scholarly journals The epidemiologic evidence linking prenatal and postnatal exposure to endocrine disrupting chemicals with male reproductive disorders: a systematic review and meta-analysis

2016 ◽  
Vol 23 (1) ◽  
pp. 104-125 ◽  
Author(s):  
Jens Peter Bonde ◽  
Esben Meulengracht Flachs ◽  
Susie Rimborg ◽  
Clara Helene Glazer ◽  
Aleksander Giwercman ◽  
...  
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Endocrine Disrupting Chemicals ◽  
Postnatal Exposure ◽  
Reproductive Disorders ◽  
Epidemiologic Evidence ◽  
Endocrine Disrupting

Endocrine Disrupting Chemicals and Risk of Testicular Cancer A Systematic Review and Meta-analysis

2021 ◽  
Author(s):  
Elvira V Bräuner ◽  
Youn-Hee Lim ◽  
Trine Koch ◽  
Cecilie S Uldbjerg ◽  
Laura S Gregersen ◽  
...  
Keyword(s):  
Systematic Review ◽  
Testicular Cancer ◽  
Adult Male ◽  
Meta Analysis ◽  
Endocrine Disrupting Chemicals ◽  
Fetal Life ◽  
Endocrine Disrupting ◽  
Meta Analyses ◽  
Completeness Of Reporting

Abstract The incidence of many hormone-dependent diseases, including testicular cancer, have sharply increased in all high-income countries during the 20th century. This is not fully explained by established risk factors. Concurrent, increasing exposure to antiandrogenic environmental endocrine disrupting chemicals (EDCs) in fetal life may partially explain this trend. This systematic review assessed available evidence regarding the association between environmental EDC exposure and risk of testicular cancer (seminomas and non-seminomas). Following PRISMA guidelines, a search of English peer-reviewed literature published prior to December 14 th, 2020, in the databases PubMed and Embase® was performed. Among the 279 identified records, 19 were eligible for quality assessment and 10 for further meta-analysis. The completeness of reporting was high across papers, but over 50% were considered subject to potential risk of bias. Mean age at diagnosis was 31.9 years. None considered effects of EDCs multipollutant mixtures. The meta-analyses showed that maternal exposure to combined EDCs was associated with a higher risk of testicular cancer in male offspring (summary RRs: 2.16, (95% CI:1.78-2.62); 1.93 (95% CI:1.49-2.48); 2.78 (95% CI:2.27-3.41) for all, seminoma, non-seminoma respectively). Similarly, high maternal exposures to grouped organochlorines and organo-halogens were associated with higher risk of seminoma and non-seminoma in the offspring. Summary estimates related to postnatal adult male EDC exposures were inconsistent.Maternal but not postnatal adult male, EDC exposures were consistently associated with a higher risk of testicular cancer, particularly risk of non-seminomas. However, the quality of studies was mixed and considering the fields complexity, more prospective studies of prenatal EDC multipollutant mixture exposures and testicular cancer are needed.

Endocrine-disrupting chemicals, risk of type 2 diabetes, and diabetes-related metabolic traits: A systematic review and meta-analysis

2015 ◽  
Vol 8 (4) ◽  
pp. 516-532 ◽  
Author(s):  
Yan Song ◽  
Elizabeth L. Chou ◽  
Aileen Baecker ◽  
Nai-Chieh Y. You ◽  
Yiqing Song ◽  
...  
Keyword(s):  
Systematic Review ◽  
Type 2 Diabetes ◽  
Meta Analysis ◽  
Endocrine Disrupting Chemicals ◽  
Metabolic Traits ◽  
Endocrine Disrupting

scholarly journals Unravelling the link between phthalate exposure and endometriosis in humans: a systematic review and meta-analysis of the literature

2021 ◽  
Author(s):  
Alessandro Conforti ◽  
Luigi Carbone ◽  
Vittorio Simeon ◽  
Paolo Chiodini ◽  
Vincenzo Marrone ◽  
...  
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Endocrine Disrupting Chemicals ◽  
Reproductive Age ◽  
Review Of Literature ◽  
Chemical Agents ◽  
Endocrine Disrupting ◽  
Urinary Levels ◽  
Newcastle Ottawa Scale ◽  
Ottawa Scale

