scholarly journals 940Physical frailty and the onset of depressive symptom in older Japanese women

2021 ◽  
Vol 50 (Supplement_1) ◽  
Author(s):  
Hiroyuki Sasai ◽  
Narumi Kojima ◽  
Yosuke Osuka ◽  
Hunkyung Kim
Keyword(s):  
Depressive Symptoms ◽  
Depressive Symptom ◽  
Depression Scale ◽  
Later Life ◽  
Japanese Women ◽  
Community Dwelling ◽  
Health Study ◽  
Cardiovascular Health Study ◽  
Physical Frailty ◽  
Frailty Status

Abstract Background The co-occurrence of physical frailty and depressive symptoms is highly prevalent in late life. However, their causal direction remains unclear. This study examined whether frailty and its components (slowness, weakness, exhaustion, low activity, and weight loss) predict the onset of depressive symptoms among older Japanese women. Methods In a two-year cohort study conducted in a metropolitan area of Tokyo, we collected baseline data in October 2017 and follow-up data in September 2019. Participants were community-dwelling older Japanese women, aged 65 to 80 years without any neurological diseases or depressive symptoms. Logistic regression analyses were applied to estimate odds ratios (OR) of the onset of depressive symptoms (15-item Geriatric Depression Scale [GDS] score ≥ 6) across the baseline frailty status or its components classified by the Japanese version of Cardiovascular Health Study criteria. Results Of the 477 women analysed (275 robust and 202 prefrail/frail). 6 (2.2%) robust and 16 (7.9%) prefrail or frail women developed depressive symptoms. After being adjusted for various covariates including baseline GDS score, the OR of the depressive symptom onset was 3.04 (95% confidence interval [CI]: 0.99, 10.47) in the prefrail or frail women. Among the five frailty components, slowness (OR: 7.55, 95%CI: 1.11, 48.98) and exhaustion (OR: 5.00, 95%CI: 1.60, 16.13) were independently associated with the onset of depressive symptoms. Conclusions Physical frailty status, particularly slowness and exhaustion, predict future depressive symptoms in older women. Key messages Early detection and intervention targeting physical frailty may help prevent depressive symptoms in later life.

scholarly journals Association between Physical Frailty Subdomains and Oral Frailty in Community-Dwelling Older Adults

2021 ◽  
Vol 18 (6) ◽  
pp. 2931
Author(s):  
Ryo Komatsu ◽  
Koutatsu Nagai ◽  
Yoko Hasegawa ◽  
Kazuki Okuda ◽  
Yuto Okinaka ◽  
...  
Keyword(s):  
Older Adults ◽  
Gait Speed ◽  
Community Dwelling ◽  
Health Study ◽  
Cardiovascular Health Study ◽  
Physical Frailty ◽  
Cross Sectional ◽  
Important Indicator ◽  
Community Dwelling Older Adults ◽  
Oral Frailty

This cross-sectional study aimed to demonstrate the association between physical frailty subdomains and oral frailty. This study involved community-dwelling older adults (aged ≥65 years). Physical frailty was assessed with the Japanese version of the Cardiovascular Health Study criteria. Oral frailty was defined as limitations in at least three of six domains. Logistic regression analysis was used to analyze the association between physical frailty risk and oral frailty. In addition, we examined the association between physical frailty subdomains (gait speed, grip strength, exhaustion, low physical activity, and weight loss) and oral frailty. A total of 380 participants were recruited for this study. Overall, 18% and 14% of the participants were at risk of physical frailty and had oral frailty, respectively. Physical frailty risk (odds ratio (OR) = 2.40, 95% confidence interval (CI): 1.22–4.75, p = 0.012) was associated with oral frailty in multivariate analysis. In secondary analysis, among physical frailty subdomains, gait speed (OR = 0.85, 95% CI: 0.73–0.97, p = 0.019) was associated with oral frailty. The present findings suggest that physical frailty is closely related to oral frailty. Among physical frailty subdomains, decreased gait speed in particular is an important indicator related to the development of oral frailty.

