scholarly journals P0732DOES KIDNEY FUNCTION INFLUENCE PLASMA ADIPONECTIN CONCENTRATION IN ELDERLY CAUCASIANS?

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Marcin Adamczak ◽  
Sylwia Dudzicz ◽  
Jerzy Chudek ◽  
Jan Zejda ◽  
Tomasz Zdrojewski ◽  
...  
Keyword(s):  
Plasma Concentration ◽  
Kidney Function ◽  
Multivariate Regression Analysis ◽  
Population Based ◽  
Cross Sectional Study ◽  
Elderly Subjects ◽  
Study Cohort ◽  
Adiponectin Concentration ◽  
Cross Sectional ◽  
Plasma Adiponectin

Abstract Background and Aims Adiponectin is a hormone produced almost exclusively by the adipose tissue with vaso-protective activity and mostly metabolized in the kidneys. Glomerular filtration rate (GFR) is declining with age in elderly subjects and therefore it is expected to be followed by accumulation of adiponectin in the circulation. The aim of this study was to assess the plasma concentration of adiponectin in relation to GFR in the older population-based on the PolSenior study cohort. Method The PolSenior study was a multicenter cross-sectional study which assessed the health status of older adults in Poland. In 3913 subjects aged 65 years or above (2041 male and 1872 female, BMI 28.1±5.1 kg/m2, mean age 79±9 years) plasma adiponectin concentration (ELISA; B-Bridge International) was measured. GFR was estimated using a short MDRD formula. All results are presented as means with standard deviations. Results In studied subjects eGFR was 76 ml/min/1.73 m2. eGFR below 60 ml/min/1.73 m2 was observed in 842 (22%) subjects. Plasma concentration of adiponectin was 11.9±6.4 µg/ml. In subjects with eGFR < 60 ml/min/1.73 m2 significantly higher plasma adiponectin concentrations were observed compared to subjects with eGFR ≥ 60 ml/min/1.73 m2 (12.5±6.7 vs. 11.8±6.3 respectively, p=0.01). Plasma adiponectin concentration depends strongly on BMI (R= -0.28; p<0.001) and marginally on the kidney function (R=-0.05; p=0.005). Multivariate regression analysis including plasma adiponectin concentration, BMI, eGFR, occurrence of diabetes mellitus and hypertension, showed that BMI and prevalence of diabetes (b=-0.24, p<0.001, b=-0.11, p<0.0001, respectively) but not eGFR explain variability of plasma adiponectin concentration. Conclusion Plasma adiponectin concentration is only slightly affected by kidney function in elderly Caucasians from the PolSenior study.

scholarly journals Sodium intake and kidney function in the general population: an observational, population-based study

2020 ◽  
Author(s):  
Massimo Cirillo ◽  
Giancarlo Bilancio ◽  
Pierpaolo Cavallo ◽  
Raffaele Palladino ◽  
Oscar Terradura-Vagnarelli ◽  
...  
Keyword(s):  
General Population ◽  
Serum Creatinine ◽  
Kidney Function ◽  
Sodium Intake ◽  
Multivariable Analysis ◽  
Population Based ◽  
Study Cohort ◽  
Cross Sectional ◽  
Adult Participants

Abstract Background The relationships of sodium intake to kidney function within the population have been poorly investigated and are the objective of the study. Methods This observational, population-based, cross-sectional and longitudinal study targeted 4595 adult participants of the Gubbio study with complete data at baseline exam. Of these participants, 3016 participated in the 15-year follow-up (mortality-corrected response rate 78.4%). Baseline measures included sodium:creatinine ratio in timed overnight urine collection, used as an index of sodium intake, together with serum creatinine, sex, age and other variables. Follow-up measures included serum creatinine and other variables. Estimated glomerular filtration rate (eGFR, mL/min/1.73 m2) was calculated using serum creatinine, sex and age and was taken as an index of kidney function. Results The study cohort was stratified in sex- and age-controlled quintiles of baseline urine sodium:creatinine ratio. A higher quintile associated with higher baseline eGFR (P < 0.001). In multivariable analysis, the odds ratio (OR) of Stage1 kidney function (eGFR ≥90 mL/min/1.73 m2) was 1.98 times higher in Quintile 5 compared with Quintile 1 [95% confidence interval (CI) 1.50–2.59, P < 0.001]. The time from baseline to follow-up was 14.1 ± 2.5 years. Baseline to follow-up, the eGFR change was more negative along quintiles (P < 0.001). In multivariable analysis, the OR in Quintile 5 compared with Quintile 1 was 2.21 for eGFR decline ≥30% (1.18–4.13, P = 0.001) and 1.38 for worsened stage of kidney function (1.05–1.82, P = 0.006). Findings were consistent within subgroups. Conclusions Within the general population, an index of higher sodium intake associated cross-sectionally with higher kidney function but longitudinally with greater kidney function decline.

scholarly journals Epidemiology of physiotherapy utilization among adults and elderly

