In-vitro antifungal activity of sertaconazole, econazole, and bifonazole against Candida spp

1995 ◽  
Vol 36 (4) ◽  
pp. 713-716 ◽  
Author(s):  
A. J. Carrillo-Muñioz ◽  
J. M. Torres-Rodriguez
Keyword(s):  
Antifungal Activity ◽  
Candida Spp ◽  
In Vitro Antifungal Activity

scholarly journals Orodispersible Film Loaded with Enterococcus faecium CRL183 Presents Anti-Candida albicans Biofilm Activity In Vitro

Pharmaceutics ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 998
Author(s):  
Virgínia Barreto Lordello ◽  
Andréia Bagliotti Meneguin ◽  
Sarah Raquel de Annunzio ◽  
Maria Pía Taranto ◽  
Marlus Chorilli ◽  
...  
Keyword(s):  
Candida Albicans ◽  
Antifungal Activity ◽  
Enterococcus Faecium ◽  
Potato Starch ◽  
Oral Candidiasis ◽  
Candida Spp ◽  
Sem Images ◽  
Control Film ◽  
In Vitro Antifungal Activity

Background: Probiotic bacteria have been emerging as a trustworthy choice for the prevention and treatment of Candida spp. infections. This study aimed to develop and characterize an orodispersible film (ODF) for delivering the potentially probiotic Enterococcus faecium CRL 183 into the oral cavity, evaluating its in vitro antifungal activity against Candida albicans. Methods and Results: The ODF was composed by carboxymethylcellulose, gelatin, and potato starch, and its physical, chemical, and mechanical properties were studied. The probiotic resistance and viability during processing and storage were evaluated as well as its in vitro antifungal activity against C. albicans. The ODFs were thin, resistant, and flexible, with neutral pH and microbiologically safe. The probiotic resisted the ODF obtaining process, demonstrating high viability (>9 log10 CFU·g−1), up to 90 days of storage at room temperature. The Probiotic Film promoted 68.9% of reduction in fungal early biofilm and 91.2% in its mature biofilm compared to the group stimulated with the control film. Those results were confirmed through SEM images. Conclusion: The probiotic ODF developed is a promising strategy to prevent oral candidiasis, since it permits the local probiotic delivery, which in turn was able to reduce C. albicans biofilm formation.

scholarly journals Essential oils against Candida spp: in vitro antifungal activity of Origanum vulgare

2013 ◽  
Vol 7 (20) ◽  
pp. 2245-2250 ◽  
Author(s):  
Brum Cleff Marlete ◽  
Madrid Isabel ◽  
Raquel Meinerz Ana ◽  
Carlos Arauacute jo Meireles Maacute rio ◽  
Roberto Braga de Mello Joatilde o ◽  
...  
Keyword(s):  
Antifungal Activity ◽  
Essential Oils ◽  
Origanum Vulgare ◽  
Candida Spp ◽  
In Vitro Antifungal Activity

scholarly journals Antifungal Activity of Extracts, Fractions, and Constituents from Coccoloba cowellii Leaves

2021 ◽  
Vol 14 (9) ◽  
pp. 917
Author(s):  
Daniel Méndez ◽  
Julio C. Escalona-Arranz ◽  
Enrique Molina Pérez ◽  
Kenn Foubert ◽  
An Matheeussen ◽  
...  
Keyword(s):  
Antifungal Activity ◽  
Methanolic Extract ◽  
Preliminary Investigation ◽  
Planktonic Cells ◽  
Candida Spp ◽  
Resazurin Assay ◽  
Bioassay Guided Fractionation ◽  
Trimethyl Ether ◽  
In Vitro Antifungal Activity

Coccoloba cowellii Britton (Polygonaceae, order Caryophyllales) is an endemic and critically endangered plant species that only grows in the municipality of Camagüey, a province of Cuba. A preliminary investigation of its total methanolic extract led to the discovery of promising antifungal activity. In this study, a bioassay-guided fractionation allowed the isolation of quercetin and four methoxyflavonoids: 3-O-methylquercetin, myricetin 3,3′,4′-trimethyl ether, 6-methoxymyricetin 3,4′-dimethyl ether, and 6-methoxymyricetin 3,3′,4′-trimethyl ether. The leaf extract, fractions, and compounds were tested against various fungi and showed strong in vitro antifungal activity against Cryptococcus neoformans and various Candida spp. with no cytotoxicity (CC50 > 64.0 µg/mL) on MRC-5 SV2 cells, determined by a resazurin assay. A Candida albicans SC5314 antibiofilm assay indicated that the antifungal activity of C. cowellii extracts and constituents is mainly targeted to planktonic cells. The total methanolic extract showed higher and broader activity compared with the fractions and mixture of compounds.