Prospective Associations of Physical Frailty With Future Falls and Fear of Falling: A 48-Month Cohort Study

2021 ◽  
Author(s):  
K Makino ◽  
S Lee ◽  
S Bae ◽  
I Chiba ◽  
K Harada ◽  
...  
Keyword(s):  
Older Adults ◽  
Cohort Study ◽  
Fear Of Falling ◽  
Community Dwelling ◽  
Cardiovascular Health Study ◽  
Physical Frailty ◽  
Frailty Status ◽  
Community Dwelling Older Adults ◽  
The Relationship

Abstract Objective The present study aimed to examine the prospective associations of physical frailty with future falls and fear of falling (FOF) among community-dwelling older adults. Methods A prospective cohort study with a 48-month follow-up was conducted in a Japanese community. Participants were 2469 community-dwelling older adults aged 65 years or older who completed baseline and follow-up assessments at intervals of 48±2 months. Primary outcomes were recent falls (defined as at least one fall within the past year) and FOF (determined by response to “Are you afraid of falling?”) at follow-up survey. Physical frailty, operationalized by the frailty phenotype (slowness, weakness, exhaustion, weight loss, and low activity) based on the criteria of the Japanese version of the Cardiovascular Health Study (J-CHS), was also assessed as a predictor of future falls and FOF. Results Multivariate logistic regression showed that pre-frailty or frailty increase the risk of not only future falls (OR: 1.57; 95%CI = 1.20-2.05) but also FOF (OR: 1.33; 95%CI = 1.05-1.69). In addition, the relationship between baseline frailty status and future falls remained significant after adjusting for baseline FOF (OR: 1.55; 95%CI = 1.19-2.02), and the relationship between baseline frailty status and future FOF also remained significant after adjusting for baseline falls (OR: 1.32; 95%CI = 1.04-1.68). Conclusions Frailty status may predict future falls and FOF among community-dwelling older adults. Strategies to prevent frailty may be beneficial to prevent not only future falls but also future FOF in a community setting. Impact Falls and FOF have a close relationship but a different clinical meaning. Older adults with physical frailty may require monitoring as high-risk not only for falls but also for FOF.

CONCURRENCE OF FRAILTY AND PARKINSON’S DISEASE

2012 ◽  
pp. 1-5
Author(s):  
K.P. ROLAND ◽  
K.M.D. CORNETT ◽  
O. THEOU ◽  
J.M. JAKOBI ◽  
G.R. JONES
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cardiovascular Health ◽  
Community Dwelling ◽  
Health Study ◽  
Cardiovascular Health Study ◽  
Physical Frailty ◽  
Levodopa Dose ◽  
Frailty Phenotype ◽  
Age Related

Background: Females with Parkinson’s disease (PD) are at greater risk of frailty than males. Little is known about how age and disease-related characteristics influence frailty in females with PD because frailty studies often exclude persons with underlying neurological pathologies. Objective: To determine age and diseaserelated characteristics that best explain physical frailty in community-dwelling females with and without PD. Design & Measurement: Correlation coefficients described relationships between PD-related characteristics and physical frailty phenotype criteria (Cardiovascular Health Study). Regression analysis identified associations between disease-related characteristics and frailty in non-PD and PD females. Setting: Community-dwelling. Participants: Females with mild to moderate PD (n = 17, mean age = 66 ± 8.5 years) and non-PD (n = 18, mean age = 72 ± 13.2 years) participated. Results: Daily carbidopa-levodopa dose best explained frailty in PD females (β = 0.5), whereas in non-PD females, age (β = 0.7) and comorbidity (β = 0.5) were most associated with frailty. Conclusions: Dopaminergic medication explained frailty in PD and not measures of disease progression (i.e. severity, duration). In females without PD age-related accumulation of comorbidities resulted in greater risk of frailty. This indicates dopaminergic management of PD symptoms may better reflect frailty in females with PD than disease severity or duration. These data suggest the influence of underlying frailty should be considered when managing neurological conditions. Understanding how frailty concurrently exists with PD and how these conditions progress within the aging female will facilitate future care management.