Abstract Purpose Endometriosis is a chronic debilitating inflammatory pathology which interests females in their reproductive age. Its pathogenesis has not yet been clearly defined. Recent evidence linked chemical agents as endocrine-disrupting chemicals to endometriosis. Phthalates are a widely used class of such compounds. This study aimed to summarize the current literature evaluating the link between exposure to phthalates and occurrence of endometriosis. Methods A systematic review of literature and meta-analysis has been carried out following PRISMA guidelines to assess such link. Fourteen studies have been included in the review. Risk of bias has been assessed through the Newcastle Ottawa Scale. Results We observed association between endometriosis and increased urinary levels of MBP/MnBP, MEOHP, and MEHHP, but not for others. Blood-derived analysis showed statistically significant link between endometriosis and BBP, DEHP, DnBP, and MEHP. Conclusion Given the wide heterogeneity of included studies, results should be taken with caution. Further studies with more rigorous methodology are encouraged to unravel the true link between this class of toxic compounds and manifestation of endometriosis.

scholarly journals Exposure to endocrine-disrupting chemicals and anthropometric measures of obesity: a systematic review and meta-analysis

BMJ Open ◽  
2020 ◽  
Vol 10 (6) ◽  
pp. e033509 ◽  
Author(s):  
Carolina Martins Ribeiro ◽  
Bruna Teles Soares Beserra ◽  
Nadyellem Graciano Silva ◽  
Caroline Lourenço Lima ◽  
Priscilla Roberta Silva Rocha ◽  
...  
Keyword(s):  
Systematic Review ◽  
Bisphenol A ◽  
Data Extraction ◽  
Meta Analysis ◽  
Endocrine Disrupting Chemicals ◽  
Risk Of Bias ◽  
Anthropometric Measures ◽  
Cross Sectional ◽  
Endocrine Disrupting ◽  
Obesity In Children

ObjectiveEndocrine-disrupting chemicals (EDCs) are viewed as a major potential link between the environment and obesity development. We did a systematic review and meta-analysis to examine the association between exposure to EDCs and obesity.Data sources, design and eligibility criteriaPubMed, Scopus and Web of Science were searched from inception to 6 June 2018 for studies primarily addressing the association between exposure to EDCs after the age of 2 years and anthropometric measures of obesity or body fat. The Newcastle-Ottawa scale was used to assess the risk of bias.Data extraction and synthesisTwo independent reviewers screened and conducted data extraction and synthesis. A third reviewer resolved disagreements.ResultsA total of 73 studies investigating bisphenol A (32 286 individuals), organochlorine compounds (34 567 individuals), phthalates (21 401 individuals), polybrominated biphenyls (2937 individuals), polycyclic aromatic hydrocarbons (5174 individuals), parabens (4097 individuals), benzoic acid (3671 individuals) and polyfluoroalkyl substances (349 individuals) met our inclusion criteria. Most had a cross-sectional design and low or medium risk of bias. In qualitative analysis, bisphenol A and phthalates were consistently associated with general and abdominal obesity, in children and adults, and some studies suggested this association was age-dependent and gender-dependent. Meta-analysis indicated a significant association between exposure to bisphenol A and overweight (OR 1.254, 95% CI 1.005 to 1.564), obesity (OR 1.503, 95% CI 1.273 to 1.774) and increased waist circumference (OR 1.503, 95% CI 1.267 to 1.783) in adults, and between exposure to 2,5-dichlorophenol and obesity in children (OR 1.8, 95% CI 1.1018 to 3.184).ConclusionMost observational studies supported a positive association between obesity and exposure to EDCs. Although causality cannot be determined from these data, they underscore the need to limit human exposure to EDCs in light of the evidence from animal and cell-based studies indicating the effects of these chemicals on adiposity.PROSPERO registration numberCRD42018074548.

Endocrine disrupting chemicals and reproductive disorders in women, men, and animal models

2021 ◽  
Author(s):  
Mary Jo Laws ◽  
Alison M. Neff ◽  
Emily Brehm ◽  
Genoa R. Warner ◽  
Jodi A. Flaws
Keyword(s):  
Animal Models ◽  
Endocrine Disrupting Chemicals ◽  
Reproductive Disorders ◽  
Endocrine Disrupting

scholarly journals Relationship between Prenatal or Postnatal Exposure to Pesticides and Obesity: A Systematic Review

2021 ◽  
Vol 18 (13) ◽  
pp. 7170
Author(s):  
Helena Pinos ◽  
Beatriz Carrillo ◽  
Ana Merchán ◽  
Judit Biosca-Brull ◽  
Cristian Pérez-Fernández ◽  
...  
Keyword(s):  
Systematic Review ◽  
Body Weight ◽  
Weight Control ◽  
Animal Studies ◽  
Pesticide Exposure ◽  
Endocrine Disrupting Chemicals ◽  
Overweight And Obesity ◽  
Postnatal Exposure ◽  
Body Weight Control ◽  
The Impact

