Antioxidants Associated with Oncogenic HPV Infection in women

2021 ◽  
Author(s):  
Hui-Yi Lin ◽  
Qiufan Fu ◽  
Yu-Hsiang Kao ◽  
Tung-sung Tseng ◽  
Krzysztof Reiss ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Hpv Infection ◽  
Host Immune System ◽  
Nutrition Examination Survey ◽  
Infection Status ◽  
Dietary Antioxidants ◽  
Health And Nutrition ◽  
High Risk Hpv ◽  
Cancer Studies ◽  
Oncogenic Hpv

Abstract Background Human papillomavirus (HPV) infection is a major cause of cervical cancer. Studies showed the onset of HPV carcinogenesis may be induced by oxidative stress affecting the host immune system. The association between antioxidants and oncogenic HPV remains unclear. In this study, we aim to identify antioxidants associated with vaginal HPV infection in women. Methods The associations between the 15 antioxidants and vaginal HPV infection status (no, low-risk, and high-risk HPV [LR- and HR-HPV]) were evaluated using 11,070 women who participated in the 2003-2016 National Health and Nutrition Examination Survey (NHANES). Results We identified serum albumin and four dietary antioxidants (vitamin-A, -B2, -E, and folate) inversely associated with HR-HPV infection. Women with a low level of albumin (≤39 g/L) have a significantly higher risk of HR-HPV (OR=1.4, p=0.009 vs. >44 g/L). A nutritional antioxidant score (NAS) was developed based on these four dietary antioxidants. The women with the lowest quartile NAS had a higher chance of HR-HPV (OR=1.3, p=0.030) and LR-HPV (OR=1.4, p=0.002) compared with the women with the highest quartile NAS. Conclusions We identified five antioxidants negatively associated with vaginal HR-HPV infection in women. Our findings provide valuable insights into understanding antioxidants’ impact on HPV carcinogenesis.

scholarly journals Detection Rates of Human Papillomavirus Associated with Cervical Cancer in Women of Nizhny Novgorod

2020 ◽  
pp. 44-47
Author(s):  
NF Brusnigina ◽  
MA Makhova ◽  
OM Chernevskaya ◽  
KA Orlova ◽  
EA Kolesnikova ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Human Papillomavirus ◽  
High Risk ◽  
Hpv Infection ◽  
Human Papillomaviruses ◽  
Hpv 16 ◽  
Detection Rates ◽  
High Risk Hpv ◽  
Incident Cases ◽  
Oncogenic Hpv

The purpose of the study was to assess detection rates of human papillomavirus in cervical cancer cases of Nizhny Novgorod. Materials and methods. We used the real-time polymerase chain reaction (PCR) to test samples of mucosa lining of the cervical canal and/or transformation zone taken from 630 women with cervical dysplasia of different degrees and 107 incident cases of cervical cancer that did not undergo treatment. The detection and differentiation of 14 genotypes of high-risk human papillomaviruses (HPV) was carried out using the AmpliSens® HPV HCR-genotype-FRT PRC kit. Results. The overall infection rate of women with oncogenic human papillomaviruses was 41.8%. Among the genotypes, HPV 16 (39.2%), 18 (15.5%), 33 (16.6%), and 56 (11.9%) predominated. A high prevalence of oncogenic HPV was detected in the women with cervical intraepithelial neoplasia (58.1%) and cervical cancer (90%). The spectrum of genotypes in women with neoplasia of various degrees differed. In women with CIN II and CIN III, vaccine-preventable HPV genotypes (HPV 16 and 18) playing the leading role in the development of cervical cancer were the most frequent. The same genotypes dominated in the women with invasive cervical cancer. One oncogenic HPV genotype was usually found in the infected women (69%). The high-risk HPV infection was often combined with Ureaplasma ssp (49.3%), Mycoplasma hominis (20.1%), Cytomegalovirus (21.1%), and Herpes simplex I/II (18.2%) infections. Combinations of high-risk HPV with Chlamydia trachomatis and Herpes 6 were found in 8.3% and 5% of the cases, respectively. Conclusions. Our findings proved a wide prevalence of high carcinogenic risk HPV 16 and 18 genotypes, thus indicating the expediency of using Cervarix and Gardasil vaccines registered in the Russian Federation and containing antigens to these types of virus for specific prevention of the HPV infection.