Abstract P370: Healthcare utilization in older adults with chronic heart failure and elevated depressive symptoms: Cardiovascular Health Study

Circulation ◽  
2014 ◽  
Vol 129 (suppl_1) ◽  
Author(s):  
Mercedes R Carnethon ◽  
Joseph A Delaney ◽  
Norrina B Allen ◽  
Clyde Yancy ◽  
Calvin Hirsch ◽  
...  
Keyword(s):  
Heart Failure ◽  
Older Adults ◽  
Depressive Symptoms ◽  
Healthcare Utilization ◽  
Healthcare Costs ◽  
Cardiovascular Health ◽  
Consumer Price Index ◽  
Depression Scale ◽  
Health Study ◽  
Cardiovascular Health Study

Background: Elevated depressive symptoms (EDS) are common in adults with heart failure (HF) and their joint prevalence is associated with worse short- (1 year) and long-term health outcomes. The contribution of EDS to healthcare costs and utilization in a contemporary population of older adults with HF is unknown. Hypothesis: Adults with HF who report EDS will have higher annual healthcare costs and use more resources than their counterparts without EDS. Methods: Participants from the Cardiovascular Health Study who developed HF between baseline and the 11-year follow up and whose data were linked to Medicare Part A and Part B claims were included in the analysis (n=441). HF was adjudicated based on review of medical records and physician questionnaires. EDS was determined if participants scored ≥8 on the abbreviated Centers for Epidemiologic Studies Depression scale. Medicare payments were adjusted using the Medical Consumer Price Index and represented in 2009 dollars. Annual healthcare utilization (i.e., total provider visits, inpatient and outpatient visits) is based on Part B. Linear regression with robust variance estimation was used to determine the relationship of EDS with medical costs or provider counts adjusted for confounders. Results: Participants were 75.9 years old (SD= 5.3), 55% female, 15% black, and 147 (33%) had EDS. Within 2 years, 19% of patients with EDS died vs. 14% in those without EDS. Differences in annual costs between participants with and without EDS were not statistically significant. However, participants with EDS had more provider visits than their counterparts (Table). Conclusion: Despite adults with HF and EDS using more healthcare resources than those without EDS, expenditures did not differ. Higher short-term mortality in adults with EDS could be an explanation.

scholarly journals The Influence of Dysphagia on Nutritional and Frailty Status among Community-Dwelling Older Adults

Nutrients ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 512
Author(s):  
Takahiro Nishida ◽  
Kazumi Yamabe ◽  
Sumihisa Honda
Keyword(s):  
Older Adults ◽  
At Risk ◽  
Short Form ◽  
Multiple Logistic Regression Analysis ◽  
Community Dwelling ◽  
Health Study ◽  
Cardiovascular Health Study ◽  
Swallowing Function ◽  
Frailty Status ◽  
Community Dwelling Older Adults

Malnutrition is a core symptom of the frailty cycle in older adults. The purpose of this study was to investigate whether dysphagia influences nutrition or frailty status in community-dwelling older adults. The study participants were 320 Japanese community-dwelling older adults aged ≥65 years. All participants completed a questionnaire survey that included items on age, sex, family structure, self-rated health, nutritional and frailty status, and swallowing function. Nutritional status was categorized as malnourished, at risk of malnutrition, and well-nourished based on the Mini Nutrition Assessment-Short Form. The participants were then classified into a malnutrition (malnourished/at risk) or a well-nourished group (well-nourished). Frailty was assessed using the Cardiovascular Health Study criteria. The participants were then divided into a frailty (frail/pre-frail) or a non-frailty group (robust). Dysphagia was screened using the 10-item Eating Assessment Tool. Multiple logistic regression analysis was conducted to determine whether dysphagia was associated with nutritional or frailty status. The results revealed that dysphagia influenced both nutrition (odds ratio [OR]: 4.0; 95% confidence interval [CI]: 1.9–8.2) and frailty status (OR: 2.3; 95% CI: 1.0–5.2); therefore, the swallowing function would be an important factor for community-dwelling older adults on frailty prevention programs.

