Background/Aim. As significant advances in cancer treatment have occurred
over the decades, the crucial questions in oncology nowadays are not related
only to the treatment of illness, but also to the quality of life (QOL) of
patients. The goal of our study was to explore which set of determinants
(clinical, functional, affective, or social) has the greatest impact on
explaining QOL in women who live with diagnosis of breast cancer in Serbia.
Methods. The research was conducted on 64 women (Mage=58.36, SD=11.30) while
undergoing radiation therapy at Oncology institute of Vojvodina. QOL-BC was
used as a measure of physical, psychological, social, spiritual and general
well-being, UEFI was applied for the assessment of the upper extremity
function, DASS-21 was used for measuring symptoms of depression, anxiety and
stress, MOS-SSS served as a measure of social support, while demographic and
clinical data were also collected. Results. ANOVA with repeated measures,
F(2.03, 127.80 )=20.24, p<.001, showed that in our sample, physical QOL was
significantly better from all other domains, while social QOL was
significantly lower from both physical and psychological aspect. A
hierarchical regression analysis, F(8, 55)=7.16, p<.001, R2=.51, showed that
patients who received adjuvant chemotherapy, who experienced high levels of
stress and poor social support, tend to have diminished general QOL.
Intoduction of affective-related variables, ?R2=.16, p(?F)<.01, and social
support, ?R2=.05, p(?F)<.05, led to a significant increase in proportion of
explained variance over and above clinical and functional variables.
Conclusion. Our results indicate that psychological and social resources are
more important in predicting QOL, compared to clinical and funcitonal
factors. At the same time, social, psychological and spiritual well-being of
patients is significantly worse compared to physical QOL, meaning that there
is still much left to be done regarding the progress from a purely somatic
to a holistic approach in treatment of breast cancer.