Detection of Marine Toxins Using Reconstituted Sodium Channels
1995 ◽
Vol 78
(2)
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pp. 570-573
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Keyword(s):
Abstract Specific binding of the marine toxins saxitoxin, tetrodotoxin, and brevetoxin to the rat brain sodium channel is demonstrated using purified sodium channels reconstituted into phospholipid vesicles. Restoration of sodium channel function and binding activity by incorporation into phospholipid vesicles provides the only rigorous proof that the purified protein contains the neurotoxin receptor sites. In addition, reconstitution provides a valuable experimental preparation for biochemical analysis of neurotoxin binding sites and may facilitate the development of a specific toxin detection system.
2017 ◽
Vol 114
(49)
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pp. 12922-12927
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2013 ◽
Vol 106
(3)
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pp. 101-112
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Keyword(s):
2016 ◽
Vol 72
(9)
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pp. 713-719
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1986 ◽
Vol 6
(4)
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pp. 463-470
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1979 ◽
Vol 254
(22)
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pp. 11379-11387
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1989 ◽
Vol 9
(10)
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pp. 4204-4212
1992 ◽
Vol 12
(5)
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pp. 1940-1949
2013 ◽
Vol 142
(3)
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pp. 181-190
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