In recent years, the worldwide prevalence of overweight and obesity among adults and children has dramatically increased. The conventional model regarding the onset of obesity is based on an imbalance between energy intake and expenditure. However, other possible environmental factors involved, such as the exposure to chemicals like pesticides, cannot be discarded. These compounds could act as endocrine-disrupting chemicals (EDC) that may interfere with hormone activity related to several mechanisms involved in body weight control. The main objective of this study was to systematically review the data provided in the scientific literature for a possible association between prenatal and postnatal exposure to pesticides and obesity in offspring. A total of 25 human and 9 animal studies were analyzed. The prenatal, perinatal, and postnatal exposure to organophosphate, organochlorine, pyrethroid, neonicotinoid, and carbamate, as well as a combined pesticide exposure was reviewed. This systematic review reveals that the effects of pesticide exposure on body weight are mostly inconclusive, finding conflicting results in both humans and experimental animals. The outcomes reviewed are dependent on many factors, including dosage and route of administration, species, sex, and treatment duration. More research is needed to effectively evaluate the impact of the combined effects of different pesticides on human health.

scholarly journals Prevalence of diabetes in the 2009 influenza A (H1N1) and the Middle East respiratory syndrome coronavirus: a systematic review and meta-analysis

2016 ◽  
Vol 5 (3) ◽  
Author(s):  
Alaa Badawi ◽  
Sueng Gwan Ryoo
Keyword(s):  
Systematic Review ◽  
Middle East ◽  
Influenza A ◽  
Meta Analysis ◽  
Middle East Respiratory Syndrome ◽  
Global Public Health ◽  
Epidemiologic Evidence ◽  
Severe Acute Respiratory Infection ◽  
Influenza A H1n1 ◽  
Prevalence Of Obesity

Over the past two decades a number of severe acute respiratory infection outbreaks such as the 2009 influenza A (H1N1) and the Middle East respiratory syndrome coronavirus (MERS-CoV) have emerged and presented a considerable global public health threat. Epidemiologic evidence suggests that diabetic subjects are more susceptible to these conditions. However, the prevalence of diabetes in H1N1 and MERS-CoV has not been systematically described. The aim of this study is to conduct a systematic review and meta-analysis of published reports documenting the prevalence of diabetes in H1N1 and MERS-CoV and compare its frequency in the two viral conditions. Meta-analysis for the proportions of subjects with diabetes was carried out in 29 studies for H1N1 (n=92,948) and 9 for MERS-CoV (n=308). Average age of H1N1 patients (36.2±6.0 years) was significantly younger than that of subjects with MERS-CoV (54.3±7.4 years, P<0.05). Compared to MERS-CoV patients, subjects with H1N1 exhibited 3-fold lower frequency of cardiovascular diseases and 2- and 4-fold higher prevalence of obesity and immunosuppression, respectively. The overall prevalence of diabetes in H1N1 was 14.6% (95% CI: 12.3- 17.0%; P<0.001), a 3.6-fold lower than in MERS-CoV (54.4%; 95% CI: 29.4-79.5; P<0.001). The prevalence of diabetes among H1N1 cases from Asia and North America was ~two-fold higher than those from South America and Europe. The prevalence of diabetes in MERS-CoV cases is higher than in H1N1. Regional comparisons suggest that an etiologic role of diabetes in MERS-CoV may exist distinctive from that in H1N1.

scholarly journals Sex-Change Chemicals and their Influence on the Brain

2001 ◽  
Vol 1 ◽  
pp. 681-683 ◽  
Author(s):  
Catherine A. Harris
Keyword(s):  
Endocrine Disrupting Chemicals ◽  
Reproductive Disorders ◽  
Developmental Abnormalities ◽  
Scientific World ◽  
Endocrine Disrupting ◽  
Causative Agents ◽  
Wide Variability ◽  
Wildlife Populations ◽  
Natural Hormones ◽  
The Brain

The potential for man-made chemicals to mimic or antagonise natural hormones is a controversial issue, but one for which increasing amounts of evidence are being gathered worldwide. The controversy surrounds not so much the matter of whether these chemicals can mimic hormones invitro— this phenomenon has been widely accepted in the scientific world — but more whether, as a result, they can disrupt reproduction in a wildlife situation. It has, nevertheless, been acknowledged that many wildlife populations are exhibiting reproductive and/or developmental abnormalities such as intersex gonads in wild roach populations in the U.K.[1] and various reproductive disorders in alligators in Lake Apopka, Florida[2]. However, the causative agents for many of these effects are difficult to specify, due to the extensive mixtures of chemicals — each of which may act via different pathways — to which wild populations are exposed, together with the wide variability observed even in natural (uncontaminated) habitats. As a result, any information detailing fundamental mechanism of action of the so-called endocrine disrupting chemicals (EDCs) is of use in determining whether or not these chemicals, as they are present in the environment, may in fact be capable of causing some of the effects observed in wildlife over recent years.

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