scholarly journals 1,3,4-Thiadiazole Derivatives. Part 91. Synthesis and Biological Activity of Metal Complexes of 5-(2-Aminoethyl)-2-Amino-1,3,4-Thiadiazole

1996 ◽  
Vol 3 (5) ◽  
pp. 227-232 ◽  
Author(s):  
Mihai Barboiu ◽  
Marilena Cimpoesu ◽  
Cornelia Guran ◽  
Claudiu T. Supuran
Keyword(s):  
Biological Activity ◽  
Antifungal Activity ◽  
Metal Complexes ◽  
Elemental Analysis ◽  
Electronic Spectroscopy ◽  
Candida Spp ◽  
Thiadiazole Derivatives ◽  
In Vitro Antifungal Activity

Metal complexes of the title ligand (L) containing Co(II), Ni(II) and Cu(II) were prepared and characterized by elemental analysis, IR, electronic spectroscopy and conductimetry. The new derivatives, possessing the following formulae, CuL2(OH)2, NiL2Cl2, and [Co2LCl4]n showed in vitro antifungal activity against Aspergillus and Candida spp.

scholarly journals Effect of ozonized olive oil on oral levels of Candida spp. in patients with denture stomatitis

2018 ◽  
Vol 21 (1) ◽  
pp. 111 ◽  
Author(s):  
Erica Crastechini ◽  
Cristiane Yumi Koga-Ito ◽  
Suzan De Fátima Machado ◽  
Guilherme Rodrigues Teodoro ◽  
Graziella Nuernberg Back-Brito ◽  
...  
Keyword(s):  
Antifungal Activity ◽  
Olive Oil ◽  
In Vitro Tests ◽  
Candida Spp ◽  
Isolation And Identification ◽  
Denture Stomatitis ◽  
Viable Cells ◽  
In Vitro Antifungal Activity

<p><strong>Objective</strong>: The aim of this study was to evaluate the effect of ozonized oil (OZ) on the oral levels of <em>Candida </em>spp. in patients with denture stomatitis. <strong>Material and Methods</strong>: In vitro tests were performed to validate antifungal activity and to standardize OZ conditions. Antifungal activity was screened against <em>C. albicans </em>and five non-<em>albicans </em>species (<em>C. tropicalis, C. dubliniensis, C. krusei, C. guilliermondii,</em> and <em>C. parapsilosis</em>). Also, the effects on <em>C. albicans </em>planktonic and biofilm were evaluated. After validation, OZ was included in a therapeutic protocol of denture stomatitis in vivo. Thirty patients used OZ and 20 used sodium bicarbonate (SB) for 14 days. After 7 and 14 days, clinical evaluation, isolation and identification of yeasts were performed. Isolates were identified by phenotypic and genotypic tests. Ozonized oil showed in vitro antifungal activity against all species of <em>Candida</em>. Ozonized oil reduced the number of viable cells in <em>C. albicans </em>biofilms. Oral candidal levels were lower in relation to baseline both after after 14 days of treatment with SB and OZ. <strong>Results</strong>: A total of 493 <em>Candida </em>spp. isolates was obtained and 80% were identified as <em>C. albicans</em>. Remission of denture stomatitis was observed in all patients after 7 days of treatment in both groups. <strong>Conclusion</strong>: Within the limits of the study we can conclude that ozonized olive oil can be a new alternative for the control of biofilm in patients with denture stomatitis.</p><p align="left"> </p><p><strong>Keywords<em></em></strong></p><p>Ozone; <em>Candida</em>; Antifungal Agents; Stomatitis; Denture.</p><p> </p>

In vitro Antifungal Activity of a 29-kDa Glycoprotein Purified from the Galls of Quercus infectoria

