scholarly journals Development of a repository of computable phenotype definitions using the clinical quality language

JAMIA Open ◽  
2021 ◽  
Vol 4 (4) ◽  
Author(s):  
Pascal S Brandt ◽  
Jennifer A Pacheco ◽  
Luke V Rasmussen
Keyword(s):  
Structured Data ◽  
Future Research ◽  
Test Cases ◽  
Inclusion Criteria ◽  
Specialized Knowledge ◽  
Development Environment ◽  
Clinical Quality ◽  
Cohort Identification ◽  
Value Sets ◽  
Published Research

Abstract Objective The objective of this study is to create a repository of computable, technology-agnostic phenotype definitions for the purposes of analysis and automatic cohort identification. Materials and Methods We selected phenotype definitions from PheKB and excluded definitions that did not use structured data or were not used in published research. We translated these definitions into the Clinical Quality Language (CQL) and Fast Healthcare Interoperability Resources (FHIR) and validated them using code review and automated tests. Results A total of 33 phenotype definitions met our inclusion criteria. We developed 40 CQL libraries, 231 value sets, and 347 test cases. To support these test cases, a total of 1624 FHIR resources were created as test data. Discussion and Conclusion Although a number of challenges were encountered while translating the phenotypes into structured form, such as requiring specialized knowledge, or imprecise, ambiguous, and conflicting language, we have created a repository and a development environment that can be used for future research on computable phenotypes.

Dysfunctional Behavior in Organizations: Insights from the Management Control Literature

2017 ◽  
Vol 37 (4) ◽  
pp. 117-141 ◽  
Author(s):  
Krista Fiolleau ◽  
Theresa Libby ◽  
Linda Thorne
Keyword(s):  
Risk Factors ◽  
Internal Control ◽  
Management Control ◽  
Future Research ◽  
Fraud Triangle ◽  
Audit Risk ◽  
Research Opportunities ◽  
Dysfunctional Behavior ◽  
Research Questions ◽  
Published Research

SUMMARY As the scope of the audit continues to broaden (Cohen, Krishnamoorthy, and Wright 2017), research questions in management control and internal control are beginning to overlap. Even so, there is little overlap between these fields in terms of published research to date. The purpose of this paper is to take a step in bridging the gap between the management control and the internal control literatures. We survey relevant findings from the extant management control literature published between 2003 and 2016 on dysfunctional behavior and the ways in which it might be mitigated. We then use the fraud triangle as an organizing framework to consider how the management control literature might help to address audit risk factors identified in SAS 99/AU SEC 316 (AICPA 2002). The outcome of our analysis is meant to identify and classify the extant management control literature of relevance to research on internal control in a manner that researchers new to the management control literature will find accessible. We conclude with a set of future research opportunities that can help to broaden the scope of current research in internal control.

Accounting for natural disasters from a historical perspective: A literature review and research agenda

2021 ◽  
Vol 26 (2) ◽  
pp. 179-204
Author(s):  
Massimo Sargiacomo ◽  
Stefania Servalli ◽  
Serena Potito ◽  
Antonio D’Andreamatteo ◽  
Antonio Gitto
Keyword(s):  
Natural Disasters ◽  
Economic History ◽  
Research Agenda ◽  
Historical Research ◽  
Future Research ◽  
Research Topics ◽  
Open Research ◽  
Emerging Themes ◽  
Published Research ◽  
Selection Of

This study offers an analysis of published historical research on accounting for natural disasters. Drawing on the insights provided by an examination of 35 accounting/business/economic history and generalist journals, 11 articles have been selected and analysed. The analysis conducted on the scattered literature identified the emerging themes, disasters investigated, periods of time explored and main contributions of published research. The analysis is extended by the examination of some key conferences of interdisciplinary history associations, and of the eventual journals/issues where the papers presented were published. The investigation has also been complemented by a brief selection of books showing historical analyses of diverse disasters, typologies and periods of investigation. The stimuli provided by the study have helped to portray the main features of an open research agenda, highlighting possible future research topics and suggesting ancient and recent disasters’ loci to be investigated worldwide.

