scholarly journals Bitter Melon (Momordica charantia) Reduces Adiposity, Lowers Serum Insulin and Normalizes Glucose Tolerance in Rats Fed a High Fat Diet

2003 ◽  
Vol 133 (4) ◽  
pp. 1088-1093 ◽  
Author(s):  
Qixuan Chen ◽  
Laureen L. Y. Chan ◽  
Edmund T. S. Li
Keyword(s):  
Glucose Tolerance ◽  
High Fat Diet ◽  
Serum Insulin ◽  
Momordica Charantia ◽  
Bitter Melon ◽  
High Fat

scholarly journals The Combination of Ephedrae herba and Coicis semen in Gambihwan Attenuates Obesity and Metabolic Syndrome in High-Fat Diet–Induced Obese Mice

2018 ◽  
Vol 2018 ◽  
pp. 1-10 ◽  
Author(s):  
Jun-Woo Jang ◽  
Dong-Woo Lim ◽  
Ji-Ung Chang ◽  
Jai-Eun Kim
Keyword(s):  
Glucose Tolerance ◽  
Lipid Accumulation ◽  
High Fat Diet ◽  
Serum Insulin ◽  
Obese Mice ◽  
Hepatic Enzyme ◽  
High Fat ◽  
Cytokine Levels ◽  
The Difference ◽  
Commercial Kits

Gambihwan is a herbal prescription used in Korean medicine to treat obesity. The authors evaluated the effects and mechanisms of two types of Gambihwan (GBH1 and 2) administered to high-fat diet– (HFD-) induced obese mice. Four-week-old C57BL/6 mice were fed a HFD for 8 weeks with or without GBH1 or 2 (100-200 mg/kg/day by oral gavage). All mice were subjected to glucose tolerance testing after the 8-week treatment period and then euthanized. Serum insulin, lipids, and inflammatory cytokine levels were analyzed using commercial kits. Hepatic enzyme levels and lipid profiles were also investigated. Liver section slides were stained with Oil Red O (ORO) or hematoxylin and eosin (H&E) to assess lipid accumulation. GBH1 and 2 both significantly decreased body, liver, or adipose tissue weights in HFD-fed mice and significantly improved glucose tolerance (p<0.05 in all groups). Cholesterol levels in both sera and liver homogenates were significantly decreased by GBH1 and 2 (p<0.05 in all groups). In addition, serum inflammatory cytokines (p<0.05 in 200 mg/kg/day groups) and hepatic enzyme levels were significantly diminished by GBH administration at 200mg/kg/day (p<0.05 in all groups). Furthermore, histologic analyses of liver sections revealed GBH suppressed lipid accumulation. Both GBH types suppressed HFD-induced increases in body weight and obesity-related markers in HFD-fed mice despite the difference in constituents between GBH1 and 2. It is strongly assumed that the combination of Ephedrae herba and Coicis semen exerted the antiobesity effect. The results obtained show that the antiobesity effects of GBH warrant further investigation.

scholarly journals Momordica charantia improves body weight and glucose tolerance in mice fed high fat diet.

2009 ◽  
Vol 23 (S1) ◽  
Author(s):  
Fatima Pina ◽  
Angela Brown ◽  
Emily Luebcke ◽  
Penny Perkins‐Veazie ◽  
Stephen Clarke ◽  
...  
Keyword(s):  
Body Weight ◽  
Glucose Tolerance ◽  
High Fat Diet ◽  
Momordica Charantia ◽  
High Fat

scholarly journals Momordica charantia (bitter melon) attenuates high-fat diet-associated oxidative stress and neuroinflammation

2011 ◽  
Vol 8 (1) ◽  
pp. 64 ◽  
Author(s):  
Pratibha V Nerurkar ◽  
Lisa M Johns ◽  
Lance M Buesa ◽  
Gideon Kipyakwai ◽  
Esther Volper ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
High Fat Diet ◽  
Momordica Charantia ◽  
Bitter Melon ◽  
High Fat

scholarly journals Pemberian Ekstrak Buah Pare dan Diet Tinggi Lemak pada Penurunan Berat Badan Tikus Putih Jantan