scholarly journals Prevalence of Physical Frailty: Results from the DO-HEALTH Study

2021 ◽  
pp. 1-8
Author(s):  
M. Gagesch ◽  
P.O. Chocano-Bedoya ◽  
L.A. Abderhalden ◽  
G. Freystaetter ◽  
A. Sadlon ◽  
...  
Keyword(s):  
Controlled Trial ◽  
Frailty Index ◽  
Female Gender ◽  
Community Dwelling ◽  
Health Study ◽  
Geriatric Syndrome ◽  
Physical Frailty ◽  
Frailty Phenotype ◽  
Cross Sectional ◽  
Frailty Status

Background: Frailty is a geriatric syndrome associated with multiple negative health outcomes. However, its prevalence varies by population and instrument used. We investigated frailty and pre-frailty prevalence by 5 instruments in community-dwelling older adults enrolled to a randomized-controlled trial in 5 European countries. METHODS: Cross-sectional baseline analysis in 2,144 DO-HEALTH participants recruited from Switzerland, Austria, France, Germany, and Portugal with complete data for frailty. Frailty status was assessed by the Physical Frailty Phenotype [PFP], SOF-Frailty Index [SOF-FI], FRAIL-Scale, SHARE-Frailty Instrument [SHARE-FI], and a modified SHARE-FI, and compared by country, age, and gender. Logistic regression was used to determine relevant factors associated with frailty and pre-frailty. RESULTS: Mean age was 74.9 (±4.4) years, 61.6% were women. Based on the PFP, overall frailty and pre-frailty prevalence was 3.0% and 43.0%. By country, frailty prevalence was highest in Portugal (13.7%) and lowest in Austria (0%), and pre-frailty prevalence was highest in Portugal (57.3%) and lowest in Germany (37.1%). By instrument and overall, frailty and pre-frailty prevalence was highest based on SHARE-FI (7.0% / 43.7%) and lowest based on SOF-FI (1.0% / 25.9%). Frailty associated factors were residing in Coimbra (Portugal) [OR 12.0, CI 5.30-27.21], age above 75 years [OR 2.0, CI 1.17-3.45], and female gender [OR 2.8, CI 1.48-5.44]. The same three factors predicted pre-frailty. CONCLUSIONS: Among relatively healthy adults age 70 and older enroled to DO-HEALTH, prevalence of frailty and pre-frailty differed significantly by instrument, country, gender, and age. Among instruments, the highest prevalence of frailty and pre-frailty was documented by the SHARE-FI and the lowest by the SOF-FI.

scholarly journals Frailty and driving status associated with disability: a 24-month follow-up longitudinal study

BMJ Open ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. e042468
Author(s):  
Takehiko Doi ◽  
Kota Tsutsumimoto ◽  
Hideaki Ishii ◽  
Sho Nakakubo ◽  
Satoshi Kurita ◽  
...  
Keyword(s):  
Older Adults ◽  
Cardiovascular Health ◽  
Community Setting ◽  
Community Dwelling ◽  
Health Study ◽  
Cardiovascular Health Study ◽  
Term Care ◽  
Frailty Status ◽  
A Prospective Study