scholarly journals Dietary Supplementation for Para-Athletes: A Systematic Review

Nutrients ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 2016
Author(s):  
Keely A. Shaw ◽  
Gordon A. Zello ◽  
Brian Bandy ◽  
Jongbum Ko ◽  
Leandy Bertrand ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Dietary Supplements ◽  
Sports Medicine ◽  
Spinal Cord Injuries ◽  
Sport Performance ◽  
Future Research ◽  
Inclusion Criteria ◽  
Supplement Use ◽  
Sport Supplements ◽  
Cord Injury

The use of dietary supplements is high among athletes and non-athletes alike, as well as able-bodied individuals and those with impairments. However, evidence is lacking in the use of dietary supplements for sport performance in a para-athlete population (e.g., those training for the Paralympics or similar competition). Our objective was to examine the literature regarding evidence for various sport supplements in a para-athlete population. A comprehensive literature search was conducted using PubMed, SPORTDiscus, MedLine, and Rehabilitation and Sports Medicine Source. Fifteen studies met our inclusion criteria and were included in our review. Seven varieties of supplements were investigated in the studies reviewed, including caffeine, creatine, buffering agents, fish oil, leucine, and vitamin D. The evidence for each of these supplements remains inconclusive, with varying results between studies. Limitations of research in this area include the heterogeneity of the subjects within the population regarding functionality and impairment. Very few studies included individuals with impairments other than spinal cord injury. Overall, more research is needed to strengthen the evidence for or against supplement use in para-athletes. Future research is also recommended on performance in para-athlete populations with classifiable impairments other than spinal cord injuries.

scholarly journals Children’s outdoor active mobility behaviour and neighbourhood safety: a systematic review in measurement methods and future research directions

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Roula Zougheibe ◽  
Jianhong (Cecilia) Xia ◽  
Ashraf Dewan ◽  
Ori Gudes ◽  
Richard Norman
Keyword(s):  
Three Dimensional ◽  
Measurement Methods ◽  
Future Research ◽  
Inclusion Criteria ◽  
Eligibility Criteria ◽  
Research Directions ◽  
Spatial Locality ◽  
Mobility Behaviour ◽  
Health Studies ◽  
Future Research Directions

Abstract Background Numerous studies have examined the association between safety and primary school-aged children’s forms of active mobility. However, variations in studies’ measurement methods and the elements addressed have contributed to inconsistencies in research outcomes, which may be forming a barrier to advancing researchers’ knowledge about this field. To assess where current research stands, we have synthesised the methodological measures in studies that examined the effects of neighbourhood safety exposure (perceived and measured) on children’s outdoor active mobility behaviour and used this analysis to propose future research directions. Method A systematic search of the literature in six electronic databases was conducted using pre-defined eligibility criteria and was concluded in July 2020. Two reviewers screened the literature abstracts to determine the studies’ inclusion, and two reviewers independently conducted a methodological quality assessment to rate the included studies. Results Twenty-five peer-reviewed studies met the inclusion criteria. Active mobility behaviour and health characteristics were measured objectively in 12 out of the 25 studies and were reported in another 13 studies. Twenty-one studies overlooked spatiotemporal dimensions in their analyses and outputs. Delineations of children’s neighbourhoods varied within 10 studies’ objective measures, and the 15 studies that opted for subjective measures. Safety perceptions obtained in 22 studies were mostly static and primarily collected via parents, and dissimilarities in actual safety measurement methods were present in 6 studies. The identified schematic constraints in studies’ measurement methods assisted in outlining a three-dimensional relationship between ‘what’ (determinants), ‘where’ (spatial) and ‘when’ (time) within a methodological conceptual framework. Conclusions The absence of standardised measurement methods among relevant studies may have led to the current diversity in findings regarding active mobility, spatial (locality) and temporal (time) characteristics, the neighbourhood, and the representation of safety. Ignorance of the existing gaps and heterogeneity in measures may impact the reliability of evidence and poses a limitation when synthesising findings, which could result in serious biases for policymakers. Given the increasing interest in children’s health studies, we suggested alternatives in the design and method of measures that may guide future evidence-based research for policymakers who aim to improve children’s active mobility and safety.