2005 ◽  
Vol 40 (1-2) ◽  
pp. 43-54 ◽  
Author(s):  
K. Yamunarani ◽  
R. Jaganathan ◽  
R. Bhaskaran ◽  
P. Govindaraju ◽  
R. Velazhahan
Keyword(s):  
Antifungal Activity ◽  
Quercus Infectoria ◽  
In Vitro Antifungal Activity

Formulation and Evaluation of Carbopol Gel Containing Liposomes of Ketoconazole. (Part-II)

2009 ◽  
Vol 1 (2) ◽  
Author(s):  
Rakesh Patel ◽  
Hardik Patel ◽  
Ashok Baria
Keyword(s):  
Antifungal Activity ◽  
Rat Skin ◽  
Albino Rat ◽  
In Vitro Drug Release ◽  
Carbopol Gel ◽  
Liposomal Formulations ◽  
Release Drug ◽  
In Vitro Permeation ◽  
In Vitro Antifungal Activity

The aim of this work was to prepare and evaluate the topical carbopol gel formulation containing ketoconazole encapsulated liposomes. Ketoconazole loaded liposomes were prepared by thin film hydration technique. The prepared liposomes were incorporated into 1% carbopol gel, and the systems were evaluated for in-vitro drug release, drug retention into skin and in-vitro antifungal activity. The in-vitro permeation of ketoconazole using wistar albino rat skin from liposomal gel was compared with that of plain drug gel and also with plain drug cream containing 2% w/w of ketoconazole. The release of ketoconazole from liposomal gel was much slower than from non liposomal formulations. Gel containing liposomal ketoconazole showed maximum antifungal activity after 30 hours over plain ketoconazole gel and cream formulations.

scholarly journals Rhizosphere-enriched microbes as a pool to design synthetic communities for reproducible beneficial outputs

2019 ◽  
Author(s):  
Maria-Dimitra Tsolakidou ◽  
Ioannis A Stringlis ◽  
Natalia Fanega-Sleziak ◽  
Stella Papageorgiou ◽  
Antria Tsalakou ◽  
...  
Keyword(s):  
Antifungal Activity ◽  
Fungal Pathogens ◽  
Growth Parameters ◽  
Tomato Plants ◽  
Beneficial Effects ◽  
Negative Effect ◽  
Tomato Growth ◽  
In Vitro Antifungal Activity

Abstract Composts represent a sustainable way to suppress diseases and improve plant growth. Identification of compost-derived microbial communities enriched in the rhizosphere of plants and characterization of their traits, could facilitate the design of microbial synthetic communities (SynComs) that upon soil inoculation could yield consistent beneficial effects towards plants. Here, we characterized a collection of compost-derived bacteria, previously isolated from tomato rhizosphere, for in vitro antifungal activity against soil-borne fungal pathogens and for their potential to change growth parameters in Arabidopsis. We further assessed root-competitive traits in the dominant rhizospheric genus Bacillus. Certain isolated rhizobacteria displayed antifungal activity against the tested pathogens and affected growth of Arabidopsis, and Bacilli members possessed several enzymatic activities. Subsequently, we designed two SynComs with different composition and tested their effect on Arabidopsis and tomato growth and health. SynCom1, consisting of different bacterial genera, displayed negative effect on Arabidopsis in vitro, but promoted tomato growth in pots. SynCom2, consisting of Bacilli, didn't affect Arabidopsis growth, enhanced tomato growth and suppressed Fusarium wilt symptoms. Overall, we found selection of compost-derived microbes with beneficial properties in the rhizosphere of tomato plants, and observed that application of SynComs on poor substrates can yield reproducible plant phenotypes.

scholarly journals In Vitro Antifungal Activity of Sanguinarine and Chelerythrine Derivatives against Phytopathogenic Fungi

Molecules ◽  
2012 ◽  
Vol 17 (11) ◽  
pp. 13026-13035 ◽  
Author(s):  
Xin-Juan Yang ◽  
Fang Miao ◽  
Yao Yao ◽  
Fang-Jun Cao ◽  
Rui Yang ◽  
...  
Keyword(s):  
Antifungal Activity ◽  
Phytopathogenic Fungi ◽  
Sanguinarine And Chelerythrine ◽  
In Vitro Antifungal Activity
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