ObjectivesTo examine the relationship of driving status and frailty with disability in older adults.DesignA prospective study.Setting and participantsThe study included 8533 participants (mean age: 72.0±6.1 years (range: 60–98 years), women: 54.1%) in a community setting.MeasuresDriving status and frailty were assessed at baseline. The clinical definition of frailty was used according to the Japanese Cardiovascular Health Study index. Disability was prospectively determined using a record of Japanese long-term care insurance (LTCI).ResultsDuring the follow-up period (mean duration: 23.5 months), 58 (0.7%) participants were regarded as moving out of the city, 80 (0.9%) participants had died and 311 (3.6%) participants were certified by LTCI. The proportion of disability was 1.3% among the not-frail group and 5.3% among the frail group. The proportion of disability was 2.5% in participants who were currently driving and 7.5% in those not driving. Based on frailty status and driving, participants were further classified into four groups: not frail and currently driving (n=2945), not frail and not driving (n=642), frail and currently driving (n=3598) and frail and not driving (n=1348). Compared with older adults who are not frail and driving, the combined status of frail and not driving (adjusted HR: 2.28; 95% CI: 1.47 to 3.52) and frail and driving (HR: 1.91; 95% CI: 1.30–2.81) were risk factors for disability.ConclusionsNot driving and frail were associated with a risk of disability in community-dwelling older adults.

scholarly journals SLEEP QUALITY AND DEPRESSIVE SYMPTOMS IN LATER-LIFE: CROSS-SECTIONAL EXAMINATION OF COGNITIVE MECHANISMS

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S872-S872
Author(s):  
David Brush ◽  
Daniel Paulson ◽  
Manuel Herrera Legon ◽  
Nicholas James ◽  
Jennifer Scheurich ◽  
...  
Keyword(s):  
Older Adults ◽  
Depressive Symptoms ◽  
Sleep Quality ◽  
Inhibitory Control ◽  
Depression Scale ◽  
Later Life ◽  
Community Dwelling ◽  
Mediating Effect ◽  
Poor Sleep ◽  
Community Dwelling Older Adults

Abstract Sleep quality relates to depressive symptom endorsement. The mechanisms relating these variables are not clearly elucidated, though inhibitory control and rumination are believed to play key roles. The current study aims to elucidate the relationship between sleep quality and depressive symptoms by examining the moderated mediating effect of inhibitory control and rumination. The sample included 41 community-dwelling older adults (age 70 and older). Measures included the Pittsburg Sleep Quality Inventory, a Stroop task (inhibitory control), the Ruminative Responses Scale, and the Geriatric Depression Scale. A series of bootstrapped models were employed to test hypotheses using a stepped approach. Poorer sleep quality was associated with higher rumination and depressive symptoms; however, these associations were no longer significant among older adults with higher inhibitory control. The association between sleep quality and depression was fully attenuated by rumination, and inhibitory control significantly moderated the association between sleep quality and rumination in the final model. Among community-dwelling older adults, the association between sleep quality and depression is mediated by rumination, and this effect is mitigated by inhibitory control. As such, these findings suggest that inhibitory control may be a relevant target for intervention in older adults with poor sleep quality, rumination, and depressive symptoms.

Associations between healthy Japanese dietary patterns and depression in Japanese women

2020 ◽  
pp. 1-13
Author(s):  
Kanae Konishi
Keyword(s):  
Depressive Symptoms ◽  
Dietary Patterns ◽  
Dietary Pattern ◽  
Depression Scale ◽  
Principal Component ◽  
Epidemiologic Studies ◽  
Japanese Women ◽  
Health Study ◽  
Food Groups ◽  
Cross Sectional