scholarly journals Manual Therapy in Cervical and Lumbar Radiculopathy: A Systematic Review of the Literature

2021 ◽  
Vol 18 (11) ◽  
pp. 6176
Author(s):  
Tomasz Kuligowski ◽  
Anna Skrzek ◽  
Błażej Cieślik
Keyword(s):  
Manual Therapy ◽  
Functional Outcomes ◽  
Web Of Science ◽  
Current Knowledge ◽  
Controlled Trial ◽  
Future Research ◽  
Lumbar Radiculopathy ◽  
Inclusion Criteria ◽  
Randomized Controlled ◽  
The Mean

The aim of this study was to describe and update current knowledge of manual therapy accuracy in treating cervical and lumbar radiculopathy, to identify the limitations in current studies, and to suggest areas for future research. The study was conducted according to PRISMA guidelines for systematic reviews. A comprehensive literature review was conducted using PubMed and Web of Science databases up to April 2020. The following inclusion criteria were used: (1) presence of radiculopathy; (2) treatment defined as manual therapy (i.e., traction, manipulation, mobilization); and (3) publication defined as a Randomized Controlled Trial. The electronic literature search resulted in 473 potentially relevant articles. Finally, 27 articles were accepted: 21 on cervical (CR) and 6 in lumbar radiculopathy (LR). The mean PEDro score for CR was 6.6 (SD 1.3), and for LR 6.7 (SD 1.6). Traction-oriented techniques are the most frequently chosen treatment form for CR and are efficient in reducing pain and improving functional outcomes. In LR, each of the included publications used a different form of manual therapy, which makes it challenging to summarize knowledge in this group. Of included publications, 93% were either of moderate or low quality, which indicates that quality improvement is necessary for this type of research.

scholarly journals Does the model of additive effect in placebo research still hold true? A narrative review

JRSM Open ◽  
2017 ◽  
Vol 8 (3) ◽  
pp. 205427041668143 ◽  
Author(s):  
Katja Boehm ◽  
Bettina Berger ◽  
Ulrich Weger ◽  
Peter Heusser
Keyword(s):  
Context Effects ◽  
Experimental Studies ◽  
Additive Model ◽  
Drug Effects ◽  
Future Research ◽  
Inclusion Criteria ◽  
Integrative Study ◽  
Additive Relation ◽  
Specific Factors ◽  
Study Designs

Personalised and contextualised care has been turned into a major demand by people involved in healthcare suggesting to move toward person-centred medicine. The assessment of person-centred medicine can be most effectively achieved if treatments are investigated using ‘with versus without’ person-centredness or integrative study designs. However, this assumes that the components of an integrative or person-centred intervention have an additive relationship to produce the total effect. Beecher’s model of additivity assumes an additive relation between placebo and drug effects and is thus presenting an arithmetic summation. So far, no review has been carried out assessing the validity of the additive model, which is to be questioned and more closely investigated in this review. Initial searches for primary studies were undertaken in July 2016 using Pubmed and Google Scholar. In order to find matching publications of similar magnitude for the comparison part of this review, corresponding matches for all included reviews were sought. A total of 22 reviews and 3 clinical and experimental studies fulfilled the inclusion criteria. The results pointed to the following factors actively questioning the additive model: interactions of various effects, trial design, conditioning, context effects and factors, neurobiological factors, mechanism of action, statistical factors, intervention-specific factors (alcohol, caffeine), side-effects and type of intervention. All but one of the closely assessed publications was questioning the additive model. A closer examination of study design is necessary. An attempt in a more systematic approach geared towards solutions could be a suggestion for future research in this field.

