scholarly journals Antimicrobial peptide KR-32 alleviates Escherichia coli K88–induced fatty acid malabsorption by improving expression of fatty acid transporter protein 4 (FATP4)1

2019 ◽  
Vol 97 (6) ◽  
pp. 2342-2356 ◽  
Author(s):  
Heyuan Liu ◽  
Xiaoxuan Cao ◽  
Hong Wang ◽  
Jian Zhao ◽  
Xinxia Wang ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Fatty Acid ◽  
Antimicrobial Peptide ◽  
Transporter Protein ◽  
Fatty Acid Transporter ◽  
Acid Transporter

Prepartum maternal diets supplemented with oilseeds alter the fatty acid profile in bovine neonatal plasma possibly through reduced placental expression of fatty acid transporter protein 4 and fatty acid translocase

2017 ◽  
Vol 29 (9) ◽  
pp. 1846 ◽  
Author(s):  
Reza Salehi ◽  
Divakar J. Ambrose
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Placental Tissue ◽  
Peroxisome Proliferator ◽  
Peroxisome Proliferator Activated Receptor ◽  
Total N ◽  
Fatty Acid Translocase ◽  
Transporter Protein ◽  
Fatty Acid Transporter ◽  
Acid Transporter

In the present study, we determined the effects of maternal dietary fat and the type of fat on plasma fatty acids and the expression of placental fatty acid transporter genes. In Experiment 1, Holstein cows in the last 35 days of gestation received diets containing sunflower seed (n = 8; high in linoleic acid (LA)), canola seed (n = 7; high in oleic acid (OLA)) or no oilseed (n = 7; control). Fatty acids were quantified in dam and neonate plasma at calving. In Experiment 2, placental cotyledons were collected (LA: n = 4; OLA: n = 4; control: n = 5) to quantify gene expression. Maternal long-chain polyunsaturated fatty acids, neonatal total n-3 fatty acids and eicosapentaenoic acid (EPA) declined, whereas docosahexaenoic acid (DHA) and total fat tended to decline following fat supplementation prepartum. Feeding of LA versus OLA prepartum tended to increase peroxisome proliferator-activated receptor α (PPARA) expression, whereas peroxisome proliferator-activated receptor δ (PPARD) and peroxisome proliferator-activated receptor γ (PPARG) expression tended to be higher in OLA- than LA-fed cows. Expression of fatty acid transporter protein 4 (FATP4) and fatty acid translocase (FAT/CD36) expression was lower in placental tissue of cows fed fat compared with control cows. Reduced total n-3 fatty acids, EPA and DHA in neonates born of dams fed fat prepartum is likely due to changes in PPARs and reduced expression of placental FATP4 and FAT/CD36.

scholarly journals Fatty acid transporter expression and regulation is impaired in placental macrovascular endothelial cells in obese women

2017 ◽  
Vol 32 (6) ◽  
pp. 971-978 ◽  
Author(s):  
Xiaohua Yang ◽  
Patricia Glazebrook ◽  
Geraldine C. Ranasinghe ◽  
Maricela Haghiac ◽  
Virtu Calabuig-Navarro ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Fatty Acid ◽  
Obese Women ◽  
Fatty Acid Transporter ◽  
Acid Transporter ◽  
Transporter Expression

scholarly journals Hyperinsulinemia Enhances Hepatic Expression of the Fatty Acid Transporter Cd36 and Provokes Hepatosteatosis and Hepatic Insulin Resistance

2015 ◽  
Vol 290 (31) ◽  
pp. 19034-19043 ◽  
Author(s):  
Pär Steneberg ◽  
Alexandros G. Sykaras ◽  
Fredrik Backlund ◽  
Jurate Straseviciene ◽  
Ingegerd Söderström ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Fatty Acid ◽  
Hepatic Insulin Resistance ◽  
Hepatic Expression ◽  
Fatty Acid Transporter ◽  
Acid Transporter
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