scholarly journals Urolithin A enhances muscle performance in elderly and positively impacts biomarkers linked to cellular health

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. 674-675
Author(s):  
Sophia Liu ◽  
David Marcinek
Keyword(s):  
Muscle Fatigue ◽  
Positive Impact ◽  
Mitochondrial Gene ◽  
Muscle Performance ◽  
Walking Distance ◽  
Controlled Study ◽  
Elderly Subjects ◽  
Muscle Endurance ◽  
Plasma Biomarkers ◽  
Urolithin A

Abstract Background Aging is associated with decline in mitochondrial function and reduced exercise capacity. Urolithin A (UA) is a natural gut metabolite shown to stimulate mitophagy and improve muscle function in aged animals, and induce mitochondrial gene expression in elderly. Purpose Investigate if oral administration of UA improved walking distance (6MWT), muscle fatigue resistance in hand (FDI) and leg (TA) muscles, and had an impact on plasma biomarkers. Method: We conducted a randomized, double-blind, placebo-controlled study (NCT03283462) in elderly subjects (65-90 yrs.) supplemented daily with 1000mg UA or placebo for 4 months. 128 subjects were screened and 66 randomized. 6MWT and ATPmax via MRS were assessed at baseline and at 4 months. Muscle fatigue tests and plasma analysis of biomarkers were assessed at baseline, 2 and 4 months. Results UA significantly improved muscle endurance (i.e., change in number of muscle contractions from baseline) in two different muscles (hand: PL 11.6 ±147.5, UA 95.3 ± 115.5; and leg: PL 5.7± 127.1, UA 41.4 ±65.5) compared with placebo at 2-months. Plasma levels of several acylcarnitines, ceramides and C-reactive-protein were decreased by UA at the end-of study. 6MWT distance (PL 42.5 ± 73.3 m, UA 60.8± 67.2 m) and ATPmax increased in both groups from baseline (PL 13.7±31.4%, UA19.4± 56.8%) with UA supplemented group exhibiting greater improvements, although these were not statistically different between groups. Conclusion UA supplementation improved muscle endurance, metabolic and inflammatory plasma biomarkers after 2-months, suggesting that UA can have a positive impact on muscle and cellular health in the elderly.

scholarly journals Correlation between two physical activity programs in the gait of sedentary elderly subjects

2010 ◽  
Vol 8 (3) ◽  
pp. 281-284
Author(s):  
Mariana Varkala Lanuez ◽  
Fernanda Varkala Lanuez ◽  
Eduardo Gunther Montero ◽  
Wilson Jacob Filho
Keyword(s):  
The Elderly ◽  
Controlled Study ◽  
Elderly Subjects ◽  
Male And Female ◽  
The Past ◽  
Physical Exercises ◽  
Balance Exercises ◽  
Group A ◽  
Group B ◽  
De Medicina

ABSTRACT Objectives: To assess the effect of exercise on gait using two different programs: a group of aerobic exercises (Group A, n = 18) and a group of flexibility and balance exercises (Group B, n = 19). Methods: A casualized controlled study, in which each sample controlled itself, was undertaken. The sample comprised 37 male and female subjects, aged from 60 to 90 years, from the outpatient clinic of the Geriatrics Unit of Hospital das Clínicas of Faculdade de Medicina of Universidade de São Paulo; the patients were sedentary and had not exercised regularly during the past six months. Results: Improvement of gait was seen mainly in the group that did specific exercises. Conclusion: The results of this study underline the importance of physical exercises in sedentary elderly subjects, but show the need for programming the exercises towards specific goals, which can optimize the results of this tool of health promotion for the elderly.

scholarly journals Effects of Laser Acupuncture on Delayed Onset Muscle Soreness of the Biceps Brachii Muscle: A Randomized Controlled Trial

2019 ◽  
Vol 2019 ◽  
pp. 1-10 ◽  
Author(s):  
Wen-Dien Chang ◽  
Jih-Huah Wu ◽  
Nai-Jen Chang ◽  
Chia-Lun Lee ◽  
Shuya Chen
Keyword(s):  
Muscle Strength ◽  
Muscle Soreness ◽  
Biceps Brachii ◽  
Controlled Trial ◽  
Pressure Pain Threshold ◽  
Muscle Performance ◽  
Laser Acupuncture ◽  
Controlled Study ◽  
Arm Circumference ◽  
Delayed Muscle Soreness