2019 ◽  
Vol 17 (1) ◽  
pp. 60
Author(s):  
I MADE SUBHAWA HARSA
Keyword(s):  
Rattus Norvegicus ◽  
High Fat Diet ◽  
Negative Control Group ◽  
Positive Control ◽  
Negative Control ◽  
Momordica Charantia ◽  
Control Group ◽  
Bitter Melon ◽  
High Fat ◽  
White Rats

<div class="Section1"><p align="center"><strong>Abstra</strong><strong>ct</strong></p><p><strong>Background</strong> : Obesity is an energy balance disorder, ketogenic diet can reduce body weight. Bitter melon (<em>Momordica charantia L.)</em> is a type of vegetable material that is often used as an antioxidant, hypocholesterolemia and hypotriglyceridemia drug. <em>Cucurbitasin</em> is a substance produced by bitter melon (<em>Momordica charantia L.)</em> with a bitter taste which causes in decreasing appetite, resulting in a decrease in triglycerides. This is caused by the bioactivity of bitter melon (<em>Momordica charantia L.)</em> which can increase lipid oxidation, which causes the accumulation of decreased fat tissue which can reduce weight.</p><p><strong>Methods</strong>: This research using pre and post test randomized controlled group design with sample size of 30 male white rats (<em>Rattus norvegicus</em>) wistar lines divided into 3 groups, group 1 as negative control group given standard feed, group 2 as positive control group given high-fat diet with a dose of 2.5 ml and group 3 as a treatment group given a high-fat feed with dose of 2.5 ml and extract of bitter melon (<em>Momordica charantia L.)</em> at dose of 37.5 mg / 150 gBB by feeding tube every morning for 28 days. Data were analyzed by T-paired tests.</p><p><strong>Result</strong>: The T-paired test in each group found a significantly different result of p = 0,000.</p><p><strong>Conclusion</strong>: given bitter melon (<em>Momordica charantia L.)</em> extract and high-fat diet can reduce weight in male white rats (<em>Rattus norvegicus</em>).</p><p> </p><p><strong>Keywords</strong>:Bitter molon extract, high fat feed, weight loss.</p><p> </p></div><strong><br clear="all" /></strong>

scholarly journals Effect Administration of Ethanol Extract of Bitter Melon (Momordica Charantia L.) On The Reduction of MDA (Malondialdehyde) Levels Serum in Rats Given a High-Fat Diet

2018 ◽  
Vol 7 (2) ◽  
pp. 196
Author(s):  
Andiani Andiani ◽  
Made Subhawa Harsa
Keyword(s):  
Rattus Norvegicus ◽  
High Fat Diet ◽  
Ethanol Extract ◽  
Momordica Charantia ◽  
The Body ◽  
Control Group ◽  
Bitter Melon ◽  
High Fat ◽  
White Rats ◽  
Ad Libitum

Hyperlipidemia is a disease whichthe effect in increased fat levels in the blood. In hyperlipidemia, the condition of high oxidative stress is obtained due to the oxidation process of LDL (Low Density Lipoprotein) in the body, this condition showed by increased of MDA (Malondialdehyde) levels in serum. Bitter melon (Momordica Charantia L.) contains a lot of active ingredients, one of the ingredients of bitter melon that is thought to have antilipidemic effects is flavonoid compounds. This study was experimental study using a randomized posttest only control group design study with a sample size of 30 male white rats (Rattus norvegicus) wistar strain which was divided into 3 groups, namely K1, K2, and K3. In each group, different treatments are given. Negative control group (K1), given standard feed, water ad libitum; Positive control group (K2), given standard feed, high fat feed with a dose of 2.5 ml water ad libitum; The treatment group (K3) was given a standard diet, high-fat feed with a dose of 2.5 ml water ad libitum and extract of bitter melonat a dose of 250 mg / kg BB by orally every morning for 3 weeks. Data analysis using One Way Anova Test. From the results of the test shows the significance of p-value = 0.000 which is <α (0.05). The results showed that there was an effect of  administration ethanol extract of bitter melon (Momordica charantia L.) to decrease in serum MDA (malondialdehyde) levels in male white wistar rats (Rattus norvegicus) given a high-fat diet.

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