PATH-43. RAMAN SPECTROSCOPY AS A TOOL IN NEUROSURGERY

2021 ◽  
Vol 23 (Supplement_6) ◽  
pp. vi125-vi125
Author(s):  
Felix Kleine Borgmann ◽  
Gilbert Georg Klamminger ◽  
Laurent Mombaerts ◽  
Karoline Klein ◽  
Finn Jelke ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Tumor Tissue ◽  
Central Nervous System Lymphoma ◽  
Surrounding Tissue ◽  
Sample Analysis ◽  
Tissue Identification ◽  
Important Differential Diagnosis ◽  
Wide Range ◽  
Neuronavigation System ◽  
Non Destructive

Abstract BACKGROUND Raman Spectra have been shown to be sufficiently characteristic to their samples of origin that they can be used in a wide range of applications including distinction of intracranial tumors. While not replacing pathological analysis, the advantage of non-destructive sample analysis and extremely fast feedback make this technique an interesting tool for surgical use. METHODS We sampled intractanial tumors from more than 300 patients at the Centre Hospitalier Luxembourg over a period of three years and compared the spectra of different tumor entities, different tumor subregions and healthy surrounding tissue. We created machine-learning based classifiers that include tissue identification as well as diagnostics. RESULTS To this end, we solved several classes in the intracranial tumor classification, and developed classifiers to distinguish primary central nervous system lymphoma from glioblastoma, which is an important differential diagnosis, as well as meningioma from the surrounding healthy dura mater for identification of tumor tissue. Within glioblastoma, we resolve necrotic, vital tumor tissue and peritumoral infiltration zone.We are currently developing a multi-class classifier incorporating all tissue types measured. CONCLUSIONS Raman Spectroscopy has the potential to aid the surgeon in the surgery theater by providing a quick assessment of the tissue analyzed with regards to both tumor identity and tumor margin identification. Once a reliable classifier based on sufficient patient samples is developed, this may even be integrated into a surgical microscope or a neuronavigation system.

scholarly journals Micro-Raman Spectroscopy Assessment of Chemical Compounds of Mantle Clinopyroxenes

Minerals ◽  
2020 ◽  
Vol 10 (12) ◽  
pp. 1084
Author(s):  
Anastasiya D. Kalugina ◽  
Dmitry A. Zedgenizov
Keyword(s):  
Raman Spectroscopy ◽  
Chemical Composition ◽  
Chemical Compounds ◽  
Peak Position ◽  
Mantle Xenoliths ◽  
Wide Range ◽  
Stretching Vibration ◽  
Raman Modes ◽  
Non Destructive ◽  
Heterovalent Isomorphism

The composition of clinopyroxenes is indicative for chemical and physical properties of mantle substrates. In this study, we present the results of Raman spectroscopy examination of clinopyroxene inclusions in natural diamonds (n = 51) and clinopyroxenes from mantle xenoliths of peridotites and eclogites from kimberlites (n = 28). The chemical composition of studied clinopyroxenes shows wide variations indicating their origin in different mantle lithologies. All clinopyroxenes have intense Raman modes corresponding to metal-oxygen translation (~300–500 cm−1), stretching vibrations of bridging O-Si-Obr (ν11~670 cm−1), and nonbridging atoms O-Si-Onbr (ν16~1000 cm−1). The peak position of the stretching vibration mode (ν11) for the studied clinopyroxenes varies in a wide range (23 cm−1) and generally correlates with their chemical composition and reflects the diopside-jadeite heterovalent isomorphism. These correlations may be used for rough estimation of these compounds using the non-destructive Raman spectroscopy technique.