Osteopathic manipulative treatment and the Spanish flu: a historical literature review

2021 ◽  
Vol 121 (2) ◽  
pp. 181-190
Author(s):  
Francesca Baroni ◽  
Damiana Mancini ◽  
Silvia Clara Tuscano ◽  
Simone Scarlata ◽  
Christian Lunghi ◽  
...  
Keyword(s):  
Healthy Lifestyle ◽  
Influenza Pandemic ◽  
Future Research ◽  
Osteopathic Manipulative Treatment ◽  
Inclusion Criteria ◽  
Medical Subject Headings ◽  
National Library ◽  
Hand Search ◽  
Spanish Flu ◽  
Osteopathic Physicians

Abstract Context The Spanish flu pandemic of 1918 was approached with a variety of management techniques available at that time, including osteopathic care in addition to standard medical care. Objective To analyze the osteopathic manipulative treatment (OMT) techniques used for the management of patients affected by the Spanish flu according to four themes: the principles and procedures used, frequency and length of OMT, reported side effects, and advice for patients. Methods A structured review of the literature was performed by hand-searching texts at the Museum of Osteopathic Medicine International Center for Osteopathic History in Kirksville, Missouri, and online via PubMed (National Library of Medicine), ScienceDirect (Elsevier), and Google Scholar (Google, Inc). The literature search was carried out between February and March 2020. Three keywords were selected from the medical subject headings database of the National Library of Medicine: manipulation, osteopathic; influenza pandemic, 1918–1919; epidemics. Articles were then reviewed for relevance by screening for articles published between 1900 and 1940 that contained at least 1 of the following keywords in their title: Spanish influenza, flu, epidemic, grippe, pneumonia, or osteopathic management/treatment. All articles that provided information about OMT and advice met the inclusion criteria. Articles that did not report descriptions of manipulative intervention were excluded. Results Our search yielded 63 articles: 23 from the hand-search and 40 from the electronic search. No electronic source was selected for the review because none met inclusion criteria. A total of 16 articles from the hand-searched set met inclusion criteria and were analyzed according to the four main themes stated in the objective. The range of OMT approaches reported to be administered to patients with Spanish flu suggests that early osteopathic physicians treated patients with this disease using OMT in addition to offering advice on healthy lifestyle behaviors. Conclusion Conclusions from this study are limited by the historical and descriptive nature of the data gathered, which lacked the rigor of modern-day scientific studies. However, this review could lead to future research inquiries on the effectiveness of these approaches. Osteopathic physicians and osteopaths should embrace their historical osteopathic heritage by continuing the work of our predecessors and combining their hands-on experience and osteopathic principles with modern medical treatment and rigorous scientific standards.

scholarly journals Volatile Anaesthetic Depression of the Carotid Body Chemoreflex-Mediated Ventilatory Response to Hypoxia: Directions for Future Research

Scientifica ◽  
2014 ◽  
Vol 2014 ◽  
pp. 1-15 ◽  
Author(s):  
J. J. Pandit
Keyword(s):  
Quantitative Analysis ◽  
Carotid Body ◽  
Meta Analysis ◽  
Future Research ◽  
Inclusion Criteria ◽  
Molecular Processes ◽  
Similar Dose ◽  
Hypercapnic Response ◽  
Ventilatory Response To Hypoxia ◽  
Body Response

In assessing whether volatile anaesthetics directly depress the carotid body response to hypoxia it is necessary to combine in meta-analysis studies of when it is “functionally isolated” (e.g., recordings are made from its afferent nerve). Key articles were retrieved (full papers in English) and subjected to quantitative analysis to yield an aggregate estimate of effect. Results from articles that did not use such methodology were assessed separately from this quantitative approach, to see what could be learned also from a nonquantitative overview. Just 7 articles met the inclusion criteria for hypoxia and just 6 articles for hypercapnia. Within these articles, the anaesthetic (mean dose 0.75, standard deviation (SD) 0.40 minimum alveolar concentration, MAC) statistically significantly depressed carotid body hypoxic response by 24% (P=0.041), but a similar dose (mean 0.81 (0.42) MAC) did not affect the hypercapnic response. The articles not included in the quantitative analysis (31 articles), assessed qualitatively, also indicated that anaesthetics depress carotid body function. This conclusion helps direct future research on the anaesthetic effects on putative cellular/molecular processes that underlie the transduction of hypoxia in the carotid body.

