape, this is a must-read for every music lover.

Gendered Secularization and the Body Policing of Muslim Women

2018 ◽  
Author(s):  
Raissa Killoran
Keyword(s):  
Muslim Women ◽  
The State ◽  
The Body ◽  
Religious Expression ◽  
Women's Bodies ◽  
Cultural Symbols ◽  
Religious Symbols ◽  
Female Bodies ◽  
The Many ◽  
A Site

The many usages of the term ‘secularism’ have generated an ambiguity in the word; as a political guise, it may be used to engender anti-religious fervor. Particularly in regards to veiling among female Muslim adherents, the attainment of a secular state and touting of the necessity of dismantling religious symbols have functioned as linguistic shields. By calling a “burka ban” necessary or even egalitarian secularization, legislators employ ‘secularization’ as jargon for political ends, enacting a stance of supremacy under the semblance of progress. Secularization has come to function as a political tool - in the name of it, governments may prescribe which cultural symbols are normative and which are of ‘other’ cultures or religious origins. As such, the identification of some religious symbols as foreign and others as normative is a usage of secularization for normalization of dominant religious expression. In this, there is an implicit neocolonialism; by imposing standards of cultural normalcy which are definitively nonMuslim, such policies attempt to divorce Muslims from Islam.  Further, I intend to investigate the gendered aspect of secularization politics. By critiquing clothing and body policing of women, I will demonstrate how secularization projects use the female body and dress as a site for display. By rendering the female physically emblematic of the honor and virtue of an ‘other’ culture, those enacting secularization norms target women’s bodies to act as visual exhibitions of the dominant culture’s hegemony. Here, we see gendered secularization at work - female bodies become controlled by the antireligious zeal of the state, while the state carries out this control on the predicate that it is the religious group enacting unjust control. As such, the policing of female Muslim bodies is symbolic of the policing of Islam as a whole; it acts as an illustration of an imposed, gendered secularization project.

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