Archaeological investigations (archaeometry)

2018 ◽  
Vol 3 (9) ◽  
Author(s):  
Anastasia Rousaki ◽  
Luc Moens ◽  
Peter Vandenabeele
Keyword(s):  
Raman Spectroscopy ◽  
Organic Materials ◽  
Research Area ◽  
Fundamental Interest ◽  
Non Invasive ◽  
Wide Range ◽  
Research Questions ◽  
Non Destructive ◽  
Speed Of Analysis ◽  
Straightforward Interpretation

Abstract Archaeometry is the research area on the edge between humanities and natural sciences: it uses and optimises methods from chemistry, spectroscopy, physics, biology, etc. to help answering research questions from humanities. In general, these objects are investigated for several reasons. Besides the fundamental interest to know about the materials that were used in the past, the study of artefacts can support their preservation, either by helping to select optimal storage or display conditions, either by investigating decay pathways and suggesting solutions. Other reasons for art analysis include provenance studies, dating the artefact or identifying forgeries. Since several years, Raman spectroscopy is increasingly applied for the investigation of objects of art or archaeology. The technique is well-appreciated for the limited (or even absent) sample preparation, the relative straightforward interpretation of the spectra (by fingerprinting - comparing them against a database of reference pigments) and its speed of analysis. Moreover, the small spectral footprint – allowing to record a molecular spectrum of particles down to 1 µm, the typical size of pigment grains – is certainly a positive property of the technique. Raman spectroscopy can be considered as rather versatile, as inorganic as well as organic materials can be studied, and as the technique can gather information on crystalline as well as on non-crystalline phases. As a consequence, Raman spectroscopy can be used to study antique objects and twentieth-century synthetic (organic) materials – illustrating the wide range of applications. Finally, the technique is as non-destructive, provided the laser power is kept sufficiently low not to damage the artwork. In literature, the terms “non-invasive” and “non-destructive” are used, where the first term means that no sampling is involved, and the latter term indicates that no sample is taken or that during analysis the sample is not consumed (destroyed) and remains available for further analysis.

scholarly journals Inline cartridge extraction for rapid brain tumor tissue identification by molecular profiling

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Stanislav I. Pekov ◽  
Vasily A. Eliferov ◽  
Anatoly A. Sorokin ◽  
Vsevolod A. Shurkhay ◽  
Evgeny S. Zhvansky ◽  
...  
Keyword(s):  
High Performance ◽  
Metabolic Disorders ◽  
Tumor Tissue ◽  
Diagnostic Techniques ◽  
Screening Rate ◽  
Sample Analysis ◽  
Tissue Samples ◽  
Lipidomic Analysis ◽  
Tissue Identification ◽  
Cancer Pathogenesis

AbstractThe development of perspective diagnostic techniques in medicine requires efficient high-throughput biological sample analysis methods. Here, we present an inline cartridge extraction that facilitates the screening rate of mass spectrometry shotgun lipidomic analysis of tissue samples. We illustrate the method by its application to tumor tissue identification in neurosurgery. In perspective, this high-performance method provides new possibilities for the investigation of cancer pathogenesis and metabolic disorders.

Luminescence from individual dislocations in II-VI and III-V semiconductors

1991 ◽  
Vol 49 ◽  
pp. 834-835
Author(s):  
J W Steeds
Keyword(s):  
Group Iv ◽  
Luminescence Properties ◽  
Carrier Recombination ◽  
Transmission Electron ◽  
Wide Range ◽  
Basic Physics ◽  
Semiconducting Compounds ◽  
Diamond Group ◽  
Non Destructive ◽  
Technological Significance

There is a wide range of experimental results related to dislocations in diamond, group IV, II-VI, III-V semiconducting compounds, but few of these come from isolated, well-characterized individual dislocations. We are here concerned with only those results obtained in a transmission electron microscope so that the dislocations responsible were individually imaged. The luminescence properties of the dislocations were studied by cathodoluminescence performed at low temperatures (~30K) achieved by liquid helium cooling. Both spectra and monochromatic cathodoluminescence images have been obtained, in some cases as a function of temperature.There are two aspects of this work. One is mainly of technological significance. By understanding the luminescence properties of dislocations in epitaxial structures, future non-destructive evaluation will be enhanced. The second aim is to arrive at a good detailed understanding of the basic physics associated with carrier recombination near dislocations as revealed by local luminescence properties.

scholarly journals Raman Spectroscopy Investigation of Graphene Oxide Reduction by Laser Scribing