scholarly journals Associations of Dietary Antioxidants and Risk of Type 2 Diabetes: Data from the 2007–2012 Korea National Health and Nutrition Examination Survey

Molecules ◽  
2017 ◽  
Vol 22 (10) ◽  
pp. 1664 ◽  
Author(s):  
Dan Quansah ◽  
Kyungho Ha ◽  
Shinyoung Jun ◽  
Seong-Ah Kim ◽  
Sangah Shin ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
National Health ◽  
Nutrition Examination Survey ◽  
Dietary Antioxidants ◽  
Health And Nutrition

Human papillomavirus vaccine timing associated with eventual human papillomavirus diagnosis in women

2020 ◽  
Vol 31 (10) ◽  
pp. 976-981
Author(s):  
Robert J Zeglin ◽  
Juliet L Fetteroll
Keyword(s):  
Human Papillomavirus ◽  
Hpv Vaccine ◽  
Sexual Debut ◽  
Secondary Data ◽  
Hpv Infection ◽  
Nutrition Examination Survey ◽  
Human Papillomavirus Vaccine ◽  
Vaccination Rates ◽  
Health And Nutrition ◽  
Papillomavirus Vaccine

Nearly all cases of cervical cancer are attributable to human papillomavirus (HPV), making it a significant women’s health issue. Though there have been advances in the prevention of HPV via vaccination, significant barriers continue to suppress vaccination rates for girls. Delaying vaccination until after sexual debut increases a woman’s chance of HPV infection, but there has been no quantification of this risk in the literature. The present study sought to address this gap via secondary data analysis with 173 female participants from the 2015–2016 National Health and Nutrition Examination Survey dataset. Results indicate that women in the sample who received the HPV vaccine after their sexual debut were 2.63 times more likely than women who receive the vaccine before their sexual debut to report an HPV diagnosis. These results have clear public and sexual health implications.

scholarly journals Human Papillomavirus (HPV) Infection in Early Pregnancy: Prevalence and Implications

2019 ◽  
Vol 2019 ◽  
pp. 1-5 ◽  
Author(s):  
Deeksha Pandey ◽  
Vani Solleti ◽  
Gazal Jain ◽  
Anwesha Das ◽  
Kabekkodu Shama Prasada ◽  
...  
Keyword(s):  
High Risk ◽  
Early Pregnancy ◽  
First Trimester ◽  
Hpv Infection ◽  
Host Immune System ◽  
Pregnancy And Childbirth ◽  
Vaginal Cytology ◽  
Prelabor Rupture Of Membranes ◽  
High Risk Hpv ◽  
Hormonal Milieu

Introduction. Young women (20-35 years) are at high risk of HPV infection, although the majority of the infections are asymptomatic and are cleared spontaneously by the host immune system. These are also the group of women who are sexually active and are in the population of pregnant women. During pregnancy, the changes in the hormonal milieu and immune response may favor persistence of HPV infection and may aid in transgenerational transmission thereby furthering the cancer risk. In the present study, we determined the prevalence of vaginal HPV infection in early pregnancy and attempted to relate with pregnancy outcome. Material and Methods. Vaginal cytology samples were collected from the condoms used to cover the vaginal sonography probe during a routine first trimester visit to the hospital. All women were followed up throughout pregnancy and childbirth. Maternal and neonatal outcomes were recorded. Results. We found a prevalence of HPV infection around 39.4% in our population. Interestingly all HPV positive women were infected with one or more high risk HPV viruses with an overlap of intermediate and low risk in 43% and 7.3%, respectively. Women with preterm prelabor rupture of membranes (PPROM) showed a statistically higher incidence in HPV positive (7.3%) group as compared to the HPV negative (3.2%) group. Conclusion. The prevalence of genital HPV infection is high during pregnancy (around 40%) and was associated with higher incidence of PPROM.