Objectives. The aim of this study was to explore the effects of laser acupuncture on improvement of recovery and muscle performance in delayed muscle soreness (DOMS) when applied before exercise. Methods. This randomized, blinded, and controlled study included healthy participants (n = 40) who were randomized into laser acupuncture and placebo groups. Laser acupuncture was applied to the Tianquan (PC2) and Chihtseh acupoints (LU5) at a dose of 36 J and energy density of 9.7 J/cm2 before inducing DOMS. The placebo group received sham laser acupuncture with no laser output. Visual analog scale (VAS), proprioception, pressure pain threshold (PPT), arm circumference, and muscle strength were observed at the baseline and 24, 48, 72, and 96 h after induction of DOMS. Results. Significant changes in the VAS (F4,  43.96 = 31.47; p = 0.001), PPT (F4,  1.35 = 35.07; p = 0.001), normalized arm circumference (F4,  0.001 = 3.87; p = 0.005), and normalized muscle strength (F4,  0.31 = 24.99; p = 0.001) were observed within the groups over time (p < 0.05), but there were no significant differences between the two groups (p > 0.05). Normalized arm circumference was significantly different between the two groups at 48 and 72 h after induction of DOMS (p < 0.05). Conclusion. Photobiomodulation therapy on Tianquan (PC2) and Chihtseh acupoints (LU5) before the exercise did not significantly decrease DOMS and increase muscle performance. Laser acupuncture as a supplemental therapy seemed to have no effect on DOMS prevention.

Treating Cognitive Impairments in Bipolar Disorders: New Leads in the Cognitive Remediation Field

2017 ◽  
Vol 41 (S1) ◽  
pp. S118-S118
Author(s):  
C. Isaac ◽  
M.C. Castillo ◽  
D. Januel
Keyword(s):  
Quality Of Life ◽  
Positive Impact ◽  
Brain Plasticity ◽  
Neuropsychological Functioning ◽  
Cognitive Impairments ◽  
Cognitive Remediation ◽  
Bipolar Disorders ◽  
Controlled Study ◽  
Bipolar Patients

Cognitive deficits have been overlooked in bipolar spectrum disorders, despite their significant impact on patients’ quality of life. Indeed, nearly sixty percent of stabilized bipolar patients suffer from major cognitive impairments that impede their everyday life functioning. Without proper care, these impairments remain throughout lifespan and increase with hospitalisations, social isolation or pharmacological treatments. Cognitive remediation is a cost-effective tool well accepted by patients and caregivers that has proven its efficacy for treating cognitive impairments in several disorders such as schizophrenia. However, for bipolar disorders, this psychosocial intervention based on brain plasticity is still in its early stages. After depicting the state of the art on cognitive impairments and cognitive remediation in mood disorders, we will introduce the ECo program that was specifically designed for bipolar disorders. We will then present the preliminary results (n = 18) of a double-blind randomised controlled study that assessed the effect of this program on cognitive impairments and psychosocial functioning, at short term and long term (three and nine months). First results support the hypothesis of a positive impact of the ECo cognitive remediation program on bipolar patients’ neuropsychological functioning, self-efficacy and quality of life. Cognitive remediation may be a promising tool for bipolar disorders that meets the needs of patients, their caregivers and the community.Disclosure of interestThe authors have not supplied their declaration of competing interest.

SAFETY AND EFFICACY OF ESLICARBAZEPINE ACETATE IN ELDERLY PATIENTS

2015 ◽  
Vol 86 (11) ◽  
pp. e4.143-e4
Author(s):  
R Costa ◽  
N Lopes ◽  
H Gama ◽  
R Sousa ◽  
T Nunes ◽  
...  
Keyword(s):  
Elderly Patients ◽  
Seizure Frequency ◽  
Adjunctive Therapy ◽  
Vital Signs ◽  
Phase Iii ◽  
Controlled Study ◽  
Elderly Subjects ◽  
Maintenance Period ◽  
Eslicarbazepine Acetate ◽  
Once Daily

PurposeTo evaluate the safety/tolerability and efficacy of eslicarbazepine acetate (ESL) as adjunctive therapy in elderly patients with partial-onset seizures (POS).MethodPhase III, multicentre, open-label, non-controlled study in patients aged ≥65 years with ≥2 POS during an 8-week baseline and treated with 1–2 antiepileptic drugs. Following baseline, patients entered a 26-week maintenance period. ESL was initiated at 400 mg once-daily and adjusted (400–1200 mg/day) based on individual response. Safety/tolerability evaluations included treatment-emergent adverse events (TEAEs), vital signs, 12-lead electrocardiogram and physical/neurological examinations. Efficacy evaluations included change in standardised seizure frequency (SSF; seizure frequency/4 weeks).ResultsOf the 72 patients included, 47 (65.3%) experienced 152 TEAEs; most commonly, dizziness (12.5%), somnolence (9.7%), fatigue (8.3%), convulsion (8.3%) and hyponatraemia (8.3%). Three patients died of cardiac failure, glioblastoma multiforme and ischaemic stroke (relationship unlikely/not related). Overall, 16 (22.2%) patients discontinued due to TEAEs. Incidence of clinically significant findings was low for vital signs, electrocardiogram and physical/neurological examinations. SSF decreased from 2.9 at baseline to 1.2 during the maintenance period (median relative change: –54.1%).ConclusionOnce-daily ESL (400–1200 mg) as adjunctive therapy in elderly subjects with POS did not raise major safety concerns and was efficacious. Supported by Bial.

Sign in / Sign up

Export Citation Format

Share Document