2021 ◽  
Vol 7 (2) ◽  
pp. 48
Author(s):  
Vittorio Scardaci ◽  
Giuseppe Compagnini
Keyword(s):  
Raman Spectroscopy ◽  
Graphene Oxide ◽  
Reduce Graphene Oxide ◽  
Oxide Reduction ◽  
Material Parameters ◽  
Laser Scribing ◽  
Wide Range ◽  
Scan Speed ◽  
Laser Reduction

Laser scribing has been proposed as a fast and easy tool to reduce graphene oxide (GO) for a wide range of applications. Here, we investigate laser reduction of GO under a range of processing and material parameters, such as laser scan speed, number of laser passes, and material coverage. We use Raman spectroscopy for the characterization of the obtained materials. We demonstrate that laser scan speed is the most influential parameter, as a slower scan speed yields poor GO reduction. The number of laser passes is influential where the material coverage is higher, producing a significant improvement of GO reduction on a second pass. Material coverage is the least influential parameter, as it affects GO reduction only under restricted conditions.

scholarly journals Overview of Popular Techniques of Raman Spectroscopy and Their Potential in the Study of Plant Tissues

Molecules ◽  
2021 ◽  
Vol 26 (6) ◽  
pp. 1537
Author(s):  
Aneta Saletnik ◽  
Bogdan Saletnik ◽  
Czesław Puchalski
Keyword(s):  
Raman Spectroscopy ◽  
Cell Walls ◽  
Structural Changes ◽  
Spatial Information ◽  
Technological Development ◽  
Analytical Techniques ◽  
High Sensitivity ◽  
Plant Tissues ◽  
Wide Range ◽  
Identification Technique

Raman spectroscopy is one of the main analytical techniques used in optical metrology. It is a vibration, marker-free technique that provides insight into the structure and composition of tissues and cells at the molecular level. Raman spectroscopy is an outstanding material identification technique. It provides spatial information of vibrations from complex biological samples which renders it a very accurate tool for the analysis of highly complex plant tissues. Raman spectra can be used as a fingerprint tool for a very wide range of compounds. Raman spectroscopy enables all the polymers that build the cell walls of plants to be tracked simultaneously; it facilitates the analysis of both the molecular composition and the molecular structure of cell walls. Due to its high sensitivity to even minute structural changes, this method is used for comparative tests. The introduction of new and improved Raman techniques by scientists as well as the constant technological development of the apparatus has resulted in an increased importance of Raman spectroscopy in the discovery and defining of tissues and the processes taking place in them.

Optical Diagnostics of Microstructures Fabricated Using Quantum Well Intermixing

1999 ◽  
Vol 607 ◽  
Author(s):  
A. Saher Helmy ◽  
A.C. Bryce ◽  
C.N. Ironside ◽  
J.S. Aitchison ◽  
J.H. Marsh ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Quantum Well ◽  
Spatial Resolution ◽  
Optical Diagnostics ◽  
Complete Suppression ◽  
Quantum Well Intermixing ◽  
Spatially Resolved ◽  
Non Destructive ◽  
Insight Into ◽  
Free Vacancy

AbstractIn this paper we shall discuss techniques for accurate, non-destructive, optical characterisation of structures fabricated using quantum well intermixing (QWI). Spatially resolved photoluminescence and Raman spectroscopy were used to characterise the lateral bandgap profiles produced by impurity free vacancy disordering (IFVD) technology. Different features were used to examine the spatial resolution of the intermixing process. Features include 1:1 gratings as well as isolated stripes. From the measurements, the spatial selectivity of IFVD could be identified, and was found to be ∼4.5 μm, in contrast with the spatial resolution of the process of sputtering induced intermixing, which was found to be ∼2.5 μm. In addition, PL measurements on 1:1 gratings fabricated using IFVD show almost complete suppression of intermixing dielectric cap gratings with periods less than 10 microns. Finally, some insight into the limitations and merits of PL and Raman for the precision characterisation of QWI will be presented.