Are associations between HIV and human papillomavirus transmission due to behavioural confounding or biological effects?

2018 ◽  
Vol 95 (2) ◽  
pp. 122-128
Author(s):  
Cari van Schalkwyk ◽  
Jennifer Moodley ◽  
Alex Welte ◽  
Leigh Francis Johnson
Keyword(s):  
Human Papillomavirus ◽  
Hpv Infection ◽  
Sensitivity Analyses ◽  
Infection Status ◽  
Biological Interactions ◽  
Empirical Estimates ◽  
Increased Risk ◽  
The Mean ◽  
Hiv Acquisition ◽  
Oncogenic Hpv

ObjectivesCohort studies have shown significant increased risk of HIV acquisition following human papillomavirus (HPV) detection and increased risk of new HPV detection in individuals with HIV infection, after adjusting for behavioural risk factors. This study uses an individual-based model to assess whether confounding sexual behaviour factors and network level effects can explain these associations between HIV and HPV infection status, without biological interactions.MethodsThe model simulates infection with 13 oncogenic HPV types and HIV. It allows for different relationship types, with heterogeneity in probabilities of concurrency and rates of partner change. No effect of prevalent HPV infection on HIV acquisition is assumed and vice versa. The model is calibrated to South African HIV and type-specific HPV prevalence data using a Bayesian approach. The model is used to simulate cohorts with quarterly HIV and HPV testing from 2000 to 2002. These simulated data are analysed using proportional hazard models.ResultsThe mean of the unadjusted HRs of HIV acquisition following detection of an oncogenic HPV type calculated for each simulated cohort is 2.6 (95% CI 2.2 to 3.1). The mean of the unadjusted HRs for the effect of HIV on newly detected HPV is 2.5 (95% CI 2.2 to 2.8). Simulated associations between HIV and HPV infection status are similar to corresponding empirical estimates. In sensitivity analyses in which HIV and HPV were assumed to increase each other’s transmission risk, simulated associations were stronger but not inconsistent with empirical estimates.ConclusionsAlthough we cannot rule out the possibility that associations between HIV and HPV transmission may be due in part to biological interactions, these results suggest that observed associations could be explained entirely by residual confounding by behavioural factors and network-level effects that observational studies cannot account for.

scholarly journals Effect of Polyethylene Glycol Microspheres Adsorbed with Melatonin on Oxidative Stress and Viscosity of Cervical Mucus Samples Infected with Human Papillomavirus

2020 ◽  
Vol 10 (6) ◽  
pp. 6757-6772 ◽  
Keyword(s):  
Oxidative Stress ◽  
Human Papillomavirus ◽  
Polyethylene Glycol ◽  
Superoxide Anion ◽  
Therapeutic Potential ◽  
Cervical Mucus ◽  
Main Function ◽  
Melatonin Concentration ◽  
High Risk Hpv ◽  
Oncogenic Hpv

The interfaces of hormones and endogenous molecules associated with nanostructured materials is one of the ways to evaluate the therapeutic potential. Melatonin is a neurohormone that is related to oxidative metabolism. Human Papillomavirus (HPV) is the principal etiological agent of cervical cancer. Cervical mucus is a biological system whose main function is the protection of the uterine cervix. This study aims to evaluate the immunomodulatory effect of melatonin on oxidative stress and rheological behavior of cervical mucus. The cervical mucus was analyzed the melatonin concentration, viscosity, superoxide, and the superoxide dismutase. Melatonin showed lower concentration in the cervical mucus from women infected with HPV. The viscosity was lowest in mucus from women infected with oncogenic HPV. The positive samples for HPV also showed high superoxide release and reduced CuZn-SOD levels indicating oxidative stress. Melatonin adsorbed to the polyethylene glycol microsphere (PEG-MLT) was efficient in restoring the viscosity, superoxide anion, and CuZn-SOD at similar levels to mucus from women negative for HPV. These data suggest that in high-risk HPV infections, there is a decrease in melatonin levels and the viscosity of cervical mucus. PEG-MLT was efficient in reducing oxidative stress and restoring viscosity of cervical mucus.

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