Psychiatric consequences of cancer treatments: therapeutic monoclonal antibodies
Keyword(s):
Jc Virus
◽
The adverse psychiatric consequences of a range of monoclonal antibodies used to treat cancer are reviewed. Bevacizumab disrupts endothelial function at the blood–brain barrier and can provoke posterior reversible encephalopathy syndrome. The immune checkpoint inhibitors cause autoimmune hypophysitis and thyroiditis with associated psychopathology. Rituximab causes profound immunosuppression of B lymphocytes, and hence can reactivate childhood JC virus infection to cause progressive multifocal leucoencephalopathy. The marked neuropsychiatric toxicity of blinatumomab is described.
2019 ◽
Vol 380
(17)
◽
pp. 1667-1668
◽
2019 ◽
Vol 17
(4)
◽
pp. 506-523
2019 ◽
Vol 20
(10)
◽
pp. 2560
◽
2017 ◽
Vol 35
(15_suppl)
◽
pp. e14605-e14605
◽
2015 ◽
2011 ◽
Vol 2
(2)
◽
pp. 87-94
2015 ◽