PSI-B-26 Association of leptin gene polymorphisms (C73T and C528T) on the development of internal organs in Aberdeen-angus cattle

2021 ◽  
Vol 99 (Supplement_3) ◽  
pp. 224-225
Author(s):  
Alexandra Lapshina ◽  
Nikolay Gerasimov ◽  
Kinispay Dzhulamanov ◽  
Vladimir Kolpakov ◽  
Erzhan Dzhulamanov
Keyword(s):  
Financial Support ◽  
Gene Polymorphisms ◽  
Energy Exchange ◽  
Spleen Weight ◽  
Metabolic Processes ◽  
Internal Organs ◽  
Plant Foods ◽  
Angus Cattle ◽  
Relationship Of ◽  
The Relationship

Abstract Numerous studies have established the relationship of SNPs in the leptin gene with fat and energy exchange, nutritional behavior in cattle. In turn, the intensity of metabolic processes in body is determined by the development of internal organs. The purpose of research was to study the relationship between the complex of polymorphisms C73T and C528T in leptin gene for the formation of internal organs in Aberdeen-Angus cows and heifers. Cows (n = 30) and heifers (n = 49) were genotyped and identified respectively 7 and 8 various combinations of genotypes of C73T (GenBank AF120500) and C528T (GenBank AB070368). There were no homozygous CC/CC and TT/TT combinations in cows, and no TT/TT combination in heifers. Cows were slaughtered at the age of 3 years, and heifers - at 20 months. Cows with haplotype CT/CC had the highest liver, heart, lung, kidney and spleen weight with superiority relative to peers of 6.5–16.0% (P > 0.05). The minimum development of stomachs was established at cows with a combination of genotypes of CC/TT which conceded to analogs for 7.6–13.8% (P > 0.05). Haplotypes CT/CT and TT/CT in heifers were associated with greater internal organ massiveness. Carriers of complex CT/CT genotype outperformed peers in terms of liver, heart, lung, kidney and spleen weight by 1.75–6.59% (P < 0.05, P > 0.05), and individuals with a combination of TT/CT by 3.50–8.84% (P < 0.05, P > 0.05). Less developed stomachs were established in bodies with haplotype TT/CC, which were inferior to other genotypes by 1.20–7.49% (P < 0.05, P > 0.05). This indirectly indicates a relatively weak ability to use coarse plant foods. Thus, the complex genotype inleptin gene is associated with the variability in the development of internal organs, which determines the intensity of metabolic processes. This research was performed with financial support from the project of RAS0526-2021-0001.

The relationship of oral disturbances of diabetes mellitus patients with paraoxonase gene polymorphisms

2008 ◽  
Vol 26 (8) ◽  
pp. 870-873 ◽  
Author(s):  
Meral Ünür ◽  
Erdinç Demirez ◽  
Bedia Ağaçhan ◽  
Uzay Görmüş ◽  
Arzu Ergen ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gene Polymorphisms ◽  
Relationship Of ◽  
The Relationship

scholarly journals Lecture of the cycle of specialization in reflexology "Practical application of the theory of U-Sin in traditional Chinese medicine"

2019 ◽  
pp. 24-31
Author(s):  
G. Chuprina ◽  
T. Parnikoza ◽  
N. Svyrydova
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Pathological Process ◽  
Diagnosis And Treatment ◽  
Practical Application ◽  
Internal Organs ◽  
Syndromic Diagnosis ◽  
Five Elements ◽  
Relationship Of ◽  
The Relationship

The theory of the five elements is widely used in traditional Chinese medicine, and the division of natural phenomena according to the properties of the five elements and the nature of the relationship between them, is practical in clinical acupuncture: to characterize the structural, physiological and pathological features of the patient, diagnosis and treatment. With the development of diseases there is a pathological relationship between Zhang-Fu organs and tissues that they are subordinated to. The human body is an organic whole, in which there are numerous interconnections in the development of the pathological process due to the existing modified interconnections. It is established that the theory of five elements is a simple theory with certain limitations. The laws of the relationship between the elements of the U-Syin cycle are not a reflection of all possible interconnections between the Zhang-Fu organs and the related tissues. In clinical practice, these laws show objective physiological and pathological communications between the internal organs and can be used in the process of acupuncture diagnosis and treatment. The theory of the five elements lies at the heart of the methodology of traditional acupuncture diagnostics, used during its implementation and data analysis, it determines the pathological states in accordance with the characteristics and laws of the relationship of the five elements and formulates the syndromic diagnosis of traditional Chinese Medicine (TCM).

scholarly journals The relationship of polymorphic variants of genes GSTM1, GSTT1, GSTP1 with the risk of developing diseases (literature review)

2021 ◽  
Vol 100 (12) ◽  
pp. 1385-1390
Author(s):  
A. M. Amromina ◽  
I. A. Sitnikov ◽  
D. R. Shaikhova
Keyword(s):  
Russian Federation ◽  
Gene Polymorphisms ◽  
Glutathione Transferase ◽  
Glutathione S Transferase ◽  
Scientific Publications ◽  
Scientific Papers ◽  
Oncological Diseases ◽  
The Russian Federation ◽  
Relationship Of ◽  
The Relationship

Authors analyzed the relationship of the most studied polymorphisms of glutathione-S-transferase genes (GSTT1, GSTM1, GSTP1) with the risk of developing diseases in the territory of the Russian Federation. The authors analyzed domestic articles on gene polymorphisms and their association with various conditions. A systematic review of scientific papers was carried out using the following electronic databases: Cyberleninka, Electronic Library and Google Scholar, which searched for glutathione transferase (GST) gene polymorphisms from 1900 to 2020. The following keywords were used for the search: “GST polymorphism”. The search for articles was carried out in English but took into account the results obtained only in the territory of the Russian Federation. The search for scientific publications was independently checked and compared to filter out duplicate articles. The sample size, the number of loci included in the analysis, and the analyzed population (ethnic group) are essential in studying the relationship between glutathione S-transferase gene polymorphisms and the development of diseases. In general, the analysis of the articles makes it possible to reveal the association between the polymorphisms of the glutathione-S-transferase genes and the high risk of developing oncological diseases, respiratory diseases and other pathologies. This article did not consider the relationship of polymorphisms with reproductive pathologies because this topic includes a large amount of work and requires separate consideration. The least studied issue is the relationship between polymorphisms of genes for biotransformation of xenobiotics and the development of occupational diseases.

Spleen and liver weight changes in NZB mice with haemolytic anaemia

1975 ◽  
Vol 9 (4) ◽  
pp. 261-273 ◽  
Author(s):  
L. O. Simpson
Keyword(s):  
Multivariate Analysis ◽  
Liver Weight ◽  
Spleen Weight ◽  
Red Cell ◽  
Weight Changes ◽  
Haemolytic Disease ◽  
3 Dimensional ◽  
Dominant Feature ◽  
Relationship Of ◽  
The Relationship

Spleen and liver weights from 998 NZB mice were subjected to computerised multivariate analysis. 3-dimensional graphs relating predicted spleen and liver weights to age and body weight were prepared and the relationship of the fitted surface to the histology and pathological autoantibody is discussed. On the basis of spleen weight increase, red-cell destruction throughout the greater part of life seems to be mainly intrasplenic, while intrahepatic destruction does not become important until later, when it is probably a dominant feature in the terminal period of the disease. Only limited organ weight increases occur in breeding females, and it is suggested that pregnancy lessens the effect of the haemolytic disease, the 'protective' effect extending long after the cessation of breeding.

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