2005 ◽  
Vol 39 (4) ◽  
pp. 662-668 ◽  
Author(s):  
Fernando Vinholes Siqueira ◽  
Luiz Augusto Facchini ◽  
Pedro Curi Hallal
Keyword(s):  
Public Health ◽  
Health Services ◽  
Population Based ◽  
Cross Sectional Study ◽  
Elderly Subjects ◽  
Public Health Services ◽  
Cross Sectional ◽  
Health Authorities ◽  
Primary Sample ◽  
Public Health Authorities

OBJECTIVE: To analyze the prevalence of physiotherapy utilization and to explore the variables associated to its utilization. METHODS: A population-based cross-sectional study, including 3,100 subjects aged 20 years or more living in the urban area of Pelotas, southern Brazil, was carried out. The sample was selected following a multiple-stage protocol; the census tracts delimited by the Instituto Brasileiro de Geografia e Estatística (Brazilian Institute of Geography and Statistics) were the primary sample units. Following descriptive and crude analyses, Poisson regression models taking the clustering of the sample into account were carried out. Data were collected through face-to-face interviews using a standardized and pre-tested questionnaire. RESULTS: The lifetime utilization of physiotherapy was 30.2%; and physiotherapy utilization in the 12 months prior to the interview was reported by 4.9%. Women, elderly subjects, and those from higher socioeconomic levels were more likely to use physiotherapy. Restricting analysis to subjects who attended physiotherapy, 66% used public health services, 25% used insurance health services and 9% had private sessions. CONCLUSIONS: This is the first population-based study on physiotherapy utilization carried out in Brazil. Utilization of physio therapy was lower than reported in both developed and developing countries. The study findings might help public health authorities to organize healthcare service in terms of this important demand.

scholarly journals Physical Therapy Use and Associated Factors in Adults with and without Osteoarthritis—An Analysis of the Population-Based German Health Update Study

Healthcare ◽  
2021 ◽  
Vol 9 (11) ◽  
pp. 1544
Author(s):  
Kim Elisa Sussmann ◽  
Hannes Jacobs ◽  
Falk Hoffmann
Keyword(s):  
Physical Therapy ◽  
General Health ◽  
Associated Factors ◽  
Smoking Behavior ◽  
Multivariate Regression Analysis ◽  
Population Based ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Poor General Health ◽  
German Health

Background: Physical therapy (PT) is recommended as first-line management for osteoarthritis (OA). The purpose of this study was to assess the PT use among adults with OA and those without (Non-OA) and subsequently identify associated factors among these populations. Methods: This cross-sectional study obtained national data from the population-based German Health Update (GEDA2014/2015-EHIS) study containing 24,016 participants aged 18 years and older. Analyses were stratified by sex, age, socioeconomic status (SES), residence, smoking behavior, body mass index, pain and general health. Multivariate regression analysis was conducted to evaluate factors associated with PT use within the past 12 months. Results: PT was used more frequently in the OA population compared with the Non-OA population (35.8% vs. 18.7%). In both populations, women, participants with high SES, residence in Eastern Germany, severe pain, poor general health and non-smokers received PT more frequently. Multivariate analysis confirmed these findings, in addition to people aged 80 years and older. The influence of SES was higher among OA participants. Conclusion: The underutilization of PT in OA patients (35.8%) was particularly evident among males, people with a low SES and those being older than 60 years, which aids to develop strategies increasing PT use towards guideline-oriented OA management.

scholarly journals Urinary Potassium and Kidney Function Decline in the Population—Observational Study

Nutrients ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 2747
Author(s):  
Massimo Cirillo ◽  
Giancarlo Bilancio ◽  
Pierpaolo Cavallo ◽  
Raffaele Palladino ◽  
Enrico Zulli ◽  
...  
Keyword(s):  
Kidney Function ◽  
Population Based ◽  
Dietary Sodium ◽  
Study Cohort ◽  
Creatinine Ratio ◽  
Time Data ◽  
High Potassium ◽  
Cross Sectional ◽  
Potassium Intake ◽  
Urinary Potassium

Background—Some data suggest favorable effects of a high potassium intake on kidney function. The present population-based study investigated cross-sectional and longitudinal relations of urinary potassium with kidney function. Methods—Study cohort included 2027 Gubbio Study examinees (56.9% women) with age ≥ 18 years at exam-1 and with complete data on selected variables at exam-1 (1983–1985), exam-2 (1989–1992), and exam-3 (2001–2007). Urinary potassium as urinary potassium/creatinine ratio was measured in daytime spot samples at exam-1 and in overnight timed collections at exam-2. Estimated glomerular filtration rate (eGFR) was measured at all exams. Covariates in analyses included demographics, anthropometry, blood pressure, drug treatments, diabetes, smoking, alcohol intake, and urinary markers of dietary sodium and protein. Results—In multivariable regression, urinary potassium/creatinine ratio cross-sectionally related to eGFR neither at exam-1 (standardized coefficient and 95%CI = 0.020 and −0.059/0.019) nor at exam-2 (0.024 and −0.013/0.056). Exam-1 urinary potassium/creatinine ratio related to eGFR change from exam-1 to exam-2 (0.051 and 0.018/0.084). Exam-2 urinary potassium/creatinine ratio related to eGFR change from exam-2 to exam-3 (0.048 and 0.005/0.091). Mean of urinary potassium/creatinine ratio at exam-1 and exam-2 related to eGFR change from exam-1 to exam-3 (0.056 and 0.027/0.087) and to incidence of eGFR < 60 mL/min per 1.73 m2 from exam-1 to exam-3 (odds ratio and 95%CI = 0.78 and 0.61/0.98). Conclusion—In the population, urinary potassium did not relate cross-sectionally to eGFR but related to eGFR decline over time. Data support the existence of favorable effects of potassium intake on ageing-associated decline in kidney function.