Cracking and Phase Transformation in Silicon During Nanoindentation

2003 ◽  
Vol 795 ◽  
Author(s):  
Jae-il Jang ◽  
Songqing Wen ◽  
M. J. Lance ◽  
I. M. Anderson ◽  
G. M. Pharr
Keyword(s):  
Raman Spectroscopy ◽  
Phase Transformation ◽  
Single Crystals ◽  
Transformation Behavior ◽  
Amorphous Phases ◽  
Phase Transformation Behavior ◽  
Wide Range ◽  
Load Displacement ◽  
Indenter Geometry

ABSTRACTNanoindentation experiments were performed on single crystals of (100) Si using a series of triangular pyramidal indenters with centerline-to-face angles in the range 35.3° to 85.0°. The influences of the indenter geometry on cracking and phase transformation during indentation were systematically studied. Although reducing the indenter angle reduces the threshold load for cracking and increases the crack lengths, c, at a given indention load, P, the frequently observed relation between P and c3/2 is maintained for all of the indenters over a wide range of load. Features in the nanoindentation load-displacement curves in conjunction with Raman spectroscopy of the crystalline and amorphous phases in and around the contact impression show that the indenter geometry also plays a role in the phase transformation behavior. Results are discussed in relation to prevailing ideas about indentation cracking and phase transformation in silicon.

Development of Deep Learning Algorithms to Discriminate Giant Cell Tumor of Bone from Adjacent Normal Tissues by Confocal Raman Spectroscopy

The Analyst ◽  
2022 ◽  
Author(s):  
Carol PY Lau ◽  
Wenao Ma ◽  
Kwan Yau Law ◽  
Maribel Lacambra ◽  
Kwok Chuen Wong ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Giant Cell Tumor ◽  
Giant Cell ◽  
Chemical Structure ◽  
Cell Tumor ◽  
Confocal Raman Spectroscopy ◽  
Normal Tissues ◽  
Analysis Technique ◽  
Destructive Analysis ◽  
Non Destructive

Raman spectroscopy is a non-destructive analysis technique that provides detailed information about the chemical structure of the tumor. Raman spectra of 52 giant cell tumor of bone (GCTB), and 21...

Control of properties and structure of steel vessels by cooling in various media at the outlet of rolling and pressing lines

2021 ◽  
pp. 34-38
Author(s):  
R. L. Shatalov ◽  
V. A. Medvedev
Keyword(s):  
Mechanical Properties ◽  
Physical And Mechanical Properties ◽  
Metal Structure ◽  
Machine Building ◽  
Regression Equations ◽  
Wide Range ◽  
Industrial Mineral ◽  
Cooling Media ◽  
Technological Limitations ◽  
Non Destructive

When controlling the mechanical properties and structure of vessels made of carbon structural steels manufactured by hot deformation on rolling and pressing lines (PPL) of machine-building enterprises of Russia, such cooling media as water, I20 industrial mineral oil, air are used. The applied cooling media are able to provide the workpieces with a given structure with a wide range of mechanical properties. However, the cooling media have a number of technological limitations and conditions of the use, non-compliance with which leads to reject. When cooled in oil, the probability of ignition is high; when cooled in water, hardening cracks may form, and air is not always able to provide the required rate and uniformity of heat transfer to the environment. The efficiency of control of physical and mechanical properties and structure of deformed vessels made of 50 steel by cooling in TERMAT polymer aqueous solutions in different concentrations on PPL of the plant of JSC NPO Pribor was studied. The effect of varying the concentration from 2 to 9% of TERMAT polymer on the formation of metal structure, as well as physical and mechanical properties of hot-deformed vessels was studied. The results of testing the strength and plastic characteristics of vessels by destructive and non-destructive control methods are presented. According to the results of physical and mechanical properties, regression equations were obtained with at least 95% reliability of R2, which establish the relationship between the controlled plastic and strength parameters of the vessel metal`s properties. The conducted researches allowed to compare the indicators of the main physical and mechanical properties of steel vessels at the PPL outlet and to propose methods of inhomogeneity control that reduce time and material costs by 5–10% during the tests.

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