Abstract Objective: Higher quality dietary patterns such as healthy/prudent and Mediterranean dietary patterns have been protectively associated with depression. This study examined whether healthy Japanese dietary patterns, which differ from dietary patterns derived from Western areas, are associated with depressive symptoms among Japanese women. Design: A cross-sectional study (the Nagano Nutrition and Health Study). Depressive symptoms were assessed using the Center for Epidemiologic Studies Depression Scale. Dietary patterns were derived with a principal component analysis of the consumption of fifty-six food and beverage items, which were assessed by a validated brief diet history questionnaire. Setting: Nagano, Japan. Participants: Japanese women (n 1337) aged 20–72 years. Results: We identified three dietary patterns: ‘healthy Japanese’, ‘sweets-fat’ and ‘seafood–alcohol’. The highest quality dietary pattern was ‘healthy Japanese’. It is characterised by a high intake of vegetables, mushrooms, seaweed, soyabean products, potatoes, fish/shellfish and fruit. The age- and multivariate-adjusted OR (95 % CI) of depressive symptoms for the highest quartiles of the ‘healthy Japanese’ pattern score were 0·58 (95 % CI 0·41, 0·82) and 0·69 (95 % CI 0·45, 1·06), respectively. Meanwhile, no associations were observed for ‘sweets-fat’ and ‘seafood–alcohol’ patterns. Conclusions: The ‘healthy Japanese’ pattern may be inversely associated with depressive symptoms with an exposure-response association. The specific Japanese food groups in the ‘healthy Japanese’ pattern included mushrooms, seaweed, soyabean products and potatoes, as well as vegetables, fish/shellfish and fruit. These seem to create an anti-inflammation-prone dietary pattern, and this factor might be associated with better mental health.

scholarly journals A comparison of Geriatric Depression Scale scores in older Australian and Japanese women

2016 ◽  
Vol 26 (1) ◽  
pp. 70-78 ◽  
Author(s):  
K. E. Campbell ◽  
L. Dennerstein ◽  
M. Tacey ◽  
N. Fujise ◽  
M. Ikeda ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
Depressive Symptom ◽  
Japanese Population ◽  
Geriatric Depression Scale ◽  
Depression Scale ◽  
Japanese Women ◽  
Geriatric Depression ◽  
Factors Associated ◽  
Health Factors ◽  
Australian Sample

Aims:The aim of this study was to compare the prevalence of depressive symptoms in Australian and Japanese populations of community-dwelling older women using the Geriatric Depression Scale (GDS-15). In addition, the relationship between lifestyle and health factors and higher ratings of depressive symptoms was also examined to determine if there were culturally consistent risk factors associated with higher depressive symptom scores.Methods:A total of 444 community based women aged between 65 and 77 years completed a depressive symptom measure (GDS-15) and provided information on common lifestyle factors. The Australian sample (n = 222) were drawn from the Women's Healthy Ageing Project and the age-matched, Japanese sample from the Kumamoto Ageing Study of Mental Health (n = 222). The GDS was chosen to; (1) reduce the impact of physical symptoms associated with old age and, (2) reduce the inflation in scores that may result from the Japanese tendency to endorse somatic items more often than Western adults.Results:Mean GDS total scores were significantly higher for the Japanese population 3.97 ± 3.69 compared with 1.73 ± 2.7 for Australian women. The percentages of women scoring in the normal; mild and moderate ranges for depression were 91, 7 and 2% for Australia and 67, 24 and 9% for Japan. Scores remained significantly higher for the Japanese cohort when controlling for lifestyle and health factors associated with depression. The analysis of lifestyle and health characteristics showed that the greatest difference between cohorts was in the area of living status, with more Australian women living with their partner and more than three times as many Japanese women living with their children. When the data for the countries was considered independently employment status affected the likelihood of higher depression scores in the Australian sample while heart disease and poor sleep impacted the risk for the Japanese population.Conclusions:Significantly more Japanese women scored within the mild and moderate ranges on the GDS compared with their Australian peers, even when controlling for possible confounding factors. Of the lifestyle and health factors assessed in this analysis no single variable was a common risk factor for higher depressive scores for both countries. The presence of cultural influences that may impact the risk of experiencing depressive symptoms, and culture specific patterns of item endorsement on depressive symptom measures, needs to be explored in more detail.

Sign in / Sign up

Export Citation Format

Share Document