Association of plasma and urine metals levels with kidney function: A population-based cross-sectional study in China

Chemosphere ◽  
2019 ◽  
Vol 226 ◽  
pp. 321-328 ◽  
Author(s):  
Fei Yang ◽  
Xiping Yi ◽  
Jian Guo ◽  
Shuaishuai Xu ◽  
Yi Xiao ◽  
...  
Keyword(s):  
Kidney Function ◽  
Population Based ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional

scholarly journals The association between kidney function decline and hearing loss: a cross-sectional study

2020 ◽  
Author(s):  
Wenwen Liu ◽  
Qinqin Meng ◽  
Yafeng Wang ◽  
Chao Yang ◽  
Lili Liu ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Kidney Function ◽  
Integrated Management ◽  
Large Population ◽  
Population Based ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Increased Risk ◽  
Kidney Function Decline

Abstract Background: The relationship between kidney function and hearing loss has long been recognized, but evidence of this association mostly comes from small observational studies or other populations. The aim of this study is to explore the association between kidney function decline and hearing loss in a large population-based study among the middle-aged and elderly Chinese. Methods: Data collected from the Chinese Health and Retirement Longitudinal Study (CHARLS) in 2015 were used for analysis. A cross-sectional study was conducted among 12508 participants aged 45 years and older. Hearing loss, the outcome of this study, was defined according to interviewees’ responses to three survey questions related to hearing in the CHARLS. Estimated glomerular filtration rate (eGFR) was employed to assess kidney function, and participants were classified into three categories based on eGFR: ≥90, 60-89 and <60 mL/min/1.73 m 2 . Multivariable logistic regression was employed to adjust for potential confounders, including demographics, health-related behaviors, and cardiovascular risk factors. Results: The overall prevalence of self-reported hearing loss in the study population was 23.55%. Compared with participants with eGFR ≥90 mL/min/1.73 m 2 , participants with eGFR of 60–89 mL/min/1.73 m 2 (odds ratio [OR]: 1.11, 95% confidence interval [CI]: 1.00–1.23) and eGFR <60 mL/min/1.73 m 2 (OR: 1.25, 95% CI: 1.04–1.49) showed increased risk of hearing loss after adjusting for potential confounders. Conclusions: Kidney function decline is independently associated with hearing loss. Testing for hearing should be included in the integrated management of patients with chronic kidney disease.

Minerals Intake Distributions in a Large Sample of Iranian at-Risk Population Using the National Cancer Institute Method: Do They Meet Their Requirements?

2015 ◽  
Vol 85 (3-4) ◽  
pp. 129-144 ◽  
Author(s):  
Zahra Heidari ◽  
Awat Feizi ◽  
Leila Azadbakht ◽  
Nizal Sarrafzadegan
Keyword(s):  
At Risk ◽  
National Cancer Institute ◽  
Population Based ◽  
Cross Sectional Study ◽  
Normal Function ◽  
Dietary Intakes ◽  
Middle Aged ◽  
Cross Sectional ◽  
Nutritional Interventions ◽  
High Prevalence

Abstract. Background: Minerals are required for the body’s normal function. Aim: The current study assessed the intake distribution of minerals and estimated the prevalence of inadequacy and excess among a representative sample of healthy middle aged and elderly Iranian people. Methods: In this cross-sectional study, the second follow up to the Isfahan Cohort Study (ICS), 1922 generally healthy people aged 40 and older were investigated. Dietary intakes were collected using 24 hour recalls and two or more consecutive food records. Distribution of minerals intake was estimated using traditional (averaging dietary intake days) and National Cancer Institute (NCI) methods, and the results obtained from the two methods, were compared. The prevalence of minerals intake inadequacy or excess was estimated using the estimated average requirement (EAR) cut-point method, the probability approach and the tolerable upper intake levels (UL). Results: There were remarkable differences between values obtained using traditional and NCI methods, particularly in the lower and upper percentiles of the estimated intake distributions. A high prevalence of inadequacy of magnesium (50 - 100 %), calcium (21 - 93 %) and zinc (30 - 55 % for males > 50 years) was observed. Significant gender differences were found regarding inadequate intakes of calcium (21 - 76 % for males vs. 45 - 93 % for females), magnesium (92 % vs. 100 %), iron (0 vs. 15 % for age group 40 - 50 years) and zinc (29 - 55 % vs. 0 %) (all; p < 0.05). Conclusion: Severely imbalanced intakes of magnesium, calcium and zinc were observed among the middle-aged and elderly Iranian population. Nutritional interventions and population-based education to improve healthy diets among the studied population at risk are needed.

Sign in / Sign up

Export Citation Format

Share Document