scholarly journals A review of Waste Tyre Rubber as an Alternative Concrete Consituent Material

2018 ◽  
Vol 199 ◽  
pp. 11003 ◽  
Author(s):  
Kudzai Mushunje ◽  
Mike Otieno ◽  
Yunus Ballim
Keyword(s):  
Health And Safety ◽  
Engineering Properties ◽  
Future Research ◽  
Rubber Material ◽  
Safety Risks ◽  
Concrete Production ◽  
Potential Benefits ◽  
Waste Tyre ◽  
Health And Safety Risks ◽  
Published Research

The current global waste tyre generation far exceeds its consumption in terms of recycling and re-use. The traditional recycling and re-use methods like thermal incineration have proven ineffective, costly and in some cases environmentally unsustainable. Particularly, in developing countries where some of the sophisticated techniques required to process tyres to allow them to be utilised are either too costly or have not yet been developed. The situation has resulted in accumulation of large waste tyre stockpiles that pose health and safety risks. To combat the problem, the use of waste tyre rubber in concrete construction has been proposed. Several studies have been conducted to assess the effects of the inclusion of waste tyre rubber in its different forms (fibres, particles), for concrete production and the results are promising. Although there are some apparent demerits to the inclusion of tyre rubber in concrete, the potential benefits seem to overshadow the negatives. This paper reviews published research on the scientific and technical viability of using waste tyre rubber in concrete production. It discusses the production and properties of waste tyre particles. It highlights advances made with regards to the incorporation of tyre rubber material in concrete, focusing on the engineering properties of the tyre rubber modified concrete. In conclusion, recommendations for future research and possible application for the material will be discussed.

Explanatory Theories of Intimate Partner Homicide Perpetration: A Systematic Review

2020 ◽  
pp. 152483802095380
Author(s):  
Laurie M. Graham ◽  
Rebecca J. Macy ◽  
Cynthia F. Rizo ◽  
Sandra L. Martin
Keyword(s):  
Systematic Review ◽  
Ecological Model ◽  
Intimate Partner ◽  
Future Research ◽  
Intimate Partner Homicide ◽  
Inclusion Criteria ◽  
Search Terms ◽  
Social Ecological ◽  
Theoretical Perspectives ◽  
The Social

Theories play an important role in guiding intimate partner homicide (IPH) prevention research and practice. This study is the first systematic review of theories employed to explain why someone might kill their intimate partner. This review used rigorous methods to locate and synthesize literature that described explanatory theories of IPH perpetration. Using set search terms, we systematically searched 15 databases and repositories for theory-focused documents (i.e., theory papers or analyses) published in English from 2003 to 2018. Eighteen documents met these inclusion criteria and identified 22 individual theories that seek to explain why people might kill their intimate partners. These theories fell within four broader theoretical perspectives: feminist, evolutionary, sociological/criminological, and combined. Key tenets and focal populations of these 22 theories were identified and organized into a compendium of explanatory theories of IPH perpetration. Potential strengths and limitations of each of the four perspectives were described. Review findings underscored the likely importance of addressing gender as well as risk and protective factors at all levels of the social ecological model in efforts to understand IPH perpetration. The review findings highlighted the need for both integrated theories and a broader conceptual organizing framework to guide work aimed at IPH perpetration prevention to leverage the strengths of disparate theoretical perspectives. With the goal of informing future research, a preliminary iteration of such a framework is presented.

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